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The map label for this gene is adrB [H]

Identifier: 157371051

GI number: 157371051

Start: 3090810

End: 3092426

Strand: Direct

Name: adrB [H]

Synonym: Spro_2811

Alternate gene names: 157371051

Gene position: 3090810-3092426 (Clockwise)

Preceding gene: 157371050

Following gene: 157371053

Centisome position: 56.72

GC content: 55.84

Gene sequence:

>1617_bases
ATGTTGATGACCCAACTTGCCGTGAGCAAATACCGCTATTACCGTTGGCTACTGGCCGGGGCGGTCGGGTTGGCTATTCT
GCTGTTATCGCTCTACACCCGTTATTATCAAGAGATTGGCACTATTGAACAAAACCGGCAGGTGCTCGCGACCCGCACCG
TCGCCAAGATTAACGATCTGCTGACACCGGCAAAGCAACAGGCCGAGCGTTCCATGCCACTGCTGGGCTCCACCTGTGAA
GAGGTGATGCCAACGCTGCGTTTTCGCGCTGCGCAAAACCAGGCTCTGCGGGCAATGCTGTTGGTTAAGGACGGGGTTAT
TTACTGTTCCAGCCTGTTTGGCACCCGTAAGTACCTTTTCAGCACTATTTTGCCCAGCGTAGCAAACGATGGCGCGAAGC
TGGTATTGCGCCCTTCGCTCTCTGTCGCCAAAGGCGTGCCGACCCTGATCATGTGGACTCCCGCGCAGCCGGATAACAAC
AGTAACGGCGTGTTGCACGTGTTCAATATTGAGCTATTGGCGAACTTCCTGCTGGAACCTCAGGAACCCTACGCGCAGCG
AGTAGTGCTGAACGTCGGCAACTACAGCCTGGAGTATGGGCGTCGGGAAATCCTGCGCAGCGATACCCTGACCACTGACC
TGCGCTATACCGCGAAATCCACTCGGTATCCGTTCTCTATTTCACTGTTCGGCCCGCAGGCCAGCATGCTGGCGCTGGCG
GCGCTGCCGCGCCATATCCCGCTGTCGTTGTTGATCAGTCTGCTGGCGGCCTATGTGGTGTATCTGCTCACCGCTAATCG
CATGAGCCTGTCGTACCACATTGGTCATGCCATTTCCCGCCGCGAATTCCGTGTTTACTGTCAGCCCATCATCAATGCTG
AAACCGGCCGCTGTGTCGGGGTTGAAATGCTGCTGCGCTGGAAAAACAAACGACAGGGCTGGATTTCCCCCGACGTGTTT
ATCCCGCTGGCGGAACAGCATGGCTTGATCATCGCTCTGACCCGTTACCTGATGAGCACCGTGGTGGAAAACCTGCAGTT
GTTCCCGCCACGCCCGTCGTTTTATATCAGCATCAACGTCGCGGCCGAGCATTTCAACGGGGTGACCATTATCGATGATA
TCCGCCGTCTGTGGCTTCCCGCGCATCCTATGCCTTCGCTGATGCTTGAGTTGACCGAACGTACCGCCCTGTCGGAAATT
CAGTATGAACAAATCAAAACGCTGAAGGAAATGGGCATCATGTTGGCTATCGACGACTTTGGCACCGGGCACAGTTCACT
CAGTTACCTGAAAAAACTCAGCCCTGACGTGTTGAAAATCGACCGGGGTTTCACCGCGGCCATAGGTACCGATGCGATTA
ACGCCACCGTCACCGATACCATCATTACCCTGGCACATCGCCTGAAGCTGAAACTGGTGGCGGAAGGGGTAGAAACCGCC
GAACAGGCGGATTATCTGCGTTCGCGCGATGTGAACGCGTTGCAGGGGTTCTATTTCGCCAAACCGATGCCAATCAATGT
ATTCCCACTGTGGTTACAGCAGTATGAGTCGCGGTTGCGGGCGGTGAATCAGCGGGAGGAACGGCGGATGGAGCAGGAAA
GCAAGCCGGAGGCGTGA

Upstream 100 bases:

>100_bases
TCACTCTTGTATAACGACAGGCTAGAATTAGCCAAGTATCATTCAGGGCAGTTTTGCCTGACGGTGATTCAGGGCTGGCT
TACCGAACAAGGATTTAGCG

Downstream 100 bases:

>100_bases
TGCCTCCGGCCCGTAGGTTACTGGTGTTCCTCGTCGTGAGGTTCAACTTTGGTAATACGCACCAGTTCAATGCGGTACTC
GGACACGGCAACGACTTCGA

Product: EAL domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MLMTQLAVSKYRYYRWLLAGAVGLAILLLSLYTRYYQEIGTIEQNRQVLATRTVAKINDLLTPAKQQAERSMPLLGSTCE
EVMPTLRFRAAQNQALRAMLLVKDGVIYCSSLFGTRKYLFSTILPSVANDGAKLVLRPSLSVAKGVPTLIMWTPAQPDNN
SNGVLHVFNIELLANFLLEPQEPYAQRVVLNVGNYSLEYGRREILRSDTLTTDLRYTAKSTRYPFSISLFGPQASMLALA
ALPRHIPLSLLISLLAAYVVYLLTANRMSLSYHIGHAISRREFRVYCQPIINAETGRCVGVEMLLRWKNKRQGWISPDVF
IPLAEQHGLIIALTRYLMSTVVENLQLFPPRPSFYISINVAAEHFNGVTIIDDIRRLWLPAHPMPSLMLELTERTALSEI
QYEQIKTLKEMGIMLAIDDFGTGHSSLSYLKKLSPDVLKIDRGFTAAIGTDAINATVTDTIITLAHRLKLKLVAEGVETA
EQADYLRSRDVNALQGFYFAKPMPINVFPLWLQQYESRLRAVNQREERRMEQESKPEA

Sequences:

>Translated_538_residues
MLMTQLAVSKYRYYRWLLAGAVGLAILLLSLYTRYYQEIGTIEQNRQVLATRTVAKINDLLTPAKQQAERSMPLLGSTCE
EVMPTLRFRAAQNQALRAMLLVKDGVIYCSSLFGTRKYLFSTILPSVANDGAKLVLRPSLSVAKGVPTLIMWTPAQPDNN
SNGVLHVFNIELLANFLLEPQEPYAQRVVLNVGNYSLEYGRREILRSDTLTTDLRYTAKSTRYPFSISLFGPQASMLALA
ALPRHIPLSLLISLLAAYVVYLLTANRMSLSYHIGHAISRREFRVYCQPIINAETGRCVGVEMLLRWKNKRQGWISPDVF
IPLAEQHGLIIALTRYLMSTVVENLQLFPPRPSFYISINVAAEHFNGVTIIDDIRRLWLPAHPMPSLMLELTERTALSEI
QYEQIKTLKEMGIMLAIDDFGTGHSSLSYLKKLSPDVLKIDRGFTAAIGTDAINATVTDTIITLAHRLKLKLVAEGVETA
EQADYLRSRDVNALQGFYFAKPMPINVFPLWLQQYESRLRAVNQREERRMEQESKPEA
>Mature_538_residues
MLMTQLAVSKYRYYRWLLAGAVGLAILLLSLYTRYYQEIGTIEQNRQVLATRTVAKINDLLTPAKQQAERSMPLLGSTCE
EVMPTLRFRAAQNQALRAMLLVKDGVIYCSSLFGTRKYLFSTILPSVANDGAKLVLRPSLSVAKGVPTLIMWTPAQPDNN
SNGVLHVFNIELLANFLLEPQEPYAQRVVLNVGNYSLEYGRREILRSDTLTTDLRYTAKSTRYPFSISLFGPQASMLALA
ALPRHIPLSLLISLLAAYVVYLLTANRMSLSYHIGHAISRREFRVYCQPIINAETGRCVGVEMLLRWKNKRQGWISPDVF
IPLAEQHGLIIALTRYLMSTVVENLQLFPPRPSFYISINVAAEHFNGVTIIDDIRRLWLPAHPMPSLMLELTERTALSEI
QYEQIKTLKEMGIMLAIDDFGTGHSSLSYLKKLSPDVLKIDRGFTAAIGTDAINATVTDTIITLAHRLKLKLVAEGVETA
EQADYLRSRDVNALQGFYFAKPMPINVFPLWLQQYESRLRAVNQREERRMEQESKPEA

Specific function: May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); over-expression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surfa

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI87081980, Length=512, Percent_Identity=43.5546875, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1788502, Length=462, Percent_Identity=32.6839826839827, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI87081845, Length=460, Percent_Identity=31.9565217391304, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1790496, Length=256, Percent_Identity=37.109375, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87081743, Length=273, Percent_Identity=38.0952380952381, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1786507, Length=239, Percent_Identity=37.6569037656904, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI87081921, Length=259, Percent_Identity=32.8185328185328, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI1787541, Length=254, Percent_Identity=30.7086614173228, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI226510982, Length=250, Percent_Identity=30.4, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1787055, Length=254, Percent_Identity=32.6771653543307, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1788849, Length=248, Percent_Identity=29.4354838709677, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082096, Length=235, Percent_Identity=32.3404255319149, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI1787410, Length=117, Percent_Identity=32.4786324786325, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 60831; Mature: 60831

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMTQLAVSKYRYYRWLLAGAVGLAILLLSLYTRYYQEIGTIEQNRQVLATRTVAKINDL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHH
LTPAKQQAERSMPLLGSTCEEVMPTLRFRAAQNQALRAMLLVKDGVIYCSSLFGTRKYLF
HCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
STILPSVANDGAKLVLRPSLSVAKGVPTLIMWTPAQPDNNSNGVLHVFNIELLANFLLEP
HHHHHHHCCCCCEEEEECCCHHHCCCCEEEEECCCCCCCCCCCEEEEEEHHHHHHHHCCC
QEPYAQRVVLNVGNYSLEYGRREILRSDTLTTDLRYTAKSTRYPFSISLFGPQASMLALA
CCCHHHEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEEEECCCHHHHHHH
ALPRHIPLSLLISLLAAYVVYLLTANRMSLSYHIGHAISRREFRVYCQPIINAETGRCVG
HCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHEEEEEECCCCCCCCCHH
VEMLLRWKNKRQGWISPDVFIPLAEQHGLIIALTRYLMSTVVENLQLFPPRPSFYISINV
HHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCEECCCCCCEEEEEEE
AAEHFNGVTIIDDIRRLWLPAHPMPSLMLELTERTALSEIQYEQIKTLKEMGIMLAIDDF
EEHHCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC
GTGHSSLSYLKKLSPDVLKIDRGFTAAIGTDAINATVTDTIITLAHRLKLKLVAEGVETA
CCCHHHHHHHHHCCCCCEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EQADYLRSRDVNALQGFYFAKPMPINVFPLWLQQYESRLRAVNQREERRMEQESKPEA
HHHHHHHHCCCHHHHCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLMTQLAVSKYRYYRWLLAGAVGLAILLLSLYTRYYQEIGTIEQNRQVLATRTVAKINDL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHH
LTPAKQQAERSMPLLGSTCEEVMPTLRFRAAQNQALRAMLLVKDGVIYCSSLFGTRKYLF
HCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
STILPSVANDGAKLVLRPSLSVAKGVPTLIMWTPAQPDNNSNGVLHVFNIELLANFLLEP
HHHHHHHCCCCCEEEEECCCHHHCCCCEEEEECCCCCCCCCCCEEEEEEHHHHHHHHCCC
QEPYAQRVVLNVGNYSLEYGRREILRSDTLTTDLRYTAKSTRYPFSISLFGPQASMLALA
CCCHHHEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEEEECCCHHHHHHH
ALPRHIPLSLLISLLAAYVVYLLTANRMSLSYHIGHAISRREFRVYCQPIINAETGRCVG
HCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHEEEEEECCCCCCCCCHH
VEMLLRWKNKRQGWISPDVFIPLAEQHGLIIALTRYLMSTVVENLQLFPPRPSFYISINV
HHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCEECCCCCCEEEEEEE
AAEHFNGVTIIDDIRRLWLPAHPMPSLMLELTERTALSEIQYEQIKTLKEMGIMLAIDDF
EEHHCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECC
GTGHSSLSYLKKLSPDVLKIDRGFTAAIGTDAINATVTDTIITLAHRLKLKLVAEGVETA
CCCHHHHHHHHHCCCCCEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EQADYLRSRDVNALQGFYFAKPMPINVFPLWLQQYESRLRAVNQREERRMEQESKPEA
HHHHHHHHCCCHHHHCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]