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The map label for this gene is thrB [H]

Identifier: 157368929

GI number: 157368929

Start: 753274

End: 754203

Strand: Direct

Name: thrB [H]

Synonym: Spro_0684

Alternate gene names: 157368929

Gene position: 753274-754203 (Clockwise)

Preceding gene: 157368928

Following gene: 157368930

Centisome position: 13.82

GC content: 58.17

Gene sequence:

>930_bases
ATGGTTAAGGTGTATGCGCCGGCCTCAATTGGTAATGTCAGCGTCGGTTTCGACGTTCTGGGTGCAGCGGTGTCGCCGAT
TGACGGTACCTTGCTGGGCGACTGCGTCAGTGTAGAGGCCGCCGAAACGTTCAGTTTGCAAAATGCCGGTCGCTTCGTCA
GCAAGCTGCCGGACGATCCGAAAGAGAACATCGTTTACCAATGTTGGGAGCGCTTCTGCCAGGAAATCGGTCAGCAGATC
CCGGTGGCGATGCGGCTCGAGAAAAATATGCCTATCGGTTCAGGTCTGGGATCCAGTGCCTGCTCGGTGGTCGCCGGGTT
GATGGCGATGAACGAGTTCTGCAACCGCCCGCTGGATAAAATGACGCTGCTGGGCCTGATGGGTGAGTTGGAAGGCCGCA
TCTCCGGCAGCGTGCATTACGATAACGTAGCGCCTTGCTACCTCGGCGGCCTGCAGTTGATGTTGGAAGAAGAAGGCTTC
ATCAGCCAGGAAGTGCCATGCTTTAAAGACTGGCTGTGGGTGATGGCCTATCCGGGCATCAAGGTATCCACCGCCGAAGC
GCGTGCGATCCTGCCCGCGCAGTATCGTCGTCAGGACTGTATCAGCCACGGTCGCTATCTGGCGGGCTTTATCCATGCCT
GCCATACCCAACAACCGCGCCTGGCCGCCAAACTGATGCAGGACGTGATTGCCGAGCCGTACCGCACCCGCCTGTTGCCG
GGTTTTGCCGACGCACGCAAAGCCGCTCAGGATATCGGTGCTTTGGCTTGCGGTATTTCCGGTTCCGGCCCGACGCTGTT
CGCCGTTTGTGATGACGGCGCAACGGCGCAACGCATGGCCGACTGGCTGACTAATCACTATCTGCAAAACGACGAAGGTT
TTGTTCATATTTGCCGCCTGGATACCGCAGGCGCACGACTACTGGGATAA

Upstream 100 bases:

>100_bases
CCACTGGTGCTGCGCGGCTACGGTGCCGGTAACGATGTGACCGCCGCAGGGGTATTTGCCGACCTGTTGCGCACACTGTC
ATGGAAGTTGGGAGTTTAAT

Downstream 100 bases:

>100_bases
CGCATGAAACTGTACAACCTTAAGGATCATAACGAGCAGGTCAGCTTCACACAGGCGATCAAACAGGGCCTTGGCAAACA
GCAAGGGCTGTTTTTCCCGC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MVKVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDCVSVEAAETFSLQNAGRFVSKLPDDPKENIVYQCWERFCQEIGQQI
PVAMRLEKNMPIGSGLGSSACSVVAGLMAMNEFCNRPLDKMTLLGLMGELEGRISGSVHYDNVAPCYLGGLQLMLEEEGF
ISQEVPCFKDWLWVMAYPGIKVSTAEARAILPAQYRRQDCISHGRYLAGFIHACHTQQPRLAAKLMQDVIAEPYRTRLLP
GFADARKAAQDIGALACGISGSGPTLFAVCDDGATAQRMADWLTNHYLQNDEGFVHICRLDTAGARLLG

Sequences:

>Translated_309_residues
MVKVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDCVSVEAAETFSLQNAGRFVSKLPDDPKENIVYQCWERFCQEIGQQI
PVAMRLEKNMPIGSGLGSSACSVVAGLMAMNEFCNRPLDKMTLLGLMGELEGRISGSVHYDNVAPCYLGGLQLMLEEEGF
ISQEVPCFKDWLWVMAYPGIKVSTAEARAILPAQYRRQDCISHGRYLAGFIHACHTQQPRLAAKLMQDVIAEPYRTRLLP
GFADARKAAQDIGALACGISGSGPTLFAVCDDGATAQRMADWLTNHYLQNDEGFVHICRLDTAGARLLG
>Mature_309_residues
MVKVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDCVSVEAAETFSLQNAGRFVSKLPDDPKENIVYQCWERFCQEIGQQI
PVAMRLEKNMPIGSGLGSSACSVVAGLMAMNEFCNRPLDKMTLLGLMGELEGRISGSVHYDNVAPCYLGGLQLMLEEEGF
ISQEVPCFKDWLWVMAYPGIKVSTAEARAILPAQYRRQDCISHGRYLAGFIHACHTQQPRLAAKLMQDVIAEPYRTRLLP
GFADARKAAQDIGALACGISGSGPTLFAVCDDGATAQRMADWLTNHYLQNDEGFVHICRLDTAGARLLG

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=308, Percent_Identity=78.8961038961039, Blast_Score=518, Evalue=1e-148,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33455; Mature: 33455

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDCVSVEAAETFSLQNAGRFVSKLPDDP
CEEEECCCCCCCCEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
KENIVYQCWERFCQEIGQQIPVAMRLEKNMPIGSGLGSSACSVVAGLMAMNEFCNRPLDK
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
MTLLGLMGELEGRISGSVHYDNVAPCYLGGLQLMLEEEGFISQEVPCFKDWLWVMAYPGI
HHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHCCCCC
KVSTAEARAILPAQYRRQDCISHGRYLAGFIHACHTQQPRLAAKLMQDVIAEPYRTRLLP
EEECCHHHHHCCHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCC
GFADARKAAQDIGALACGISGSGPTLFAVCDDGATAQRMADWLTNHYLQNDEGFVHICRL
CHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEE
DTAGARLLG
CCCCHHCCC
>Mature Secondary Structure
MVKVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDCVSVEAAETFSLQNAGRFVSKLPDDP
CEEEECCCCCCCCEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
KENIVYQCWERFCQEIGQQIPVAMRLEKNMPIGSGLGSSACSVVAGLMAMNEFCNRPLDK
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
MTLLGLMGELEGRISGSVHYDNVAPCYLGGLQLMLEEEGFISQEVPCFKDWLWVMAYPGI
HHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHCCCCC
KVSTAEARAILPAQYRRQDCISHGRYLAGFIHACHTQQPRLAAKLMQDVIAEPYRTRLLP
EEECCHHHHHCCHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCC
GFADARKAAQDIGALACGISGSGPTLFAVCDDGATAQRMADWLTNHYLQNDEGFVHICRL
CHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEE
DTAGARLLG
CCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8423151 [H]