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The map label for this gene is tyrP [H]

Identifier: 157371513

GI number: 157371513

Start: 3618404

End: 3619612

Strand: Direct

Name: tyrP [H]

Synonym: Spro_3276

Alternate gene names: 157371513

Gene position: 3618404-3619612 (Clockwise)

Preceding gene: 157371510

Following gene: 157371515

Centisome position: 66.41

GC content: 57.9

Gene sequence:

>1209_bases
GTGAAGAATCGCACGCTTGGCAGTGTTTTTATCGTGGCAGGAACCACCATTGGCGCAGGGATGTTGGCGATGCCACTGGC
GGCGGCCGGTGTCGGCTTTGGCGTCACGCTGGGTCTGTTGGTCGGACTGTGGCTGTTGATGTGTTATACCGCGCTGCTGC
TGGTCGAGGTTTATCAGCATGAACAGGCGGATACCGGCCTCGGGACTCTGGCAAAACGCTATCTTGGCGGCGGCGGCCAA
TGGCTGACCAGTTTCAGCATGATGTTCCTGATGTATGCCCTGACCGCGGCCTATATCAGCGGTGCCGGCGAATTACTGGC
GGCCAGCATCAGTCAATGGACCTCGCAGGATTTCCCCACCACGCTCGGCGTGCTGCTGTTTACTCTGGTGGCCGGCGGCG
TCGTCTGCATCGGCACCCATTCGGTCGATCTGTTTAACCGTATCCTGTTCAGCGCCAAAGTGGTGTTCCTGATTGTCATG
CTGGGTCTGATGTTGCCCAATATCCATCAAACCAACCTGATGACCCTACCGCTGGAGCAAGGGCTGGCGCTGTCGGCCAT
TCCGGTGATTTTCACTTCGTTCGGCTTCCACGGCAGCGTGCCCAGCATTGTTAACTACATGGGCGGCAATATCCGTAAAC
TGCGCTGGGTGTTCATTATCGGCAGCGCCATTCCACTGGTGGCCTATATTTTCTGGCAGTTGGCGACGCTAGGCAGCATC
AGCTCCACCACTTTCGTCGGCATTCTGGCACAGCAAGCCGGTCTGAACGGCCTGTTGCAGGCGGTACGAGACGTCGTGGC
GTCTCCCCATGTCGAACTGGCGGTACACCTGTTTGCCGATCTGGCGCTGGCAACCTCGTTCCTTGGTGTCGCACTCGGGC
TGTTTGATTTCCTGGCCGATCTGTTTAAACGCCAGGACAACGTGCGGGGTCGTCTGCAGACCGGTGCCATCACTTTCTTG
CCGCCGTTGGCTTTCGCTCTGTTCTATCCGCGAGGCTTTGTGTTGGCTCTGGGTTTTGCCGCCATTGCGCTGGCGGTGCT
GGCGCTGTTGCTGCCATCATTATTGGTGTGGAAAACACGTCAGCAGCATCAGGCAAAATACCGCGTTTGGGGCGGCACAC
CGGCACTGGCACTGGTGTTTGTTTGCGGAATAACGGTGATTGCCATTCAGTTGGGCATTGCCAGCGGCATTCTGCCGGCA
GTTGGGTAA

Upstream 100 bases:

>100_bases
CGTAACGCCTGTTTGACACAAAATAATCCATCAACTATCCTGCCGCACTTAGAATGAGTTACCTATAATTTTCCAAAATC
TTTGGCTGGTAGAGAAAAAC

Downstream 100 bases:

>100_bases
TAGATTGAACGATAAAACAAAGGGGCCGCTTGGCCCCTTTGTTATTTGCATCAGAAACTCAGACCAACACCAATATACGG
GCCATCGGCCAGGGTGTTGT

Product: aromatic amino acid transporter

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFGVTLGLLVGLWLLMCYTALLLVEVYQHEQADTGLGTLAKRYLGGGGQ
WLTSFSMMFLMYALTAAYISGAGELLAASISQWTSQDFPTTLGVLLFTLVAGGVVCIGTHSVDLFNRILFSAKVVFLIVM
LGLMLPNIHQTNLMTLPLEQGLALSAIPVIFTSFGFHGSVPSIVNYMGGNIRKLRWVFIIGSAIPLVAYIFWQLATLGSI
SSTTFVGILAQQAGLNGLLQAVRDVVASPHVELAVHLFADLALATSFLGVALGLFDFLADLFKRQDNVRGRLQTGAITFL
PPLAFALFYPRGFVLALGFAAIALAVLALLLPSLLVWKTRQQHQAKYRVWGGTPALALVFVCGITVIAIQLGIASGILPA
VG

Sequences:

>Translated_402_residues
MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFGVTLGLLVGLWLLMCYTALLLVEVYQHEQADTGLGTLAKRYLGGGGQ
WLTSFSMMFLMYALTAAYISGAGELLAASISQWTSQDFPTTLGVLLFTLVAGGVVCIGTHSVDLFNRILFSAKVVFLIVM
LGLMLPNIHQTNLMTLPLEQGLALSAIPVIFTSFGFHGSVPSIVNYMGGNIRKLRWVFIIGSAIPLVAYIFWQLATLGSI
SSTTFVGILAQQAGLNGLLQAVRDVVASPHVELAVHLFADLALATSFLGVALGLFDFLADLFKRQDNVRGRLQTGAITFL
PPLAFALFYPRGFVLALGFAAIALAVLALLLPSLLVWKTRQQHQAKYRVWGGTPALALVFVCGITVIAIQLGIASGILPA
VG
>Mature_402_residues
MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFGVTLGLLVGLWLLMCYTALLLVEVYQHEQADTGLGTLAKRYLGGGGQ
WLTSFSMMFLMYALTAAYISGAGELLAASISQWTSQDFPTTLGVLLFTLVAGGVVCIGTHSVDLFNRILFSAKVVFLIVM
LGLMLPNIHQTNLMTLPLEQGLALSAIPVIFTSFGFHGSVPSIVNYMGGNIRKLRWVFIIGSAIPLVAYIFWQLATLGSI
SSTTFVGILAQQAGLNGLLQAVRDVVASPHVELAVHLFADLALATSFLGVALGLFDFLADLFKRQDNVRGRLQTGAITFL
PPLAFALFYPRGFVLALGFAAIALAVLALLLPSLLVWKTRQQHQAKYRVWGGTPALALVFVCGITVIAIQLGIASGILPA
VG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=80.6451612903226, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1789552, Length=384, Percent_Identity=32.03125, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1790145, Length=409, Percent_Identity=30.3178484107579, Blast_Score=192, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42632; Mature: 42632

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFGVTLGLLVGLWLLMCYTALLLVEVYQH
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQADTGLGTLAKRYLGGGGQWLTSFSMMFLMYALTAAYISGAGELLAASISQWTSQDFPT
HCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHH
TLGVLLFTLVAGGVVCIGTHSVDLFNRILFSAKVVFLIVMLGLMLPNIHQTNLMTLPLEQ
HHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHC
GLALSAIPVIFTSFGFHGSVPSIVNYMGGNIRKLRWVFIIGSAIPLVAYIFWQLATLGSI
CCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHHHHCCC
SSTTFVGILAQQAGLNGLLQAVRDVVASPHVELAVHLFADLALATSFLGVALGLFDFLAD
CHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFKRQDNVRGRLQTGAITFLPPLAFALFYPRGFVLALGFAAIALAVLALLLPSLLVWKTR
HHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQHQAKYRVWGGTPALALVFVCGITVIAIQLGIASGILPAVG
HHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFGVTLGLLVGLWLLMCYTALLLVEVYQH
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQADTGLGTLAKRYLGGGGQWLTSFSMMFLMYALTAAYISGAGELLAASISQWTSQDFPT
HCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHH
TLGVLLFTLVAGGVVCIGTHSVDLFNRILFSAKVVFLIVMLGLMLPNIHQTNLMTLPLEQ
HHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHC
GLALSAIPVIFTSFGFHGSVPSIVNYMGGNIRKLRWVFIIGSAIPLVAYIFWQLATLGSI
CCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHHHHCCC
SSTTFVGILAQQAGLNGLLQAVRDVVASPHVELAVHLFADLALATSFLGVALGLFDFLAD
CHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFKRQDNVRGRLQTGAITFLPPLAFALFYPRGFVLALGFAAIALAVLALLLPSLLVWKTR
HHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQHQAKYRVWGGTPALALVFVCGITVIAIQLGIASGILPAVG
HHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]