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The map label for this gene is serC

Identifier: 157369949

GI number: 157369949

Start: 1872883

End: 1873968

Strand: Direct

Name: serC

Synonym: Spro_1706

Alternate gene names: 157369949

Gene position: 1872883-1873968 (Clockwise)

Preceding gene: 157369948

Following gene: 157369950

Centisome position: 34.37

GC content: 54.6

Gene sequence:

>1086_bases
ATGACTCAGGTTTATAATTTTAGCTCTGGTCCGGCCATGTTGCCGGTTGAAGTTTTGCGTCGTGCGGAACAGGAGCTGTG
CAACTGGCACGGTCTTGGTACCTCGGTGATGGAAATCAGCCATCGCAGTAAAGAGTTTATCGAAGTTGCTCAGCAGTCCG
AACAGGACCTGCGCGATCTGCTGAAAATCCCCTCCAATTATAAAGTCCTGTTCTGCCACGGCGGTGCCCGCGCACAGTTT
GCCGCGCTGCCGCTGAACCTGCTGGGTGACAAAACTACCGCGGACTATATCGACGGCGGTTATTGGGCGCACAGCGCTAT
CACCGAAGCGCAAAAATACTGCACGCCAAACACCATCGACGTGAAAACTTCCGTCGACGGCCTGCTCGGCATCAAACCGA
TGAAAGAGTGGCAGTTGAGCGACGACGCGGCCTACGTGCACTATTGCCCTAATGAAACCATCGACGGCGTGGCTATCGAT
GAATTACCGGATTTTGGCGATAAAGTCGTGATCGGCGATTACTCTTCTACCATTTTATCTGGTCCGCTGGACGTCAGTCG
TTTTGGCGTGATTTATGCCGGCGCCCAGAAAAACATTGGCCCGGCCGGCCTGACGCTGGTGATTGTGCGTGAAGATCTGC
TGGGTAAGGCGCGCCGCGAAGTGCCGTCGATCCTCGATTACACCGTGCTGGCCGAAAACGACTCGATGTTCAACACGCCG
CCGACCTTTGCCTGGTATCTGTCCGGGCTGGTGTTCAAATGGCTGAAAGAGCAGGGTGGTCTGGTAGAGATGCACAAACG
CAATCAGGCCAAGGCCGAACTGCTGTATGCGACTATCGATAAGTCTGATTTTTACCGCAGCCGGGTGGCGCTTGCCAACC
GTTCCTGGATGAACGTGCCTTTCCAGTTGGCGGATCCCGCGCTGGACAAAGTGTTTCTCAGCGAAGCTGAAGCCATTGGC
TTGCAGGCGTTGAAAGGCCATCGAGTGGTTGGCGGTATGCGCGCTTCTATTTACAATGCCATGCCGTTGGCTGGCGTGAA
GACATTAACCGACTTTATGGTCGACTTCGAACGTCGTCACGGTTAA

Upstream 100 bases:

>100_bases
CATTGCAGGCAGGGGGCGCGAGTGATAAAACCGATGGGTTAGTTCGGGCGTATTTCGGTAGGCCAGTTTCATTGGCGAAT
AGTGAATGTGGTGAGGGGAA

Downstream 100 bases:

>100_bases
GCCGGGTAGCCTGCCTTGAGCGGGCCGCCTTCGCTGTTGTCCTTTTTGAATTAAAGCGGCTCCGGCATTTTCCCGGGGCC
GTTTCGTTTATCAGATTTTG

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTQVYNFSSGPAMLPVEVLRRAEQELCNWHGLGTSVMEISHRSKEFIEVAQQSEQDLRDLLKIPSNYKVLFCHGGARAQF
AALPLNLLGDKTTADYIDGGYWAHSAITEAQKYCTPNTIDVKTSVDGLLGIKPMKEWQLSDDAAYVHYCPNETIDGVAID
ELPDFGDKVVIGDYSSTILSGPLDVSRFGVIYAGAQKNIGPAGLTLVIVREDLLGKARREVPSILDYTVLAENDSMFNTP
PTFAWYLSGLVFKWLKEQGGLVEMHKRNQAKAELLYATIDKSDFYRSRVALANRSWMNVPFQLADPALDKVFLSEAEAIG
LQALKGHRVVGGMRASIYNAMPLAGVKTLTDFMVDFERRHG

Sequences:

>Translated_361_residues
MTQVYNFSSGPAMLPVEVLRRAEQELCNWHGLGTSVMEISHRSKEFIEVAQQSEQDLRDLLKIPSNYKVLFCHGGARAQF
AALPLNLLGDKTTADYIDGGYWAHSAITEAQKYCTPNTIDVKTSVDGLLGIKPMKEWQLSDDAAYVHYCPNETIDGVAID
ELPDFGDKVVIGDYSSTILSGPLDVSRFGVIYAGAQKNIGPAGLTLVIVREDLLGKARREVPSILDYTVLAENDSMFNTP
PTFAWYLSGLVFKWLKEQGGLVEMHKRNQAKAELLYATIDKSDFYRSRVALANRSWMNVPFQLADPALDKVFLSEAEAIG
LQALKGHRVVGGMRASIYNAMPLAGVKTLTDFMVDFERRHG
>Mature_360_residues
TQVYNFSSGPAMLPVEVLRRAEQELCNWHGLGTSVMEISHRSKEFIEVAQQSEQDLRDLLKIPSNYKVLFCHGGARAQFA
ALPLNLLGDKTTADYIDGGYWAHSAITEAQKYCTPNTIDVKTSVDGLLGIKPMKEWQLSDDAAYVHYCPNETIDGVAIDE
LPDFGDKVVIGDYSSTILSGPLDVSRFGVIYAGAQKNIGPAGLTLVIVREDLLGKARREVPSILDYTVLAENDSMFNTPP
TFAWYLSGLVFKWLKEQGGLVEMHKRNQAKAELLYATIDKSDFYRSRVALANRSWMNVPFQLADPALDKVFLSEAEAIGL
QALKGHRVVGGMRASIYNAMPLAGVKTLTDFMVDFERRHG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=365, Percent_Identity=47.3972602739726, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI10863955, Length=361, Percent_Identity=42.6592797783933, Blast_Score=286, Evalue=3e-77,
Organism=Escherichia coli, GI1787136, Length=362, Percent_Identity=76.7955801104972, Blast_Score=595, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI17506897, Length=361, Percent_Identity=40.7202216066482, Blast_Score=285, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6324758, Length=385, Percent_Identity=37.6623376623377, Blast_Score=236, Evalue=4e-63,
Organism=Drosophila melanogaster, GI21356589, Length=363, Percent_Identity=48.4848484848485, Blast_Score=344, Evalue=4e-95,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_SERP5 (A8GCH0)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477938.1
- ProteinModelPortal:   A8GCH0
- SMR:   A8GCH0
- STRING:   A8GCH0
- GeneID:   5604398
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1706
- eggNOG:   COG1932
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- BioCyc:   SPRO399741:SPRO_1706-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40031; Mature: 39900

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 9-9 BINDING 42-42 BINDING 102-102 BINDING 153-153 BINDING 173-173 BINDING 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVYNFSSGPAMLPVEVLRRAEQELCNWHGLGTSVMEISHRSKEFIEVAQQSEQDLRDL
CCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKIPSNYKVLFCHGGARAQFAALPLNLLGDKTTADYIDGGYWAHSAITEAQKYCTPNTID
HHCCCCCEEEEEECCCCCEEEECCHHHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCEE
VKTSVDGLLGIKPMKEWQLSDDAAYVHYCPNETIDGVAIDELPDFGDKVVIGDYSSTILS
EEECCCCCCCCCCCHHCCCCCCCEEEEECCCCCCCCEECCCCCCCCCEEEEECCCHHHHC
GPLDVSRFGVIYAGAQKNIGPAGLTLVIVREDLLGKARREVPSILDYTVLAENDSMFNTP
CCCCHHHCEEEEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCEEEEECCCCCCCCC
PTFAWYLSGLVFKWLKEQGGLVEMHKRNQAKAELLYATIDKSDFYRSRVALANRSWMNVP
CHHHHHHHHHHHHHHHHCCCEEEEHHCCCHHHEEEEEECCCHHHHHHHHHHHCCCCCCCC
FQLADPALDKVFLSEAEAIGLQALKGHRVVGGMRASIYNAMPLAGVKTLTDFMVDFERRH
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHC
G
C
>Mature Secondary Structure 
TQVYNFSSGPAMLPVEVLRRAEQELCNWHGLGTSVMEISHRSKEFIEVAQQSEQDLRDL
CEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKIPSNYKVLFCHGGARAQFAALPLNLLGDKTTADYIDGGYWAHSAITEAQKYCTPNTID
HHCCCCCEEEEEECCCCCEEEECCHHHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCEE
VKTSVDGLLGIKPMKEWQLSDDAAYVHYCPNETIDGVAIDELPDFGDKVVIGDYSSTILS
EEECCCCCCCCCCCHHCCCCCCCEEEEECCCCCCCCEECCCCCCCCCEEEEECCCHHHHC
GPLDVSRFGVIYAGAQKNIGPAGLTLVIVREDLLGKARREVPSILDYTVLAENDSMFNTP
CCCCHHHCEEEEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCEEEEECCCCCCCCC
PTFAWYLSGLVFKWLKEQGGLVEMHKRNQAKAELLYATIDKSDFYRSRVALANRSWMNVP
CHHHHHHHHHHHHHHHHCCCEEEEHHCCCHHHEEEEEECCCHHHHHHHHHHHCCCCCCCC
FQLADPALDKVFLSEAEAIGLQALKGHRVVGGMRASIYNAMPLAGVKTLTDFMVDFERRH
HHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA