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The map label for this gene is pdhA [H]

Identifier: 157825476

GI number: 157825476

Start: 353506

End: 354486

Strand: Direct

Name: pdhA [H]

Synonym: A1C_01885

Alternate gene names: 157825476

Gene position: 353506-354486 (Clockwise)

Preceding gene: 157825475

Following gene: 157825477

Centisome position: 28.72

GC content: 39.04

Gene sequence:

>981_bases
GTGGATATTAAGTTAGGAAAATATAAGCCGATCAAAGAGGAATATTTAAGAGCTTTTAAGGAAGTACTATTAGTGCGTCG
TTTTGAAGAAAAATGCGGGCAGCTATACGGAGTGGGAGAAATAGGCGGTTTTTGTCATTTATATATAGGTCAGGAAGCAG
GGATTGTTGCTGTAAATATGGTCAGGCAAAAAGGTGATAGTATGATTACTAGCTATCGTGACCATGCTCATATTATTTTA
GCCGGAACTGAGCCTAAAGACGTTCTTGCCGAGCTTATGGGGCGCGCTACAGGCTGCTCAAAAGGCAAGGGCGGTTCGAT
GCATTTATTTGACGTACCGCGCAAATTCTACGGTGGACATGGTATAGTGGGAGCTCAAGTACCTATAGGCACAGGGCTTG
CTTTTGCAGAGAAATATAACGGTACGAATAATATCTGTTTTACTTTTTTAGGTGACGGTGCGGTTAATCAAGGTCAGGTA
TATGAAGCTTTGAATATGGCTGCTTTATGGGGTTTACCTGTAGTTTATATTATTGAAAATAACGAATATTCGATGGGAAC
ATCTGTAGCACGTTCTACCTTTATGTGTGATTTATATAAAAAAGGGGAATCGTTTGGGATTAAAGGATGTCAGTTAGACG
GTATGGATTTTGAAGAAATGTATAACGGCTTTAAGCAAGCAGCCGAGTATGTTAGGGAAAATAGCTTCCCGTTGATATTA
GAGGTAAAAACTTATCGTTATCGTGGGCATTCGATGTCTGACCCGGCAAAATATCGCAGTAAAGAAGAAGTTGAGAAATA
TAAAGAGCGTGACCCATTAGTAATAATAAGAAAAACGATACTTGACAATAAATATGCAACCGAAGCGGATTTAAAAGAGA
TAGAACAGTCAGTTAAGGAAATTGTGAAAGAAGCAGTAGAGTTTTCAGAAAATTCACCGTTGCCTGATGAGTCGGAGTTG
TATACAAATGTATACGTTTAG

Upstream 100 bases:

>100_bases
TGGATGTCATTCCCGTGGAGGCGGGCATCCAAAAACAGATGTCATCCAGTGGCTCTTGACCACTGGATGAAAATATACTA
TAGGAGTATAGGAGTAATGA

Downstream 100 bases:

>100_bases
TATTTTCTATGTCATTCCTGCAAAAGCAGGAATGACATAGATATCCACGCAACAATACCATAGGCACTATGTGAATGACA
CAAACTTTAATCAAATAAAA

Product: pyruvate dehydrogenase e1 component, alpha subunit precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MDIKLGKYKPIKEEYLRAFKEVLLVRRFEEKCGQLYGVGEIGGFCHLYIGQEAGIVAVNMVRQKGDSMITSYRDHAHIIL
AGTEPKDVLAELMGRATGCSKGKGGSMHLFDVPRKFYGGHGIVGAQVPIGTGLAFAEKYNGTNNICFTFLGDGAVNQGQV
YEALNMAALWGLPVVYIIENNEYSMGTSVARSTFMCDLYKKGESFGIKGCQLDGMDFEEMYNGFKQAAEYVRENSFPLIL
EVKTYRYRGHSMSDPAKYRSKEEVEKYKERDPLVIIRKTILDNKYATEADLKEIEQSVKEIVKEAVEFSENSPLPDESEL
YTNVYV

Sequences:

>Translated_326_residues
MDIKLGKYKPIKEEYLRAFKEVLLVRRFEEKCGQLYGVGEIGGFCHLYIGQEAGIVAVNMVRQKGDSMITSYRDHAHIIL
AGTEPKDVLAELMGRATGCSKGKGGSMHLFDVPRKFYGGHGIVGAQVPIGTGLAFAEKYNGTNNICFTFLGDGAVNQGQV
YEALNMAALWGLPVVYIIENNEYSMGTSVARSTFMCDLYKKGESFGIKGCQLDGMDFEEMYNGFKQAAEYVRENSFPLIL
EVKTYRYRGHSMSDPAKYRSKEEVEKYKERDPLVIIRKTILDNKYATEADLKEIEQSVKEIVKEAVEFSENSPLPDESEL
YTNVYV
>Mature_326_residues
MDIKLGKYKPIKEEYLRAFKEVLLVRRFEEKCGQLYGVGEIGGFCHLYIGQEAGIVAVNMVRQKGDSMITSYRDHAHIIL
AGTEPKDVLAELMGRATGCSKGKGGSMHLFDVPRKFYGGHGIVGAQVPIGTGLAFAEKYNGTNNICFTFLGDGAVNQGQV
YEALNMAALWGLPVVYIIENNEYSMGTSVARSTFMCDLYKKGESFGIKGCQLDGMDFEEMYNGFKQAAEYVRENSFPLIL
EVKTYRYRGHSMSDPAKYRSKEEVEKYKERDPLVIIRKTILDNKYATEADLKEIEQSVKEIVKEAVEFSENSPLPDESEL
YTNVYV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=316, Percent_Identity=46.5189873417722, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI4505685, Length=316, Percent_Identity=44.620253164557, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI291084742, Length=316, Percent_Identity=44.620253164557, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI291084744, Length=323, Percent_Identity=43.6532507739938, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI291084757, Length=316, Percent_Identity=38.9240506329114, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI258645172, Length=317, Percent_Identity=26.1829652996845, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI11386135, Length=317, Percent_Identity=25.8675078864353, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32564172, Length=317, Percent_Identity=44.1640378548896, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17536047, Length=317, Percent_Identity=44.1640378548896, Blast_Score=272, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI86563357, Length=286, Percent_Identity=26.9230769230769, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI86563355, Length=286, Percent_Identity=26.9230769230769, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=323, Percent_Identity=46.1300309597523, Blast_Score=285, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24639740, Length=319, Percent_Identity=42.6332288401254, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24639744, Length=319, Percent_Identity=42.6332288401254, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI28571106, Length=319, Percent_Identity=42.6332288401254, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24639746, Length=303, Percent_Identity=43.8943894389439, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24639748, Length=328, Percent_Identity=41.1585365853659, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI21355903, Length=314, Percent_Identity=23.5668789808917, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36623; Mature: 36623

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKLGKYKPIKEEYLRAFKEVLLVRRFEEKCGQLYGVGEIGGFCHLYIGQEAGIVAVNM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCCCEEEHHH
VRQKGDSMITSYRDHAHIILAGTEPKDVLAELMGRATGCSKGKGGSMHLFDVPRKFYGGH
HHHCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHCCCC
GIVGAQVPIGTGLAFAEKYNGTNNICFTFLGDGAVNQGQVYEALNMAALWGLPVVYIIEN
CEEECCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEC
NEYSMGTSVARSTFMCDLYKKGESFGIKGCQLDGMDFEEMYNGFKQAAEYVRENSFPLIL
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEE
EVKTYRYRGHSMSDPAKYRSKEEVEKYKERDPLVIIRKTILDNKYATEADLKEIEQSVKE
EEEEEEECCCCCCCHHHHCCHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHH
IVKEAVEFSENSPLPDESELYTNVYV
HHHHHHHHCCCCCCCCCHHHHEEECC
>Mature Secondary Structure
MDIKLGKYKPIKEEYLRAFKEVLLVRRFEEKCGQLYGVGEIGGFCHLYIGQEAGIVAVNM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCCCEEEHHH
VRQKGDSMITSYRDHAHIILAGTEPKDVLAELMGRATGCSKGKGGSMHLFDVPRKFYGGH
HHHCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHCCCC
GIVGAQVPIGTGLAFAEKYNGTNNICFTFLGDGAVNQGQVYEALNMAALWGLPVVYIIEN
CEEECCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEC
NEYSMGTSVARSTFMCDLYKKGESFGIKGCQLDGMDFEEMYNGFKQAAEYVRENSFPLIL
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEE
EVKTYRYRGHSMSDPAKYRSKEEVEKYKERDPLVIIRKTILDNKYATEADLKEIEQSVKE
EEEEEEECCCCCCCHHHHCCHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHH
IVKEAVEFSENSPLPDESELYTNVYV
HHHHHHHHCCCCCCCCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA