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The map label for this gene is xseA

Identifier: 157371832

GI number: 157371832

Start: 3974264

End: 3975640

Strand: Direct

Name: xseA

Synonym: Spro_3597

Alternate gene names: 157371832

Gene position: 3974264-3975640 (Clockwise)

Preceding gene: 157371827

Following gene: 157371835

Centisome position: 72.94

GC content: 59.62

Gene sequence:

>1377_bases
ATGTCGCTACCTGTTTCGCCGTCTATTTTTACCGTAAGCCGCCTGAATCAGACGGTTCGACAGCTGCTGGAAATGGAAAT
GGGCCAGATTTGGCTCTCCGCCGAGATTTCCAACTTCTCTCAACCCTCTTCCGGCCACTGGTATTTCACGCTGAAAGACG
ATCGTGCGCAGGTGCGTTGCGCGATGTTCCGCAACACTAACCGCCGCACCACTTTCCGTCCGCAGAATGGCCAACAGGTA
CTGGTTCGCGCCAGCATTACGCTGTATGAACCGCGCGGCGACTACCAACTGATTGCCGAAAGCATGCAGCCTGCCGGTGA
CGGCCTGTTGCAACAGCAGTTCGACCAGTTGAAACAGCGCCTGAGCGCCGAAGGCCTGTTCGACCAACAGTTCAAGCAAC
CCTTGCCCAGCCCGGCCAAACGCGTCGGGGTCATTACCTCCGCCAGCGGTGCGGCGCTGCACGATGTGCTGCAGGTGCTG
CAACGGCGTGATCCTTCACTGCCTATCATTATTTACCCTACTTCGGTGCAGGGCGCAGAAGCGCCATTGCAGATTGTGCG
TGCCATCGAAACGGCTAACCGCCGCGACGAGTGTGACGTGCTAATCGTCGGCCGTGGTGGCGGTTCGCTGGAAGATCTGT
GGAGTTTTAATGACGAACGCGTGGCGCGGGCAATTTTCGCCAGCCGCATTCCGATCGTCAGTGCCGTCGGCCATGAAACC
GACGTCACCATTGCCGATTTTGTCGCCGACCTGCGTGCGCCAACCCCTTCAGCCGCCGCCGAACTGGTCAGCCGCAATCA
GCTGGAGCTGCTGCGCCAGTTGCAGTCCCAGCAGCAGCGGATGGAAATGGCGATGGATTACTACCTGGCACAGCGCCAGC
AACAGTTCACCCGCATCAACCACCGTTTGCAGCAACAGCATCCGCACCTGCGCCTGGCGCGTCAGCAGACGCTGTTGTTC
AAACTGCAGCGTCGGTTGGAAGATGGCATGCAGAACCAACTGCGCTTGTCTTCACGCCGCAGCGAGCGGGCGCAACAGCG
CTTGGCGCAGATGCAGCCACAGGCACGCATTCATCGCTATCAGCAACGCGTGCAGCAGCAGGAATACCGTTTACAGCAGG
CGCTGGAGCGGCAGCTCAACGCCTGGCGTCAGCGCTTTGGTGTGGCCTGCAGCCAGCTTGAGGCGGTCAGTCCGCTGGCA
ACGCTGGCGCGTGGCTACAGCGTGACGCAAACGCCACGCGGCGAACTGCTGAAAACCACCAAACAGGCACAGGTGGGTGA
ATTGCTGAAAACCCGTCTGCAGGATGGCTGGGTGGAAAGCGAGGTGAAAACCATCACCCTGGCCAAAAAACCGCGCAAAA
AGCGCGCGGCTGAATAA

Upstream 100 bases:

>100_bases
GGTTGCCTCCAGTACTTTCGCACAAAAACTCTTGATTACCTTTTTCAGCCATGTAGTATCGACCAATTAAGTGCTTGTTT
TGAAATTTGATCTGGGTCAC

Downstream 100 bases:

>100_bases
TTCCGCTTATTCCAGCGTAAAACTGTTGCCGGGCGCGCCGTTGATCCACAACTCGCGCGCTTCTCCGGCAGGCAAGCTGA
AGGTGATGGTTCGCCATGCC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSLPVSPSIFTVSRLNQTVRQLLEMEMGQIWLSAEISNFSQPSSGHWYFTLKDDRAQVRCAMFRNTNRRTTFRPQNGQQV
LVRASITLYEPRGDYQLIAESMQPAGDGLLQQQFDQLKQRLSAEGLFDQQFKQPLPSPAKRVGVITSASGAALHDVLQVL
QRRDPSLPIIIYPTSVQGAEAPLQIVRAIETANRRDECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPIVSAVGHET
DVTIADFVADLRAPTPSAAAELVSRNQLELLRQLQSQQQRMEMAMDYYLAQRQQQFTRINHRLQQQHPHLRLARQQTLLF
KLQRRLEDGMQNQLRLSSRRSERAQQRLAQMQPQARIHRYQQRVQQQEYRLQQALERQLNAWRQRFGVACSQLEAVSPLA
TLARGYSVTQTPRGELLKTTKQAQVGELLKTRLQDGWVESEVKTITLAKKPRKKRAAE

Sequences:

>Translated_458_residues
MSLPVSPSIFTVSRLNQTVRQLLEMEMGQIWLSAEISNFSQPSSGHWYFTLKDDRAQVRCAMFRNTNRRTTFRPQNGQQV
LVRASITLYEPRGDYQLIAESMQPAGDGLLQQQFDQLKQRLSAEGLFDQQFKQPLPSPAKRVGVITSASGAALHDVLQVL
QRRDPSLPIIIYPTSVQGAEAPLQIVRAIETANRRDECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPIVSAVGHET
DVTIADFVADLRAPTPSAAAELVSRNQLELLRQLQSQQQRMEMAMDYYLAQRQQQFTRINHRLQQQHPHLRLARQQTLLF
KLQRRLEDGMQNQLRLSSRRSERAQQRLAQMQPQARIHRYQQRVQQQEYRLQQALERQLNAWRQRFGVACSQLEAVSPLA
TLARGYSVTQTPRGELLKTTKQAQVGELLKTRLQDGWVESEVKTITLAKKPRKKRAAE
>Mature_457_residues
SLPVSPSIFTVSRLNQTVRQLLEMEMGQIWLSAEISNFSQPSSGHWYFTLKDDRAQVRCAMFRNTNRRTTFRPQNGQQVL
VRASITLYEPRGDYQLIAESMQPAGDGLLQQQFDQLKQRLSAEGLFDQQFKQPLPSPAKRVGVITSASGAALHDVLQVLQ
RRDPSLPIIIYPTSVQGAEAPLQIVRAIETANRRDECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPIVSAVGHETD
VTIADFVADLRAPTPSAAAELVSRNQLELLRQLQSQQQRMEMAMDYYLAQRQQQFTRINHRLQQQHPHLRLARQQTLLFK
LQRRLEDGMQNQLRLSSRRSERAQQRLAQMQPQARIHRYQQRVQQQEYRLQQALERQLNAWRQRFGVACSQLEAVSPLAT
LARGYSVTQTPRGELLKTTKQAQVGELLKTRLQDGWVESEVKTITLAKKPRKKRAAE

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=449, Percent_Identity=73.9420935412027, Blast_Score=687, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_SERP5 (A8GHV3)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001479821.1
- STRING:   A8GHV3
- GeneID:   5605785
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3597
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   ANERREC
- ProtClustDB:   PRK00286
- BioCyc:   SPRO399741:SPRO_3597-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 52382; Mature: 52250

Theoretical pI: Translated: 10.80; Mature: 10.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPVSPSIFTVSRLNQTVRQLLEMEMGQIWLSAEISNFSQPSSGHWYFTLKDDRAQVRC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCCCCCEEEEEEECCHHHHHH
AMFRNTNRRTTFRPQNGQQVLVRASITLYEPRGDYQLIAESMQPAGDGLLQQQFDQLKQR
HHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
LSAEGLFDQQFKQPLPSPAKRVGVITSASGAALHDVLQVLQRRDPSLPIIIYPTSVQGAE
HHHCCCHHHHHHCCCCCHHHHHEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
APLQIVRAIETANRRDECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPIVSAVGHET
HHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHCCCCC
DVTIADFVADLRAPTPSAAAELVSRNQLELLRQLQSQQQRMEMAMDYYLAQRQQQFTRIN
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLQQQHPHLRLARQQTLLFKLQRRLEDGMQNQLRLSSRRSERAQQRLAQMQPQARIHRY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QQRVQQQEYRLQQALERQLNAWRQRFGVACSQLEAVSPLATLARGYSVTQTPRGELLKTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
KQAQVGELLKTRLQDGWVESEVKTITLAKKPRKKRAAE
HHHHHHHHHHHHHHCCCHHHHHHEEEECCCCCCCCCCC
>Mature Secondary Structure 
SLPVSPSIFTVSRLNQTVRQLLEMEMGQIWLSAEISNFSQPSSGHWYFTLKDDRAQVRC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCCCCCEEEEEEECCHHHHHH
AMFRNTNRRTTFRPQNGQQVLVRASITLYEPRGDYQLIAESMQPAGDGLLQQQFDQLKQR
HHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
LSAEGLFDQQFKQPLPSPAKRVGVITSASGAALHDVLQVLQRRDPSLPIIIYPTSVQGAE
HHHCCCHHHHHHCCCCCHHHHHEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
APLQIVRAIETANRRDECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPIVSAVGHET
HHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHCCCCC
DVTIADFVADLRAPTPSAAAELVSRNQLELLRQLQSQQQRMEMAMDYYLAQRQQQFTRIN
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLQQQHPHLRLARQQTLLFKLQRRLEDGMQNQLRLSSRRSERAQQRLAQMQPQARIHRY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QQRVQQQEYRLQQALERQLNAWRQRFGVACSQLEAVSPLATLARGYSVTQTPRGELLKTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
KQAQVGELLKTRLQDGWVESEVKTITLAKKPRKKRAAE
HHHHHHHHHHHHHHCCCHHHHHHEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA