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The map label for this gene is lacA [H]

Identifier: 157961336

GI number: 157961336

Start: 1831042

End: 1831602

Strand: Reverse

Name: lacA [H]

Synonym: Spea_1510

Alternate gene names: 157961336

Gene position: 1831602-1831042 (Counterclockwise)

Preceding gene: 157961342

Following gene: 157961327

Centisome position: 35.4

GC content: 40.29

Gene sequence:

>561_bases
ATGTTCAAAAAAACAAGCCTTCGTCGAAAATTGAAAGGCCTTTCCATTAAGTTATTCTGTAAAAGAAAGAAGATTACGAT
TACAGATACGCCTTCATTTAGTGGTGCATGGCCATATATTAGTAATAAAGGTGTAATACGACTTGGCGGACAATGTAGTT
TTCGCTCTTTCCGTTTGCATCAAACCATTACCGTACAAGCAGAGGCAACATTAGAAATTGGTGAAGGCTCATTCTTTAAT
GACGGGGTTAACATCTGTGCATCACAATCTATAAAAATCGGGCGTAACGCCAAAATTGGCGATATGACTTACGTTTTCGA
CACCGACTTTCACCAATTATCTCCAGACCGTGATGTAAAAAAGGCCTCGGTAGTGATTGGCAATAATGTGTGGGTTGGTG
CAAATTCAATGATCCTTGCTGGTTCTTCTATTGGGGATAACTCTGTCATTGCTGCAGGTTCGATAGTTGTTGGAGAAATA
CCACCAAATTGCTTAGCAGCAGGTACCCCAGCAAAAGTGATAAAGTCACTCAATATTCCAGATGGTTGGCTGAGACAATA
A

Upstream 100 bases:

>100_bases
ATACTTGGTCGCGTGCATTAATAATTCCAAATGGGCAAGTAACAGTAAATCATGACTCTATACAAATTGATCTTCTCGTG
CTCATTCTCTGGAACAAAAC

Downstream 100 bases:

>100_bases
AACATTTGGAAATTAAACTCGTAAACACCAACGCTATAGACATTCGTAGCCATGTATTAATATGTTAGTTTCATAGCTGT
CCAAGTAAACTCAGCGGCAC

Product: acetyltransferase

Products: NA

Alternate protein names: GAT; Thiogalactoside acetyltransferase [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MFKKTSLRRKLKGLSIKLFCKRKKITITDTPSFSGAWPYISNKGVIRLGGQCSFRSFRLHQTITVQAEATLEIGEGSFFN
DGVNICASQSIKIGRNAKIGDMTYVFDTDFHQLSPDRDVKKASVVIGNNVWVGANSMILAGSSIGDNSVIAAGSIVVGEI
PPNCLAAGTPAKVIKSLNIPDGWLRQ

Sequences:

>Translated_186_residues
MFKKTSLRRKLKGLSIKLFCKRKKITITDTPSFSGAWPYISNKGVIRLGGQCSFRSFRLHQTITVQAEATLEIGEGSFFN
DGVNICASQSIKIGRNAKIGDMTYVFDTDFHQLSPDRDVKKASVVIGNNVWVGANSMILAGSSIGDNSVIAAGSIVVGEI
PPNCLAAGTPAKVIKSLNIPDGWLRQ
>Mature_186_residues
MFKKTSLRRKLKGLSIKLFCKRKKITITDTPSFSGAWPYISNKGVIRLGGQCSFRSFRLHQTITVQAEATLEIGEGSFFN
DGVNICASQSIKIGRNAKIGDMTYVFDTDFHQLSPDRDVKKASVVIGNNVWVGANSMILAGSSIGDNSVIAAGSIVVGEI
PPNCLAAGTPAKVIKSLNIPDGWLRQ

Specific function: May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell [H]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1786537, Length=113, Percent_Identity=37.1681415929204, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1788345, Length=111, Percent_Identity=36.9369369369369, Blast_Score=73, Evalue=9e-15,
Organism=Escherichia coli, GI1786664, Length=91, Percent_Identity=37.3626373626374, Blast_Score=64, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322243, Length=161, Percent_Identity=31.055900621118, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.18 [H]

Molecular weight: Translated: 20105; Mature: 20105

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKTSLRRKLKGLSIKLFCKRKKITITDTPSFSGAWPYISNKGVIRLGGQCSFRSFRLH
CCCHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCCCCEECCCCEEEECCCCCCEEEEEE
QTITVQAEATLEIGEGSFFNDGVNICASQSIKIGRNAKIGDMTYVFDTDFHQLSPDRDVK
EEEEEEEEEEEEECCCCEECCCCCEEECCCEEECCCCCCCCEEEEEECCHHHCCCCCCCC
KASVVIGNNVWVGANSMILAGSSIGDNSVIAAGSIVVGEIPPNCLAAGTPAKVIKSLNIP
EEEEEECCCEEECCCCEEEEECCCCCCCEEEECCEEEECCCCCCCCCCCHHHHHHHCCCC
DGWLRQ
CHHHCC
>Mature Secondary Structure
MFKKTSLRRKLKGLSIKLFCKRKKITITDTPSFSGAWPYISNKGVIRLGGQCSFRSFRLH
CCCHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCCCCEECCCCEEEECCCCCCEEEEEE
QTITVQAEATLEIGEGSFFNDGVNICASQSIKIGRNAKIGDMTYVFDTDFHQLSPDRDVK
EEEEEEEEEEEEECCCCEECCCCCEEECCCEEECCCCCCCCEEEEEECCHHHCCCCCCCC
KASVVIGNNVWVGANSMILAGSSIGDNSVIAAGSIVVGEIPPNCLAAGTPAKVIKSLNIP
EEEEEECCCEEECCCCEEEEECCCCCCCEEEECCEEEECCCCCCCCCCCHHHHHHHCCCC
DGWLRQ
CHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3922433; 3901000; 9278503; 6444453; 11937062 [H]