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The map label for this gene is trpE [H]

Identifier: 157961416

GI number: 157961416

Start: 1928606

End: 1930189

Strand: Reverse

Name: trpE [H]

Synonym: Spea_1590

Alternate gene names: 157961416

Gene position: 1930189-1928606 (Counterclockwise)

Preceding gene: 157961422

Following gene: 157961415

Centisome position: 37.3

GC content: 49.18

Gene sequence:

>1584_bases
ATGACAACCGACACTATCGCTAAAGTCGTCACTCAAAAAGAGGCGTTGGCGTATCATGAAGATCCGCTTAGCTTATACCA
GCATGTGACCCAGAACGCCCCTCACACTATGCTGCTGGAATCTGCTGAAATTGATAGCAAGGACCACTTAAAGAGTATCG
TGCTGACTCACGCAGCCATGCAGATCCGCTGTGACGGTTACCAACTTCAATTTAACGCATTAACAGATAATGGTAAGACT
CTGCTCTCACCAATAAAGTCCTTCTTCGAAAAAGATTTTCCGACCACGGAAATAAACCACTGTGATGAGTCAAGCTTAAG
CCTTACCCTGCAAAAAGAGTCTAACCAACTCGATGAGGATGCGCGTTTAAAGTCAACCTCTCCGCTTGATGGCTTAAGAA
TGTTGGTTAAGCATATCCGCTGCGATGAAAGCCCCGAGTTTGAAGATCTGTTTTTAGGCGGCGTGCTCTCTTATGATTTG
ATTGATACCGTTGAGCCACTGCCAAGCGTGCCTGAAGGTGATAACACCTGCCCTGATTACCTGTTTTATCTCGCCGAAAC
GTTAATCCTAGTGGATCATCAGCAGCAAAGCGCTGAAATCGTCACTCACCAATTTGTTCAGCCAGTCCAAAGCGCTGTCG
ATTGCATTACAAACTCACTCGCTCAGCGTATGACTGAGCTACAGCAAGCTTGCCAGTCATTGGCTCCCATTGCCGAGTTA
CAAGCCGTTGAAGCTGAAACGCAAGTGAATATCTCAGACAGCGACTTTAAAGACACAGTCAATGGCCTTAAAGAGCACAT
CATCGCAGGTGATATTTTCCAGGTAGTGCCATCACGCAGTTTTAGCCTGCCTTGCCCCAATACATTAGGCGCCTACCGCG
CATTAAGACTGACCAACCCAAGCCCTTACATGTTCTACTTTCGCGGCGATGACTTCACCCTGTTTGGCGCCTCACCAGAG
AGCGCGCTCAAGTATGAGGCCGCAAGCAACCAAGTCGAGATCTACCCGATTGCCGGAACGCGAAAGCGCGGCAAAACTGC
CAGCGGTGAAATCGATTTCGATCTCGATAGCCGTAACGAGCTTGAGCTTCGCTTAGACAAGAAAGAGTTGTCCGAACATA
TCATGCTTGTAGACTTGGCTCGTAACGATATCGCCCGCATCAGCCAAAGTGGTACCCGCAAAGTGCCAGAGTTATTAAAA
GTCGATAGATACAGCCATGTTATGCATCTCGTTAGCCGAGTCACTGGCCAGCTTAGAACCGATTTAGATGCACTGCATGC
CTACCAAGCTTGCATGAATATGGGCACTTTAACTGGCGCCCCAAAAGTGAGCGCGGCGCAGCTTATTCGCGGTGCAGAGA
AAACCCGTCGCGGCAGCTACGGTGGCGCTGTCGGCTACTTAAATGGCCTAGGTGACATGGATACCTGCATTGTTATCCGC
TCTGCCTTTGTCAAAGATGGCACAGCCTTTATTCAAGCAGGCGCTGGCGTGGTGTACGACTCAGACCCACAAGCCGAAGC
CGATGAAACGCGCCAAAAGGCACAAGCCGTTATTTCAGCTATAAAAATGGGAGGTGGACTATGA

Upstream 100 bases:

>100_bases
TAAATCGGCAAGAAGAGAGAAAACCCAGAGCAGCAGGCTTAAAGATAAAGTGAGATAAAATAATGAATAATGCGTTACCC
TACAAGGCAGGAGCATAAGC

Downstream 100 bases:

>100_bases
AAATCTATCTACTCGATAACTTCGACTCATTCACCTACAACTTAGTGGATCAGTTTAGAAGCTTAGGCTATGAAGTAGTC
ATTTATCGTAACGACGTCGA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MTTDTIAKVVTQKEALAYHEDPLSLYQHVTQNAPHTMLLESAEIDSKDHLKSIVLTHAAMQIRCDGYQLQFNALTDNGKT
LLSPIKSFFEKDFPTTEINHCDESSLSLTLQKESNQLDEDARLKSTSPLDGLRMLVKHIRCDESPEFEDLFLGGVLSYDL
IDTVEPLPSVPEGDNTCPDYLFYLAETLILVDHQQQSAEIVTHQFVQPVQSAVDCITNSLAQRMTELQQACQSLAPIAEL
QAVEAETQVNISDSDFKDTVNGLKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFRGDDFTLFGASPE
SALKYEAASNQVEIYPIAGTRKRGKTASGEIDFDLDSRNELELRLDKKELSEHIMLVDLARNDIARISQSGTRKVPELLK
VDRYSHVMHLVSRVTGQLRTDLDALHAYQACMNMGTLTGAPKVSAAQLIRGAEKTRRGSYGGAVGYLNGLGDMDTCIVIR
SAFVKDGTAFIQAGAGVVYDSDPQAEADETRQKAQAVISAIKMGGGL

Sequences:

>Translated_527_residues
MTTDTIAKVVTQKEALAYHEDPLSLYQHVTQNAPHTMLLESAEIDSKDHLKSIVLTHAAMQIRCDGYQLQFNALTDNGKT
LLSPIKSFFEKDFPTTEINHCDESSLSLTLQKESNQLDEDARLKSTSPLDGLRMLVKHIRCDESPEFEDLFLGGVLSYDL
IDTVEPLPSVPEGDNTCPDYLFYLAETLILVDHQQQSAEIVTHQFVQPVQSAVDCITNSLAQRMTELQQACQSLAPIAEL
QAVEAETQVNISDSDFKDTVNGLKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFRGDDFTLFGASPE
SALKYEAASNQVEIYPIAGTRKRGKTASGEIDFDLDSRNELELRLDKKELSEHIMLVDLARNDIARISQSGTRKVPELLK
VDRYSHVMHLVSRVTGQLRTDLDALHAYQACMNMGTLTGAPKVSAAQLIRGAEKTRRGSYGGAVGYLNGLGDMDTCIVIR
SAFVKDGTAFIQAGAGVVYDSDPQAEADETRQKAQAVISAIKMGGGL
>Mature_526_residues
TTDTIAKVVTQKEALAYHEDPLSLYQHVTQNAPHTMLLESAEIDSKDHLKSIVLTHAAMQIRCDGYQLQFNALTDNGKTL
LSPIKSFFEKDFPTTEINHCDESSLSLTLQKESNQLDEDARLKSTSPLDGLRMLVKHIRCDESPEFEDLFLGGVLSYDLI
DTVEPLPSVPEGDNTCPDYLFYLAETLILVDHQQQSAEIVTHQFVQPVQSAVDCITNSLAQRMTELQQACQSLAPIAELQ
AVEAETQVNISDSDFKDTVNGLKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFRGDDFTLFGASPES
ALKYEAASNQVEIYPIAGTRKRGKTASGEIDFDLDSRNELELRLDKKELSEHIMLVDLARNDIARISQSGTRKVPELLKV
DRYSHVMHLVSRVTGQLRTDLDALHAYQACMNMGTLTGAPKVSAAQLIRGAEKTRRGSYGGAVGYLNGLGDMDTCIVIRS
AFVKDGTAFIQAGAGVVYDSDPQAEADETRQKAQAVISAIKMGGGL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787518, Length=506, Percent_Identity=53.1620553359684, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1788114, Length=421, Percent_Identity=30.4038004750594, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1786809, Length=228, Percent_Identity=28.5087719298246, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082077, Length=301, Percent_Identity=25.2491694352159, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320935, Length=532, Percent_Identity=33.4586466165414, Blast_Score=222, Evalue=9e-59,
Organism=Saccharomyces cerevisiae, GI6324361, Length=380, Percent_Identity=22.6315789473684, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 58047; Mature: 57916

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDTIAKVVTQKEALAYHEDPLSLYQHVTQNAPHTMLLESAEIDSKDHLKSIVLTHAAM
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
QIRCDGYQLQFNALTDNGKTLLSPIKSFFEKDFPTTEINHCDESSLSLTLQKESNQLDED
EEEECCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCH
ARLKSTSPLDGLRMLVKHIRCDESPEFEDLFLGGVLSYDLIDTVEPLPSVPEGDNTCPDY
HHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LFYLAETLILVDHQQQSAEIVTHQFVQPVQSAVDCITNSLAQRMTELQQACQSLAPIAEL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
QAVEAETQVNISDSDFKDTVNGLKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNP
HHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEECCC
SPYMFYFRGDDFTLFGASPESALKYEAASNQVEIYPIAGTRKRGKTASGEIDFDLDSRNE
CCEEEEEECCCEEEECCCCHHHHEECCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCC
LELRLDKKELSEHIMLVDLARNDIARISQSGTRKVPELLKVDRYSHVMHLVSRVTGQLRT
EEEEECHHHHHCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLDALHAYQACMNMGTLTGAPKVSAAQLIRGAEKTRRGSYGGAVGYLNGLGDMDTCIVIR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHH
SAFVKDGTAFIQAGAGVVYDSDPQAEADETRQKAQAVISAIKMGGGL
HHHHCCCHHHEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTDTIAKVVTQKEALAYHEDPLSLYQHVTQNAPHTMLLESAEIDSKDHLKSIVLTHAAM
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
QIRCDGYQLQFNALTDNGKTLLSPIKSFFEKDFPTTEINHCDESSLSLTLQKESNQLDED
EEEECCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCH
ARLKSTSPLDGLRMLVKHIRCDESPEFEDLFLGGVLSYDLIDTVEPLPSVPEGDNTCPDY
HHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LFYLAETLILVDHQQQSAEIVTHQFVQPVQSAVDCITNSLAQRMTELQQACQSLAPIAEL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
QAVEAETQVNISDSDFKDTVNGLKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNP
HHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEECCC
SPYMFYFRGDDFTLFGASPESALKYEAASNQVEIYPIAGTRKRGKTASGEIDFDLDSRNE
CCEEEEEECCCEEEECCCCHHHHEECCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCC
LELRLDKKELSEHIMLVDLARNDIARISQSGTRKVPELLKVDRYSHVMHLVSRVTGQLRT
EEEEECHHHHHCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLDALHAYQACMNMGTLTGAPKVSAAQLIRGAEKTRRGSYGGAVGYLNGLGDMDTCIVIR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHH
SAFVKDGTAFIQAGAGVVYDSDPQAEADETRQKAQAVISAIKMGGGL
HHHHCCCHHHEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]