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The map label for this gene is aroA

Identifier: 157369950

GI number: 157369950

Start: 1874084

End: 1875370

Strand: Direct

Name: aroA

Synonym: Spro_1707

Alternate gene names: 157369950

Gene position: 1874084-1875370 (Clockwise)

Preceding gene: 157369949

Following gene: 157369951

Centisome position: 34.39

GC content: 57.73

Gene sequence:

>1287_bases
ATGGTGGATTCCCTGACGTTACAACCGGTTGCCCTGGTCAATGGCACCGTCAACTTACCCGGCTCCAAGAGCGTATCCAA
CCGTGCTCTGTTGCTGGCTGCGCTGGCGGAGGGAACGACAACGCTGACTAACCTGCTGGACAGCGACGATGTGCGCCATA
TGTTAAATGCGCTGCAGGCGCTGGGCGTGAGCTATCAGCTGTCAGACGATCGCACCACCTGTAAAGTGGACGGTGTGGGC
GGCCCGCTGGTGGCCAGCAAGCCGCTTGAACTGTTCCTCGGCAATGCCGGTACCGCGATGCGCCCATTGGCAGCCGCTCT
GTGCCTGGGCAGCAACGATGTGGTGCTGACCGGCGAACCGCGCATGAAAGAGCGTCCGATCGGTCATCTGGTCGATGCTC
TGCGTCAGGGCGGCGCACAGATTGATTACCTGGAACAGACTGATTATCCGCCATTGCGTCTGCGCGGCGGTTTCCGCGGC
GGCGATGTCACCGTCGATGGCAGCGTTTCCAGCCAGTTTCTGACCGCATTGCTGATGACGGCCCCTTTGGCAGAACAGGA
CACCCATATCCATATCAAGGGCGAACTGGTTTCCAAGCCGTACATTGATATCACGTTGCACCTGATGCGTACTTTCGGCG
TCGAGGTTAGCCACGACAACTACCGCGTGTTCCACATTAATGGTCGCCAGACCTACCGTTCTCCGGGCGACTACCTGGTC
GAGGGAGATGCTTCTTCCGCCTCTTACTTCCTGGCGGCAGCCGCGATTAAAGGTGGCACCGTGCGCGTAACCGGCATCGG
CAAGAAAAGTGTTCAGGGCGATACCAAGTTCGCCGATGTTCTGGAGAAAATGGGCGCGCGCATTACCTGGGGCGATGATT
ATATCGAATGCAGCCGCGGTGAATTGCGCGGCATCGACATGGATATGAACCATATTCCTGATGCGGCGATGACCATTGCG
ACCGCGGCCCTGTTTGCCGAAGGCCCAACGACCATTCGCAACATTTATAACTGGCGGGTGAAAGAGACCGATCGGCTGGC
TGCGATGGCGACAGAGTTGCGTAAAGTGGGCGCTGAGGTAGATGAAGGCGAGGACTATATCCACGTAGTCCCACCGGCCA
AGCTGAAGTTTGCCGATATAGGCACCTACAACGATCACCGTATGGCGATGTGCTTCTCGCTGGTGGCGCTGTCTGATACG
CCGGTGACCATTCTTGATCCTAAATGCACCGCGAAAACCTTCCCGGACTATTTCGAACAGTTGGCGCGCATCAGCCAATT
GGCGTGA

Upstream 100 bases:

>100_bases
TTGAGCGGGCCGCCTTCGCTGTTGTCCTTTTTGAATTAAAGCGGCTCCGGCATTTTCCCGGGGCCGTTTCGTTTATCAGA
TTTTGGAGATTTTTGTTCAC

Downstream 100 bases:

>100_bases
TCCGCAGTCAGATACTTTCTTTTAAGGCCCTTGATTGGGCCTTTATTGTTTTTAACGCCCGTAGCCTGGATCCGTCCGCT
ATACTTTTGCGCGGTCATAC

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MVDSLTLQPVALVNGTVNLPGSKSVSNRALLLAALAEGTTTLTNLLDSDDVRHMLNALQALGVSYQLSDDRTTCKVDGVG
GPLVASKPLELFLGNAGTAMRPLAAALCLGSNDVVLTGEPRMKERPIGHLVDALRQGGAQIDYLEQTDYPPLRLRGGFRG
GDVTVDGSVSSQFLTALLMTAPLAEQDTHIHIKGELVSKPYIDITLHLMRTFGVEVSHDNYRVFHINGRQTYRSPGDYLV
EGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGARITWGDDYIECSRGELRGIDMDMNHIPDAAMTIA
TAALFAEGPTTIRNIYNWRVKETDRLAAMATELRKVGAEVDEGEDYIHVVPPAKLKFADIGTYNDHRMAMCFSLVALSDT
PVTILDPKCTAKTFPDYFEQLARISQLA

Sequences:

>Translated_428_residues
MVDSLTLQPVALVNGTVNLPGSKSVSNRALLLAALAEGTTTLTNLLDSDDVRHMLNALQALGVSYQLSDDRTTCKVDGVG
GPLVASKPLELFLGNAGTAMRPLAAALCLGSNDVVLTGEPRMKERPIGHLVDALRQGGAQIDYLEQTDYPPLRLRGGFRG
GDVTVDGSVSSQFLTALLMTAPLAEQDTHIHIKGELVSKPYIDITLHLMRTFGVEVSHDNYRVFHINGRQTYRSPGDYLV
EGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGARITWGDDYIECSRGELRGIDMDMNHIPDAAMTIA
TAALFAEGPTTIRNIYNWRVKETDRLAAMATELRKVGAEVDEGEDYIHVVPPAKLKFADIGTYNDHRMAMCFSLVALSDT
PVTILDPKCTAKTFPDYFEQLARISQLA
>Mature_428_residues
MVDSLTLQPVALVNGTVNLPGSKSVSNRALLLAALAEGTTTLTNLLDSDDVRHMLNALQALGVSYQLSDDRTTCKVDGVG
GPLVASKPLELFLGNAGTAMRPLAAALCLGSNDVVLTGEPRMKERPIGHLVDALRQGGAQIDYLEQTDYPPLRLRGGFRG
GDVTVDGSVSSQFLTALLMTAPLAEQDTHIHIKGELVSKPYIDITLHLMRTFGVEVSHDNYRVFHINGRQTYRSPGDYLV
EGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGARITWGDDYIECSRGELRGIDMDMNHIPDAAMTIA
TAALFAEGPTTIRNIYNWRVKETDRLAAMATELRKVGAEVDEGEDYIHVVPPAKLKFADIGTYNDHRMAMCFSLVALSDT
PVTILDPKCTAKTFPDYFEQLARISQLA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=427, Percent_Identity=81.7330210772834, Blast_Score=705, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320332, Length=446, Percent_Identity=39.9103139013453, Blast_Score=264, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_SERP5 (A8GCH1)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477939.1
- ProteinModelPortal:   A8GCH1
- SMR:   A8GCH1
- STRING:   A8GCH1
- GeneID:   5604413
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1707
- eggNOG:   COG0128
- HOGENOM:   HBG646626
- OMA:   RIAAMAC
- ProtClustDB:   PRK02427
- BioCyc:   SPRO399741:SPRO_1707-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 46289; Mature: 46289

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSLTLQPVALVNGTVNLPGSKSVSNRALLLAALAEGTTTLTNLLDSDDVRHMLNALQA
CCCCCCCCEEEEECCEEECCCCCCCCCCEEEEEEHHCCHHHHHHHHCCHHHHHHHHHHHH
LGVSYQLSDDRTTCKVDGVGGPLVASKPLELFLGNAGTAMRPLAAALCLGSNDVVLTGEP
HCCEEEECCCCCEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHEECCCCEEEECCC
RMKERPIGHLVDALRQGGAQIDYLEQTDYPPLRLRGGFRGGDVTVDGSVSSQFLTALLMT
CCCCCCHHHHHHHHHHCCCEEEEHHCCCCCCEEEECCCCCCCEEECCCHHHHHHHHHHHH
APLAEQDTHIHIKGELVSKPYIDITLHLMRTFGVEVSHDNYRVFHINGRQTYRSPGDYLV
CCCCCCCCEEEEEEEECCCCCHHHHHEEHHHHCCEEECCCEEEEEECCCCCCCCCCCEEE
EGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGARITWGDDYIECSRG
ECCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHCCEEEECCCCEECCCC
ELRGIDMDMNHIPDAAMTIATAALFAEGPTTIRNIYNWRVKETDRLAAMATELRKVGAEV
CEEEECCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCEECCHHHHHHHHHHHHHHCCCC
DEGEDYIHVVPPAKLKFADIGTYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQ
CCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
LARISQLA
HHHHHHCC
>Mature Secondary Structure
MVDSLTLQPVALVNGTVNLPGSKSVSNRALLLAALAEGTTTLTNLLDSDDVRHMLNALQA
CCCCCCCCEEEEECCEEECCCCCCCCCCEEEEEEHHCCHHHHHHHHCCHHHHHHHHHHHH
LGVSYQLSDDRTTCKVDGVGGPLVASKPLELFLGNAGTAMRPLAAALCLGSNDVVLTGEP
HCCEEEECCCCCEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHEECCCCEEEECCC
RMKERPIGHLVDALRQGGAQIDYLEQTDYPPLRLRGGFRGGDVTVDGSVSSQFLTALLMT
CCCCCCHHHHHHHHHHCCCEEEEHHCCCCCCEEEECCCCCCCEEECCCHHHHHHHHHHHH
APLAEQDTHIHIKGELVSKPYIDITLHLMRTFGVEVSHDNYRVFHINGRQTYRSPGDYLV
CCCCCCCCEEEEEEEECCCCCHHHHHEEHHHHCCEEECCCEEEEEECCCCCCCCCCCEEE
EGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGARITWGDDYIECSRG
ECCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHCCEEEECCCCEECCCC
ELRGIDMDMNHIPDAAMTIATAALFAEGPTTIRNIYNWRVKETDRLAAMATELRKVGAEV
CEEEECCCHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCEECCHHHHHHHHHHHHHHCCCC
DEGEDYIHVVPPAKLKFADIGTYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQ
CCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
LARISQLA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA