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The map label for this gene is cpxR [H]

Identifier: 157963744

GI number: 157963744

Start: 4781386

End: 4782069

Strand: Direct

Name: cpxR [H]

Synonym: Spea_3933

Alternate gene names: 157963744

Gene position: 4781386-4782069 (Clockwise)

Preceding gene: 157963741

Following gene: 157963745

Centisome position: 92.4

GC content: 48.39

Gene sequence:

>684_bases
ATGAGCCGTATATTATTGGTAGATGATGACTTAGGTCTATCTGAGTTGCTTGCACAACTGCTGGAACTTGAAGGTTTCAA
ACTGACACTCGCCCATGATGGTCAGTCGGGACTCGATCTTGCTATTGAGCAACAATTCGATCTCATTTTACTCGATGTTA
TGCTGCCAAAGCTCAATGGCTTCGAGGTGTTACGCGCACTTCGCAGTAAAAAGCAGACTCCAGTATTGATGCTCACCGCC
CGCGGTGATGAAATCGATCGCGTTGTCGGCTTAGAGATTGGCGCCGACGATTACCTGCCTAAACCGTTTAACGACAGAGA
ACTCGTGGCGCGTATTCGAGCCATTATCCGCCGCACTCATATACAACCGAGTGAAGCCCCTCAGGCTATACACCAGTATG
GTGACATCCATTTAGATCCCGCTCGTCAGGAAGTGCACTGCCAAGATCAGCTCATCATACTCACAGGAACCGAATTCAGT
CTGCTGTTTGAACTGGTTAAAAATGCCGGCGAGCTCGCGAGTAAAGAGGCCCTAAGCGAAAAGGTGCTAGGCAAAAAATT
AATGCCTTTCGACCGCAGCTTAGACATGCACCTTTCTAACCTGCGTAAGAAGATGCCAGAGCGTGATGATGGCCGCCCTC
GAGTGAAAACTATTCGTGGTAAAGGCTACATTTGGTTACCTTAA

Upstream 100 bases:

>100_bases
CCTGGCTAGTGGGATCTTTACGTTGAATTACACTCCTAAACCGCAATTGACATCAAACAGGGTATACTCACCGCAGTAAA
GGTAGAGTAAAAGGGTAAAT

Downstream 100 bases:

>100_bases
ATGCAGCTAACAAAAACCCCCAACAATATATTCGTCAAGCTACTGCTGGGTTTTTGGCTGTGTAGCTCCTTGATCATAGC
CCTTATCGGCATGCTGCCGT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MSRILLVDDDLGLSELLAQLLELEGFKLTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNGFEVLRALRSKKQTPVLMLTA
RGDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTHIQPSEAPQAIHQYGDIHLDPARQEVHCQDQLIILTGTEFS
LLFELVKNAGELASKEALSEKVLGKKLMPFDRSLDMHLSNLRKKMPERDDGRPRVKTIRGKGYIWLP

Sequences:

>Translated_227_residues
MSRILLVDDDLGLSELLAQLLELEGFKLTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNGFEVLRALRSKKQTPVLMLTA
RGDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTHIQPSEAPQAIHQYGDIHLDPARQEVHCQDQLIILTGTEFS
LLFELVKNAGELASKEALSEKVLGKKLMPFDRSLDMHLSNLRKKMPERDDGRPRVKTIRGKGYIWLP
>Mature_226_residues
SRILLVDDDLGLSELLAQLLELEGFKLTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNGFEVLRALRSKKQTPVLMLTAR
GDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTHIQPSEAPQAIHQYGDIHLDPARQEVHCQDQLIILTGTEFSL
LFELVKNAGELASKEALSEKVLGKKLMPFDRSLDMHLSNLRKKMPERDDGRPRVKTIRGKGYIWLP

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=55.7017543859649, Blast_Score=242, Evalue=1e-65,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=40, Blast_Score=164, Evalue=3e-42,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=40.1785714285714, Blast_Score=145, Evalue=1e-36,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=37.10407239819, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=37.219730941704, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=35.8744394618834, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=36.6071428571429, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=36.1607142857143, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=36.283185840708, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=34.2342342342342, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=29.7872340425532, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1787229, Length=206, Percent_Identity=32.0388349514563, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=30.3571428571429, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790437, Length=190, Percent_Identity=32.1052631578947, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788550, Length=239, Percent_Identity=27.1966527196653, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790299, Length=148, Percent_Identity=31.0810810810811, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25704; Mature: 25573

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRILLVDDDLGLSELLAQLLELEGFKLTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNG
CCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCCEEEHHHCCCCH
FEVLRALRSKKQTPVLMLTARGDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTH
HHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHC
IQPSEAPQAIHQYGDIHLDPARQEVHCQDQLIILTGTEFSLLFELVKNAGELASKEALSE
CCCCHHHHHHHHHCCEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
KVLGKKLMPFDRSLDMHLSNLRKKMPERDDGRPRVKTIRGKGYIWLP
HHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECC
>Mature Secondary Structure 
SRILLVDDDLGLSELLAQLLELEGFKLTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNG
CEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCCEEEHHHCCCCH
FEVLRALRSKKQTPVLMLTARGDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTH
HHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHC
IQPSEAPQAIHQYGDIHLDPARQEVHCQDQLIILTGTEFSLLFELVKNAGELASKEALSE
CCCCHHHHHHHHHCCEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
KVLGKKLMPFDRSLDMHLSNLRKKMPERDDGRPRVKTIRGKGYIWLP
HHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]