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The map label for this gene is malY [H]

Identifier: 157370502

GI number: 157370502

Start: 2461882

End: 2463063

Strand: Reverse

Name: malY [H]

Synonym: Spro_2262

Alternate gene names: 157370502

Gene position: 2463063-2461882 (Counterclockwise)

Preceding gene: 157370503

Following gene: 157370499

Centisome position: 45.2

GC content: 59.9

Gene sequence:

>1182_bases
ATGTTTGATTTTTCCACCCCGGTTGATCGCCACGGCACCTGGTGCACGCAATGGGATTATATCGCTGACCGCTTTGGCAG
CGATGACCTGCTGCCGTTCACCATCTCCGATATGGATTTCGCCACCGCCCCCTGCATTCTCGAGGCGCTGCAACAGCGCC
TGCAGCATGGCGTGCTGGGCTACAGTCGCTGGCAGCATGAAGATTTCCTCGGCGCGGTGCGCCACTGGTATCAGCAGCGC
TTCAATACGCCCATCGACACCCAGATGGCGGTGTATGGCCCGTCGGTGATCTACATGGTGGCGCAGTTAATCCGCCTGTG
GTCGGCACCGGGGGAATACGTCGTCACCCACACCCCGGCCTATGACGCGTTTTATAAGGTGATCCTCGGTAATCAGCGCC
AACTGCTGGCCTGCCCGTTGCACAAAGACGGCAACGACTGGCAGTGTGATATGGCCCACCTGGAGGCGTTGCTGGCACGG
CCGCAAACCAAAATTCTGTTGCTGTGCAGCCCGCATAACCCGACCGGCAAGGTATGGCGTACCGAGGAACTGCAGCAAAT
GGCCGAGCTGTGCGAACGCCACGATGTGCGGGTGATCAGCGATGAGATCCATATGGATATGGTGTGGGGCGAGCAACGCC
ATACGCCGTGGAGTCAGGTTGCCAGCACGCCCTGGGCACTGCTGACCTCCGGATCCAAAACCTTCAATATCCCGGCGCTG
ACCGGGGCCTACGGCTTTATCAGCGATGATGCCACGCGCGACGCCTACAACCAGCAGCTCAAGGCCCGCGACGGGCTGTC
TTCCCCGGCGGTGTTGGCGGTAGTGGCGCATATTGCCGCTTATCGCCACGGTGAACCCTGGCTGGACGCGCTGCGCGATT
ACCTGCAGGACAACCTGACCTACGTCGCCGAAAGGCTCCAGCAGGCGTTCCCGCAACTGGCCTGGCAACCGCCGCAATCG
ACCTATCTGGCCTGGATCGATCTGCGCCCGTTGGGCATTGACGACCAACAGTTACAGCAGGTGCTTATCGAGCGTGAGAA
GGTCGCCATTATGCCGGGTTTCACCTACGGCGAAGAAGGCCGTGGCTTCTTGCGGCTGAACGTCGGTTGTCCGCGCAGCA
AGGTAGAGGCCGGTATGGATAAGCTGATTAACGGACTGAAATTTGTGTTGGACGAGGTTTAA

Upstream 100 bases:

>100_bases
CTGCAGGTGGTGATCGGCCCGCAGGTGCAATCGGTGAAAGATGAATTAGACTCACTGATAGCGGCAGCGCCTCCTGCTGC
GGCCCTGCAGGGAGCGTCAA

Downstream 100 bases:

>100_bases
TCCACAGAGGCAGGCGAAAGCCTGCCTTTCCAGAAGCTTACAACGCCACCTGCGGAATATCGTCCAGACGGTAATAAACG
CCTAATCCTCGCTCATTGGC

Product: class I and II aminotransferase

Products: NA

Alternate protein names: Cystathionine beta-lyase MalY; CBL; Beta-cystathionase; Cysteine lyase; Maltose regulon modulator [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MFDFSTPVDRHGTWCTQWDYIADRFGSDDLLPFTISDMDFATAPCILEALQQRLQHGVLGYSRWQHEDFLGAVRHWYQQR
FNTPIDTQMAVYGPSVIYMVAQLIRLWSAPGEYVVTHTPAYDAFYKVILGNQRQLLACPLHKDGNDWQCDMAHLEALLAR
PQTKILLLCSPHNPTGKVWRTEELQQMAELCERHDVRVISDEIHMDMVWGEQRHTPWSQVASTPWALLTSGSKTFNIPAL
TGAYGFISDDATRDAYNQQLKARDGLSSPAVLAVVAHIAAYRHGEPWLDALRDYLQDNLTYVAERLQQAFPQLAWQPPQS
TYLAWIDLRPLGIDDQQLQQVLIEREKVAIMPGFTYGEEGRGFLRLNVGCPRSKVEAGMDKLINGLKFVLDEV

Sequences:

>Translated_393_residues
MFDFSTPVDRHGTWCTQWDYIADRFGSDDLLPFTISDMDFATAPCILEALQQRLQHGVLGYSRWQHEDFLGAVRHWYQQR
FNTPIDTQMAVYGPSVIYMVAQLIRLWSAPGEYVVTHTPAYDAFYKVILGNQRQLLACPLHKDGNDWQCDMAHLEALLAR
PQTKILLLCSPHNPTGKVWRTEELQQMAELCERHDVRVISDEIHMDMVWGEQRHTPWSQVASTPWALLTSGSKTFNIPAL
TGAYGFISDDATRDAYNQQLKARDGLSSPAVLAVVAHIAAYRHGEPWLDALRDYLQDNLTYVAERLQQAFPQLAWQPPQS
TYLAWIDLRPLGIDDQQLQQVLIEREKVAIMPGFTYGEEGRGFLRLNVGCPRSKVEAGMDKLINGLKFVLDEV
>Mature_393_residues
MFDFSTPVDRHGTWCTQWDYIADRFGSDDLLPFTISDMDFATAPCILEALQQRLQHGVLGYSRWQHEDFLGAVRHWYQQR
FNTPIDTQMAVYGPSVIYMVAQLIRLWSAPGEYVVTHTPAYDAFYKVILGNQRQLLACPLHKDGNDWQCDMAHLEALLAR
PQTKILLLCSPHNPTGKVWRTEELQQMAELCERHDVRVISDEIHMDMVWGEQRHTPWSQVASTPWALLTSGSKTFNIPAL
TGAYGFISDDATRDAYNQQLKARDGLSSPAVLAVVAHIAAYRHGEPWLDALRDYLQDNLTYVAERLQQAFPQLAWQPPQS
TYLAWIDLRPLGIDDQQLQQVLIEREKVAIMPGFTYGEEGRGFLRLNVGCPRSKVEAGMDKLINGLKFVLDEV

Specific function: Acts as a beta-cystathionase and as a repressor of the maltose regulon [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=197, Percent_Identity=27.9187817258883, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI56713256, Length=197, Percent_Identity=27.9187817258883, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787909, Length=389, Percent_Identity=70.4370179948586, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1788722, Length=379, Percent_Identity=23.2189973614776, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859735, Length=368, Percent_Identity=23.6413043478261, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44850; Mature: 44850

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDFSTPVDRHGTWCTQWDYIADRFGSDDLLPFTISDMDFATAPCILEALQQRLQHGVLG
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCC
YSRWQHEDFLGAVRHWYQQRFNTPIDTQMAVYGPSVIYMVAQLIRLWSAPGEYVVTHTPA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHCCHHHHHHHHHHHHHCCCCCEEEEECCH
YDAFYKVILGNQRQLLACPLHKDGNDWQCDMAHLEALLARPQTKILLLCSPHNPTGKVWR
HHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
TEELQQMAELCERHDVRVISDEIHMDMVWGEQRHTPWSQVASTPWALLTSGSKTFNIPAL
HHHHHHHHHHHHHCCCEEEECHHEEEEEECCCCCCCHHHHHCCCEEEEECCCCEEECCEE
TGAYGFISDDATRDAYNQQLKARDGLSSPAVLAVVAHIAAYRHGEPWLDALRDYLQDNLT
CCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
YVAERLQQAFPQLAWQPPQSTYLAWIDLRPLGIDDQQLQQVLIEREKVAIMPGFTYGEEG
HHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCEEEECCCCCCCCC
RGFLRLNVGCPRSKVEAGMDKLINGLKFVLDEV
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFDFSTPVDRHGTWCTQWDYIADRFGSDDLLPFTISDMDFATAPCILEALQQRLQHGVLG
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCC
YSRWQHEDFLGAVRHWYQQRFNTPIDTQMAVYGPSVIYMVAQLIRLWSAPGEYVVTHTPA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHCCHHHHHHHHHHHHHCCCCCEEEEECCH
YDAFYKVILGNQRQLLACPLHKDGNDWQCDMAHLEALLARPQTKILLLCSPHNPTGKVWR
HHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
TEELQQMAELCERHDVRVISDEIHMDMVWGEQRHTPWSQVASTPWALLTSGSKTFNIPAL
HHHHHHHHHHHHHCCCEEEECHHEEEEEECCCCCCCHHHHHCCCEEEEECCCCEEECCEE
TGAYGFISDDATRDAYNQQLKARDGLSSPAVLAVVAHIAAYRHGEPWLDALRDYLQDNLT
CCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
YVAERLQQAFPQLAWQPPQSTYLAWIDLRPLGIDDQQLQQVLIEREKVAIMPGFTYGEEG
HHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCEEEECCCCCCCCC
RGFLRLNVGCPRSKVEAGMDKLINGLKFVLDEV
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856179; 9097039; 9278503; 7665481; 10698925 [H]