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The map label for this gene is malX [H]

Identifier: 157370503

GI number: 157370503

Start: 2463056

End: 2464480

Strand: Reverse

Name: malX [H]

Synonym: Spro_2263

Alternate gene names: 157370503

Gene position: 2464480-2463056 (Counterclockwise)

Preceding gene: 157370504

Following gene: 157370502

Centisome position: 45.23

GC content: 59.44

Gene sequence:

>1425_bases
ATGAGCAAGATCGGCTCCTTTGCCTTTAGCTTCCTGCCGGTGATGTTCGCCATCGCCATTCCATTGGGCATGGCGCGTGA
AAACAAAGGGGTCGCCGCGTTCTCCGGCTTTGTCGGCTTCGCGGTGCTGAACCTGGCCACCAACTTCTATCTGACCACCA
CCGGCATTTTGCCCACCACCGATCCGCTGGTGCTGAAAGCCAACAACATCCAAAACATTCTCGGGATCCAGTCGATTGAT
ACCGGCATTCTGGGTGCGGTGATCGTCGGGATTATCGTTTATCAATTGCATGAGCGTTTCCACAACATTCGCCTGCCGGA
TGCGCTGGCATTTTTCGGCGGCACCCGTTTTGTGCCGATCGTCACTACCCTGGTTCTGGGTCTGTGTGGTCTGGTGATCC
CGCTGATCTGGCCGTGGTTCGCCGCCGGCATTACCGGTCTGGGCTGGGTGATCAACAGCGCCGGTGCCTTTGGCCCGATG
CTGTTTGGCACCGGTGAACGTCTGCTGTTACCGTTCGGGCTGCAACATATTCTGGTGGCGCTGATCCGCTTTACCGAAGC
GGGCGGCACGCTGGACGTCTGCGGCCATAGCGTGAGCGGCGCGCTGACCATTTTCCAGGCGCAACTCTCTTGCCCGACCA
CCACCGGCTTTGCTGAAAGCGCCACCCGCTTCCTGTCCCAGGGCAAAATGCCGGCCTTCCTCGGCGGTCTGCCTGGGGCG
GCGCTGGCGATGTACCACTGCGCCAAGCCGGAAAACCGCCATAAAATTAAGGGCCTGCTGATCTCCGGCGTAGTAGCCTG
CGTGGTCGGTGGCACCACCGAACCGATCGAGTTCCTGTTCCTGTTTGTCGCGCCTTTCCTCTACCTCATTCACGCCGTCC
TGACCGGGCTGGGCTTCACCGTGATGGCGCTGCTGGGCGTGACCATCGGCAATACCAACGGTAATATCATCGACTTCGTG
GTGTTCGGCATTCTGCATGGCACCGCCACCAAGTGGTATCTGGTGCCCGTCGTCGCAGCCATTTGGTTCGCTGCCTACTA
CGCCATTTTCCGTTTCTCCATTCAGCGCTTTAATATCAAAACGCCGGGCCGCGAGAGCGAAACCACCGCCAGCCAGAGCG
CATCTGCAGGCCCGGTCGGCAAATCCGGCTATAACGTACCGGCCATTTTGGCGGCGCTGGGCGGCAGTGAGAATATTGTT
TCGCTGGATAACTGCATTACCCGTCTGCGCCTGTCGGTCGACGACATGAGCAAGGTGGATGACGCCGCGCTGAAGGCCAA
TCGCGCCATCGGCGTGGTGCCTCTCAACGAGCACAATCTGCAGGTGGTGATCGGCCCGCAGGTGCAATCGGTGAAAGATG
AATTAGACTCACTGATAGCGGCAGCGCCTCCTGCTGCGGCCCTGCAGGGAGCGTCAAATGTTTGA

Upstream 100 bases:

>100_bases
GTTTTTCACAGAATGCCCCACAGGTGCCCCATGAGCAAATCATAAACATCTAACCAACTGATTTTACACCAACAAAACAC
ACCAACTACGCTTTACCTGG

Downstream 100 bases:

>100_bases
TTTTTCCACCCCGGTTGATCGCCACGGCACCTGGTGCACGCAATGGGATTATATCGCTGACCGCTTTGGCAGCGATGACC
TGCTGCCGTTCACCATCTCC

Product: PTS system maltose and glucose-specific transporter IIBC

Products: NA

Alternate protein names: Maltose and glucose permease IIC component; PTS system maltose- and glucose-specific EIIC component; Maltose- and glucose-specific phosphotransferase enzyme IIB component; PTS system maltose- and glucose-specific EIIB component [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSKIGSFAFSFLPVMFAIAIPLGMARENKGVAAFSGFVGFAVLNLATNFYLTTTGILPTTDPLVLKANNIQNILGIQSID
TGILGAVIVGIIVYQLHERFHNIRLPDALAFFGGTRFVPIVTTLVLGLCGLVIPLIWPWFAAGITGLGWVINSAGAFGPM
LFGTGERLLLPFGLQHILVALIRFTEAGGTLDVCGHSVSGALTIFQAQLSCPTTTGFAESATRFLSQGKMPAFLGGLPGA
ALAMYHCAKPENRHKIKGLLISGVVACVVGGTTEPIEFLFLFVAPFLYLIHAVLTGLGFTVMALLGVTIGNTNGNIIDFV
VFGILHGTATKWYLVPVVAAIWFAAYYAIFRFSIQRFNIKTPGRESETTASQSASAGPVGKSGYNVPAILAALGGSENIV
SLDNCITRLRLSVDDMSKVDDAALKANRAIGVVPLNEHNLQVVIGPQVQSVKDELDSLIAAAPPAAALQGASNV

Sequences:

>Translated_474_residues
MSKIGSFAFSFLPVMFAIAIPLGMARENKGVAAFSGFVGFAVLNLATNFYLTTTGILPTTDPLVLKANNIQNILGIQSID
TGILGAVIVGIIVYQLHERFHNIRLPDALAFFGGTRFVPIVTTLVLGLCGLVIPLIWPWFAAGITGLGWVINSAGAFGPM
LFGTGERLLLPFGLQHILVALIRFTEAGGTLDVCGHSVSGALTIFQAQLSCPTTTGFAESATRFLSQGKMPAFLGGLPGA
ALAMYHCAKPENRHKIKGLLISGVVACVVGGTTEPIEFLFLFVAPFLYLIHAVLTGLGFTVMALLGVTIGNTNGNIIDFV
VFGILHGTATKWYLVPVVAAIWFAAYYAIFRFSIQRFNIKTPGRESETTASQSASAGPVGKSGYNVPAILAALGGSENIV
SLDNCITRLRLSVDDMSKVDDAALKANRAIGVVPLNEHNLQVVIGPQVQSVKDELDSLIAAAPPAAALQGASNV
>Mature_473_residues
SKIGSFAFSFLPVMFAIAIPLGMARENKGVAAFSGFVGFAVLNLATNFYLTTTGILPTTDPLVLKANNIQNILGIQSIDT
GILGAVIVGIIVYQLHERFHNIRLPDALAFFGGTRFVPIVTTLVLGLCGLVIPLIWPWFAAGITGLGWVINSAGAFGPML
FGTGERLLLPFGLQHILVALIRFTEAGGTLDVCGHSVSGALTIFQAQLSCPTTTGFAESATRFLSQGKMPAFLGGLPGAA
LAMYHCAKPENRHKIKGLLISGVVACVVGGTTEPIEFLFLFVAPFLYLIHAVLTGLGFTVMALLGVTIGNTNGNIIDFVV
FGILHGTATKWYLVPVVAAIWFAAYYAIFRFSIQRFNIKTPGRESETTASQSASAGPVGKSGYNVPAILAALGGSENIVS
LDNCITRLRLSVDDMSKVDDAALKANRAIGVVPLNEHNLQVVIGPQVQSVKDELDSLIAAAPPAAALQGASNV

Specific function: MalX encodes a phosphotransferase system enzyme II that can recognize glucose and maltose as substrates even though these sugars may not represent the natural substrates of the system [H]

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787908, Length=460, Percent_Identity=82.6086956521739, Blast_Score=775, Evalue=0.0,
Organism=Escherichia coli, GI1787343, Length=463, Percent_Identity=37.3650107991361, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1786894, Length=389, Percent_Identity=37.0179948586118, Blast_Score=215, Evalue=6e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018113
- InterPro:   IPR004719
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013
- InterPro:   IPR011535
- InterPro:   IPR011301 [H]

Pfam domain/function: PF00367 PTS_EIIB; PF02378 PTS_EIIC [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 49932; Mature: 49801

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS01035 PTS_EIIB_TYPE_1_CYS ; PS51098 PTS_EIIB_TYPE_1 ; PS51103 PTS_EIIC_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIGSFAFSFLPVMFAIAIPLGMARENKGVAAFSGFVGFAVLNLATNFYLTTTGILPTT
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCC
DPLVLKANNIQNILGIQSIDTGILGAVIVGIIVYQLHERFHNIRLPDALAFFGGTRFVPI
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHH
VTTLVLGLCGLVIPLIWPWFAAGITGLGWVINSAGAFGPMLFGTGERLLLPFGLQHILVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCEEECCCHHHHHHH
LIRFTEAGGTLDVCGHSVSGALTIFQAQLSCPTTTGFAESATRFLSQGKMPAFLGGLPGA
HHHHHCCCCCHHHCCCCCCCCEEEEEEHHCCCCCCCHHHHHHHHHHCCCCCHHHCCCCHH
ALAMYHCAKPENRHKIKGLLISGVVACVVGGTTEPIEFLFLFVAPFLYLIHAVLTGLGFT
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMALLGVTIGNTNGNIIDFVVFGILHGTATKWYLVPVVAAIWFAAYYAIFRFSIQRFNIK
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
TPGRESETTASQSASAGPVGKSGYNVPAILAALGGSENIVSLDNCITRLRLSVDDMSKVD
CCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHCCHHHHHHHH
DAALKANRAIGVVPLNEHNLQVVIGPQVQSVKDELDSLIAAAPPAAALQGASNV
HHHHHCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCC
>Mature Secondary Structure 
SKIGSFAFSFLPVMFAIAIPLGMARENKGVAAFSGFVGFAVLNLATNFYLTTTGILPTT
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCC
DPLVLKANNIQNILGIQSIDTGILGAVIVGIIVYQLHERFHNIRLPDALAFFGGTRFVPI
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHH
VTTLVLGLCGLVIPLIWPWFAAGITGLGWVINSAGAFGPMLFGTGERLLLPFGLQHILVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCEEECCCHHHHHHH
LIRFTEAGGTLDVCGHSVSGALTIFQAQLSCPTTTGFAESATRFLSQGKMPAFLGGLPGA
HHHHHCCCCCHHHCCCCCCCCEEEEEEHHCCCCCCCHHHHHHHHHHCCCCCHHHCCCCHH
ALAMYHCAKPENRHKIKGLLISGVVACVVGGTTEPIEFLFLFVAPFLYLIHAVLTGLGFT
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMALLGVTIGNTNGNIIDFVVFGILHGTATKWYLVPVVAAIWFAAYYAIFRFSIQRFNIK
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
TPGRESETTASQSASAGPVGKSGYNVPAILAALGGSENIVSLDNCITRLRLSVDDMSKVD
CCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHCCHHHHHHHH
DAALKANRAIGVVPLNEHNLQVVIGPQVQSVKDELDSLIAAAPPAAALQGASNV
HHHHHCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1856179; 9097039; 9278503; 2670898 [H]