Click here to switch to the map view.

The map label for this gene is pepA1 [H]

Identifier: 157960217

GI number: 157960217

Start: 469272

End: 470804

Strand: Reverse

Name: pepA1 [H]

Synonym: Spea_0388

Alternate gene names: 157960217

Gene position: 470804-469272 (Counterclockwise)

Preceding gene: 157960218

Following gene: 157960212

Centisome position: 9.1

GC content: 48.08

Gene sequence:

>1533_bases
ATGCTAACAAAGAAAACCCTACTAAGCAGTGCATTAAGCCTAGGCCTGTTAACCAGCTATTCGGCGCAAGCGGAAACGTT
TGATTTTGTCGAAAATCAATCTAACAACATCGACACTTTAGTGGTCTTTCAAGCTGGCGAAGAAACATCAAGCGCCTTAA
GCAAGTTAGACAAACAATCAAAGCAACAAATTAGCAGTGCATTAGCACTACAAGAGTTTACTGGCGAGAAAAAACAGCTA
GTTGAAATTTTAATGCCTACAGGCATAGACGCTAAACGCCTAGTGGTTATTGGCGTTGGTGATAAAGAAAAGCTAACCCC
TGGTGAAGTGAATAAGCTTGGCGCTGAAATCACCGCTCATTTCAACGGCATTGAAGTAAAGAATATTCAACTGCTAACCG
ATGGCATTAGTGATGCCAGCAGCAACGCTAGCTTTGCTGCAGAGCTTGCACATGGCATCAACCTGCGCGCTTACAAGTTT
GATAAGTACTTTTCAGAGAAAAAGCCCGCTGAGAAGAACTACAGGGTACACGTGAGTGACTCAAAAGCAGCTGACAGGCT
ATACACTCAGCTAGCAGCCATTGAGCAAGGGGTATTTCTCGCCCGTGACTTAACCTCTGAAACACCGACCGAGATGACCC
CAGTCGATTTTGCTAATGCAGCAAAAGAACTGAAAAAACTGGGCGTTAAAATTACCGTGCTTGAGCCAAAGAAAATAGCC
AAGTTAGGCATGGGCGCATTGCACGCAGTTGGCCGTGGCTCCAAAGAAGGCTCTCGCCTTATAGTCGCCCACTGGGAAGG
CAATGATGATGCGCCTATCGCTTTAGTCGGTAAAGGCATTACCTTCGATTCTGGCGGCTACAACATTAAAGCATCTGGCG
ACTCTATCTCACGTATGAAGTCGGATATGGCAGGTGCTGCCGCAGTACTTGGTGCAGTAAAGGCCATGGCACTACAAAAA
GCCGATGTAAACTTAGTGGCTGTAATGCCAATGGCTGCGAACATGGTATCTGAAACCGCACTGGCTCCAGGTGATGTACT
GATGACAGCCGAAGGCTTAAGTGTTGAAGTGCTCAATACCGACGCTGAAGGCCGCCTGATCTTAGCCGATGGCATGTGGT
ATGCCCGCGAATTCTATCAGCCACAAGTCATGGTTGATGTTGCCACGCTAACAGGCTCTAAGGTACGTGCATTAGGTAAA
CGCTACACGGCAGTGTTTAGTGAAGACGACACTTTAGTCGATGAGCTGACCTTCTCTGGTCAAGCCGTGGATGAAAAGCT
ATGGCGCTTACCGCTTGCCTATGAAGATTTGCTTAAAAGCCCAATTGCCGATTTGAAAAACGCAGGCTTCGGTGGCCCTG
GGGCGACAACAGCCGCCGTTTTCCTACAGCAGTTCACTGGCGACACTAAGTGGGCGCACCTTGATATTGCAGGCAGTGCT
CTTGCAGCTAAAGATGTAGGCGTTACCCCAGCTGGCGGTACAGGCCATGGCGTACGTTTGCTAAGCCACTGGATCATGAC
GCAAAGCAAATAA

Upstream 100 bases:

>100_bases
ACAGTGCGGCTAAAAAACAATAACGACATATACAACAAAAAGAAGCTGCGACATGTTTGGCAAAACCTGATCGCAGAACT
AAATCCCGATAGAGGACAGT

Downstream 100 bases:

>100_bases
GCTTTTAGCGCTAAATCTAAGGCTCTGCTCCAGAATTAGCTTTAGACTTAGATTCTGCTTTTATAAAATAGAAAAAGCCC
TGCAAATGCAGGGCTTTTGT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase 1; LAP 1; Leucyl aminopeptidase 1 [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MLTKKTLLSSALSLGLLTSYSAQAETFDFVENQSNNIDTLVVFQAGEETSSALSKLDKQSKQQISSALALQEFTGEKKQL
VEILMPTGIDAKRLVVIGVGDKEKLTPGEVNKLGAEITAHFNGIEVKNIQLLTDGISDASSNASFAAELAHGINLRAYKF
DKYFSEKKPAEKNYRVHVSDSKAADRLYTQLAAIEQGVFLARDLTSETPTEMTPVDFANAAKELKKLGVKITVLEPKKIA
KLGMGALHAVGRGSKEGSRLIVAHWEGNDDAPIALVGKGITFDSGGYNIKASGDSISRMKSDMAGAAAVLGAVKAMALQK
ADVNLVAVMPMAANMVSETALAPGDVLMTAEGLSVEVLNTDAEGRLILADGMWYAREFYQPQVMVDVATLTGSKVRALGK
RYTAVFSEDDTLVDELTFSGQAVDEKLWRLPLAYEDLLKSPIADLKNAGFGGPGATTAAVFLQQFTGDTKWAHLDIAGSA
LAAKDVGVTPAGGTGHGVRLLSHWIMTQSK

Sequences:

>Translated_510_residues
MLTKKTLLSSALSLGLLTSYSAQAETFDFVENQSNNIDTLVVFQAGEETSSALSKLDKQSKQQISSALALQEFTGEKKQL
VEILMPTGIDAKRLVVIGVGDKEKLTPGEVNKLGAEITAHFNGIEVKNIQLLTDGISDASSNASFAAELAHGINLRAYKF
DKYFSEKKPAEKNYRVHVSDSKAADRLYTQLAAIEQGVFLARDLTSETPTEMTPVDFANAAKELKKLGVKITVLEPKKIA
KLGMGALHAVGRGSKEGSRLIVAHWEGNDDAPIALVGKGITFDSGGYNIKASGDSISRMKSDMAGAAAVLGAVKAMALQK
ADVNLVAVMPMAANMVSETALAPGDVLMTAEGLSVEVLNTDAEGRLILADGMWYAREFYQPQVMVDVATLTGSKVRALGK
RYTAVFSEDDTLVDELTFSGQAVDEKLWRLPLAYEDLLKSPIADLKNAGFGGPGATTAAVFLQQFTGDTKWAHLDIAGSA
LAAKDVGVTPAGGTGHGVRLLSHWIMTQSK
>Mature_510_residues
MLTKKTLLSSALSLGLLTSYSAQAETFDFVENQSNNIDTLVVFQAGEETSSALSKLDKQSKQQISSALALQEFTGEKKQL
VEILMPTGIDAKRLVVIGVGDKEKLTPGEVNKLGAEITAHFNGIEVKNIQLLTDGISDASSNASFAAELAHGINLRAYKF
DKYFSEKKPAEKNYRVHVSDSKAADRLYTQLAAIEQGVFLARDLTSETPTEMTPVDFANAAKELKKLGVKITVLEPKKIA
KLGMGALHAVGRGSKEGSRLIVAHWEGNDDAPIALVGKGITFDSGGYNIKASGDSISRMKSDMAGAAAVLGAVKAMALQK
ADVNLVAVMPMAANMVSETALAPGDVLMTAEGLSVEVLNTDAEGRLILADGMWYAREFYQPQVMVDVATLTGSKVRALGK
RYTAVFSEDDTLVDELTFSGQAVDEKLWRLPLAYEDLLKSPIADLKNAGFGGPGATTAAVFLQQFTGDTKWAHLDIAGSA
LAAKDVGVTPAGGTGHGVRLLSHWIMTQSK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=383, Percent_Identity=36.5535248041775, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI47155554, Length=323, Percent_Identity=33.7461300309598, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1790710, Length=494, Percent_Identity=32.7935222672065, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI87082123, Length=316, Percent_Identity=38.6075949367089, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=286, Percent_Identity=37.4125874125874, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=241, Percent_Identity=28.6307053941909, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24662227, Length=507, Percent_Identity=25.6410256410256, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21355645, Length=451, Percent_Identity=27.0509977827051, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24662223, Length=451, Percent_Identity=27.0509977827051, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI20129969, Length=407, Percent_Identity=28.2555282555283, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21355725, Length=283, Percent_Identity=31.4487632508834, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24661038, Length=283, Percent_Identity=30.7420494699647, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI161077148, Length=288, Percent_Identity=30.5555555555556, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI20130057, Length=288, Percent_Identity=30.5555555555556, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI20129963, Length=449, Percent_Identity=27.1714922048998, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI221379063, Length=288, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI221379062, Length=288, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI21357381, Length=288, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI19922386, Length=297, Percent_Identity=29.6296296296296, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24646701, Length=239, Percent_Identity=32.2175732217573, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646703, Length=239, Percent_Identity=32.2175732217573, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21358201, Length=239, Percent_Identity=32.2175732217573, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54331; Mature: 54331

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKKTLLSSALSLGLLTSYSAQAETFDFVENQSNNIDTLVVFQAGEETSSALSKLDKQS
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHH
KQQISSALALQEFTGEKKQLVEILMPTGIDAKRLVVIGVGDKEKLTPGEVNKLGAEITAH
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHCCEEEEE
FNGIEVKNIQLLTDGISDASSNASFAAELAHGINLRAYKFDKYFSEKKPAEKNYRVHVSD
ECCEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCEEEECC
SKAADRLYTQLAAIEQGVFLARDLTSETPTEMTPVDFANAAKELKKLGVKITVLEPKKIA
CHHHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCHHHH
KLGMGALHAVGRGSKEGSRLIVAHWEGNDDAPIALVGKGITFDSGGYNIKASGDSISRMK
HHCCHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCEEECCCCCEEEECCCHHHHHH
SDMAGAAAVLGAVKAMALQKADVNLVAVMPMAANMVSETALAPGDVLMTAEGLSVEVLNT
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCEEEEECCCEEEEEEC
DAEGRLILADGMWYAREFYQPQVMVDVATLTGSKVRALGKRYTAVFSEDDTLVDELTFSG
CCCCCEEEECCCHHHHHHCCCEEEEEEEECCCHHHHHHHHHHEEEECCCCHHHHHHCCCC
QAVDEKLWRLPLAYEDLLKSPIADLKNAGFGGPGATTAAVFLQQFTGDTKWAHLDIAGSA
CHHHHHHHHCCCHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCC
LAAKDVGVTPAGGTGHGVRLLSHWIMTQSK
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTKKTLLSSALSLGLLTSYSAQAETFDFVENQSNNIDTLVVFQAGEETSSALSKLDKQS
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHH
KQQISSALALQEFTGEKKQLVEILMPTGIDAKRLVVIGVGDKEKLTPGEVNKLGAEITAH
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHCCEEEEE
FNGIEVKNIQLLTDGISDASSNASFAAELAHGINLRAYKFDKYFSEKKPAEKNYRVHVSD
ECCEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCEEEECC
SKAADRLYTQLAAIEQGVFLARDLTSETPTEMTPVDFANAAKELKKLGVKITVLEPKKIA
CHHHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCHHHH
KLGMGALHAVGRGSKEGSRLIVAHWEGNDDAPIALVGKGITFDSGGYNIKASGDSISRMK
HHCCHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEECCEEECCCCCEEEECCCHHHHHH
SDMAGAAAVLGAVKAMALQKADVNLVAVMPMAANMVSETALAPGDVLMTAEGLSVEVLNT
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCEEEEECCCEEEEEEC
DAEGRLILADGMWYAREFYQPQVMVDVATLTGSKVRALGKRYTAVFSEDDTLVDELTFSG
CCCCCEEEECCCHHHHHHCCCEEEEEEEECCCHHHHHHHHHHEEEECCCCHHHHHHCCCC
QAVDEKLWRLPLAYEDLLKSPIADLKNAGFGGPGATTAAVFLQQFTGDTKWAHLDIAGSA
CHHHHHHHHCCCHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCC
LAAKDVGVTPAGGTGHGVRLLSHWIMTQSK
HHHCCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]