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The map label for this gene is sdaC [H]

Identifier: 157369873

GI number: 157369873

Start: 1786423

End: 1787718

Strand: Reverse

Name: sdaC [H]

Synonym: Spro_1630

Alternate gene names: 157369873

Gene position: 1787718-1786423 (Counterclockwise)

Preceding gene: 157369874

Following gene: 157369872

Centisome position: 32.81

GC content: 54.01

Gene sequence:

>1296_bases
ATGGACACTACACAGACCGGCACTATAGCCTCTGCGGCTTCTGGCTCTACCAGTACCTGGCGTAAAACCGACACCATGTG
GATGTTGGGCCTGTATGGCACCGCGATTGGCGCGGGCGTTTTGTTCCTGCCAATCAATGCCGGTATCGGTGGTTTGATCC
CCCTGATCATCATGGCCATCATTGCGTTCCCGATGACCTTCTTTGCGCACCGTGGCCTGTGCCGCTTCGTTCTTTCCGGC
AAAAACGCCGGTGAAGACATCACCGAAGTCGTTGAAGAACACTTTGGTATCAGCGCCGGTAAGCTGATCACCCTGCTCTA
CTTCTTTGCCATTTACCCCATTCTGTTGGTTTACAGCGTCGCCATCACCAACACCGTCGACAGCTTCATTACCCACCAAC
TGGGGATGGCTTCGCCGCCACGTGCCATTTTGTCGTTGATCCTGATTGTCGGCCTGATGACCATCGTGCGTTTCGGCGAG
CAGGCTATCGTGAAGACCATGAGTATCCTGGTGTTCCCGTTTGTCGCCGTATTGATGCTGCTGGCTGTGTACCTGATCCC
GAACTGGACCACCGCCATCTTCGATAACGTTTCTCTGTCCGGCGCAGGCACGGGTATGGGTCATGGTCTGGTTATCACCC
TGTGGCTGGCGATCCCGGTGATGGTGTTCTCCTTCAACCACTCACCAATCATCTCTGCCTTTGCCGTAGCCAAGCGTGAA
GAGTACGGTCAGGAAGAGGCCGAGAAGAAATGCTCCCGCATTCTGGGCTTCGCTCACATCATGATGGTGTTGACCGTAAT
GTTCTTCGTGTTCAGCTGCGTGCTGAGCCTGTCGCCGGAAAACCTGGCGGAAGCCAAGGCGCAGAACATCTCCATTCTGT
CTTACCTGGCTAACCACTTTAATAACCCGATGATTGCCTACATCGCACCGGTTATCGCCTTTATCGCCATCACCAAATCG
TTCCTCGGTCACTATCTGGGTGCACGTGAAGGCTTTAACGGTCTGATTGCCAAGTCGATGAAAAGCCGCGGTAAAACCAT
CAGCACCAACAAACTGAACCGTATCACCGCCCTGTTTATGCTGGTGACTACCTGGATTGTTGCGACCCTGAACCCAAGCA
TCCTCGGCATGATCGAGAATATGGGTGGCCCAATCATCGCCATGCTGCTGTTCCTGATGCCGATGTACGCTATCCGTAAA
GTGCCGGCCATGCGCAAATACAGCGGCCACATCAGTAACGTGTTCGTGGTAGTGATGGGCCTGATCGCCATCTCCGCAAT
CCTGTACAGCTTCTAA

Upstream 100 bases:

>100_bases
CTGATTCTTACCGATGCCGCCATCTGATATTGCGTCATTCGGATTTAACCTTAAGTTTTGCCTTTAATTTTAAATTAGCG
TGTTCACTTCGGAGATATTT

Downstream 100 bases:

>100_bases
TCAAGCCCAGCCGGCGCTACCTTGCGCCGGCTTTTCAGCACGGCCCCCTTTCCTGCATTAACGCCTAACACCTGAAGAAG
GAGGCGAGACCATGGTCAGC

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MDTTQTGTIASAASGSTSTWRKTDTMWMLGLYGTAIGAGVLFLPINAGIGGLIPLIIMAIIAFPMTFFAHRGLCRFVLSG
KNAGEDITEVVEEHFGISAGKLITLLYFFAIYPILLVYSVAITNTVDSFITHQLGMASPPRAILSLILIVGLMTIVRFGE
QAIVKTMSILVFPFVAVLMLLAVYLIPNWTTAIFDNVSLSGAGTGMGHGLVITLWLAIPVMVFSFNHSPIISAFAVAKRE
EYGQEEAEKKCSRILGFAHIMMVLTVMFFVFSCVLSLSPENLAEAKAQNISILSYLANHFNNPMIAYIAPVIAFIAITKS
FLGHYLGAREGFNGLIAKSMKSRGKTISTNKLNRITALFMLVTTWIVATLNPSILGMIENMGGPIIAMLLFLMPMYAIRK
VPAMRKYSGHISNVFVVVMGLIAISAILYSF

Sequences:

>Translated_431_residues
MDTTQTGTIASAASGSTSTWRKTDTMWMLGLYGTAIGAGVLFLPINAGIGGLIPLIIMAIIAFPMTFFAHRGLCRFVLSG
KNAGEDITEVVEEHFGISAGKLITLLYFFAIYPILLVYSVAITNTVDSFITHQLGMASPPRAILSLILIVGLMTIVRFGE
QAIVKTMSILVFPFVAVLMLLAVYLIPNWTTAIFDNVSLSGAGTGMGHGLVITLWLAIPVMVFSFNHSPIISAFAVAKRE
EYGQEEAEKKCSRILGFAHIMMVLTVMFFVFSCVLSLSPENLAEAKAQNISILSYLANHFNNPMIAYIAPVIAFIAITKS
FLGHYLGAREGFNGLIAKSMKSRGKTISTNKLNRITALFMLVTTWIVATLNPSILGMIENMGGPIIAMLLFLMPMYAIRK
VPAMRKYSGHISNVFVVVMGLIAISAILYSF
>Mature_431_residues
MDTTQTGTIASAASGSTSTWRKTDTMWMLGLYGTAIGAGVLFLPINAGIGGLIPLIIMAIIAFPMTFFAHRGLCRFVLSG
KNAGEDITEVVEEHFGISAGKLITLLYFFAIYPILLVYSVAITNTVDSFITHQLGMASPPRAILSLILIVGLMTIVRFGE
QAIVKTMSILVFPFVAVLMLLAVYLIPNWTTAIFDNVSLSGAGTGMGHGLVITLWLAIPVMVFSFNHSPIISAFAVAKRE
EYGQEEAEKKCSRILGFAHIMMVLTVMFFVFSCVLSLSPENLAEAKAQNISILSYLANHFNNPMIAYIAPVIAFIAITKS
FLGHYLGAREGFNGLIAKSMKSRGKTISTNKLNRITALFMLVTTWIVATLNPSILGMIENMGGPIIAMLLFLMPMYAIRK
VPAMRKYSGHISNVFVVVMGLIAISAILYSF

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=430, Percent_Identity=82.7906976744186, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI1789504, Length=434, Percent_Identity=51.8433179723502, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1789211, Length=418, Percent_Identity=37.3205741626794, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI145693183, Length=432, Percent_Identity=28.0092592592593, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1789961, Length=396, Percent_Identity=26.2626262626263, Blast_Score=112, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46810; Mature: 46810

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTTQTGTIASAASGSTSTWRKTDTMWMLGLYGTAIGAGVLFLPINAGIGGLIPLIIMAI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
IAFPMTFFAHRGLCRFVLSGKNAGEDITEVVEEHFGISAGKLITLLYFFAIYPILLVYSV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AITNTVDSFITHQLGMASPPRAILSLILIVGLMTIVRFGEQAIVKTMSILVFPFVAVLML
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
LAVYLIPNWTTAIFDNVSLSGAGTGMGHGLVITLWLAIPVMVFSFNHSPIISAFAVAKRE
HHHHHHCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EYGQEEAEKKCSRILGFAHIMMVLTVMFFVFSCVLSLSPENLAEAKAQNISILSYLANHF
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NNPMIAYIAPVIAFIAITKSFLGHYLGAREGFNGLIAKSMKSRGKTISTNKLNRITALFM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LVTTWIVATLNPSILGMIENMGGPIIAMLLFLMPMYAIRKVPAMRKYSGHISNVFVVVMG
HHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHH
LIAISAILYSF
HHHHHHHHHCC
>Mature Secondary Structure
MDTTQTGTIASAASGSTSTWRKTDTMWMLGLYGTAIGAGVLFLPINAGIGGLIPLIIMAI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
IAFPMTFFAHRGLCRFVLSGKNAGEDITEVVEEHFGISAGKLITLLYFFAIYPILLVYSV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AITNTVDSFITHQLGMASPPRAILSLILIVGLMTIVRFGEQAIVKTMSILVFPFVAVLML
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
LAVYLIPNWTTAIFDNVSLSGAGTGMGHGLVITLWLAIPVMVFSFNHSPIISAFAVAKRE
HHHHHHCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EYGQEEAEKKCSRILGFAHIMMVLTVMFFVFSCVLSLSPENLAEAKAQNISILSYLANHF
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NNPMIAYIAPVIAFIAITKSFLGHYLGAREGFNGLIAKSMKSRGKTISTNKLNRITALFM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LVTTWIVATLNPSILGMIENMGGPIIAMLLFLMPMYAIRKVPAMRKYSGHISNVFVVVMG
HHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHH
LIAISAILYSF
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]