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The map label for this gene is cpxR [H]

Identifier: 157373042

GI number: 157373042

Start: 5329042

End: 5329740

Strand: Direct

Name: cpxR [H]

Synonym: Spro_4810

Alternate gene names: 157373042

Gene position: 5329042-5329740 (Clockwise)

Preceding gene: 157373037

Following gene: 157373043

Centisome position: 97.8

GC content: 53.79

Gene sequence:

>699_bases
ATGAACAAAATTCTGTTAGTTGACGACGACCGCGAGCTGACCTCGCTGTTAAAAGAACTTCTTGAAATGGAAGGTTTTAC
TATCGTCGTGGCCTACGATGGTGAACAGGCGTTGTCGCTTCTGGACAGCTCCATTGATCTGCTGTTGCTCGATATCATGA
TGCCGAAGAAAAACGGTATCGATACGTTAAAAGAGCTGCGTCAGCACCACCAGACGCCGGTCATTATGCTGACCGCTCGC
GGCAGCGAACTGGACCGGGTACTGGGTCTGGAACTGGGTGCCGATGACTACTTGCCAAAGCCTTTTAACGATCGCGAACT
GGTTGCGCGTATTCGTGCGATTCTGCGCCGCTCCAACTGGAGCGAGCAGCAGCAAAATGTCGATACCGGCGCACCCACGC
TGGACGTTGACGGTTTGCAGCTCAATCCGGGCCGCCAGGAAGCCAGTTTCGACGGCCAAACGCTGGATCTTACCGGCACC
GAATTTACCCTGTTGTACCTGCTGGCACAGCATCTCGGCCAGGTAGTCTCTCGTGAACTGCTGAGCCAGGAAGTGCTGGG
CAAACGTCTGACGCCGTTTGATCGCGCCATCGATATGCACATCTCTAACTTACGACGTAAACTGCCTAACCGCAAAGACG
GCCACCCGTGGTTCAAAACCTTGCGTGGACGGGGTTACTTAATGGTATCTGCAACATGA

Upstream 100 bases:

>100_bases
CTGCTGCACCTGCAAACATGCGTCAGTGCATGTAAAACTACGTAAAGTCATGGAATGCCAACAGTTGATGACGTATTTTG
CGTCAGGAGGAAAAAATACA

Downstream 100 bases:

>100_bases
TCAACAGTTTGACGGCACGTATCTTCGCCATTTTTTGGTTCACATTGGCCCTGGTGCTGATGCTGGTGTTGATGGTGCCC
AAGCTCGACTCCCGCCAAAT

Product: DNA-binding transcriptional regulator CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNKILLVDDDRELTSLLKELLEMEGFTIVVAYDGEQALSLLDSSIDLLLLDIMMPKKNGIDTLKELRQHHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSNWSEQQQNVDTGAPTLDVDGLQLNPGRQEASFDGQTLDLTGT
EFTLLYLLAQHLGQVVSRELLSQEVLGKRLTPFDRAIDMHISNLRRKLPNRKDGHPWFKTLRGRGYLMVSAT

Sequences:

>Translated_232_residues
MNKILLVDDDRELTSLLKELLEMEGFTIVVAYDGEQALSLLDSSIDLLLLDIMMPKKNGIDTLKELRQHHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSNWSEQQQNVDTGAPTLDVDGLQLNPGRQEASFDGQTLDLTGT
EFTLLYLLAQHLGQVVSRELLSQEVLGKRLTPFDRAIDMHISNLRRKLPNRKDGHPWFKTLRGRGYLMVSAT
>Mature_232_residues
MNKILLVDDDRELTSLLKELLEMEGFTIVVAYDGEQALSLLDSSIDLLLLDIMMPKKNGIDTLKELRQHHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSNWSEQQQNVDTGAPTLDVDGLQLNPGRQEASFDGQTLDLTGT
EFTLLYLLAQHLGQVVSRELLSQEVLGKRLTPFDRAIDMHISNLRRKLPNRKDGHPWFKTLRGRGYLMVSAT

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=91.3793103448276, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=40.4255319148936, Blast_Score=157, Evalue=5e-40,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=38.6666666666667, Blast_Score=153, Evalue=8e-39,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=39.3013100436681, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=33.6244541484716, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI87082012, Length=231, Percent_Identity=37.6623376623377, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=37.117903930131, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1790552, Length=232, Percent_Identity=37.5, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=35.5263157894737, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=35.3711790393013, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=32.034632034632, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=32.1739130434783, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=28.9473684210526, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790299, Length=141, Percent_Identity=41.8439716312057, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=41.2844036697248, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1787487, Length=112, Percent_Identity=39.2857142857143, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790437, Length=102, Percent_Identity=39.2156862745098, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26287; Mature: 26287

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILLVDDDRELTSLLKELLEMEGFTIVVAYDGEQALSLLDSSIDLLLLDIMMPKKNGI
CCCEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCH
DTLKELRQHHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSNW
HHHHHHHHHCCCCEEEEEECCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
SEQQQNVDTGAPTLDVDGLQLNPGRQEASFDGQTLDLTGTEFTLLYLLAQHLGQVVSREL
CHHHHCCCCCCCEECCCCEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPNRKDGHPWFKTLRGRGYLMVSAT
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEEEC
>Mature Secondary Structure
MNKILLVDDDRELTSLLKELLEMEGFTIVVAYDGEQALSLLDSSIDLLLLDIMMPKKNGI
CCCEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCH
DTLKELRQHHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSNW
HHHHHHHHHCCCCEEEEEECCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
SEQQQNVDTGAPTLDVDGLQLNPGRQEASFDGQTLDLTGTEFTLLYLLAQHLGQVVSREL
CHHHHCCCCCCCEECCCCEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPNRKDGHPWFKTLRGRGYLMVSAT
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]