BacMap

Definition	Shewanella pealeana ATCC 700345 chromosome, complete genome.
Accession	NC_009901
Length	5,174,581

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The map label for this gene is fabG [C]

Identifier: 157961983

GI number: 157961983

Start: 2616463

End: 2617341

Strand: Direct

Name: fabG [C]

Synonym: Spea_2162

Alternate gene names: 157961983

Gene position: 2616463-2617341 (Clockwise)

Preceding gene: 157961982

Following gene: 157961984

Centisome position: 50.56

GC content: 49.26

Gene sequence:

>879_bases
ATGAAAGCATGTAATTCGAGAACCGTAATTATTACCGGCAGTGGCGGTGGCCTAGGTCGAGCTTATGCGTTAGCGTTGGC
TGCAGAAGGAGCCAATGTAGTAGTTAATGATATTCGCGCCGACGCTGCTGCAGCCGTTGTTGACGAGATCTTGACTCAAG
GTGGGCAAGCTATTGCGAACTCAGATGACATTACTCGCATGGACACCGCAACCAACATTGTCGATGCAGCGTTAGAGGCA
TTTGGTGAGGTACATGTACTGATTAATAATGCCGGTGTTTTGGCTGACAGAATGTTTATTAGCCTTAGCGAAGCAGATTG
GGACAAGGTCATGCAGGTTCACTTAAAGGGCCATTTTTGTTTAGCCAATATTTTGGGGCGTCGTTGGCGTGACCTTGCAA
AGGCCGGTCAACCGGTTGACGCACGGATCATCAATACTAGCTCAGGTGCAGGGCTTCAAGGCTCTATTGGGCAGTCAAAC
TACTCTGCTGCTAAAGGTGGCATTGCATCGTTAACATTAGTTCAAGCAGCTGAACTGGGGCGTTACGGGGTAACAGTAAA
TGCACTCGCGCCCGCAGCCCGCACCTCAATGACCCAAAGTGCCATGCCTGATGTGGTAAAGAAACCAGAAGATGGTAGTT
TTGACCTGTGGGCGCCGGAAAATGTTGCGCCGCTGGTTGTATGGTTAAGCAGTTCTGAATCGAAGCATATCTCAGGACAG
ATCTTGGAAAGCCAAGGTGGACGGATCTCCTTATGTGATGGTTGGCGTACCGGTTTGACGGTAGATCATGGTAAACGATG
GGAAATTAGCGAGGTAGGCTACGCTGTTGACCAACTCATAGGAAAAGCACCTGCAGCACAAAAAGTATGGGGTAGCTAA

Upstream 100 bases:

>100_bases
GGCGGTGGCCTTGCCAATGTCACCATTATTGAGCGTTTGTCATAAGCGACTTGAGCCAATACAAAAACAATAAAAGTTAG
TGCAATTGAGGGAGCATAGA

Downstream 100 bases:

>100_bases
GGATTTTAGCTAAAAGCCTTTAGCTGAATTGAGACAATTGACCACGATAATGGATTAGCACCGAGGACAAATGGCAATGA
ACGATAATATTGATAATAAA

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKACNSRTVIITGSGGGLGRAYALALAAEGANVVVNDIRADAAAAVVDEILTQGGQAIANSDDITRMDTATNIVDAALEA
FGEVHVLINNAGVLADRMFISLSEADWDKVMQVHLKGHFCLANILGRRWRDLAKAGQPVDARIINTSSGAGLQGSIGQSN
YSAAKGGIASLTLVQAAELGRYGVTVNALAPAARTSMTQSAMPDVVKKPEDGSFDLWAPENVAPLVVWLSSSESKHISGQ
ILESQGGRISLCDGWRTGLTVDHGKRWEISEVGYAVDQLIGKAPAAQKVWGS

Sequences:

>Translated_292_residues
MKACNSRTVIITGSGGGLGRAYALALAAEGANVVVNDIRADAAAAVVDEILTQGGQAIANSDDITRMDTATNIVDAALEA
FGEVHVLINNAGVLADRMFISLSEADWDKVMQVHLKGHFCLANILGRRWRDLAKAGQPVDARIINTSSGAGLQGSIGQSN
YSAAKGGIASLTLVQAAELGRYGVTVNALAPAARTSMTQSAMPDVVKKPEDGSFDLWAPENVAPLVVWLSSSESKHISGQ
ILESQGGRISLCDGWRTGLTVDHGKRWEISEVGYAVDQLIGKAPAAQKVWGS
>Mature_292_residues
MKACNSRTVIITGSGGGLGRAYALALAAEGANVVVNDIRADAAAAVVDEILTQGGQAIANSDDITRMDTATNIVDAALEA
FGEVHVLINNAGVLADRMFISLSEADWDKVMQVHLKGHFCLANILGRRWRDLAKAGQPVDARIINTSSGAGLQGSIGQSN
YSAAKGGIASLTLVQAAELGRYGVTVNALAPAARTSMTQSAMPDVVKKPEDGSFDLWAPENVAPLVVWLSSSESKHISGQ
ILESQGGRISLCDGWRTGLTVDHGKRWEISEVGYAVDQLIGKAPAAQKVWGS

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=274, Percent_Identity=40.1459854014599, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI15277342, Length=249, Percent_Identity=34.136546184739, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI19923817, Length=266, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=30.1652892561983, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4758504, Length=217, Percent_Identity=30.4147465437788, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=29.3172690763052, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI83715985, Length=217, Percent_Identity=29.9539170506912, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI31542939, Length=215, Percent_Identity=30.6976744186047, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=25.3968253968254, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=246, Percent_Identity=29.6747967479675, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=27.4193548387097, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=28.6821705426357, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=32.2448979591837, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=29.718875502008, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=30.3643724696356, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789057, Length=263, Percent_Identity=30.7984790874525, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=27.5193798449612, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=30.7086614173228, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787526, Length=251, Percent_Identity=26.2948207171315, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=250, Percent_Identity=38, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=31.1023622047244, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=31.0204081632653, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562910, Length=276, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=270, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=283, Percent_Identity=28.9752650176678, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=197, Percent_Identity=28.4263959390863, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=272, Percent_Identity=26.1029411764706, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=26.3358778625954, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=251, Percent_Identity=26.2948207171315, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=278, Percent_Identity=27.6978417266187, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=25.6505576208178, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=288, Percent_Identity=27.0833333333333, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=199, Percent_Identity=28.1407035175879, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=28.030303030303, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=201, Percent_Identity=29.3532338308458, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=203, Percent_Identity=28.0788177339901, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=217, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=282, Percent_Identity=26.241134751773, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=200, Percent_Identity=28.5, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=268, Percent_Identity=26.1194029850746, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=26.2548262548263, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17555612, Length=223, Percent_Identity=29.1479820627803, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=24.7058823529412, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=272, Percent_Identity=26.1029411764706, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322861, Length=250, Percent_Identity=42, Blast_Score=170, Evalue=2e-43,
Organism=Drosophila melanogaster, GI18859837, Length=270, Percent_Identity=37.7777777777778, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24639444, Length=246, Percent_Identity=29.6747967479675, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28571526, Length=263, Percent_Identity=25.8555133079848, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737361, Length=208, Percent_Identity=28.8461538461538, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=27.1317829457364, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357041, Length=263, Percent_Identity=25.8555133079848, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI23397609, Length=260, Percent_Identity=26.5384615384615, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24649181, Length=159, Percent_Identity=30.8176100628931, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357673, Length=257, Percent_Identity=26.8482490272374, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640492, Length=164, Percent_Identity=26.219512195122, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356301, Length=192, Percent_Identity=29.6875, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30565; Mature: 30565

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKACNSRTVIITGSGGGLGRAYALALAAEGANVVVNDIRADAAAAVVDEILTQGGQAIAN
CCCCCCCEEEEEECCCCCHHHHEEEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCEECC
SDDITRMDTATNIVDAALEAFGEVHVLINNAGVLADRMFISLSEADWDKVMQVHLKGHFC
CCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHEEEEECCCCHHHHHHHHHCCCHH
LANILGRRWRDLAKAGQPVDARIINTSSGAGLQGSIGQSNYSAAKGGIASLTLVQAAELG
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHCC
RYGVTVNALAPAARTSMTQSAMPDVVKKPEDGSFDLWAPENVAPLVVWLSSSESKHISGQ
CCCEEEEHHCCHHHHHHHHHHCHHHHCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCE
ILESQGGRISLCDGWRTGLTVDHGKRWEISEVGYAVDQLIGKAPAAQKVWGS
EEECCCCEEEEECCCCCCEEECCCCCEEHHHHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MKACNSRTVIITGSGGGLGRAYALALAAEGANVVVNDIRADAAAAVVDEILTQGGQAIAN
CCCCCCCEEEEEECCCCCHHHHEEEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCEECC
SDDITRMDTATNIVDAALEAFGEVHVLINNAGVLADRMFISLSEADWDKVMQVHLKGHFC
CCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEHEEEEECCCCHHHHHHHHHCCCHH
LANILGRRWRDLAKAGQPVDARIINTSSGAGLQGSIGQSNYSAAKGGIASLTLVQAAELG
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHCC
RYGVTVNALAPAARTSMTQSAMPDVVKKPEDGSFDLWAPENVAPLVVWLSSSESKHISGQ
CCCEEEEHHCCHHHHHHHHHHCHHHHCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCE
ILESQGGRISLCDGWRTGLTVDHGKRWEISEVGYAVDQLIGKAPAAQKVWGS
EEECCCCEEEEECCCCCCEEECCCCCEEHHHHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]