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The map label for this gene is deoR [H]

Identifier: 157369874

GI number: 157369874

Start: 1788688

End: 1789530

Strand: Reverse

Name: deoR [H]

Synonym: Spro_1631

Alternate gene names: 157369874

Gene position: 1789530-1788688 (Counterclockwise)

Preceding gene: 157369875

Following gene: 157369873

Centisome position: 32.84

GC content: 55.4

Gene sequence:

>843_bases
ATGGCTGGGCCGCTATTACCCCGCATTTGTGTGTTCAGCCCTGATGAAACTTTCTTAACCCTGTGGGAAGACAGACAGAT
GGAAACGCGGCGCGAAGAACGTCTCAATCGATTAGTCCAGGCGTTAAAGCGCTCTGACAAGATCCACTTAAAAGAAGCCG
CCGTCCTGTTGGGCGTGTCAGAAATGACCATCCGCCGCGATCTCAGCGCAGAACCGGCGGCCGTGGTTCTGCTGGGCGGT
TACGTGGTGGCCGATCCGCGCAGTAACGGCGTGACCCACTATTTTGTTTCCGACCAAAAAGCCAAGCAGGTCACGGAAAA
ACGCCGTATCGGCCTGCTCGCCGCGCAGCTTATCAGCGAAAACGACACCGTATTTTTCGACTGCGGCACCACTACGCCGG
CGATCATCGACGCAATCGCTGACGACCTGGTCTTCACCGCGGTCTGCCACTCACTCAATACCTTCCTGGCGTTACAGGAC
AAACCGAACTGCAAGGTGATCCTGTGCGGCGGCGAATTCAAGCCGAACAACTATATATTCACCGCCGTCGGCCGCCACAG
CGAGCTGGATCATATCTGCCCCAATATCGCCTTTATCTCCGCCGCCGGTTTGAGCCTGCAGCATGGCGCAACCTGCTTTA
ACTTTGATGAACTGGAGATGAAGCACCGGGCGATAACGATGTCACAGCAAAAAATCCTGGTGGCCGACCACAGTAAATTC
GGCAAAACCAAACCCGCCTGCATCGGGCCATTGACTCAATTCGACCGGGTGATCACCGATCGCCAGCCTGACCCCGAGTT
TGCGGAGTTTTTCAGCGAAAACGCGATCGCCATTCGTTTTTAA

Upstream 100 bases:

>100_bases
TCCGGTGATCAGGCCGCTGCCGGCAGCTACTGATAACCTGAGGCGTCTGGGTACCGGGCGCACGCCGTGATAATCTGATG
CGGGGTAATAAGTTCAGCCA

Downstream 100 bases:

>100_bases
TCTGCTCCCCTGCCGTCGACCCCGGTCGGCGGTGCTCTTCATTAACGCCCTTCCGCCCGACGAAGCCGAACAAATAATGC
GCAATTGATTCGATTATTTT

Product: DNA-binding transcriptional repressor DeoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MAGPLLPRICVFSPDETFLTLWEDRQMETRREERLNRLVQALKRSDKIHLKEAAVLLGVSEMTIRRDLSAEPAAVVLLGG
YVVADPRSNGVTHYFVSDQKAKQVTEKRRIGLLAAQLISENDTVFFDCGTTTPAIIDAIADDLVFTAVCHSLNTFLALQD
KPNCKVILCGGEFKPNNYIFTAVGRHSELDHICPNIAFISAAGLSLQHGATCFNFDELEMKHRAITMSQQKILVADHSKF
GKTKPACIGPLTQFDRVITDRQPDPEFAEFFSENAIAIRF

Sequences:

>Translated_280_residues
MAGPLLPRICVFSPDETFLTLWEDRQMETRREERLNRLVQALKRSDKIHLKEAAVLLGVSEMTIRRDLSAEPAAVVLLGG
YVVADPRSNGVTHYFVSDQKAKQVTEKRRIGLLAAQLISENDTVFFDCGTTTPAIIDAIADDLVFTAVCHSLNTFLALQD
KPNCKVILCGGEFKPNNYIFTAVGRHSELDHICPNIAFISAAGLSLQHGATCFNFDELEMKHRAITMSQQKILVADHSKF
GKTKPACIGPLTQFDRVITDRQPDPEFAEFFSENAIAIRF
>Mature_279_residues
AGPLLPRICVFSPDETFLTLWEDRQMETRREERLNRLVQALKRSDKIHLKEAAVLLGVSEMTIRRDLSAEPAAVVLLGGY
VVADPRSNGVTHYFVSDQKAKQVTEKRRIGLLAAQLISENDTVFFDCGTTTPAIIDAIADDLVFTAVCHSLNTFLALQDK
PNCKVILCGGEFKPNNYIFTAVGRHSELDHICPNIAFISAAGLSLQHGATCFNFDELEMKHRAITMSQQKILVADHSKFG
KTKPACIGPLTQFDRVITDRQPDPEFAEFFSENAIAIRF

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=254, Percent_Identity=56.2992125984252, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI1789829, Length=257, Percent_Identity=26.8482490272374, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI226510968, Length=230, Percent_Identity=30.4347826086957, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790753, Length=241, Percent_Identity=28.2157676348548, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789519, Length=231, Percent_Identity=25.5411255411255, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789059, Length=252, Percent_Identity=26.5873015873016, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787540, Length=235, Percent_Identity=24.2553191489362, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788069, Length=250, Percent_Identity=23.6, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87082344, Length=253, Percent_Identity=22.9249011857708, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 31197; Mature: 31066

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGPLLPRICVFSPDETFLTLWEDRQMETRREERLNRLVQALKRSDKIHLKEAAVLLGVS
CCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCHH
EMTIRRDLSAEPAAVVLLGGYVVADPRSNGVTHYFVSDQKAKQVTEKRRIGLLAAQLISE
HHHHHHCCCCCCCEEEEECCEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
NDTVFFDCGTTTPAIIDAIADDLVFTAVCHSLNTFLALQDKPNCKVILCGGEFKPNNYIF
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCEEE
TAVGRHSELDHICPNIAFISAAGLSLQHGATCFNFDELEMKHRAITMSQQKILVADHSKF
EEECCCCCHHHHCCCEEEEEECCCEECCCCEEECHHHHHHHHHHEEECCCEEEEECCCCC
GKTKPACIGPLTQFDRVITDRQPDPEFAEFFSENAIAIRF
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCEEEEC
>Mature Secondary Structure 
AGPLLPRICVFSPDETFLTLWEDRQMETRREERLNRLVQALKRSDKIHLKEAAVLLGVS
CCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCHH
EMTIRRDLSAEPAAVVLLGGYVVADPRSNGVTHYFVSDQKAKQVTEKRRIGLLAAQLISE
HHHHHHCCCCCCCEEEEECCEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
NDTVFFDCGTTTPAIIDAIADDLVFTAVCHSLNTFLALQDKPNCKVILCGGEFKPNNYIF
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCEEE
TAVGRHSELDHICPNIAFISAAGLSLQHGATCFNFDELEMKHRAITMSQQKILVADHSKF
EEECCCCCHHHHCCCEEEEEECCCEECCCCEEECHHHHHHHHHHEEECCCEEEEECCCCC
GKTKPACIGPLTQFDRVITDRQPDPEFAEFFSENAIAIRF
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]