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The map label for this gene is gne [H]

Identifier: 157371136

GI number: 157371136

Start: 3181119

End: 3182075

Strand: Reverse

Name: gne [H]

Synonym: Spro_2896

Alternate gene names: 157371136

Gene position: 3182075-3181119 (Counterclockwise)

Preceding gene: 157371137

Following gene: 157371135

Centisome position: 58.4

GC content: 48.17

Gene sequence:

>957_bases
ATGGATAAGCGTAAAGTAGCTATCATCGGGGGTTCCGGCTTTATCGGGACGCGTTTGGTTAAACGTCTGAGTGCGCGTAA
CGACCTGCTGTTGACCATCGTGGATAAAAAGCAGAGTGAGCATTTTCCTGAACTCTATCAGTTTGGCGATGTAACCCAGC
CCGAAACCCTGCGGCAGGCGCTGGCGGGTTGTGACGCCGTGATTAATCTTGCGGCCGAGCACCAGGATAACGTCGATCCT
GTCTCACTGTATTATCAGGTTAACGTTGATGGTGCGCGCAATGTTTGCATGACGGCCTCGGCGCTGAATATCCAACAAAT
TATCTTTACCTCCTCAGTGGCGGTATACGGCTTCGTGACTCAGGAAACCGGTGAGGAAGGGCTTTTTGAACCCTTTAACC
ATTACGGCAAATCCAAGCTGGAGGCCGAGTATGTTTACGAAGCCTGGCGCAAAGCCGATGCTGGCAACAAATTAACCATC
ATCCGCCCAACGGTGGTGTTCGGTGAAAATAATCGTGGCAACGTCTATAACCTGTTCCGGCAAATCGCCAGCGGCCGATT
CGTGATGATTGGCAGCGGTAATAATATGAAGTCTATGGCTTACGTGGAAAATATTGCCGCCAGACTGGAGCATGCGTTGG
ATCAGCAGGCAACCTACCAGGTCAGCAATTATGTTGATAAGCCCGACTTCACCATGAATCAACTGGTCGACGTTATTTCT
TCTTCATTAGGAAAAAGTAATAAGACTATTCGCATTCCCTATTTATTTGGCCTCTGTGGCGCAACGGCATTGGATGTGGT
GAGCAAAATAAGTCACCGTAAATTCCCAATTAGCCGCGTGCGAGTGCAAAAATTCTGCGCCAGAACGCAATTTAAAAGCA
ATGTGCAAAATGATTTCGTGGCGCCGGTCGATCTTAATTTGGCAATCGAAAAAACAATTAAACACGAGTTTTCCTAG

Upstream 100 bases:

>100_bases
CTCTGTTTTGTCCAGTCTGGTTTCCATGTTCTAACGCCAATTAGCGTCCTGCCTCATGGTGCGGTAGGGAATAATGGGAA
ACCGGATTGAGTGACAAATT

Downstream 100 bases:

>100_bases
AGATAACTTTTTCTAAAACCAGGGCTGTTTATTTTTCGTCGATGACAACCGGATAAATCTGTAATTAACAGGATTAACTC
ATGCTGACTTATATCCTGGC

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: UDP-GlcNAc 4-epimerase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MDKRKVAIIGGSGFIGTRLVKRLSARNDLLLTIVDKKQSEHFPELYQFGDVTQPETLRQALAGCDAVINLAAEHQDNVDP
VSLYYQVNVDGARNVCMTASALNIQQIIFTSSVAVYGFVTQETGEEGLFEPFNHYGKSKLEAEYVYEAWRKADAGNKLTI
IRPTVVFGENNRGNVYNLFRQIASGRFVMIGSGNNMKSMAYVENIAARLEHALDQQATYQVSNYVDKPDFTMNQLVDVIS
SSLGKSNKTIRIPYLFGLCGATALDVVSKISHRKFPISRVRVQKFCARTQFKSNVQNDFVAPVDLNLAIEKTIKHEFS

Sequences:

>Translated_318_residues
MDKRKVAIIGGSGFIGTRLVKRLSARNDLLLTIVDKKQSEHFPELYQFGDVTQPETLRQALAGCDAVINLAAEHQDNVDP
VSLYYQVNVDGARNVCMTASALNIQQIIFTSSVAVYGFVTQETGEEGLFEPFNHYGKSKLEAEYVYEAWRKADAGNKLTI
IRPTVVFGENNRGNVYNLFRQIASGRFVMIGSGNNMKSMAYVENIAARLEHALDQQATYQVSNYVDKPDFTMNQLVDVIS
SSLGKSNKTIRIPYLFGLCGATALDVVSKISHRKFPISRVRVQKFCARTQFKSNVQNDFVAPVDLNLAIEKTIKHEFS
>Mature_318_residues
MDKRKVAIIGGSGFIGTRLVKRLSARNDLLLTIVDKKQSEHFPELYQFGDVTQPETLRQALAGCDAVINLAAEHQDNVDP
VSLYYQVNVDGARNVCMTASALNIQQIIFTSSVAVYGFVTQETGEEGLFEPFNHYGKSKLEAEYVYEAWRKADAGNKLTI
IRPTVVFGENNRGNVYNLFRQIASGRFVMIGSGNNMKSMAYVENIAARLEHALDQQATYQVSNYVDKPDFTMNQLVDVIS
SSLGKSNKTIRIPYLFGLCGATALDVVSKISHRKFPISRVRVQKFCARTQFKSNVQNDFVAPVDLNLAIEKTIKHEFS

Specific function: Converts UDP-GlcNAc to UDP-GalNAc. Essential for O antigen synthesis [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI193211614, Length=208, Percent_Identity=29.3269230769231, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI8393516, Length=208, Percent_Identity=29.3269230769231, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.7 [H]

Molecular weight: Translated: 35522; Mature: 35522

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRKVAIIGGSGFIGTRLVKRLSARNDLLLTIVDKKQSEHFPELYQFGDVTQPETLRQA
CCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHH
LAGCDAVINLAAEHQDNVDPVSLYYQVNVDGARNVCMTASALNIQQIIFTSSVAVYGFVT
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEHHHCCHHHHHHHCCEEEEEEEE
QETGEEGLFEPFNHYGKSKLEAEYVYEAWRKADAGNKLTIIRPTVVFGENNRGNVYNLFR
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCHHHHHHH
QIASGRFVMIGSGNNMKSMAYVENIAARLEHALDQQATYQVSNYVDKPDFTMNQLVDVIS
HHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
SSLGKSNKTIRIPYLFGLCGATALDVVSKISHRKFPISRVRVQKFCARTQFKSNVQNDFV
HHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCC
APVDLNLAIEKTIKHEFS
CCEECCHHHHHHHHHCCC
>Mature Secondary Structure
MDKRKVAIIGGSGFIGTRLVKRLSARNDLLLTIVDKKQSEHFPELYQFGDVTQPETLRQA
CCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHH
LAGCDAVINLAAEHQDNVDPVSLYYQVNVDGARNVCMTASALNIQQIIFTSSVAVYGFVT
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEHHHCCHHHHHHHCCEEEEEEEE
QETGEEGLFEPFNHYGKSKLEAEYVYEAWRKADAGNKLTIIRPTVVFGENNRGNVYNLFR
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCHHHHHHH
QIASGRFVMIGSGNNMKSMAYVENIAARLEHALDQQATYQVSNYVDKPDFTMNQLVDVIS
HHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
SSLGKSNKTIRIPYLFGLCGATALDVVSKISHRKFPISRVRVQKFCARTQFKSNVQNDFV
HHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCC
APVDLNLAIEKTIKHEFS
CCEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11976290; 11206551; 11258796 [H]