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The map label for this gene is paaH [H]

Identifier: 157370074

GI number: 157370074

Start: 2015313

End: 2016842

Strand: Reverse

Name: paaH [H]

Synonym: Spro_1832

Alternate gene names: 157370074

Gene position: 2016842-2015313 (Counterclockwise)

Preceding gene: 157370077

Following gene: 157370073

Centisome position: 37.01

GC content: 55.49

Gene sequence:

>1530_bases
ATGGCAGAGAATAATTCGGCAATCCATTCGGTCGCTGTTATTGGTGCCGGGACCATGGGCAGAGGTATTGCCTATCTTCT
GGCGCAAAACGGCATACGAACCCTGCTTTATAATCGTAGCGGTAATAATCTGAATCAGGCCAGGGACTATATTATTCGTG
ACCTGGATAAGAAAATAGATGGCGGAAAAATAAGCCCGCAGAAAAAAGGCGAGATATTGGCCAATCTGGTTTTCTCTCCC
ATTTTCGAGGCTATTGCCGACAGCGATCTGGTGATTGAAACCATCGCGGAACATGAGGCAACCAAGCATGAGATCCTCGC
GGCGATTGCGGCCACGGTGAAAAAAGAGGCGATTATCGCCACCAATACCTCCTCGCTGTCATTGAATAAGCTGGCCGCAG
GCGTCGAAAATAACGCCCGGTTTATCGGCCTGCACTTCTTCAATCCGGCCCCGCTGATGAAACTGATCGAAATTATTCCG
TCTTACTTTACCAGCCGGGCCACCAGCCTGCGTTGCCAGCAGTTGGTGACGGCGATAGGCAAACAGTTTGTGGTCTGCAA
AGCCACGCCGGGCTTTATCGTCAACCGGATGGCGCGACCTTTTTATCTGGAAGGGTTCCGGCTGTTGGAAGAGAACGTGG
CGCTGGCGCCGCAGATCGACCGCGCACTCAAGGCCGGTGGCCACTTTCGCATGGGACCTTTAGAGCTGACCGATTTTATC
GGCCAGGATATTAACTATCAGGTCAGCAGCCAGATTTGGCAGGACATGCAGTACGATCCCCGCTATACCCCCGGCCATTT
GCAACGTTCGCTGGTGGATGCCGGGCTGCTGGGGAAGAAAAACGGCCGATCCTTTTTTACCCCCTCTTCCGCCGAACCCA
GCTCCGCCGATGCAGGTAGCGGCACGCCGACCTCACTGAATTTTTATGGTGAACATCCCCTGTTCGACCTGTTGCAACAG
CGCGCTTTGGCGCTCTGGCCAAGGGTGCAGATTAATCGCCAATCGGAACAGCCAACGCTGGGCCGCTTTATCCGGGTGAA
TGACGCAATGGCCATCAAAATCACCGATGGCCGCACCGCCAATCTGCTGGCTGAATTGACCGAACTCGATACCTTCGTGA
TCGACGCCGCGCTCAACTACGCCGATACCGCCTATCTGGCGGCTGCCCACAGCCAGGATGCCAGCGCGGCCAATAAAGCG
CTGTTTCTGACGCTGCTGCAAACGTTGATCCCGCAGGTGGAGTTTATTAAAGACTCCCCGGGCCTGATTGTCGCCCGCGT
CCTGAGCAGCCTGATCAATGAGTCGGTGATTATGGTGGAGAGCGGGGTTTGCAGCCGGGCGGACATCGATATCGCCGCGG
TGGCCGGCGTTAACTATGCCGATGGCATCTTTAGCTGGCTGGCGCAGCTTGGGCAAAAAAACGTGAAGTCGACGCTGGAC
AATATGGCGCAACTGCTGCATTCCGCCCGCTATTACCCGCATTACTCTTTGCTCAATACCCCCCGGCCAGAGCTGGCCGT
CGCGCCCTAA

Upstream 100 bases:

>100_bases
CCCATTACCTTCGCCATAGGCACCTGGTGCTTTTTAAATCCGAATAAATTATAAGCATTTGCGAATTTCGCAAGGCAGAA
AAATACTCACGGGGATTTTT

Downstream 100 bases:

>100_bases
GGAAAAATGATGACGATTAAAGACGATGGAGTCTATCTGATCGACGGCACGCGCACGGCTATTGGCGCCTATGGCGGTAG
CCTGGCGTTAACTCGTCCAG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MAENNSAIHSVAVIGAGTMGRGIAYLLAQNGIRTLLYNRSGNNLNQARDYIIRDLDKKIDGGKISPQKKGEILANLVFSP
IFEAIADSDLVIETIAEHEATKHEILAAIAATVKKEAIIATNTSSLSLNKLAAGVENNARFIGLHFFNPAPLMKLIEIIP
SYFTSRATSLRCQQLVTAIGKQFVVCKATPGFIVNRMARPFYLEGFRLLEENVALAPQIDRALKAGGHFRMGPLELTDFI
GQDINYQVSSQIWQDMQYDPRYTPGHLQRSLVDAGLLGKKNGRSFFTPSSAEPSSADAGSGTPTSLNFYGEHPLFDLLQQ
RALALWPRVQINRQSEQPTLGRFIRVNDAMAIKITDGRTANLLAELTELDTFVIDAALNYADTAYLAAAHSQDASAANKA
LFLTLLQTLIPQVEFIKDSPGLIVARVLSSLINESVIMVESGVCSRADIDIAAVAGVNYADGIFSWLAQLGQKNVKSTLD
NMAQLLHSARYYPHYSLLNTPRPELAVAP

Sequences:

>Translated_509_residues
MAENNSAIHSVAVIGAGTMGRGIAYLLAQNGIRTLLYNRSGNNLNQARDYIIRDLDKKIDGGKISPQKKGEILANLVFSP
IFEAIADSDLVIETIAEHEATKHEILAAIAATVKKEAIIATNTSSLSLNKLAAGVENNARFIGLHFFNPAPLMKLIEIIP
SYFTSRATSLRCQQLVTAIGKQFVVCKATPGFIVNRMARPFYLEGFRLLEENVALAPQIDRALKAGGHFRMGPLELTDFI
GQDINYQVSSQIWQDMQYDPRYTPGHLQRSLVDAGLLGKKNGRSFFTPSSAEPSSADAGSGTPTSLNFYGEHPLFDLLQQ
RALALWPRVQINRQSEQPTLGRFIRVNDAMAIKITDGRTANLLAELTELDTFVIDAALNYADTAYLAAAHSQDASAANKA
LFLTLLQTLIPQVEFIKDSPGLIVARVLSSLINESVIMVESGVCSRADIDIAAVAGVNYADGIFSWLAQLGQKNVKSTLD
NMAQLLHSARYYPHYSLLNTPRPELAVAP
>Mature_508_residues
AENNSAIHSVAVIGAGTMGRGIAYLLAQNGIRTLLYNRSGNNLNQARDYIIRDLDKKIDGGKISPQKKGEILANLVFSPI
FEAIADSDLVIETIAEHEATKHEILAAIAATVKKEAIIATNTSSLSLNKLAAGVENNARFIGLHFFNPAPLMKLIEIIPS
YFTSRATSLRCQQLVTAIGKQFVVCKATPGFIVNRMARPFYLEGFRLLEENVALAPQIDRALKAGGHFRMGPLELTDFIG
QDINYQVSSQIWQDMQYDPRYTPGHLQRSLVDAGLLGKKNGRSFFTPSSAEPSSADAGSGTPTSLNFYGEHPLFDLLQQR
ALALWPRVQINRQSEQPTLGRFIRVNDAMAIKITDGRTANLLAELTELDTFVIDAALNYADTAYLAAAHSQDASAANKAL
FLTLLQTLIPQVEFIKDSPGLIVARVLSSLINESVIMVESGVCSRADIDIAAVAGVNYADGIFSWLAQLGQKNVKSTLDN
MAQLLHSARYYPHYSLLNTPRPELAVAP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=286, Percent_Identity=34.6153846153846, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI296179427, Length=303, Percent_Identity=32.6732673267327, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI20127408, Length=281, Percent_Identity=29.1814946619217, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI261878539, Length=291, Percent_Identity=31.9587628865979, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI68989263, Length=291, Percent_Identity=31.9587628865979, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI115430219, Length=237, Percent_Identity=27.4261603375527, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1787661, Length=486, Percent_Identity=36.0082304526749, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788682, Length=265, Percent_Identity=30.188679245283, Blast_Score=113, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=37.7162629757785, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=35.5400696864112, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=36.5853658536585, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI25144276, Length=290, Percent_Identity=33.7931034482759, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17508951, Length=290, Percent_Identity=33.7931034482759, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17508953, Length=290, Percent_Identity=33.7931034482759, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17558304, Length=281, Percent_Identity=33.0960854092527, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71985930, Length=286, Percent_Identity=28.6713286713287, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI71985923, Length=281, Percent_Identity=28.1138790035587, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19921000, Length=281, Percent_Identity=28.4697508896797, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24583077, Length=281, Percent_Identity=28.4697508896797, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24583079, Length=281, Percent_Identity=28.4697508896797, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI20129993, Length=237, Percent_Identity=24.4725738396624, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45549573, Length=235, Percent_Identity=24.2553191489362, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 55528; Mature: 55397

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENNSAIHSVAVIGAGTMGRGIAYLLAQNGIRTLLYNRSGNNLNQARDYIIRDLDKKID
CCCCCCHHHEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC
GGKISPQKKGEILANLVFSPIFEAIADSDLVIETIAEHEATKHEILAAIAATVKKEAIIA
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
TNTSSLSLNKLAAGVENNARFIGLHFFNPAPLMKLIEIIPSYFTSRATSLRCQQLVTAIG
ECCCCCCHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KQFVVCKATPGFIVNRMARPFYLEGFRLLEENVALAPQIDRALKAGGHFRMGPLELTDFI
CCEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCEECCCHHHHHHH
GQDINYQVSSQIWQDMQYDPRYTPGHLQRSLVDAGLLGKKNGRSFFTPSSAEPSSADAGS
CCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GTPTSLNFYGEHPLFDLLQQRALALWPRVQINRQSEQPTLGRFIRVNDAMAIKITDGRTA
CCCCEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHCEEEECCEEEEEEECCCHH
NLLAELTELDTFVIDAALNYADTAYLAAAHSQDASAANKALFLTLLQTLIPQVEFIKDSP
HHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCHHHHHHHHHHHHHHHCCHHEECCCCC
GLIVARVLSSLINESVIMVESGVCSRADIDIAAVAGVNYADGIFSWLAQLGQKNVKSTLD
CHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NMAQLLHSARYYPHYSLLNTPRPELAVAP
HHHHHHHHHHCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AENNSAIHSVAVIGAGTMGRGIAYLLAQNGIRTLLYNRSGNNLNQARDYIIRDLDKKID
CCCCCHHHEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC
GGKISPQKKGEILANLVFSPIFEAIADSDLVIETIAEHEATKHEILAAIAATVKKEAIIA
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEE
TNTSSLSLNKLAAGVENNARFIGLHFFNPAPLMKLIEIIPSYFTSRATSLRCQQLVTAIG
ECCCCCCHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KQFVVCKATPGFIVNRMARPFYLEGFRLLEENVALAPQIDRALKAGGHFRMGPLELTDFI
CCEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCEECCCHHHHHHH
GQDINYQVSSQIWQDMQYDPRYTPGHLQRSLVDAGLLGKKNGRSFFTPSSAEPSSADAGS
CCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GTPTSLNFYGEHPLFDLLQQRALALWPRVQINRQSEQPTLGRFIRVNDAMAIKITDGRTA
CCCCEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHCEEEECCEEEEEEECCCHH
NLLAELTELDTFVIDAALNYADTAYLAAAHSQDASAANKALFLTLLQTLIPQVEFIKDSP
HHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCHHHHHHHHHHHHHHHCCHHEECCCCC
GLIVARVLSSLINESVIMVESGVCSRADIDIAAVAGVNYADGIFSWLAQLGQKNVKSTLD
CHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NMAQLLHSARYYPHYSLLNTPRPELAVAP
HHHHHHHHHHCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]