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The map label for this gene is catF [H]

Identifier: 157961982

GI number: 157961982

Start: 2615253

End: 2616407

Strand: Direct

Name: catF [H]

Synonym: Spea_2161

Alternate gene names: 157961982

Gene position: 2615253-2616407 (Clockwise)

Preceding gene: 157961981

Following gene: 157961983

Centisome position: 50.54

GC content: 47.36

Gene sequence:

>1155_bases
ATGGCAAATGCTTATATCGTTGATGCGCTTCGCAGCCCAACAGGCCGCCGTAAAGGAGGCTTGTCTCATATACATGCCAT
TGATTTAGCGGCTCATTCTTTAAAGGCATTAGTAGAACGTAATGCTATTCCTGCAGCAGATTATGATGACGTTATTTTTG
GTTGTGTCGATACCATAGGTTCGCAAGCTGGCAATATTGCACGTACTTCATGGCTAGCTGCAGGTTTACCGCTGAATGTA
CCCGGAACCACAGTAGATCGCCAATGCGGCTCGTCACAGCAAGCGATACATTTTGCCGCGCAAGCAGTGATGAGCGGTAC
CCAAGATGTGATAGCAGTGGGTGGTGTGCAGACTATGACACAAATTCCGATATCTTCTGCAATGTTAGCAGGCCAACCTC
TGGGATTTAGCACACCGTTTGCAGAAAGTGAATTGTGGCATAAACGCTTTGGCGATGCGCCGGTGGATCAATTTTATGCG
GCGCAGCGAATTGCAGATAACTGGCAGATTAGCCGCGAAATGATGGAATCATTTTCGCTAGAGAGCCATAACCGCGCATT
AACTGCGATTAAAGAAGGCTATTTTGAGCGAGAAATCGTGCCATTAGCCGGAGTCACTCAAGATGAAACGCCAAGAGTAT
CAAGCCTTGAAAAAATGGCGTCTCTTGAACCTGTAGGCGATGCGTATCCGTCAATTACAGCTGCAGTGTCGAGCCAAACC
TGTGATGCGTCGGCAGCCATGTTAATTGTCTCAGAACAAGCATTAGCTAAATATCAGCTTAAACCACGGGCACGTATTCA
TCATCTAAGTGTACTTGGTGATGATCCCATCTGGCATCTAACTGCACCTATTGCTGCAACAAAAGCCGCATTACAAAAAG
CTGGCATGACTCTAGATGATATTGATCTCGTTGAAATTAATGAAGCATTCGCATCGGTTGCGATGGCGTGGCTTAAAGAA
ACGGGATATAGCCACGATAAGACCAATGTGAATGGTGGCGCAATTGCACTTGGGCATCCTTTAGGCGCGACAGGCGTACG
CTTAATGACTGGTTTGTTACACGAGCTAGAGCGGCGCGGTGGGCGCTTTGGGTTACAAACAATGTGTGAGGGCGGTGGCC
TTGCCAATGTCACCATTATTGAGCGTTTGTCATAA

Upstream 100 bases:

>100_bases
CGACTTGGGGCGATGTGAGCTTTCATAAAGCCAGAGTCAATGAGTTTGTGTTTGACGCAAATAACAAAATTGGTCCAGGC
CAAACCTTTGGGAGAACATA

Downstream 100 bases:

>100_bases
GCGACTTGAGCCAATACAAAAACAATAAAAGTTAGTGCAATTGAGGGAGCATAGAATGAAAGCATGTAATTCGAGAACCG
TAATTATTACCGGCAGTGGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MANAYIVDALRSPTGRRKGGLSHIHAIDLAAHSLKALVERNAIPAADYDDVIFGCVDTIGSQAGNIARTSWLAAGLPLNV
PGTTVDRQCGSSQQAIHFAAQAVMSGTQDVIAVGGVQTMTQIPISSAMLAGQPLGFSTPFAESELWHKRFGDAPVDQFYA
AQRIADNWQISREMMESFSLESHNRALTAIKEGYFEREIVPLAGVTQDETPRVSSLEKMASLEPVGDAYPSITAAVSSQT
CDASAAMLIVSEQALAKYQLKPRARIHHLSVLGDDPIWHLTAPIAATKAALQKAGMTLDDIDLVEINEAFASVAMAWLKE
TGYSHDKTNVNGGAIALGHPLGATGVRLMTGLLHELERRGGRFGLQTMCEGGGLANVTIIERLS

Sequences:

>Translated_384_residues
MANAYIVDALRSPTGRRKGGLSHIHAIDLAAHSLKALVERNAIPAADYDDVIFGCVDTIGSQAGNIARTSWLAAGLPLNV
PGTTVDRQCGSSQQAIHFAAQAVMSGTQDVIAVGGVQTMTQIPISSAMLAGQPLGFSTPFAESELWHKRFGDAPVDQFYA
AQRIADNWQISREMMESFSLESHNRALTAIKEGYFEREIVPLAGVTQDETPRVSSLEKMASLEPVGDAYPSITAAVSSQT
CDASAAMLIVSEQALAKYQLKPRARIHHLSVLGDDPIWHLTAPIAATKAALQKAGMTLDDIDLVEINEAFASVAMAWLKE
TGYSHDKTNVNGGAIALGHPLGATGVRLMTGLLHELERRGGRFGLQTMCEGGGLANVTIIERLS
>Mature_383_residues
ANAYIVDALRSPTGRRKGGLSHIHAIDLAAHSLKALVERNAIPAADYDDVIFGCVDTIGSQAGNIARTSWLAAGLPLNVP
GTTVDRQCGSSQQAIHFAAQAVMSGTQDVIAVGGVQTMTQIPISSAMLAGQPLGFSTPFAESELWHKRFGDAPVDQFYAA
QRIADNWQISREMMESFSLESHNRALTAIKEGYFEREIVPLAGVTQDETPRVSSLEKMASLEPVGDAYPSITAAVSSQTC
DASAAMLIVSEQALAKYQLKPRARIHHLSVLGDDPIWHLTAPIAATKAALQKAGMTLDDIDLVEINEAFASVAMAWLKET
GYSHDKTNVNGGAIALGHPLGATGVRLMTGLLHELERRGGRFGLQTMCEGGGLANVTIIERLS

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=35.7868020304569, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=36.2467866323907, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=30.7106598984772, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=32.4766355140187, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=32.3232323232323, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI194353979, Length=384, Percent_Identity=28.125, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=39.5989974937343, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=38.9578163771712, Blast_Score=250, Evalue=9e-68,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=37.8172588832487, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=37.6237623762376, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1788683, Length=407, Percent_Identity=31.4496314496315, Blast_Score=151, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=394, Percent_Identity=33.248730964467, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=31.3924050632911, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=396, Percent_Identity=31.3131313131313, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=434, Percent_Identity=29.7235023041475, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=390, Percent_Identity=27.9487179487179, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=34.0740740740741, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6322031, Length=389, Percent_Identity=30.8483290488432, Blast_Score=145, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24655093, Length=395, Percent_Identity=35.9493670886076, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=35.0383631713555, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI24640423, Length=400, Percent_Identity=31.75, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17137578, Length=429, Percent_Identity=31.9347319347319, Blast_Score=169, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 40942; Mature: 40811

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANAYIVDALRSPTGRRKGGLSHIHAIDLAAHSLKALVERNAIPAADYDDVIFGCVDTIG
CCCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
SQAGNIARTSWLAAGLPLNVPGTTVDRQCGSSQQAIHFAAQAVMSGTQDVIAVGGVQTMT
HCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
QIPISSAMLAGQPLGFSTPFAESELWHKRFGDAPVDQFYAAQRIADNWQISREMMESFSL
HCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
ESHNRALTAIKEGYFEREIVPLAGVTQDETPRVSSLEKMASLEPVGDAYPSITAAVSSQT
CCCCHHHHHHHHCCHHCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCC
CDASAAMLIVSEQALAKYQLKPRARIHHLSVLGDDPIWHLTAPIAATKAALQKAGMTLDD
CCCCCEEEEEEHHHHHHHCCCCCHHEEEEEEECCCCCEEEECHHHHHHHHHHHCCCCCCC
IDLVEINEAFASVAMAWLKETGYSHDKTNVNGGAIALGHPLGATGVRLMTGLLHELERRG
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCC
GRFGLQTMCEGGGLANVTIIERLS
CCCCHHHHHCCCCEEEEEEEEECC
>Mature Secondary Structure 
ANAYIVDALRSPTGRRKGGLSHIHAIDLAAHSLKALVERNAIPAADYDDVIFGCVDTIG
CCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
SQAGNIARTSWLAAGLPLNVPGTTVDRQCGSSQQAIHFAAQAVMSGTQDVIAVGGVQTMT
HCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
QIPISSAMLAGQPLGFSTPFAESELWHKRFGDAPVDQFYAAQRIADNWQISREMMESFSL
HCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
ESHNRALTAIKEGYFEREIVPLAGVTQDETPRVSSLEKMASLEPVGDAYPSITAAVSSQT
CCCCHHHHHHHHCCHHCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCC
CDASAAMLIVSEQALAKYQLKPRARIHHLSVLGDDPIWHLTAPIAATKAALQKAGMTLDD
CCCCCEEEEEEHHHHHHHCCCCCHHEEEEEEECCCCCEEEECHHHHHHHHHHHCCCCCCC
IDLVEINEAFASVAMAWLKETGYSHDKTNVNGGAIALGHPLGATGVRLMTGLLHELERRG
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCC
GRFGLQTMCEGGGLANVTIIERLS
CCCCHHHHHCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]