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The map label for this gene is cpxA [H]

Identifier: 157373043

GI number: 157373043

Start: 5329737

End: 5331110

Strand: Direct

Name: cpxA [H]

Synonym: Spro_4811

Alternate gene names: 157373043

Gene position: 5329737-5331110 (Clockwise)

Preceding gene: 157373042

Following gene: 157373044

Centisome position: 97.81

GC content: 58.81

Gene sequence:

>1374_bases
ATGATCAACAGTTTGACGGCACGTATCTTCGCCATTTTTTGGTTCACATTGGCCCTGGTGCTGATGCTGGTGTTGATGGT
GCCCAAGCTCGACTCCCGCCAAATGACCTCGCTGCTCGACAGCGAGCAGCGGCAGGGGCTGATGCTGGAACAACATGTCG
AGGCCGAGTTGCAAAACGATCCGGCCAACGACCTGATGTGGTGGCGGCGTTTATTCCGCGCCATTGAAAAATGGGCCCCG
CCAGGGCAGCGCCTGATCCTGGTCACCAGCGAAGGCCGGGTGATTGGCAACATGCAACGCAACGAAATGCAGTTGGTGCG
TAATTTTATCGGCCAATCTGATAATTCCGACCATCCGAAGAAGAAAAAATACGGCCGCGTCGAACTGGTCGGCCCCTTCT
CCGTACGCGATGGTGAAGACAACTACCAGTTGTACTTAATTCGTCCGGCCAACAGCCCACAATCCGACTTCATCAACCTG
ATGTTCGACCGGCCGCTGCTGCTGCTGATCGTCACCATGTTGATCAGCGCCCCATTGCTGCTATGGCTGGCCTGGAGCCT
GGCGAAACCGGCACGCAAGCTGAAAAACGCGGCCGATGACGTTGCCCGTGGCAATCTGAAACAGCATCCGGAGCTGGAAG
CCGGGCCGCAAGAGTTTCTGGCGACCGGCGCCAGTTTCAACCAAATGGTCAGTTCGCTGGAACGCATGATGACCGCTCAG
CAACGGCTGATCTCCGACATCTCGCATGAGCTGCGCACCCCGCTAACCCGTCTGCAGCTGGCTACCGCGTTAATGCGTCG
TCGCCACGGCGAAGGGCGTGAGCTGGAGCGCATCGAAACCGAGGCGCAGCGTCTGGATTCGATGATCAACGATCTGTTGG
TGCTGTCACGCGGACAGCAGAAAAGCGAGTTGGTCCGTGAGCGGCTGCTGGCCAATGAACTCTGGGCCAATGTACTCGAT
GACGCCGGCTTTGAAGCCGAGCAAATGGGCAAGCATTTGGAAGTCACCGCTCCTCCCGGTCCATGGACGTTGTTCGGCAA
CGCCGGCGCGTTGGACAGCGCACTGGAAAACATTGTGCGTAACGCACTGCGCTATTCGAACACCAGGATCGCCGTGGCGT
TCAGCGCGGACAACCAGGGCATTACCATTGTGGTCGACGATGACGGCCCTGGCGTCAGTACGGAAGATCGCGAGCAAATT
TTCCGACCGTTTTATCGCACCGACGAAGCACGCGATCGCGCCTCCGGCGGCACCGGCTTGGGCCTGGCGATCGTAGAGGC
GGCAGTCAACCAGCATCGCGGCTGGGTGAAAGCGGAAGACAGTCCGCTCGGTGGCCTGCGGTTAGTCCTGTGGTTACCGT
TGCATCAGCGCTGA

Upstream 100 bases:

>100_bases
TGCACATCTCTAACTTACGACGTAAACTGCCTAACCGCAAAGACGGCCACCCGTGGTTCAAAACCTTGCGTGGACGGGGT
TACTTAATGGTATCTGCAAC

Downstream 100 bases:

>100_bases
TCGCCTAAGACAGGTCGGTAAGATTTTGCTATTCTGCGCCCCTCGTCATGAGGGGCTTTTTACATGTTGAACATTGTTTT
ATTCGAACCCGAAATTCCAC

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MINSLTARIFAIFWFTLALVLMLVLMVPKLDSRQMTSLLDSEQRQGLMLEQHVEAELQNDPANDLMWWRRLFRAIEKWAP
PGQRLILVTSEGRVIGNMQRNEMQLVRNFIGQSDNSDHPKKKKYGRVELVGPFSVRDGEDNYQLYLIRPANSPQSDFINL
MFDRPLLLLIVTMLISAPLLLWLAWSLAKPARKLKNAADDVARGNLKQHPELEAGPQEFLATGASFNQMVSSLERMMTAQ
QRLISDISHELRTPLTRLQLATALMRRRHGEGRELERIETEAQRLDSMINDLLVLSRGQQKSELVRERLLANELWANVLD
DAGFEAEQMGKHLEVTAPPGPWTLFGNAGALDSALENIVRNALRYSNTRIAVAFSADNQGITIVVDDDGPGVSTEDREQI
FRPFYRTDEARDRASGGTGLGLAIVEAAVNQHRGWVKAEDSPLGGLRLVLWLPLHQR

Sequences:

>Translated_457_residues
MINSLTARIFAIFWFTLALVLMLVLMVPKLDSRQMTSLLDSEQRQGLMLEQHVEAELQNDPANDLMWWRRLFRAIEKWAP
PGQRLILVTSEGRVIGNMQRNEMQLVRNFIGQSDNSDHPKKKKYGRVELVGPFSVRDGEDNYQLYLIRPANSPQSDFINL
MFDRPLLLLIVTMLISAPLLLWLAWSLAKPARKLKNAADDVARGNLKQHPELEAGPQEFLATGASFNQMVSSLERMMTAQ
QRLISDISHELRTPLTRLQLATALMRRRHGEGRELERIETEAQRLDSMINDLLVLSRGQQKSELVRERLLANELWANVLD
DAGFEAEQMGKHLEVTAPPGPWTLFGNAGALDSALENIVRNALRYSNTRIAVAFSADNQGITIVVDDDGPGVSTEDREQI
FRPFYRTDEARDRASGGTGLGLAIVEAAVNQHRGWVKAEDSPLGGLRLVLWLPLHQR
>Mature_457_residues
MINSLTARIFAIFWFTLALVLMLVLMVPKLDSRQMTSLLDSEQRQGLMLEQHVEAELQNDPANDLMWWRRLFRAIEKWAP
PGQRLILVTSEGRVIGNMQRNEMQLVRNFIGQSDNSDHPKKKKYGRVELVGPFSVRDGEDNYQLYLIRPANSPQSDFINL
MFDRPLLLLIVTMLISAPLLLWLAWSLAKPARKLKNAADDVARGNLKQHPELEAGPQEFLATGASFNQMVSSLERMMTAQ
QRLISDISHELRTPLTRLQLATALMRRRHGEGRELERIETEAQRLDSMINDLLVLSRGQQKSELVRERLLANELWANVLD
DAGFEAEQMGKHLEVTAPPGPWTLFGNAGALDSALENIVRNALRYSNTRIAVAFSADNQGITIVVDDDGPGVSTEDREQI
FRPFYRTDEARDRASGGTGLGLAIVEAAVNQHRGWVKAEDSPLGGLRLVLWLPLHQR

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=457, Percent_Identity=83.3698030634573, Blast_Score=720, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=322, Percent_Identity=31.3664596273292, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789808, Length=267, Percent_Identity=32.5842696629214, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786783, Length=335, Percent_Identity=27.4626865671642, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=29.6028880866426, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=30, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=25.4166666666667, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788279, Length=276, Percent_Identity=24.6376811594203, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787374, Length=293, Percent_Identity=25.2559726962457, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=277, Percent_Identity=26.3537906137184, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=28, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=377, Percent_Identity=26.2599469496021, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=28.2786885245902, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789403, Length=239, Percent_Identity=29.2887029288703, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082128, Length=273, Percent_Identity=22.3443223443223, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790861, Length=298, Percent_Identity=24.8322147651007, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788549, Length=238, Percent_Identity=27.3109243697479, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51653; Mature: 51653

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSLTARIFAIFWFTLALVLMLVLMVPKLDSRQMTSLLDSEQRQGLMLEQHVEAELQND
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
PANDLMWWRRLFRAIEKWAPPGQRLILVTSEGRVIGNMQRNEMQLVRNFIGQSDNSDHPK
CCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCHHHHHHHHHHHHCCCCCCCCCC
KKKYGRVELVGPFSVRDGEDNYQLYLIRPANSPQSDFINLMFDRPLLLLIVTMLISAPLL
HHHCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
LWLAWSLAKPARKLKNAADDVARGNLKQHPELEAGPQEFLATGASFNQMVSSLERMMTAQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
QRLISDISHELRTPLTRLQLATALMRRRHGEGRELERIETEAQRLDSMINDLLVLSRGQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
KSELVRERLLANELWANVLDDAGFEAEQMGKHLEVTAPPGPWTLFGNAGALDSALENIVR
HHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEECCCCCEEEECCCCHHHHHHHHHHH
NALRYSNTRIAVAFSADNQGITIVVDDDGPGVSTEDREQIFRPFYRTDEARDRASGGTGL
HHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCH
GLAIVEAAVNQHRGWVKAEDSPLGGLRLVLWLPLHQR
HHHHHHHHHHHCCCCEECCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MINSLTARIFAIFWFTLALVLMLVLMVPKLDSRQMTSLLDSEQRQGLMLEQHVEAELQND
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
PANDLMWWRRLFRAIEKWAPPGQRLILVTSEGRVIGNMQRNEMQLVRNFIGQSDNSDHPK
CCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCHHHHHHHHHHHHCCCCCCCCCC
KKKYGRVELVGPFSVRDGEDNYQLYLIRPANSPQSDFINLMFDRPLLLLIVTMLISAPLL
HHHCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
LWLAWSLAKPARKLKNAADDVARGNLKQHPELEAGPQEFLATGASFNQMVSSLERMMTAQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
QRLISDISHELRTPLTRLQLATALMRRRHGEGRELERIETEAQRLDSMINDLLVLSRGQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
KSELVRERLLANELWANVLDDAGFEAEQMGKHLEVTAPPGPWTLFGNAGALDSALENIVR
HHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEEECCCCCEEEECCCCHHHHHHHHHHH
NALRYSNTRIAVAFSADNQGITIVVDDDGPGVSTEDREQIFRPFYRTDEARDRASGGTGL
HHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCH
GLAIVEAAVNQHRGWVKAEDSPLGGLRLVLWLPLHQR
HHHHHHHHHHHCCCCEECCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]