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The map label for this gene is gnd [H]

Identifier: 157369851

GI number: 157369851

Start: 1762868

End: 1764274

Strand: Direct

Name: gnd [H]

Synonym: Spro_1608

Alternate gene names: 157369851

Gene position: 1762868-1764274 (Clockwise)

Preceding gene: 157369845

Following gene: 157369860

Centisome position: 32.35

GC content: 53.09

Gene sequence:

>1407_bases
ATGTCCAAGCAACAAATCGGCGTTGTCGGCATGGCGGTAATGGGCCGCAATCTGGCACTGAACATCGAAAGCCGTGGTTA
CACCGTTTCGATCTTTAACCGTTCAGGCGATAAAACTGATGAAGTTATTGCCGAGAATCCAGGTAAAAACCTGGTGCCGC
ACTACACCGTCGAAGAGTTCGTTGAATCGCTGGAAAAACCACGCCGCATCTTGCTGATGGTGAAAGCGGGTGAAGCGACT
GACAAGACCATTGCTTCCCTGACTCCGCACCTGGATAAAGGTGACATCCTGATCGACGGTGGCAACACCTACTATCAGGA
CACCATCCGTCGTAACCGCGAACTGTCTGATCAAGGCTTCAACTTCATCGGTACCGGTGTTTCCGGTGGTGAAGAGGGCG
CGCTGAAAGGGCCTTCAATCATGCCTGGCGGTCAGAAAGAAGCTTACGAGCTGGTGGCGCCAATCTTGAAGAAAATCGCT
GCGGTAGCGGAAGGCGAGCCTTGCGTGACCTATATCGGCGCTGACGGTGCCGGTCACTATGTGAAGATGGTACACAACGG
TATCGAGTACGGCGACATGCAGCTGATTGCAGAAGCTTACTCCCTGTTGAAACAGGCGTTGAATCTGAGCAACGAACAGC
TGGCTGAAACCTTCGCCGAGTGGAACAAGGGCGAACTGAACAGCTACCTGATCGACATCACCAAAGATATCTTCACCAAG
AAAGATGAAGAAGGTAAATACCTGGTTGATGTGATCCTGGACGAAGCGGCCAACAAAGGCACCGGCAAATGGACCAGCCA
GAGCTCTCTGGATCTGGGCGAGCCGCTGTCGCTGATCACCGAATCGGTATTCGCTCGCTACCTGTCCTCACTGAAAGACC
AGCGTGTGGCTGCATCTAAAGTGCTGACCGGTCCTAAGGCGACGCCAGTTAGCGGTGACAAAGCTGAATTTATTGAGAAA
GTGCGCCGTGCACTGTACCTGGGAAAAATCGTTTCTTATGCGCAGGGCTTCTCTCAACTGAAAGCCGCTTCCAAAGAAAA
CAACTGGGATCTGCACTACGGCGATATTGCCAAGATCTTCCGCGCCGGTTGTATCATCCGCGCACAGTTCCTGCAGAAAA
TCACCGACGCTTATGCACACGACGCAGATATCGCTAACCTGCTGCTTGCGCCATACTTCAAGCAGATTGCTGATGAATAC
CAGCAGGCGCTGCGTGACGTGGTGTCCTACGCGGTGCAAAACGGCATCCCTACGCCGACCTTCTCTGCGGCGATTGCCTA
CTACGACAGCTACCGTTCAGCGGTTCTGCCTGCCAACCTGATCCAGGCGCAGCGCGACTACTTCGGTGCTCACACTTACA
AACGTATCGACAAAGAAGGCGTGTTCCATACCGAATGGATGGAATAA

Upstream 100 bases:

>100_bases
ACTACCCACGCGGCAGCTTCCTGAGTTAACATGTGTGCCACATCACAAAACCTGTTGGCCACAGTTGTTAACAGGGTCAT
CCTCAGACAGGAGTTCTTCA

Downstream 100 bases:

>100_bases
TCCCGACGTTTGAAGCATAAAAAAGCCGCCGAGGTTAACGCCCGGCGGCTTTTTTTTGCCTGAAAAACAGGGTTATTTCT
GGTGCCGTTCGCGCAACCGG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSGDKTDEVIAENPGKNLVPHYTVEEFVESLEKPRRILLMVKAGEAT
DKTIASLTPHLDKGDILIDGGNTYYQDTIRRNRELSDQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILKKIA
AVAEGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKQALNLSNEQLAETFAEWNKGELNSYLIDITKDIFTK
KDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKDQRVAASKVLTGPKATPVSGDKAEFIEK
VRRALYLGKIVSYAQGFSQLKAASKENNWDLHYGDIAKIFRAGCIIRAQFLQKITDAYAHDADIANLLLAPYFKQIADEY
QQALRDVVSYAVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWME

Sequences:

>Translated_468_residues
MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSGDKTDEVIAENPGKNLVPHYTVEEFVESLEKPRRILLMVKAGEAT
DKTIASLTPHLDKGDILIDGGNTYYQDTIRRNRELSDQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILKKIA
AVAEGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKQALNLSNEQLAETFAEWNKGELNSYLIDITKDIFTK
KDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKDQRVAASKVLTGPKATPVSGDKAEFIEK
VRRALYLGKIVSYAQGFSQLKAASKENNWDLHYGDIAKIFRAGCIIRAQFLQKITDAYAHDADIANLLLAPYFKQIADEY
QQALRDVVSYAVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWME
>Mature_467_residues
SKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSGDKTDEVIAENPGKNLVPHYTVEEFVESLEKPRRILLMVKAGEATD
KTIASLTPHLDKGDILIDGGNTYYQDTIRRNRELSDQGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILKKIAA
VAEGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYSLLKQALNLSNEQLAETFAEWNKGELNSYLIDITKDIFTKK
DEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKDQRVAASKVLTGPKATPVSGDKAEFIEKV
RRALYLGKIVSYAQGFSQLKAASKENNWDLHYGDIAKIFRAGCIIRAQFLQKITDAYAHDADIANLLLAPYFKQIADEYQ
QALRDVVSYAVQNGIPTPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWME

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=469, Percent_Identity=53.091684434968, Blast_Score=491, Evalue=1e-139,
Organism=Escherichia coli, GI1788341, Length=469, Percent_Identity=88.4861407249467, Blast_Score=856, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=470, Percent_Identity=51.2765957446809, Blast_Score=503, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6321695, Length=458, Percent_Identity=50.6550218340611, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6321977, Length=451, Percent_Identity=49.0022172949002, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24639279, Length=469, Percent_Identity=51.1727078891258, Blast_Score=471, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51615; Mature: 51484

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSGDKTDEVIAENPGKNLVPHYTVEEF
CCCCHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHH
VESLEKPRRILLMVKAGEATDKTIASLTPHLDKGDILIDGGNTYYQDTIRRNRELSDQGF
HHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCC
NFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILKKIAAVAEGEPCVTYIGADGAGHY
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHH
VKMVHNGIEYGDMQLIAEAYSLLKQALNLSNEQLAETFAEWNKGELNSYLIDITKDIFTK
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
KDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKDQRVAASK
CCCCCCEEHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLTGPKATPVSGDKAEFIEKVRRALYLGKIVSYAQGFSQLKAASKENNWDLHYGDIAKIF
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RAGCIIRAQFLQKITDAYAHDADIANLLLAPYFKQIADEYQQALRDVVSYAVQNGIPTPT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
FSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWME
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSGDKTDEVIAENPGKNLVPHYTVEEF
CCCHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHH
VESLEKPRRILLMVKAGEATDKTIASLTPHLDKGDILIDGGNTYYQDTIRRNRELSDQGF
HHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCC
NFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILKKIAAVAEGEPCVTYIGADGAGHY
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHH
VKMVHNGIEYGDMQLIAEAYSLLKQALNLSNEQLAETFAEWNKGELNSYLIDITKDIFTK
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
KDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKDQRVAASK
CCCCCCEEHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VLTGPKATPVSGDKAEFIEKVRRALYLGKIVSYAQGFSQLKAASKENNWDLHYGDIAKIF
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RAGCIIRAQFLQKITDAYAHDADIANLLLAPYFKQIADEYQQALRDVVSYAVQNGIPTPT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
FSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRIDKEGVFHTEWME
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042 [H]