Click here to switch to the map view.

The map label for this gene is fklB [H]

Identifier: 157962895

GI number: 157962895

Start: 3775138

End: 3775755

Strand: Reverse

Name: fklB [H]

Synonym: Spea_3077

Alternate gene names: 157962895

Gene position: 3775755-3775138 (Counterclockwise)

Preceding gene: 157962896

Following gene: 157962894

Centisome position: 72.97

GC content: 45.31

Gene sequence:

>618_bases
ATGTCTGATAAGTTCAGTACAATTGAAGGTCAAGCAAGCTACGGTGTTGGTCGTCAACTAGGTGAGCAACTAGCCGCTAA
CTCGTTTGAAGGTATCGATATTTCTGCTGTTCAATTGGGTCTATCTGACGCTTTCGAAGGTAAAGAAAGTGTTGTATCTA
TGCAAGATATGCAAATTGCATTCACTGAAATCAGCCAGCGTATCCAGAAAGTTCAAGAAGCTGCTGCAGCGGCTGCATCA
GAAGTAGGTGAAAAATTCCTTGCTGATAACGGTGCTCGCGAAGGCGTTGTAACTTTGGACTCAGGTCTACAATACGAAAT
CATTACCGAAGGTAATGGTGACAAGCCAGGTTACGACTCTACAGTACGTACTCACTATCACGGTACTTTCATCTCTGGTG
ATGTATTTGATAGCTCAGTAGCTCGTGGCGAGCCAGCTGAATTCCCAGTTTCTGGCGTTATCGCTGGCTGGACTGAAGCA
CTACAGCTTATGCCTACAGGTTCTAAGTGGAGACTGTTTGTACCACAGCACCTAGCATACGGTGAGCGCGGCGCAGGCGC
TGCGATCCCACCATATTCAACTTTGGTATTCGAAGTTGAATTATTAGATATTATCTAA

Upstream 100 bases:

>100_bases
TGCCAAAGACCAAAATAGCTGCAGTTTTTAGGGCAATATCACAGAAATTATGATAAAGTTCGGCGCGAAAATTCATTGAA
TCATTGAGAGTACAATCATT

Downstream 100 bases:

>100_bases
GTTAGACAATAAGCCTAAGTTAATACTTAGGCTTTTTTTTGACATTTGCAGGGAGAGACTGAGATGACTGAACAAGTAAG
AGTGGCAATCACCGGCGGCA

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSDKFSTIEGQASYGVGRQLGEQLAANSFEGIDISAVQLGLSDAFEGKESVVSMQDMQIAFTEISQRIQKVQEAAAAAAS
EVGEKFLADNGAREGVVTLDSGLQYEIITEGNGDKPGYDSTVRTHYHGTFISGDVFDSSVARGEPAEFPVSGVIAGWTEA
LQLMPTGSKWRLFVPQHLAYGERGAGAAIPPYSTLVFEVELLDII

Sequences:

>Translated_205_residues
MSDKFSTIEGQASYGVGRQLGEQLAANSFEGIDISAVQLGLSDAFEGKESVVSMQDMQIAFTEISQRIQKVQEAAAAAAS
EVGEKFLADNGAREGVVTLDSGLQYEIITEGNGDKPGYDSTVRTHYHGTFISGDVFDSSVARGEPAEFPVSGVIAGWTEA
LQLMPTGSKWRLFVPQHLAYGERGAGAAIPPYSTLVFEVELLDII
>Mature_204_residues
SDKFSTIEGQASYGVGRQLGEQLAANSFEGIDISAVQLGLSDAFEGKESVVSMQDMQIAFTEISQRIQKVQEAAAAAASE
VGEKFLADNGAREGVVTLDSGLQYEIITEGNGDKPGYDSTVRTHYHGTFISGDVFDSSVARGEPAEFPVSGVIAGWTEAL
QLMPTGSKWRLFVPQHLAYGERGAGAAIPPYSTLVFEVELLDII

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=39.622641509434, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=39.622641509434, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI206725530, Length=85, Percent_Identity=45.8823529411765, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI17149844, Length=85, Percent_Identity=45.8823529411765, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI17149842, Length=85, Percent_Identity=45.8823529411765, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI192448443, Length=85, Percent_Identity=40, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082390, Length=204, Percent_Identity=53.921568627451, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1789745, Length=218, Percent_Identity=37.1559633027523, Blast_Score=117, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=41.5094339622642, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17540882, Length=85, Percent_Identity=44.7058823529412, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=101, Percent_Identity=45.5445544554455, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324194, Length=109, Percent_Identity=41.2844036697248, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281363946, Length=96, Percent_Identity=42.7083333333333, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17352457, Length=96, Percent_Identity=42.7083333333333, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=39.622641509434, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=39.622641509434, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24647110, Length=93, Percent_Identity=39.7849462365591, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21886; Mature: 21754

Theoretical pI: Translated: 4.13; Mature: 4.13

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKFSTIEGQASYGVGRQLGEQLAANSFEGIDISAVQLGLSDAFEGKESVVSMQDMQIA
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEHHEEECCHHHCCCHHHHHHHHHHHHH
FTEISQRIQKVQEAAAAAASEVGEKFLADNGAREGVVTLDSGLQYEIITEGNGDKPGYDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCCCCCCCCC
TVRTHYHGTFISGDVFDSSVARGEPAEFPVSGVIAGWTEALQLMPTGSKWRLFVPQHLAY
CEEEEECCEEEECCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHCC
GERGAGAAIPPYSTLVFEVELLDII
CCCCCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure 
SDKFSTIEGQASYGVGRQLGEQLAANSFEGIDISAVQLGLSDAFEGKESVVSMQDMQIA
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEHHEEECCHHHCCCHHHHHHHHHHHHH
FTEISQRIQKVQEAAAAAASEVGEKFLADNGAREGVVTLDSGLQYEIITEGNGDKPGYDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCCCCCCCCC
TVRTHYHGTFISGDVFDSSVARGEPAEFPVSGVIAGWTEALQLMPTGSKWRLFVPQHLAY
CEEEEECCEEEECCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHCC
GERGAGAAIPPYSTLVFEVELLDII
CCCCCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]