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The map label for this gene is lrhA [H]

Identifier: 157963747

GI number: 157963747

Start: 4784231

End: 4785118

Strand: Direct

Name: lrhA [H]

Synonym: Spea_3936

Alternate gene names: 157963747

Gene position: 4784231-4785118 (Clockwise)

Preceding gene: 157963745

Following gene: 157963751

Centisome position: 92.46

GC content: 47.3

Gene sequence:

>888_bases
ATGTTAAAAATCGAACTATTAGAAAGCTTCATTGCCGTTGTTGAGTGTGGAAACCTTTCCAAAGCGGCAGATAAGCTCTG
TCGCACCCAGTCGACAATAAGTTTGCAAATCAAGAAGCTAGAAGAAAGTGTGGGTAAACCTTTGCTGTTGCGAGACAACA
AAGGCGTCACTTTGACTGAATCAGGCAAGACGCTACTTAACTACGCCTATAAGATGCTACAGCTCAGTTCTCAAGCAATT
GATGAGCTAAAAGATTGTCAAAATCGTGAAGTGATACGTCTAGGGGTACCGACCGACTACATCAATCGCTATCTTGGCAG
CTTCTTACTAGAGTTTATTCGTGAGTTTACTTGTATCGAATTAGTCATAGATACCGATGTTAGTGGCAACCTCTATAAAC
GGCTGCATAACGGCGAGTTTGATGTGATTGTGGCAACCCACTGGCAAACACCGGCGGCTGGCCACGGCGAGTTACTGTTT
GAGCGCCGCTTTCACTGGGTGGCGGCCAAAGGCGGCAGCGCCCATAAACGTGAAACCGTACCTATGGCGCTTTATCCAGA
GAATTGTCCTATTCGCGCCCAAGTTTTTGCTAACCACCAGATCTCTATGCGTCCAATGAGTGTTTTGCTATCGACGCCAT
CTCCAACCGCCATGTGCATGGCGGTGGAAAATGACTTAGTGATCGCGCCCATCGCCGAATTCCGCATTAACGATAAGATG
CAGATCATCGATCCGATTGAGCATAACATTCCACCACTGCCCACCTTCAACGAATCTCTGTACCTCAACCCAGAGACTCA
AACGGCAGCGACTAACCAGCTAATCAACCTGATCAAGGCCAATGTGCAAGGGCTAGGTGAAGCCAACCAAGCCAATAAGA
TGAGTTAA

Upstream 100 bases:

>100_bases
ACAATCAGTTGAAATTCAGTTCACATTGATAAGGTAGCAGCCTAGGAGCAGAGCGGGTATTGAGTAATACTGATACCACT
ATGAATAAACTCAATAGCCC

Downstream 100 bases:

>100_bases
TTGGATTTGCTAGATTAAGTAAAAGATCCACCTTCTGAAGAGGGTGGCTTTGCCCATCTGTTATAAAGCAGACTCCCTAA
AAGGGAGCTTTCCTACCGTG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MLKIELLESFIAVVECGNLSKAADKLCRTQSTISLQIKKLEESVGKPLLLRDNKGVTLTESGKTLLNYAYKMLQLSSQAI
DELKDCQNREVIRLGVPTDYINRYLGSFLLEFIREFTCIELVIDTDVSGNLYKRLHNGEFDVIVATHWQTPAAGHGELLF
ERRFHWVAAKGGSAHKRETVPMALYPENCPIRAQVFANHQISMRPMSVLLSTPSPTAMCMAVENDLVIAPIAEFRINDKM
QIIDPIEHNIPPLPTFNESLYLNPETQTAATNQLINLIKANVQGLGEANQANKMS

Sequences:

>Translated_295_residues
MLKIELLESFIAVVECGNLSKAADKLCRTQSTISLQIKKLEESVGKPLLLRDNKGVTLTESGKTLLNYAYKMLQLSSQAI
DELKDCQNREVIRLGVPTDYINRYLGSFLLEFIREFTCIELVIDTDVSGNLYKRLHNGEFDVIVATHWQTPAAGHGELLF
ERRFHWVAAKGGSAHKRETVPMALYPENCPIRAQVFANHQISMRPMSVLLSTPSPTAMCMAVENDLVIAPIAEFRINDKM
QIIDPIEHNIPPLPTFNESLYLNPETQTAATNQLINLIKANVQGLGEANQANKMS
>Mature_295_residues
MLKIELLESFIAVVECGNLSKAADKLCRTQSTISLQIKKLEESVGKPLLLRDNKGVTLTESGKTLLNYAYKMLQLSSQAI
DELKDCQNREVIRLGVPTDYINRYLGSFLLEFIREFTCIELVIDTDVSGNLYKRLHNGEFDVIVATHWQTPAAGHGELLF
ERRFHWVAAKGGSAHKRETVPMALYPENCPIRAQVFANHQISMRPMSVLLSTPSPTAMCMAVENDLVIAPIAEFRINDKM
QIIDPIEHNIPPLPTFNESLYLNPETQTAATNQLINLIKANVQGLGEANQANKMS

Specific function: Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788626, Length=296, Percent_Identity=27.7027027027027, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786713, Length=88, Percent_Identity=43.1818181818182, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI157672245, Length=139, Percent_Identity=30.2158273381295, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788887, Length=183, Percent_Identity=30.6010928961749, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790262, Length=146, Percent_Identity=26.7123287671233, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790208, Length=148, Percent_Identity=29.7297297297297, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33011; Mature: 33011

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIELLESFIAVVECGNLSKAADKLCRTQSTISLQIKKLEESVGKPLLLRDNKGVTLTE
CEEHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHEEHHHHHHHHHCCCEEEECCCCEEEEC
SGKTLLNYAYKMLQLSSQAIDELKDCQNREVIRLGVPTDYINRYLGSFLLEFIREFTCIE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCEEEE
LVIDTDVSGNLYKRLHNGEFDVIVATHWQTPAAGHGELLFERRFHWVAAKGGSAHKRETV
EEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCHHHEEEEEEEEEECCCCCCCCCCC
PMALYPENCPIRAQVFANHQISMRPMSVLLSTPSPTAMCMAVENDLVIAPIAEFRINDKM
CEEECCCCCCEEEEEEECCEEEECEEEEEEECCCCCEEEEEECCCEEEEEHHHHEECCCE
QIIDPIEHNIPPLPTFNESLYLNPETQTAATNQLINLIKANVQGLGEANQANKMS
EEECHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLKIELLESFIAVVECGNLSKAADKLCRTQSTISLQIKKLEESVGKPLLLRDNKGVTLTE
CEEHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHEEHHHHHHHHHCCCEEEECCCCEEEEC
SGKTLLNYAYKMLQLSSQAIDELKDCQNREVIRLGVPTDYINRYLGSFLLEFIREFTCIE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCEEEE
LVIDTDVSGNLYKRLHNGEFDVIVATHWQTPAAGHGELLFERRFHWVAAKGGSAHKRETV
EEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCHHHEEEEEEEEEECCCCCCCCCCC
PMALYPENCPIRAQVFANHQISMRPMSVLLSTPSPTAMCMAVENDLVIAPIAEFRINDKM
CEEECCCCCCEEEEEEECCEEEECEEEEEEECCCCCEEEEEECCCEEEEEHHHHEECCCE
QIIDPIEHNIPPLPTFNESLYLNPETQTAATNQLINLIKANVQGLGEANQANKMS
EEECHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]