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The map label for this gene is uvrB [H]

Identifier: 157962172

GI number: 157962172

Start: 2863253

End: 2865256

Strand: Reverse

Name: uvrB [H]

Synonym: Spea_2351

Alternate gene names: 157962172

Gene position: 2865256-2863253 (Counterclockwise)

Preceding gene: 157962182

Following gene: 157962169

Centisome position: 55.37

GC content: 45.66

Gene sequence:

>2004_bases
GTGTCAGAATCTGTATTTCAATTAGAGTCCATGTACAAGCCTGCAGGCGATCAGCCAACGGCCATCAACAAGCTTGTTGA
GGGACTCGAGTCCGGCGTTGCTTGCCAGACACTATTAGGTGTTACTGGATCAGGTAAGACTTTCACTGTAGCGAATGTTA
TCGCAAAAATGTCACGCCCAACCATTATTATGGCGCCCAATAAGACGCTTGCTGCTCAGCTCTACGGGGAGATGAAAGAG
TTCTTTCCCCATAACGCCGTCGAATATTTCGTTTCTTACTACGACTATTATCAACCTGAAGCGTATGTTCCTTCAACGGG
CACATTTATTGAGAAAGATGCATCGGTGAATGCACACATTGAACAGATGCGCTTATCGGCCACCAAAGCCTTATTAGAGC
GAAAAGATGTGGTGCTGATTGCCTCTGTATCGGCGATTTACGGCCTGGGCGATCCTAAAGCTTATATGAAGATGCTGTTA
CACCTTCGAGAGGGTGGCAATATGGAGCAGCGTGATATCTTAAAGCGCCTCAGTGAGCTGCAATACACCCGTAATGATAT
TGAACTGCAGCGCGGTACTTATCGAGTACGTGGTGAAGTCATCGATATCTTTCCGGCAGATTCGGACAAAAATGCCATTC
GCATCGAGCTGTTTGATGACGAGATAGAGCGCTTAAGCTTATTCGACCCACTTACTGGTCATGTGGTAAAGCGAATCGCT
CGGATCACCGTTTATCCTAAGAGTCATTATGTGACGCCTAGAGAATCAATTTTAGCGGCGACAGAAGATATTAAACAAGA
GCTCAGAGATCGTAAGAAGCAGCTACTTGAACTCAATAAGCTGATAGAAGAGCAGCGCATAACCGAACGTGTGCAGTACG
ATGTTGAGATGATGACTGAACTTGGCTACTGCTCTGGCATCGAAAACTACTCCCGATACCTATCTGGGCGAGCTCCCGGC
GATGGGCCTCCTACCTTGTTAGACTATCTGCCTGATGATGGTCTGCTGATTATTGATGAGTCACATGTCACAGTGCCGCA
AATTGGCGCCATGTATAAAGGTGACCGTTCGAGGAAGATGAACCTTGTTGAGTATGGCTTTCGTCTGCCTTCCGCACTAG
ACAATCGTCCGCTTAAGTTCGAAGAGTTTGAAGCACTTATGCCACAAAGCATCTTTGTTTCAGCGACGCCAAGTGATTAT
GAAATTGATAAGTCTGATGGGGAGATTGCCGAGCAGGTTGTGAGACCGACTGGTCTGCTTGATCCTGAGATTGAAGTGAG
GCCTGTTGGTATTCAAGTTGATGATTTGCTTTCAGAAATTGGCAAGCGAGTCGCAGTGAATGAGCGTGTGTTAGTCACAA
CACTGACTAAACGTATGTCTGAAGATCTCAGCGAGTATCTTGATGAGCACGGTGTTAAAGTCAGATATTTGCATTCAGAT
ATTGATACCGTTGAGCGTGTTGAAATCATTCGTGACTTAAGATTGGGTGTATTCGATGTACTTATCGGTATCAACTTGCT
ACGAGAAGGCTTAGATATGCCTGAGGTATCTTTAGTCTGTATTCTCGATGCCGATAAAGAAGGTTTTTTACGTTCTGAGC
GCTCACTTATTCAGACTATCGGTCGTGCGGCGCGAAACATCAACGGTAAGGTGATCCTTTACGGCGATCGAATCACTAAG
TCGATGGATAAAGCGATAACTGAAACTAATCGTCGTCGTGAAAAACAGCATCAATACAATTTAGATAATGGCATCACACC
TAAAGGTGTGGTTAAGCGCATTACTGATGTTATGGACGTTGGCGATCATCAATATGTCGATAGTGAGCGAGGCGTAGCGG
AGAAAGAAGGGGGTTACCATGTGGCTAAACCTGCAGACATCAGCCATGACATTGATAGGCTTGAAAAGCAGATGCATGAG
CATGCTAAGAACCTAGAGTTTGAAGAAGCTGCAGCTGTTCGCGATCAAGTCAGCCGACTCAGAGAGCAGTTTATAAAGGC
TTAG

Upstream 100 bases:

>100_bases
GCCTTCTTATATATATGTCGATTGATAAATTCACGATTACGCGCCATTTTTAATCGAATTAGGTTAAAATAATCGCTCAT
CTTTCTAGGGAAGTATCTGA

Downstream 100 bases:

>100_bases
TGATAATAAGCTTTTAATTAAAATCATTAATTAAAAAAGGAGAGCCAGTTAAACTTGCTCTCCTTTTTGATTATTAACCA
TGAATCACTTATTTCTGAGG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MSESVFQLESMYKPAGDQPTAINKLVEGLESGVACQTLLGVTGSGKTFTVANVIAKMSRPTIIMAPNKTLAAQLYGEMKE
FFPHNAVEYFVSYYDYYQPEAYVPSTGTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPKAYMKMLL
HLREGGNMEQRDILKRLSELQYTRNDIELQRGTYRVRGEVIDIFPADSDKNAIRIELFDDEIERLSLFDPLTGHVVKRIA
RITVYPKSHYVTPRESILAATEDIKQELRDRKKQLLELNKLIEEQRITERVQYDVEMMTELGYCSGIENYSRYLSGRAPG
DGPPTLLDYLPDDGLLIIDESHVTVPQIGAMYKGDRSRKMNLVEYGFRLPSALDNRPLKFEEFEALMPQSIFVSATPSDY
EIDKSDGEIAEQVVRPTGLLDPEIEVRPVGIQVDDLLSEIGKRVAVNERVLVTTLTKRMSEDLSEYLDEHGVKVRYLHSD
IDTVERVEIIRDLRLGVFDVLIGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNINGKVILYGDRITK
SMDKAITETNRRREKQHQYNLDNGITPKGVVKRITDVMDVGDHQYVDSERGVAEKEGGYHVAKPADISHDIDRLEKQMHE
HAKNLEFEEAAAVRDQVSRLREQFIKA

Sequences:

>Translated_667_residues
MSESVFQLESMYKPAGDQPTAINKLVEGLESGVACQTLLGVTGSGKTFTVANVIAKMSRPTIIMAPNKTLAAQLYGEMKE
FFPHNAVEYFVSYYDYYQPEAYVPSTGTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPKAYMKMLL
HLREGGNMEQRDILKRLSELQYTRNDIELQRGTYRVRGEVIDIFPADSDKNAIRIELFDDEIERLSLFDPLTGHVVKRIA
RITVYPKSHYVTPRESILAATEDIKQELRDRKKQLLELNKLIEEQRITERVQYDVEMMTELGYCSGIENYSRYLSGRAPG
DGPPTLLDYLPDDGLLIIDESHVTVPQIGAMYKGDRSRKMNLVEYGFRLPSALDNRPLKFEEFEALMPQSIFVSATPSDY
EIDKSDGEIAEQVVRPTGLLDPEIEVRPVGIQVDDLLSEIGKRVAVNERVLVTTLTKRMSEDLSEYLDEHGVKVRYLHSD
IDTVERVEIIRDLRLGVFDVLIGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNINGKVILYGDRITK
SMDKAITETNRRREKQHQYNLDNGITPKGVVKRITDVMDVGDHQYVDSERGVAEKEGGYHVAKPADISHDIDRLEKQMHE
HAKNLEFEEAAAVRDQVSRLREQFIKA
>Mature_666_residues
SESVFQLESMYKPAGDQPTAINKLVEGLESGVACQTLLGVTGSGKTFTVANVIAKMSRPTIIMAPNKTLAAQLYGEMKEF
FPHNAVEYFVSYYDYYQPEAYVPSTGTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPKAYMKMLLH
LREGGNMEQRDILKRLSELQYTRNDIELQRGTYRVRGEVIDIFPADSDKNAIRIELFDDEIERLSLFDPLTGHVVKRIAR
ITVYPKSHYVTPRESILAATEDIKQELRDRKKQLLELNKLIEEQRITERVQYDVEMMTELGYCSGIENYSRYLSGRAPGD
GPPTLLDYLPDDGLLIIDESHVTVPQIGAMYKGDRSRKMNLVEYGFRLPSALDNRPLKFEEFEALMPQSIFVSATPSDYE
IDKSDGEIAEQVVRPTGLLDPEIEVRPVGIQVDDLLSEIGKRVAVNERVLVTTLTKRMSEDLSEYLDEHGVKVRYLHSDI
DTVERVEIIRDLRLGVFDVLIGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNINGKVILYGDRITKS
MDKAITETNRRREKQHQYNLDNGITPKGVVKRITDVMDVGDHQYVDSERGVAEKEGGYHVAKPADISHDIDRLEKQMHEH
AKNLEFEEAAAVRDQVSRLREQFIKA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=668, Percent_Identity=71.8562874251497, Blast_Score=979, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=25.4071661237785, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75627; Mature: 75496

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESVFQLESMYKPAGDQPTAINKLVEGLESGVACQTLLGVTGSGKTFTVANVIAKMSRP
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCEEHHHHHHHHCCCC
TIIMAPNKTLAAQLYGEMKEFFPHNAVEYFVSYYDYYQPEAYVPSTGTFIEKDASVNAHI
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHH
EQMRLSATKALLERKDVVLIASVSAIYGLGDPKAYMKMLLHLREGGNMEQRDILKRLSEL
HHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QYTRNDIELQRGTYRVRGEVIDIFPADSDKNAIRIELFDDEIERLSLFDPLTGHVVKRIA
HHHHHHHHHHCCEEEEECEEEEEECCCCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHH
RITVYPKSHYVTPRESILAATEDIKQELRDRKKQLLELNKLIEEQRITERVQYDVEMMTE
HHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGYCSGIENYSRYLSGRAPGDGPPTLLDYLPDDGLLIIDESHVTVPQIGAMYKGDRSRKM
HHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCC
NLVEYGFRLPSALDNRPLKFEEFEALMPQSIFVSATPSDYEIDKSDGEIAEQVVRPTGLL
HHHHHCCCCCHHHCCCCCCHHHHHHHCCCCEEEEECCCCCEECCCCHHHHHHHHCCCCCC
DPEIEVRPVGIQVDDLLSEIGKRVAVNERVLVTTLTKRMSEDLSEYLDEHGVKVRYLHSD
CCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGVFDVLIGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNINGKVILYGDRITKSMDKAITETNRRREKQHQYNLDNGITPKGVVKRITDVMDV
HHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
GDHQYVDSERGVAEKEGGYHVAKPADISHDIDRLEKQMHEHAKNLEFEEAAAVRDQVSRL
CCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
REQFIKA
HHHHHCC
>Mature Secondary Structure 
SESVFQLESMYKPAGDQPTAINKLVEGLESGVACQTLLGVTGSGKTFTVANVIAKMSRP
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCEEHHHHHHHHCCCC
TIIMAPNKTLAAQLYGEMKEFFPHNAVEYFVSYYDYYQPEAYVPSTGTFIEKDASVNAHI
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCHHHH
EQMRLSATKALLERKDVVLIASVSAIYGLGDPKAYMKMLLHLREGGNMEQRDILKRLSEL
HHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QYTRNDIELQRGTYRVRGEVIDIFPADSDKNAIRIELFDDEIERLSLFDPLTGHVVKRIA
HHHHHHHHHHCCEEEEECEEEEEECCCCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHH
RITVYPKSHYVTPRESILAATEDIKQELRDRKKQLLELNKLIEEQRITERVQYDVEMMTE
HHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGYCSGIENYSRYLSGRAPGDGPPTLLDYLPDDGLLIIDESHVTVPQIGAMYKGDRSRKM
HHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCC
NLVEYGFRLPSALDNRPLKFEEFEALMPQSIFVSATPSDYEIDKSDGEIAEQVVRPTGLL
HHHHHCCCCCHHHCCCCCCHHHHHHHCCCCEEEEECCCCCEECCCCHHHHHHHHCCCCCC
DPEIEVRPVGIQVDDLLSEIGKRVAVNERVLVTTLTKRMSEDLSEYLDEHGVKVRYLHSD
CCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGVFDVLIGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNINGKVILYGDRITKSMDKAITETNRRREKQHQYNLDNGITPKGVVKRITDVMDV
HHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
GDHQYVDSERGVAEKEGGYHVAKPADISHDIDRLEKQMHEHAKNLEFEEAAAVRDQVSRL
CCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
REQFIKA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA