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The map label for this gene is wecA [H]

Identifier: 157371135

GI number: 157371135

Start: 3179889

End: 3180938

Strand: Reverse

Name: wecA [H]

Synonym: Spro_2895

Alternate gene names: 157371135

Gene position: 3180938-3179889 (Counterclockwise)

Preceding gene: 157371136

Following gene: 157371134

Centisome position: 58.38

GC content: 57.33

Gene sequence:

>1050_bases
ATGTTATATCAACTGAGTGTGATATTTATTTTGGCGCTGATGCTGGTAGTTATTGCCCGCCGCGCTGCGCTGGCGGTGGG
GTTAGTGGATAAACCCAATGCCCGTAAGCGCCATCAGGGGCATGTACCGCTGGTCGGAGGCATTGCTATCTACCTGATCA
TGACGCTGGTGACTTTCTGGCAACCGGACTGGTTGCCGCACAGTACCACCTATTTGTTGTGCGTCACCGCATTAGTGATG
CTGGGGGTGCTTGATGACCGTTTTGATCTGCCGGTGGCGCCGCGCGTCATTGTGCAGGGAGGGATCGCGCTGGCGATGAT
GCTGGCGGCAGGGATGCAACTCTCTTCATTGGGGTTCCTGTGGGGCCACCAGGAGCTGTTGCTGGGTTATGCGGCGTTGC
TGATCACCCCGTTGGCGGTATGGGGGGCGATCAACGCCTATAACATGGTTGACGGTATCGACGGCCAGCTTGGCGCACTG
TCCTGTGTCACCTTTATGGCGTTGGCCATTTTGTTCGGGCTGGCCGGGCATGAGGCTCAGGCCTTGTGGTGCCTGAGCCT
GATAGCGGCCCTGGTGGCCTACCTGCTGTTCAACCTCAGCGTATTCGGTGCGCGTAACAAGATTTTCATGGGTGATGCCG
GCAGCATGGTGATTGGTTTCAGCGTGTTGTGGTTGCTGATTGTCGCCACCCAGGGTGCGGACGCGGTCATACGACCGGTG
ACCGCACTGTGGTTAATCGCCATCCCGCTGATGGATATGGTGACCGTGATGGTACGCCGTTTAATGCGTCGCCAGAGCCC
TTTCAAGGCAGGACGCGATCACCTGCATCACATTCTGATGCGCCGCGGCCTCAATGCGCGCCAGGCGCTGGGGATGAGCT
GCATGTTGGCGGTCACTCTGGCCTGTGTCGGCATCTGTAGTGAAGTGCTGCAGACACCGGACCACCTGATGCTGCTGGCC
TTTGTATTTTGTTTCTTCGGTTATTTTGCCCTGTTGCGCGAACCGCGCCAGGCAAGCATTTTTACTGATAATCCTACCGC
CGATCGTTAA

Upstream 100 bases:

>100_bases
ATGCTGACTTATATCCTGGCAATATCAATTTTGTTTTTGTTAATAGCGCATTGGGAGCTGTAACTCAAGGGCGGTAGCGT
GCTTATTCGCTGGAGGAACC

Downstream 100 bases:

>100_bases
TCCCCAACGGGCCGCAATGGTGGCCCGTTTTCTCACGGTACCGTTATGAACCTTCATTTGCCTCATTGGATGCCACTGGT
GCTGTCCAGCGTTTTGCTCA

Product: undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MLYQLSVIFILALMLVVIARRAALAVGLVDKPNARKRHQGHVPLVGGIAIYLIMTLVTFWQPDWLPHSTTYLLCVTALVM
LGVLDDRFDLPVAPRVIVQGGIALAMMLAAGMQLSSLGFLWGHQELLLGYAALLITPLAVWGAINAYNMVDGIDGQLGAL
SCVTFMALAILFGLAGHEAQALWCLSLIAALVAYLLFNLSVFGARNKIFMGDAGSMVIGFSVLWLLIVATQGADAVIRPV
TALWLIAIPLMDMVTVMVRRLMRRQSPFKAGRDHLHHILMRRGLNARQALGMSCMLAVTLACVGICSEVLQTPDHLMLLA
FVFCFFGYFALLREPRQASIFTDNPTADR

Sequences:

>Translated_349_residues
MLYQLSVIFILALMLVVIARRAALAVGLVDKPNARKRHQGHVPLVGGIAIYLIMTLVTFWQPDWLPHSTTYLLCVTALVM
LGVLDDRFDLPVAPRVIVQGGIALAMMLAAGMQLSSLGFLWGHQELLLGYAALLITPLAVWGAINAYNMVDGIDGQLGAL
SCVTFMALAILFGLAGHEAQALWCLSLIAALVAYLLFNLSVFGARNKIFMGDAGSMVIGFSVLWLLIVATQGADAVIRPV
TALWLIAIPLMDMVTVMVRRLMRRQSPFKAGRDHLHHILMRRGLNARQALGMSCMLAVTLACVGICSEVLQTPDHLMLLA
FVFCFFGYFALLREPRQASIFTDNPTADR
>Mature_349_residues
MLYQLSVIFILALMLVVIARRAALAVGLVDKPNARKRHQGHVPLVGGIAIYLIMTLVTFWQPDWLPHSTTYLLCVTALVM
LGVLDDRFDLPVAPRVIVQGGIALAMMLAAGMQLSSLGFLWGHQELLLGYAALLITPLAVWGAINAYNMVDGIDGQLGAL
SCVTFMALAILFGLAGHEAQALWCLSLIAALVAYLLFNLSVFGARNKIFMGDAGSMVIGFSVLWLLIVATQGADAVIRPV
TALWLIAIPLMDMVTVMVRRLMRRQSPFKAGRDHLHHILMRRGLNARQALGMSCMLAVTLACVGICSEVLQTPDHLMLLA
FVFCFFGYFALLREPRQASIFTDNPTADR

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=291, Percent_Identity=50.1718213058419, Blast_Score=295, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 38134; Mature: 38134

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYQLSVIFILALMLVVIARRAALAVGLVDKPNARKRHQGHVPLVGGIAIYLIMTLVTFW
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHH
QPDWLPHSTTYLLCVTALVMLGVLDDRFDLPVAPRVIVQGGIALAMMLAAGMQLSSLGFL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
WGHQELLLGYAALLITPLAVWGAINAYNMVDGIDGQLGALSCVTFMALAILFGLAGHEAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
ALWCLSLIAALVAYLLFNLSVFGARNKIFMGDAGSMVIGFSVLWLLIVATQGADAVIRPV
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
TALWLIAIPLMDMVTVMVRRLMRRQSPFKAGRDHLHHILMRRGLNARQALGMSCMLAVTL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ACVGICSEVLQTPDHLMLLAFVFCFFGYFALLREPRQASIFTDNPTADR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCC
>Mature Secondary Structure
MLYQLSVIFILALMLVVIARRAALAVGLVDKPNARKRHQGHVPLVGGIAIYLIMTLVTFW
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHH
QPDWLPHSTTYLLCVTALVMLGVLDDRFDLPVAPRVIVQGGIALAMMLAAGMQLSSLGFL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
WGHQELLLGYAALLITPLAVWGAINAYNMVDGIDGQLGALSCVTFMALAILFGLAGHEAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
ALWCLSLIAALVAYLLFNLSVFGARNKIFMGDAGSMVIGFSVLWLLIVATQGADAVIRPV
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
TALWLIAIPLMDMVTVMVRRLMRRQSPFKAGRDHLHHILMRRGLNARQALGMSCMLAVTL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ACVGICSEVLQTPDHLMLLAFVFCFFGYFALLREPRQASIFTDNPTADR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]