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The map label for this gene is ybiC [C]

Identifier: 157370077

GI number: 157370077

Start: 2018559

End: 2019572

Strand: Reverse

Name: ybiC [C]

Synonym: Spro_1835

Alternate gene names: 157370077

Gene position: 2019572-2018559 (Counterclockwise)

Preceding gene: 157370078

Following gene: 157370074

Centisome position: 37.06

GC content: 62.03

Gene sequence:

>1014_bases
ATGACGCAAACCCAGAGTCTGACGCTGAAAGAAGCCTATGAACTAGCATTGCGCGCATTGCGCAGCAACGGTTTCAGTGC
CGAACATGCCGATGCCGTCGCGCAGAATGTGACGGCCGGTGAACGCGACGGCTGCGCCTCGCATGGTTTGTATCGGGTAC
TTGGCTGCGTGCGTTCGCTGCTGGCTGGTAAGGTATCCGCCGAGGCACTCCCGACGATTATCGATCAAGCCCCGGCGATC
TTGCGGGTGGATGCTCACGATGCTTTTTCGCTGCTGGCCTACCGTACCGCGCTGCCGGCGTTTATCGATAAGGTGCGCAC
CAACGGCATCGCTGCACTGGCGATTAATCACTGTGTGCATTACTCGGCGCTGTGGGCCGATATCGAACCCCTGACCGATC
GGGGTCTGGTGGCACTGGCCTGTACCCCCAGCCATGCCTGGGTCACGCCGGCTGGAGGAACCCGGCCGCTGTTTGGTACC
AATCCGATTGCCTTCGGCTGGCCGCGCCCGCAGCGCCCGCCCTTTATTTTCGATATGGCCACCAGCGCGGCGGCACGCGG
TGAAATCGAGCTGCATCGCCGTGCCGGTACGCCGCTGCCGCCGGGCTGGGGCATCGATCAACAAGGGGAGCCTTCTACCG
ATGCGGCCAGCGTGTTGCAGGGGGCGATGCTGACCTTTGGCGGGCATAAGGGGTCAGCGCTGGCGGCGATGGTGGAGCTG
ATCGCCGGGCCGTTGATTGGTGATATGACCAGTAAGGAGTCGCTGGCCTACGATCGGCAAACCGGCTCCTCCCCTTACGG
CGGCGAGCTGATTATCGCGATGGATCCCGATCGTTTTCTGGGGGCGGACAAGGCGGCGCATTTGGCCAGGGCAGAAACCT
TATTTGCGGATATGAGCGAGCAAGGGGCGCGTATTCCGGGGGAACGGCGTTTTGAGCGTCGACAGTACAGTGAGCAGCAC
GGCATTAGCTTGCCGCAGACACTGTATGACGAGATTGTGGCGCTCTGCCGCTGA

Upstream 100 bases:

>100_bases
GGTCATTGCGTTGGCAATCTATTACTGGGGCGCCTATACCTGTTTACCTCAGGCAAATTTTGCCGGTGATGAGGAAGAGT
AACCGTAAAGGAGATATGTA

Downstream 100 bases:

>100_bases
ATGAGACAGGCCCGCAGTTCAATACTGCGGGCCTGATTTGAAAAGATTACCTGACCACCATCACCGAGATATTGGCATGG
CGAACAATGGCTGCGGCGTT

Product: malate/L-lactate dehydrogenase

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTQTQSLTLKEAYELALRALRSNGFSAEHADAVAQNVTAGERDGCASHGLYRVLGCVRSLLAGKVSAEALPTIIDQAPAI
LRVDAHDAFSLLAYRTALPAFIDKVRTNGIAALAINHCVHYSALWADIEPLTDRGLVALACTPSHAWVTPAGGTRPLFGT
NPIAFGWPRPQRPPFIFDMATSAAARGEIELHRRAGTPLPPGWGIDQQGEPSTDAASVLQGAMLTFGGHKGSALAAMVEL
IAGPLIGDMTSKESLAYDRQTGSSPYGGELIIAMDPDRFLGADKAAHLARAETLFADMSEQGARIPGERRFERRQYSEQH
GISLPQTLYDEIVALCR

Sequences:

>Translated_337_residues
MTQTQSLTLKEAYELALRALRSNGFSAEHADAVAQNVTAGERDGCASHGLYRVLGCVRSLLAGKVSAEALPTIIDQAPAI
LRVDAHDAFSLLAYRTALPAFIDKVRTNGIAALAINHCVHYSALWADIEPLTDRGLVALACTPSHAWVTPAGGTRPLFGT
NPIAFGWPRPQRPPFIFDMATSAAARGEIELHRRAGTPLPPGWGIDQQGEPSTDAASVLQGAMLTFGGHKGSALAAMVEL
IAGPLIGDMTSKESLAYDRQTGSSPYGGELIIAMDPDRFLGADKAAHLARAETLFADMSEQGARIPGERRFERRQYSEQH
GISLPQTLYDEIVALCR
>Mature_336_residues
TQTQSLTLKEAYELALRALRSNGFSAEHADAVAQNVTAGERDGCASHGLYRVLGCVRSLLAGKVSAEALPTIIDQAPAIL
RVDAHDAFSLLAYRTALPAFIDKVRTNGIAALAINHCVHYSALWADIEPLTDRGLVALACTPSHAWVTPAGGTRPLFGTN
PIAFGWPRPQRPPFIFDMATSAAARGEIELHRRAGTPLPPGWGIDQQGEPSTDAASVLQGAMLTFGGHKGSALAAMVELI
AGPLIGDMTSKESLAYDRQTGSSPYGGELIIAMDPDRFLGADKAAHLARAETLFADMSEQGARIPGERRFERRQYSEQHG
ISLPQTLYDEIVALCR

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=314, Percent_Identity=30.8917197452229, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786727, Length=275, Percent_Identity=28, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1790000, Length=338, Percent_Identity=26.6272189349112, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17507179, Length=275, Percent_Identity=26.1818181818182, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17536633, Length=277, Percent_Identity=26.3537906137184, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667904, Length=260, Percent_Identity=30.7692307692308, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24667908, Length=260, Percent_Identity=30.7692307692308, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45553211, Length=260, Percent_Identity=30.7692307692308, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24667912, Length=260, Percent_Identity=30.7692307692308, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24648360, Length=263, Percent_Identity=26.615969581749, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24658010, Length=341, Percent_Identity=22.8739002932551, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 36068; Mature: 35937

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTQSLTLKEAYELALRALRSNGFSAEHADAVAQNVTAGERDGCASHGLYRVLGCVRSL
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LAGKVSAEALPTIIDQAPAILRVDAHDAFSLLAYRTALPAFIDKVRTNGIAALAINHCVH
HHCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YSALWADIEPLTDRGLVALACTPSHAWVTPAGGTRPLFGTNPIAFGWPRPQRPPFIFDMA
HHHHHHCCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCEECCCCCCCCCCEEEECH
TSAAARGEIELHRRAGTPLPPGWGIDQQGEPSTDAASVLQGAMLTFGGHKGSALAAMVEL
HHHHHCCCEEEHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
IAGPLIGDMTSKESLAYDRQTGSSPYGGELIIAMDPDRFLGADKAAHLARAETLFADMSE
HHCCHHCCCCCHHHHHHHCCCCCCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHH
QGARIPGERRFERRQYSEQHGISLPQTLYDEIVALCR
CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TQTQSLTLKEAYELALRALRSNGFSAEHADAVAQNVTAGERDGCASHGLYRVLGCVRSL
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LAGKVSAEALPTIIDQAPAILRVDAHDAFSLLAYRTALPAFIDKVRTNGIAALAINHCVH
HHCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YSALWADIEPLTDRGLVALACTPSHAWVTPAGGTRPLFGTNPIAFGWPRPQRPPFIFDMA
HHHHHHCCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCEECCCCCCCCCCEEEECH
TSAAARGEIELHRRAGTPLPPGWGIDQQGEPSTDAASVLQGAMLTFGGHKGSALAAMVEL
HHHHHCCCEEEHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
IAGPLIGDMTSKESLAYDRQTGSSPYGGELIIAMDPDRFLGADKAAHLARAETLFADMSE
HHCCHHCCCCCHHHHHHHCCCCCCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHH
QGARIPGERRFERRQYSEQHGISLPQTLYDEIVALCR
CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]