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The map label for this gene is ahcY [H]

Identifier: 157369594

GI number: 157369594

Start: 1481623

End: 1482726

Strand: Direct

Name: ahcY [H]

Synonym: Spro_1351

Alternate gene names: 157369594

Gene position: 1481623-1482726 (Clockwise)

Preceding gene: 157369592

Following gene: 157369595

Centisome position: 27.19

GC content: 60.96

Gene sequence:

>1104_bases
ATGTATCAGGATTTTGAGAGCGAACTGGACTGGGCGATGCGCCATATGCCACGCACCCGGGCGGCGGTAGCGGCATTACC
GGATTTAAGCGGCGTACGGCTGGCGTGCAATATGCATCTGGATTTGAAAATGGCACCGCTGGTGGCGGGCCTGCTGGACA
AGGGCGCGGCGATTTATCTGACCACCTGCAACCCAACTACGGTGCAGGATGACGTGGTGGCCTGGCTGGAGCGCCGCGGA
GCACAGGCTCACGCCTGGCGTGACATGAGCGACGCCGACTGGTCGGCATCGTTCGACCGCGCATTGGCCTGGGGGCCGAC
CCACCTGTGCGAAATGGGGGCGGATTTGACCACCCGTCTGCATCAGTCAGTCGATGGCCCGCAAATTATCGCCGGGCTGG
AGGCCACCGGTTCCGGCATCAGTAGGTTGAACGGCATGGCGCCGCGCTATCCGATCTTCAACTGGGATGACCTGCCGGTA
AAAGAAGGGCTGCATAACCGCCATATGGTCGGCTTGACCGCCTGGCACACTTTCTTCCAGACCACCCATTTGACGCTGCA
TGAAAAATGCGTGCTGGTGATCGGTTATGGCCTGGTTGGGCAGGGCGTTGCGGCGGCGGCGAAAGCCTACGGCGGGCAGG
TGATCGTGGCAGAAATCGATCCGGCGCGGGCGCTGCAGGCACGCTATGACGGCTGGGCAGTGGTCAGTCTTGCCAGTGCG
GTGAGCCAGGCCGATGTGATTGCTACCGCCACCGGGGCAAAAAACGTGCTGTCGGCGCGGCATCTGCAGCAGGCGAAGGA
CGGGGTGTTTATTCTCAATGTGGGCCATGTGACGGCAGAGATTGACGTTGGCTTCCTGCAAAACCTGCCGCACAGCGAGC
CTATGCCGTTTGTAAACGCCTACCAACTGGAAGATAAAACCCTGTATTTACTGGCCAACGGCTCGATGTTCAACCTGACG
GCGGGCTACGGTGACAGCCTGAATGCCTTTGACGTGACGCTGGCGGTGATGGCGGCGGGCATTGGTCATATTGTCGGTGA
CGGTGCCCGGCAGCAGCCCGGTTTATATCTGTTGCCGCAGTCGGCCTGGCAGCCTGCGCTGTAA

Upstream 100 bases:

>100_bases
GCCATCCCGATCCCCTATGTCTTTAATACATAAGGGTCAGTATACTCTCTGTCAGTCAGCCGCGCCCTGTCGGCGCGACG
CAGCCGTAGAGGAGCAACAG

Downstream 100 bases:

>100_bases
CTTTTCTCTCGCGGGCGCTTATCCCAGAGCGCTCGCGGTTTGCGCAATTTTTTGTTCGACAGAATTTGTCACAAATCGGC
TTGCATAATCCCAGTGCCAA

Product: adenosylhomocysteinase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MYQDFESELDWAMRHMPRTRAAVAALPDLSGVRLACNMHLDLKMAPLVAGLLDKGAAIYLTTCNPTTVQDDVVAWLERRG
AQAHAWRDMSDADWSASFDRALAWGPTHLCEMGADLTTRLHQSVDGPQIIAGLEATGSGISRLNGMAPRYPIFNWDDLPV
KEGLHNRHMVGLTAWHTFFQTTHLTLHEKCVLVIGYGLVGQGVAAAAKAYGGQVIVAEIDPARALQARYDGWAVVSLASA
VSQADVIATATGAKNVLSARHLQQAKDGVFILNVGHVTAEIDVGFLQNLPHSEPMPFVNAYQLEDKTLYLLANGSMFNLT
AGYGDSLNAFDVTLAVMAAGIGHIVGDGARQQPGLYLLPQSAWQPAL

Sequences:

>Translated_367_residues
MYQDFESELDWAMRHMPRTRAAVAALPDLSGVRLACNMHLDLKMAPLVAGLLDKGAAIYLTTCNPTTVQDDVVAWLERRG
AQAHAWRDMSDADWSASFDRALAWGPTHLCEMGADLTTRLHQSVDGPQIIAGLEATGSGISRLNGMAPRYPIFNWDDLPV
KEGLHNRHMVGLTAWHTFFQTTHLTLHEKCVLVIGYGLVGQGVAAAAKAYGGQVIVAEIDPARALQARYDGWAVVSLASA
VSQADVIATATGAKNVLSARHLQQAKDGVFILNVGHVTAEIDVGFLQNLPHSEPMPFVNAYQLEDKTLYLLANGSMFNLT
AGYGDSLNAFDVTLAVMAAGIGHIVGDGARQQPGLYLLPQSAWQPAL
>Mature_367_residues
MYQDFESELDWAMRHMPRTRAAVAALPDLSGVRLACNMHLDLKMAPLVAGLLDKGAAIYLTTCNPTTVQDDVVAWLERRG
AQAHAWRDMSDADWSASFDRALAWGPTHLCEMGADLTTRLHQSVDGPQIIAGLEATGSGISRLNGMAPRYPIFNWDDLPV
KEGLHNRHMVGLTAWHTFFQTTHLTLHEKCVLVIGYGLVGQGVAAAAKAYGGQVIVAEIDPARALQARYDGWAVVSLASA
VSQADVIATATGAKNVLSARHLQQAKDGVFILNVGHVTAEIDVGFLQNLPHSEPMPFVNAYQLEDKTLYLLANGSMFNLT
AGYGDSLNAFDVTLAVMAAGIGHIVGDGARQQPGLYLLPQSAWQPAL

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=333, Percent_Identity=30.03003003003, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI239937451, Length=326, Percent_Identity=29.4478527607362, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI195539349, Length=374, Percent_Identity=29.4117647058824, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI298286489, Length=374, Percent_Identity=29.4117647058824, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI24308043, Length=374, Percent_Identity=29.4117647058824, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI195539337, Length=374, Percent_Identity=29.4117647058824, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI21361647, Length=348, Percent_Identity=29.8850574712644, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17506425, Length=380, Percent_Identity=29.7368421052632, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320882, Length=339, Percent_Identity=29.2035398230088, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24642172, Length=312, Percent_Identity=30.1282051282051, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24656245, Length=372, Percent_Identity=29.5698924731183, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI45553385, Length=371, Percent_Identity=29.6495956873315, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45553387, Length=369, Percent_Identity=29.2682926829268, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 39578; Mature: 39578

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQDFESELDWAMRHMPRTRAAVAALPDLSGVRLACNMHLDLKMAPLVAGLLDKGAAIYL
CCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEEEECEEHHHHHHHHHCCCCEEEE
TTCNPTTVQDDVVAWLERRGAQAHAWRDMSDADWSASFDRALAWGPTHLCEMGADLTTRL
EECCCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHCCCCHHHHHCCCHHHHHH
HQSVDGPQIIAGLEATGSGISRLNGMAPRYPIFNWDDLPVKEGLHNRHMVGLTAWHTFFQ
HHCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCHHHCCCCCEEEEHHHHHHHHH
TTHLTLHEKCVLVIGYGLVGQGVAAAAKAYGGQVIVAEIDPARALQARYDGWAVVSLASA
HHCEEECCCEEEEEECCHHCCCHHHHHHHCCCEEEEEECCCHHHHHHHCCCCHHHHHHHH
VSQADVIATATGAKNVLSARHLQQAKDGVFILNVGHVTAEIDVGFLQNLPHSEPMPFVNA
HHHCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCEEEEEEHHHHHCCCCCCCCCCCEE
YQLEDKTLYLLANGSMFNLTAGYGDSLNAFDVTLAVMAAGIGHIVGDGARQQPGLYLLPQ
EEECCCEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
SAWQPAL
CCCCCCC
>Mature Secondary Structure
MYQDFESELDWAMRHMPRTRAAVAALPDLSGVRLACNMHLDLKMAPLVAGLLDKGAAIYL
CCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEEEECEEHHHHHHHHHCCCCEEEE
TTCNPTTVQDDVVAWLERRGAQAHAWRDMSDADWSASFDRALAWGPTHLCEMGADLTTRL
EECCCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHCCCCHHHHHCCCHHHHHH
HQSVDGPQIIAGLEATGSGISRLNGMAPRYPIFNWDDLPVKEGLHNRHMVGLTAWHTFFQ
HHCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCHHHCCCCCEEEEHHHHHHHHH
TTHLTLHEKCVLVIGYGLVGQGVAAAAKAYGGQVIVAEIDPARALQARYDGWAVVSLASA
HHCEEECCCEEEEEECCHHCCCHHHHHHHCCCEEEEEECCCHHHHHHHCCCCHHHHHHHH
VSQADVIATATGAKNVLSARHLQQAKDGVFILNVGHVTAEIDVGFLQNLPHSEPMPFVNA
HHHCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCEEEEEEHHHHHCCCCCCCCCCCEE
YQLEDKTLYLLANGSMFNLTAGYGDSLNAFDVTLAVMAAGIGHIVGDGARQQPGLYLLPQ
EEECCCEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
SAWQPAL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]