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The map label for this gene is sdaA [H]

Identifier: 157371050

GI number: 157371050

Start: 3088965

End: 3090350

Strand: Direct

Name: sdaA [H]

Synonym: Spro_2810

Alternate gene names: 157371050

Gene position: 3088965-3090350 (Clockwise)

Preceding gene: 157371049

Following gene: 157371051

Centisome position: 56.69

GC content: 55.99

Gene sequence:

>1386_bases
ATGCCTCTAAGGAGTTTTAGCGTGATTAGCGTTTTCGACATGTTTAAGATCGGCATCGGCCCGTCCAGCTCTCATACGGT
TGGACCGATGAAAGCCGGCAAACAGTTTGTCGACGATCTGGTAAATCAAGGCCTGATGCCTTCTATCACGCGTGTTGCCG
TAGATGTTTACGGCTCACTCTCATTGACCGGTAAAGGTCACCATACCGATATCGCTATCATCCTCGGCCTGGCGGGCAAT
ATGCCCGACACCGTTGATATCGATAGCATCCCGGGCTTTATTCGCGATGTAGAACAACGTCAACGCCTGATGCTGGCCAA
CGGCTCGCATGAGGTTGATTTCCCGCGTGACGGCGGCATGGTTTTCCGCAGCGACAATTTGCCGCTGCATGAGAACGGCA
TGCAGATCCACGCCTTCGCCGGGGATAAACAAGTTTACAGCAAGACTTACTACTCACTCGGCGGCGGTTTTATCGTCGAC
GAAGAGAACTTCGGTAAAGCCGACGCGCACGAGCTGAGCGTCCCTTATCCGTTCAGTTTTGCCCGTGATATTCTCGCCCA
CTGCCGTGATACCGGACTGTCGTTTTCCGGCCTGGTGATGCAGAACGAACTGGCGCTGCACAGCAAGCAGGATATCGAGA
CCTACTTCGGTAATATCTGGCAGACCATGCGCGCCTGTATCGATCGTGGCCTGAATACCGAGGGCGTACTGCCGGGGCCA
CTGCGTGTGCCACGTCGTGCATCCGCGCTGCGTCGCATGCTGGTGTCTTCCGACAAACTGTCCAACGATCCAATGAACGT
GATTGACTGGGTCAACATGTTCGCATTGGCGGTCAACGAAGAGAACGCGGCCGGCGGCCGAGTCGTCACCGCACCGACCA
ACGGCGCCTGTGGCATCGTCCCTGCCGTACTGGCTTACTATGACCACTTTATTGAATCCGTCAGCCCGGATATTTATATC
CGTTACTTTATGGCTGCGGGCGCAGTAGGCGCATTGTACAAGATGAACGCCTCTATCTCCGGCGCCGAAGTGGGTTGTCA
GGGTGAAGTGGGCGTGGCCTGTTCAATGGCCGCGGCCGGCCTGGCCGAACTGCTGGGCGCCAGCCCGGAGCAAGTTTGCA
TCGCGGCAGAGATCGGCATGGAACACAACCTTGGGCTGACCTGTGACCCGGTTGCCGGTCAGGTTCAGGTTCCTTGCATT
GAACGTAACGCCATTGCTTCCGTGAAGGCGATCAACTCGGCGCGTATGGCATTGCGTCGTACCAGTGAACCACGTGTCTC
GCTGGATAAGGTCATCGAAACCATGTACGAAACCGGTAAAGACATGAACGCCAAATATCGCGAAACTTCTCGCGGCGGTC
TGGCGATCAAAGTGCAGTGTGACTGA

Upstream 100 bases:

>100_bases
GATTATTTAATTTCATGCGAAAAAGGCAGCCAAACCCGTGCGGCCCTTTTACAATATCGCTGTTCCCTGCTCGGTTTTTG
ACCGCTGCAGCCATAACAAT

Downstream 100 bases:

>100_bases
CCCTCTAACCCCGCCTTCCGGCGGCAATGCTGGTCAGTTAAGGTGATATTGTTCCCTCTCCTTTGGGAGAGGGTTAGGGT
GAGGGGATACATACCAACGC

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MPLRSFSVISVFDMFKIGIGPSSSHTVGPMKAGKQFVDDLVNQGLMPSITRVAVDVYGSLSLTGKGHHTDIAIILGLAGN
MPDTVDIDSIPGFIRDVEQRQRLMLANGSHEVDFPRDGGMVFRSDNLPLHENGMQIHAFAGDKQVYSKTYYSLGGGFIVD
EENFGKADAHELSVPYPFSFARDILAHCRDTGLSFSGLVMQNELALHSKQDIETYFGNIWQTMRACIDRGLNTEGVLPGP
LRVPRRASALRRMLVSSDKLSNDPMNVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPDIYI
RYFMAAGAVGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGASPEQVCIAAEIGMEHNLGLTCDPVAGQVQVPCI
ERNAIASVKAINSARMALRRTSEPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD

Sequences:

>Translated_461_residues
MPLRSFSVISVFDMFKIGIGPSSSHTVGPMKAGKQFVDDLVNQGLMPSITRVAVDVYGSLSLTGKGHHTDIAIILGLAGN
MPDTVDIDSIPGFIRDVEQRQRLMLANGSHEVDFPRDGGMVFRSDNLPLHENGMQIHAFAGDKQVYSKTYYSLGGGFIVD
EENFGKADAHELSVPYPFSFARDILAHCRDTGLSFSGLVMQNELALHSKQDIETYFGNIWQTMRACIDRGLNTEGVLPGP
LRVPRRASALRRMLVSSDKLSNDPMNVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPDIYI
RYFMAAGAVGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGASPEQVCIAAEIGMEHNLGLTCDPVAGQVQVPCI
ERNAIASVKAINSARMALRRTSEPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
>Mature_460_residues
PLRSFSVISVFDMFKIGIGPSSSHTVGPMKAGKQFVDDLVNQGLMPSITRVAVDVYGSLSLTGKGHHTDIAIILGLAGNM
PDTVDIDSIPGFIRDVEQRQRLMLANGSHEVDFPRDGGMVFRSDNLPLHENGMQIHAFAGDKQVYSKTYYSLGGGFIVDE
ENFGKADAHELSVPYPFSFARDILAHCRDTGLSFSGLVMQNELALHSKQDIETYFGNIWQTMRACIDRGLNTEGVLPGPL
RVPRRASALRRMLVSSDKLSNDPMNVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPDIYIR
YFMAAGAVGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGASPEQVCIAAEIGMEHNLGLTCDPVAGQVQVPCIE
RNAIASVKAINSARMALRRTSEPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=454, Percent_Identity=87.2246696035242, Blast_Score=834, Evalue=0.0,
Organism=Escherichia coli, GI1789161, Length=455, Percent_Identity=77.3626373626374, Blast_Score=744, Evalue=0.0,
Organism=Escherichia coli, GI48994925, Length=453, Percent_Identity=70.8609271523179, Blast_Score=658, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 49706; Mature: 49575

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRSFSVISVFDMFKIGIGPSSSHTVGPMKAGKQFVDDLVNQGLMPSITRVAVDVYGSL
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCE
SLTGKGHHTDIAIILGLAGNMPDTVDIDSIPGFIRDVEQRQRLMLANGSHEVDFPRDGGM
EECCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCE
VFRSDNLPLHENGMQIHAFAGDKQVYSKTYYSLGGGFIVDEENFGKADAHELSVPYPFSF
EEECCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHH
ARDILAHCRDTGLSFSGLVMQNELALHSKQDIETYFGNIWQTMRACIDRGLNTEGVLPGP
HHHHHHHHHHCCCCEECEEEECHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LRVPRRASALRRMLVSSDKLSNDPMNVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIV
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHH
PAVLAYYDHFIESVSPDIYIRYFMAAGAVGALYKMNASISGAEVGCQGEVGVACSMAAAG
HHHHHHHHHHHHHCCCCCEEHHHHHHCHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHH
LAELLGASPEQVCIAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIASVKAINSARMALRR
HHHHHCCCCHHEEEEEECCCCCCCCEEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHC
TSEPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
CCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEEC
>Mature Secondary Structure 
PLRSFSVISVFDMFKIGIGPSSSHTVGPMKAGKQFVDDLVNQGLMPSITRVAVDVYGSL
CCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCE
SLTGKGHHTDIAIILGLAGNMPDTVDIDSIPGFIRDVEQRQRLMLANGSHEVDFPRDGGM
EECCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCE
VFRSDNLPLHENGMQIHAFAGDKQVYSKTYYSLGGGFIVDEENFGKADAHELSVPYPFSF
EEECCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHH
ARDILAHCRDTGLSFSGLVMQNELALHSKQDIETYFGNIWQTMRACIDRGLNTEGVLPGP
HHHHHHHHHHCCCCEECEEEECHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LRVPRRASALRRMLVSSDKLSNDPMNVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIV
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHH
PAVLAYYDHFIESVSPDIYIRYFMAAGAVGALYKMNASISGAEVGCQGEVGVACSMAAAG
HHHHHHHHHHHHHCCCCCEEHHHHHHCHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHH
LAELLGASPEQVCIAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIASVKAINSARMALRR
HHHHHCCCCHHEEEEEECCCCCCCCEEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHC
TSEPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
CCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]