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The map label for this gene is putP2 [H]

Identifier: 157369863

GI number: 157369863

Start: 1774906

End: 1776288

Strand: Direct

Name: putP2 [H]

Synonym: Spro_1620

Alternate gene names: 157369863

Gene position: 1774906-1776288 (Clockwise)

Preceding gene: 157369862

Following gene: 157369868

Centisome position: 32.57

GC content: 60.09

Gene sequence:

>1383_bases
ATGAATCTCGACCTGCTGGTAGTGGTGTTTTACTTTTTGGTGATAGGGGCGGTGGGTTGGCTTGGCGTTCGCCGGGCCAC
CACCAAGGAAGATTATCTGGTGGCCGGCCGTAATCTGGGGCCCTGTTTGTACCTGGGCACGCTGTCCGCCGTGGTGCTTG
GCGGGGCGTCGACCATTGGCAGCGTTAAGCTGGGTTACACCTACGGGATCTCGGGCGTGTGGCTGTGTGGCGCGCTGGGG
GCGGGGATTGTGGTGTTGAGCCTGGTGTTGGCCAAACCCTTGCTCAAGCTAAAGCTCTACACCGTCAGCCAGGTGCTGGC
GCGGCGCTATCATCCGGCAGCCCGGGTCACCAGCGGTGCCATCATGCTGGCTTATGACCTGATGGTGGCCGTGACCTCGA
TTATTGCTATCGGCAGTGTGATGCAGGTGATGTTTGATTTGTCGTTCACCGCATCGATTCTGCTCGGCGGCGGTTTGGTG
GTGCTTTATTCCACGCTGGGCGGCATGTGGTCGTTGACGCTAACCGACATCATCCAGTTTATCATCATGACCGTCGGCAT
GATGCTGGTGTTGATGCCGATGAGCATCGTCAAGGCCGGGGGTTGGGCGGCGTTCAGTCAACTGTTGCCGGACAGCTACT
ACCAGCTGTCGTCGATCGGGCTTGATACCATCCTGGTGTTCTTCCTGATCTACTTTTTCGGCATTCTGATTGGTCAGGAT
ATCTGGCAGCGGGTATTTACCGCCCGCAGCACCAATATTGCTCGCTATGCCGGGTTGGGGGCTGGGGTGTACTGCGTGCT
GTATGGGGTGGCCGGCGCTCTGATTGGCATGGCCGGCAAGTTGGTACTGCCGCAACTGACCAATACCGACGGTGCCTTTG
CCGCCATTGCTCAGGCGGTGCTGCCGCCGGGCGTCAGCGGGCTGGTGGCTGCGGCGGCGTTGGCGGCGCTGATGTCGACG
GCCAGTGCCTGTTTGTTGGCATCGTCAACCATCGCGCTGGAAGATGTATTGCCGGCTGTCCGCAAACGGCCCTCCGGTGG
GCTGGCGGCCGGGAGATTCACGACGTTTGTCATGGGTTGCATTATGTTGGGGCTGGCGTTCGTGGTGCGCGACGTGATGA
TGGCGCTAACACTGGCCTATAACCTGTTGGTGGGCGGTATGTTGATCCCGTTGATCGGTGCGATTTTCTGGCAACGCGCC
ACCAGCACCGGTGCTATCGCCAGCATGCTGACCGGCAGTCTGAGCGTATTGGTACTGATGTATTATCACGGCATTGAGGC
CAACAGCCCAATCTACGGGGGTCTGTTGGCGGGCGGGGCGGCCTTTCTGATTGGCAGCCTGCTGACCCGACCAGGCCCGC
TGCCGCAGGTTCAGCCCGAGTAA

Upstream 100 bases:

>100_bases
AAATGCTGTGTGTACTGCCGTCGCGATAAGGCGACCGATAACCCGATCGGCGGAGCCGTTGCGCCTGATACCGAATAATA
ACAAGCATGCGGAGTGACCG

Downstream 100 bases:

>100_bases
AGGGTAAAAACGGGGCTGTCGTGCGCAGCCCCATTGCCGCTTACAGCCAGCCGGATCTCTTCAGTTTTTGATACAGGAAG
AAGCAGCCGACGCCGGTCAC

Product: Na+/solute symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Proline permease 2 [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNLDLLVVVFYFLVIGAVGWLGVRRATTKEDYLVAGRNLGPCLYLGTLSAVVLGGASTIGSVKLGYTYGISGVWLCGALG
AGIVVLSLVLAKPLLKLKLYTVSQVLARRYHPAARVTSGAIMLAYDLMVAVTSIIAIGSVMQVMFDLSFTASILLGGGLV
VLYSTLGGMWSLTLTDIIQFIIMTVGMMLVLMPMSIVKAGGWAAFSQLLPDSYYQLSSIGLDTILVFFLIYFFGILIGQD
IWQRVFTARSTNIARYAGLGAGVYCVLYGVAGALIGMAGKLVLPQLTNTDGAFAAIAQAVLPPGVSGLVAAAALAALMST
ASACLLASSTIALEDVLPAVRKRPSGGLAAGRFTTFVMGCIMLGLAFVVRDVMMALTLAYNLLVGGMLIPLIGAIFWQRA
TSTGAIASMLTGSLSVLVLMYYHGIEANSPIYGGLLAGGAAFLIGSLLTRPGPLPQVQPE

Sequences:

>Translated_460_residues
MNLDLLVVVFYFLVIGAVGWLGVRRATTKEDYLVAGRNLGPCLYLGTLSAVVLGGASTIGSVKLGYTYGISGVWLCGALG
AGIVVLSLVLAKPLLKLKLYTVSQVLARRYHPAARVTSGAIMLAYDLMVAVTSIIAIGSVMQVMFDLSFTASILLGGGLV
VLYSTLGGMWSLTLTDIIQFIIMTVGMMLVLMPMSIVKAGGWAAFSQLLPDSYYQLSSIGLDTILVFFLIYFFGILIGQD
IWQRVFTARSTNIARYAGLGAGVYCVLYGVAGALIGMAGKLVLPQLTNTDGAFAAIAQAVLPPGVSGLVAAAALAALMST
ASACLLASSTIALEDVLPAVRKRPSGGLAAGRFTTFVMGCIMLGLAFVVRDVMMALTLAYNLLVGGMLIPLIGAIFWQRA
TSTGAIASMLTGSLSVLVLMYYHGIEANSPIYGGLLAGGAAFLIGSLLTRPGPLPQVQPE
>Mature_460_residues
MNLDLLVVVFYFLVIGAVGWLGVRRATTKEDYLVAGRNLGPCLYLGTLSAVVLGGASTIGSVKLGYTYGISGVWLCGALG
AGIVVLSLVLAKPLLKLKLYTVSQVLARRYHPAARVTSGAIMLAYDLMVAVTSIIAIGSVMQVMFDLSFTASILLGGGLV
VLYSTLGGMWSLTLTDIIQFIIMTVGMMLVLMPMSIVKAGGWAAFSQLLPDSYYQLSSIGLDTILVFFLIYFFGILIGQD
IWQRVFTARSTNIARYAGLGAGVYCVLYGVAGALIGMAGKLVLPQLTNTDGAFAAIAQAVLPPGVSGLVAAAALAALMST
ASACLLASSTIALEDVLPAVRKRPSGGLAAGRFTTFVMGCIMLGLAFVVRDVMMALTLAYNLLVGGMLIPLIGAIFWQRA
TSTGAIASMLTGSLSVLVLMYYHGIEANSPIYGGLLAGGAAFLIGSLLTRPGPLPQVQPE

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=443, Percent_Identity=25.9593679458239, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI11141885, Length=447, Percent_Identity=22.5950782997763, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI87082237, Length=481, Percent_Identity=25.5717255717256, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1787251, Length=451, Percent_Identity=24.8337028824834, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17539284, Length=373, Percent_Identity=23.3243967828418, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24645928, Length=371, Percent_Identity=25.0673854447439, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648033, Length=363, Percent_Identity=22.038567493113, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356865, Length=363, Percent_Identity=22.038567493113, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 48011; Mature: 48011

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure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HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA