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The map label for this gene is wecA [H]

Identifier: 157369845

GI number: 157369845

Start: 1755708

End: 1756745

Strand: Direct

Name: wecA [H]

Synonym: Spro_1602

Alternate gene names: 157369845

Gene position: 1755708-1756745 (Clockwise)

Preceding gene: 157369844

Following gene: 157369851

Centisome position: 32.22

GC content: 44.32

Gene sequence:

>1038_bases
ATGCAAGAAATTGTGGCCGTTTTTTTCAGTGCGCTTGCCGTTCTTTTTATGGCGAGGAAGGTCGCAAGGAGGGTTGGGCT
AGTCGACAAACCCAATAGTCGAAAACTTCATCAAGGTCATATCCCTTTGGTTGGTGGGGTTTCTGTCTATCTATCACTTT
GGATCCTTTACTTGATGCAACCGGCCTGGTTGCCGGATTTCACTCTTTATATGGTCTGCGCCACATTGCTTTTGGCTATT
GGAGTGCTCGACGATCGTTATGATTTACCGGTATGGCCCAGGGTTGCGCTACAAGCTGCAATCGCTGTATTGATGATCTG
TAACGGACTGTACCTAAAAAGTTTTGGCGAGATCTTTTTCGGACACGAACTTTTTCTGGGAATCGGCGGCACCGTGATTA
CGGTACTTGCAATATGGGGAGCAATTAACGCCTTCAATATGGTTGATGGGGTTGATGGTTTGCTAGGAGCCTTGTCTTGC
GTGACTTTTTGCGCCTTAACTGTGGTGTTCTATATTCACGGTAATACTGATATGGCTTTGTGGTGTTTATGTCTCATGGT
CTCGTGTCTACCCTATCTCTTACTTAACTTGGGTGTGATCTGGGGGCGCAAGTTCAAGGTGTTTATGGGGGATGCCGGTA
GTACTTTGATAGGTTTTACAGTTATCTGGGTGCTGATTTTGGGAAGTCAGGGGGAGAATAGAGCTATGCAACCGGTAACG
GCCCTCTGGTTGATTGCTATACCATTAATGGATATGGTCAGGGTCATGATTAGCCGCATTAGATGTGGAAATAATCCCTT
CAAACCTGATCGTCAACATTTGCATCATATTCTGATGCGTGCAGGCAGCTCTGCTCGCGGAACTGTCATGATTATGGCAT
TTTTGGCAACTCTTCTGGCAACCGTTGGTATTGTTGGAGAAATGTTGCATATTGCAGAGTTTTTCTCTCTGTTGTTATTT
ATGTGTGTTTTTGTTTTTTACTGCTTGGTTATCAAAATTCTTTCTCAAACTCGTGGCAGTCAAATTTATCTGAAATAA

Upstream 100 bases:

>100_bases
GTATGTAACGATATAGAATGTCTACATTTTTTAGTCTCTGTCTGCGGAAAAAGCTCGTGTCTGGTAGAACAGCAGGAAAA
GTACTAGGGGTATTTGATAT

Downstream 100 bases:

>100_bases
CTAGAATAAAAAGGGTAGTGAGTGCGAGTATTGACTATACAAAAAAATAGAGTGCGGTTTTGACCGCTCTCTATTTTTTT
AAATTTACTACACTAATCTT

Product: undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MQEIVAVFFSALAVLFMARKVARRVGLVDKPNSRKLHQGHIPLVGGVSVYLSLWILYLMQPAWLPDFTLYMVCATLLLAI
GVLDDRYDLPVWPRVALQAAIAVLMICNGLYLKSFGEIFFGHELFLGIGGTVITVLAIWGAINAFNMVDGVDGLLGALSC
VTFCALTVVFYIHGNTDMALWCLCLMVSCLPYLLLNLGVIWGRKFKVFMGDAGSTLIGFTVIWVLILGSQGENRAMQPVT
ALWLIAIPLMDMVRVMISRIRCGNNPFKPDRQHLHHILMRAGSSARGTVMIMAFLATLLATVGIVGEMLHIAEFFSLLLF
MCVFVFYCLVIKILSQTRGSQIYLK

Sequences:

>Translated_345_residues
MQEIVAVFFSALAVLFMARKVARRVGLVDKPNSRKLHQGHIPLVGGVSVYLSLWILYLMQPAWLPDFTLYMVCATLLLAI
GVLDDRYDLPVWPRVALQAAIAVLMICNGLYLKSFGEIFFGHELFLGIGGTVITVLAIWGAINAFNMVDGVDGLLGALSC
VTFCALTVVFYIHGNTDMALWCLCLMVSCLPYLLLNLGVIWGRKFKVFMGDAGSTLIGFTVIWVLILGSQGENRAMQPVT
ALWLIAIPLMDMVRVMISRIRCGNNPFKPDRQHLHHILMRAGSSARGTVMIMAFLATLLATVGIVGEMLHIAEFFSLLLF
MCVFVFYCLVIKILSQTRGSQIYLK
>Mature_345_residues
MQEIVAVFFSALAVLFMARKVARRVGLVDKPNSRKLHQGHIPLVGGVSVYLSLWILYLMQPAWLPDFTLYMVCATLLLAI
GVLDDRYDLPVWPRVALQAAIAVLMICNGLYLKSFGEIFFGHELFLGIGGTVITVLAIWGAINAFNMVDGVDGLLGALSC
VTFCALTVVFYIHGNTDMALWCLCLMVSCLPYLLLNLGVIWGRKFKVFMGDAGSTLIGFTVIWVLILGSQGENRAMQPVT
ALWLIAIPLMDMVRVMISRIRCGNNPFKPDRQHLHHILMRAGSSARGTVMIMAFLATLLATVGIVGEMLHIAEFFSLLLF
MCVFVFYCLVIKILSQTRGSQIYLK

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=309, Percent_Identity=51.7799352750809, Blast_Score=321, Evalue=4e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 38232; Mature: 38232

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEIVAVFFSALAVLFMARKVARRVGLVDKPNSRKLHQGHIPLVGGVSVYLSLWILYLMQ
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
PAWLPDFTLYMVCATLLLAIGVLDDRYDLPVWPRVALQAAIAVLMICNGLYLKSFGEIFF
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
GHELFLGIGGTVITVLAIWGAINAFNMVDGVDGLLGALSCVTFCALTVVFYIHGNTDMAL
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
WCLCLMVSCLPYLLLNLGVIWGRKFKVFMGDAGSTLIGFTVIWVLILGSQGENRAMQPVT
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
ALWLIAIPLMDMVRVMISRIRCGNNPFKPDRQHLHHILMRAGSSARGTVMIMAFLATLLA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TVGIVGEMLHIAEFFSLLLFMCVFVFYCLVIKILSQTRGSQIYLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
>Mature Secondary Structure
MQEIVAVFFSALAVLFMARKVARRVGLVDKPNSRKLHQGHIPLVGGVSVYLSLWILYLMQ
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
PAWLPDFTLYMVCATLLLAIGVLDDRYDLPVWPRVALQAAIAVLMICNGLYLKSFGEIFF
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
GHELFLGIGGTVITVLAIWGAINAFNMVDGVDGLLGALSCVTFCALTVVFYIHGNTDMAL
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
WCLCLMVSCLPYLLLNLGVIWGRKFKVFMGDAGSTLIGFTVIWVLILGSQGENRAMQPVT
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
ALWLIAIPLMDMVRVMISRIRCGNNPFKPDRQHLHHILMRAGSSARGTVMIMAFLATLLA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TVGIVGEMLHIAEFFSLLLFMCVFVFYCLVIKILSQTRGSQIYLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]