Click here to switch to the map view.

The map label for this gene is dapB

Identifier: 157962894

GI number: 157962894

Start: 3774250

End: 3775074

Strand: Reverse

Name: dapB

Synonym: Spea_3076

Alternate gene names: 157962894

Gene position: 3775074-3774250 (Counterclockwise)

Preceding gene: 157962895

Following gene: 157962893

Centisome position: 72.95

GC content: 47.64

Gene sequence:

>825_bases
ATGACTGAACAAGTAAGAGTGGCAATCACCGGCGGCAGTGGCCGTATGGGACGTACTCTTATTGAAGCGGCTAAGCAAAA
TGAGCTTATTTTGTTAGGCGCAGCGATTGAGCGTGCTGGATCGACCCTTATGGGCGTCGATGCGGGCGAACTTGCAGGTG
TTGGTGCAATGAATGTTGCTATCACTGACTCACTCGACAAAGCGGTAGATGATTTTGATGTGCTTATCGACTTTACCTCG
CCAGAAGCTTCTGTAGTTCATACCGATTGGTGTGCAAGAAATGGCAAAGCAATCGTTATCGGTACTACCGGGTTCAATCA
TGCTCAGAAAGAGCAAATTTCAGCCTATGGCGATCAAATACCTATTGTAATGGCCCCTAATATGGCTGTTGGCGTCAATC
TTATGTGGAAACTACTCGAAGTGGCTGCAGAGGTGATGGGTGATTACTGCGATATCGAGATCATAGAAGGTCATCACCGC
TATAAAAAAGATGCACCGTCAGGCACGGCACTAAAGATGGGCGAAGTCATTGCCGAAACCTTGGGACGTGATCTTGAGAA
ATGTGCGGTTTATGGCCGTGAAGGAATTACCGGTGAACGTGACAGAGGAACCATAGGTTTCGCGACTGTGCGTGCTGGCG
ATATCGTAGGTGAACACACAGCGCTATTTGCTGATATTGGTGAGCGTTTAGAGATCACCCATAAGGCATCGAGCCGAATG
ACCTTTGCCAATGGCGCAATGCGTGCGGCAACTTGGTTGGTTGAACAAGATGCAGGGCTTTACGATATGCAACAAGTCTT
AGGCTTGAAAGGTATAACTATTTAA

Upstream 100 bases:

>100_bases
TTTGGTATTCGAAGTTGAATTATTAGATATTATCTAAGTTAGACAATAAGCCTAAGTTAATACTTAGGCTTTTTTTTGAC
ATTTGCAGGGAGAGACTGAG

Downstream 100 bases:

>100_bases
AACCGCTATTAGCGGTTTTTTTTGCTTGAAAATTTTTTTGACAAAATACTAGAATGAACTATAGACGAGTTGATGTTTTA
CATATAAACTCGGCGGAATT

Product: dihydrodipicolinate reductase

Products: NA

Alternate protein names: DHPR

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MTEQVRVAITGGSGRMGRTLIEAAKQNELILLGAAIERAGSTLMGVDAGELAGVGAMNVAITDSLDKAVDDFDVLIDFTS
PEASVVHTDWCARNGKAIVIGTTGFNHAQKEQISAYGDQIPIVMAPNMAVGVNLMWKLLEVAAEVMGDYCDIEIIEGHHR
YKKDAPSGTALKMGEVIAETLGRDLEKCAVYGREGITGERDRGTIGFATVRAGDIVGEHTALFADIGERLEITHKASSRM
TFANGAMRAATWLVEQDAGLYDMQQVLGLKGITI

Sequences:

>Translated_274_residues
MTEQVRVAITGGSGRMGRTLIEAAKQNELILLGAAIERAGSTLMGVDAGELAGVGAMNVAITDSLDKAVDDFDVLIDFTS
PEASVVHTDWCARNGKAIVIGTTGFNHAQKEQISAYGDQIPIVMAPNMAVGVNLMWKLLEVAAEVMGDYCDIEIIEGHHR
YKKDAPSGTALKMGEVIAETLGRDLEKCAVYGREGITGERDRGTIGFATVRAGDIVGEHTALFADIGERLEITHKASSRM
TFANGAMRAATWLVEQDAGLYDMQQVLGLKGITI
>Mature_273_residues
TEQVRVAITGGSGRMGRTLIEAAKQNELILLGAAIERAGSTLMGVDAGELAGVGAMNVAITDSLDKAVDDFDVLIDFTSP
EASVVHTDWCARNGKAIVIGTTGFNHAQKEQISAYGDQIPIVMAPNMAVGVNLMWKLLEVAAEVMGDYCDIEIIEGHHRY
KKDAPSGTALKMGEVIAETLGRDLEKCAVYGREGITGERDRGTIGFATVRAGDIVGEHTALFADIGERLEITHKASSRMT
FANGAMRAATWLVEQDAGLYDMQQVLGLKGITI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; second step. [C]

COG id: COG0289

COG function: function code E; Dihydrodipicolinate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydrodipicolinate reductase family

Homologues:

Organism=Escherichia coli, GI1786214, Length=269, Percent_Identity=64.6840148698885, Blast_Score=338, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPB_SHEPA (A8H756)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001502928.1
- ProteinModelPortal:   A8H756
- SMR:   A8H756
- STRING:   A8H756
- GeneID:   5663466
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_3076
- NMPDR:   fig|398579.3.peg.2661
- eggNOG:   COG0289
- HOGENOM:   HBG594002
- OMA:   GRMGKTL
- ProtClustDB:   PRK00048
- BioCyc:   SPEA398579:SPEA_3076-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00102
- InterPro:   IPR022663
- InterPro:   IPR000846
- InterPro:   IPR022664
- InterPro:   IPR011770
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR20836
- TIGRFAMs:   TIGR00036

Pfam domain/function: PF05173 DapB_C; PF01113 DapB_N

EC number: =1.3.1.26

Molecular weight: Translated: 29227; Mature: 29096

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS01298 DAPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQVRVAITGGSGRMGRTLIEAAKQNELILLGAAIERAGSTLMGVDAGELAGVGAMNVA
CCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEHHHCCCEEEECCCHHHCCCCEEEEE
ITDSLDKAVDDFDVLIDFTSPEASVVHTDWCARNGKAIVIGTTGFNHAQKEQISAYGDQI
EECCHHHHHCCEEEEEEECCCCCEEEECHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCC
PIVMAPNMAVGVNLMWKLLEVAAEVMGDYCDIEIIEGHHRYKKDAPSGTALKMGEVIAET
CEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCHHHHHHHHHHH
LGRDLEKCAVYGREGITGERDRGTIGFATVRAGDIVGEHTALFADIGERLEITHKASSRM
HCCCHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCE
TFANGAMRAATWLVEQDAGLYDMQQVLGLKGITI
EECCCCHHHHEEEEECCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TEQVRVAITGGSGRMGRTLIEAAKQNELILLGAAIERAGSTLMGVDAGELAGVGAMNVA
CCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEHHHCCCEEEECCCHHHCCCCEEEEE
ITDSLDKAVDDFDVLIDFTSPEASVVHTDWCARNGKAIVIGTTGFNHAQKEQISAYGDQI
EECCHHHHHCCEEEEEEECCCCCEEEECHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCC
PIVMAPNMAVGVNLMWKLLEVAAEVMGDYCDIEIIEGHHRYKKDAPSGTALKMGEVIAET
CEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHCCCCCCCCHHHHHHHHHHH
LGRDLEKCAVYGREGITGERDRGTIGFATVRAGDIVGEHTALFADIGERLEITHKASSRM
HCCCHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCE
TFANGAMRAATWLVEQDAGLYDMQQVLGLKGITI
EECCCCHHHHEEEEECCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA