| Definition | Serratia proteamaculans 568 chromosome, complete genome. |
|---|---|
| Accession | NC_009832 |
| Length | 5,448,853 |
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The map label for this gene is thrA [H]
Identifier: 157368928
GI number: 157368928
Start: 750813
End: 753272
Strand: Direct
Name: thrA [H]
Synonym: Spro_0683
Alternate gene names: 157368928
Gene position: 750813-753272 (Clockwise)
Preceding gene: 157368927
Following gene: 157368929
Centisome position: 13.78
GC content: 58.09
Gene sequence:
>2460_bases ATGCGAGTGCTGAAATTTGGCGGAACCTCGGTAGCGAATGCAGAACGTTTTCTGCGCGTCGCCGACATCATGGAAAGTAA CGCACGTCAGGGACAGGTGGCCACGGTCTTGTCCGCTCCGGCTAAAATCACCAACCACCTGGTGGCGATGATTGATAAAA CGGTAGCGGGGCAGGACATTCTGCCAAATATGAGCGATGCAGAACGCATCTTTGCCGACCTGCTGAGCGGTCTGACACAG GCGTTGCCCGGCTTTGAATACGATCGTCTCAAGACGCTGGTCGACCAGGAGTTTTCCCAACTCAAACAGGTACTGCATGG CGTTGCGCTGCTGGGGCAATGCCCGGATAGCGTGAATGCGGCTATCATCTGCCGCGGTGAGAAGCTCTCTATCGCCATCA TGGAAGGGGTGTTTCGCGCCAAAGGTTTCCCGGTTACGGTGATAAACCCGGTGGAGAAACTGCTGGCGCAGGGGCATTAC CTGGAGTCCACGGTAGACATTGCCGAATCCACACTGCGCATCGCCGCCGCAGCAATCCCGGCGGATCACATCGTGCTGAT GGCCGGTTTCACCGCCGGTAACGATAAAGGGGAACTGGTGGTGCTGGGCCGTAACGGCTCCGACTACTCTGCTGCGGTAC TGGCTGCCTGTCTGCGCGCCGACTGCTGTGAGATCTGGACCGACGTCGACGGCGTTTATACCTGCGATCCTCGTACCGTG CCAGACGCCAGGTTGCTGAAATCGATGTCGTATCAGGAAGCTATGGAGCTTTCCTACTTCGGCGCCAGCGTGCTTCACCC CCGTACTATCGCTCCCATTGCCCAGTTCCAAATCCCTTGCCTGATCAAAAATACCGCCAACCCGCAGGCCCCTGGCACGC TGATTGGCGGCGAAAATCTGGATACCGATACCCCGGTGAAGGGCATCACCAATCTCAATAACATGGCGATGATCAACGTC TCCGGGCCAGGGATGAAGGGCATGGTCGGCATGGCCGCGCGCGTGTTTGCCGTGATGTCCCGTGCCGGTATCTCTGTGGT GCTGATCACCCAGTCCTCTTCCGAATACAGCATCAGCTTCTGCGTACCGCAGAGTGAGCTGCAGCGTGCCCGTCGCGCAC TGGAAGACGAATTCTATCTTGAATTGAAAGATGGCCTGCTGGAGCCGCTGGACGTGATGGAGCAGTTGGCGATTATCTCG GTCGTCGGCGATGGCATGCGCACCCTGCGCGGTATTTCGGCCAGCTTCTTCTCCGCCCTGGCGCGCGCCAACATCAATAT TGTCGCTATTGCCCAGGGGTCCTCCGAACGTTCCATCTCGGTGGTGGTCAGCAACGACTCGGCGACTACCGGGGTTCGCG TCTGCCACCAGATGCTGTTTAACACCGATCAGGTGATTGAAGTGTTTGTTATCGGCGTTGGCGGCGTCGGCGGTGCGTTG ATCGAACAGATCTACCGTCAACAGCCGTGGCTGAAGCAAAAGCATATCGACCTGCGGGTGTGCGGCATTGCCAATTCACG CGCCATGTTGACCAACATACACGGCATCGCGCTGGATAGCTGGCGTGATGAACTGGCCGGTGCACAGGAGCCATTCAACC TTGGCCGTCTGATCCGCCTGGTGAAGGAGTACCACCTGCTGAATCCGGTGATTGTCGATTGCACCTCCAGCCAGGCGGTG GCCGATCAATACGCCGATTTCCTGGCCGATGGTTTCCACGTGGTGACGCCGAACAAAAAGGCCAACACTTCGTCGATGAA TTACTACCAACAACTGCGCACCGCCGCGGCCGGTTCACGTCGCAAGTTCCTGTACGACACCAACGTCGGTGCGGGGTTGC CGGTGATCGAAAACCTGCAAAACCTGCTGAACGCCGGTGATGAGCTGACGCGCTTCTCTGGCATTCTGTCCGGTTCGCTG TCGTTTATTTTCGGTAAGCTCGATGAGGGCATGTCGCTGTCGGCCGCGACCCTGGAGGCCAAAGCCAAGGGCTATACCGA GCCGGATCCGCGTGACGATCTTTCCGGTATGGATGTGGCGCGCAAGCTGCTGATCCTGGCGCGTGAGGCGGGTTACAAAC TGGAGTTGGCCGATATCGAGGTTGAGTCGGTGCTGCCACCTTCCTTTGACGCTTCCGGTGACGTGGAAACCTTTATGGCG CGCCTGCCTGAGCTGGATAAAGAGTACGCCCGCAACGTGGCCAATGCCACCGAGCAGGGTAAGGTGCTGCGCTATGTCGG GGCGATCGAAAATGGCCGCTGTCAGGTGCGTATAGATGCGGTAGACGGTAACGATCCGTTGTATAAAGTGAAGAACGGCG AGAACGCCCTGGCTTTCTACAGCCGCTACTATCAGCCATTGCCACTGGTGCTGCGCGGCTACGGTGCCGGTAACGATGTG ACCGCCGCAGGGGTATTTGCCGACCTGTTGCGCACACTGTCATGGAAGTTGGGAGTTTAA
Upstream 100 bases:
>100_bases GGTAACGGGGCGGGCTGACGCGTACAGGAAACAAAAGAAAAAAGCCCGCACCTAACCAGTGCGGGCTTTTTTTTCGGCTT AAATTCGGGAGAGACAAGAA
Downstream 100 bases:
>100_bases TATGGTTAAGGTGTATGCGCCGGCCTCAATTGGTAATGTCAGCGTCGGTTTCGACGTTCTGGGTGCAGCGGTGTCGCCGA TTGACGGTACCTTGCTGGGC
Product: bifunctional aspartokinase I/homoserine dehydrogenase I
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 819; Mature: 819
Protein sequence:
>819_residues MRVLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIDKTVAGQDILPNMSDAERIFADLLSGLTQ ALPGFEYDRLKTLVDQEFSQLKQVLHGVALLGQCPDSVNAAIICRGEKLSIAIMEGVFRAKGFPVTVINPVEKLLAQGHY LESTVDIAESTLRIAAAAIPADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV PDARLLKSMSYQEAMELSYFGASVLHPRTIAPIAQFQIPCLIKNTANPQAPGTLIGGENLDTDTPVKGITNLNNMAMINV SGPGMKGMVGMAARVFAVMSRAGISVVLITQSSSEYSISFCVPQSELQRARRALEDEFYLELKDGLLEPLDVMEQLAIIS VVGDGMRTLRGISASFFSALARANINIVAIAQGSSERSISVVVSNDSATTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL IEQIYRQQPWLKQKHIDLRVCGIANSRAMLTNIHGIALDSWRDELAGAQEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAV ADQYADFLADGFHVVTPNKKANTSSMNYYQQLRTAAAGSRRKFLYDTNVGAGLPVIENLQNLLNAGDELTRFSGILSGSL SFIFGKLDEGMSLSAATLEAKAKGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPPSFDASGDVETFMA RLPELDKEYARNVANATEQGKVLRYVGAIENGRCQVRIDAVDGNDPLYKVKNGENALAFYSRYYQPLPLVLRGYGAGNDV TAAGVFADLLRTLSWKLGV
Sequences:
>Translated_819_residues MRVLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIDKTVAGQDILPNMSDAERIFADLLSGLTQ ALPGFEYDRLKTLVDQEFSQLKQVLHGVALLGQCPDSVNAAIICRGEKLSIAIMEGVFRAKGFPVTVINPVEKLLAQGHY LESTVDIAESTLRIAAAAIPADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV PDARLLKSMSYQEAMELSYFGASVLHPRTIAPIAQFQIPCLIKNTANPQAPGTLIGGENLDTDTPVKGITNLNNMAMINV SGPGMKGMVGMAARVFAVMSRAGISVVLITQSSSEYSISFCVPQSELQRARRALEDEFYLELKDGLLEPLDVMEQLAIIS VVGDGMRTLRGISASFFSALARANINIVAIAQGSSERSISVVVSNDSATTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL IEQIYRQQPWLKQKHIDLRVCGIANSRAMLTNIHGIALDSWRDELAGAQEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAV ADQYADFLADGFHVVTPNKKANTSSMNYYQQLRTAAAGSRRKFLYDTNVGAGLPVIENLQNLLNAGDELTRFSGILSGSL SFIFGKLDEGMSLSAATLEAKAKGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPPSFDASGDVETFMA RLPELDKEYARNVANATEQGKVLRYVGAIENGRCQVRIDAVDGNDPLYKVKNGENALAFYSRYYQPLPLVLRGYGAGNDV TAAGVFADLLRTLSWKLGV >Mature_819_residues MRVLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIDKTVAGQDILPNMSDAERIFADLLSGLTQ ALPGFEYDRLKTLVDQEFSQLKQVLHGVALLGQCPDSVNAAIICRGEKLSIAIMEGVFRAKGFPVTVINPVEKLLAQGHY LESTVDIAESTLRIAAAAIPADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV PDARLLKSMSYQEAMELSYFGASVLHPRTIAPIAQFQIPCLIKNTANPQAPGTLIGGENLDTDTPVKGITNLNNMAMINV SGPGMKGMVGMAARVFAVMSRAGISVVLITQSSSEYSISFCVPQSELQRARRALEDEFYLELKDGLLEPLDVMEQLAIIS VVGDGMRTLRGISASFFSALARANINIVAIAQGSSERSISVVVSNDSATTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL IEQIYRQQPWLKQKHIDLRVCGIANSRAMLTNIHGIALDSWRDELAGAQEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAV ADQYADFLADGFHVVTPNKKANTSSMNYYQQLRTAAAGSRRKFLYDTNVGAGLPVIENLQNLLNAGDELTRFSGILSGSL SFIFGKLDEGMSLSAATLEAKAKGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPPSFDASGDVETFMA RLPELDKEYARNVANATEQGKVLRYVGAIENGRCQVRIDAVDGNDPLYKVKNGENALAFYSRYYQPLPLVLRGYGAGNDV TAAGVFADLLRTLSWKLGV
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=820, Percent_Identity=83.2926829268293, Blast_Score=1383, Evalue=0.0, Organism=Escherichia coli, GI1790376, Length=820, Percent_Identity=31.5853658536585, Blast_Score=360, Evalue=1e-100, Organism=Escherichia coli, GI1790455, Length=465, Percent_Identity=29.8924731182796, Blast_Score=156, Evalue=4e-39, Organism=Saccharomyces cerevisiae, GI6320893, Length=506, Percent_Identity=27.0750988142292, Blast_Score=163, Evalue=1e-40, Organism=Saccharomyces cerevisiae, GI6322599, Length=340, Percent_Identity=31.4705882352941, Blast_Score=155, Evalue=2e-38,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 88493; Mature: 88493
Theoretical pI: Translated: 5.13; Mature: 5.13
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 4.2 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRVLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIDKTVAGQDI CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCHHHHHHHHHHHHHHCCCCCC LPNMSDAERIFADLLSGLTQALPGFEYDRLKTLVDQEFSQLKQVLHGVALLGQCPDSVNA CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE AIICRGEKLSIAIMEGVFRAKGFPVTVINPVEKLLAQGHYLESTVDIAESTLRIAAAAIP EEEEECCCEEEHHHHHHHHCCCCCEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC ADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV CCEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC PDARLLKSMSYQEAMELSYFGASVLHPRTIAPIAQFQIPCLIKNTANPQAPGTLIGGENL CHHHHHHHCCHHHHHHHHHCCHHHCCCCHHCCHHHEECCEEEECCCCCCCCCEEECCCCC DTDTPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRAGISVVLITQSSSEYSISF CCCCCCHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEE CVPQSELQRARRALEDEFYLELKDGLLEPLDVMEQLAIISVVGDGMRTLRGISASFFSAL ECCHHHHHHHHHHHCHHHHHEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ARANINIVAIAQGSSERSISVVVSNDSATTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL HHCCCEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCHHHEEEEEEEECCCCCHHH IEQIYRQQPWLKQKHIDLRVCGIANSRAMLTNIHGIALDSWRDELAGAQEPFNLGRLIRL HHHHHHCCCCCHHCCCCEEEEECCCCCEEEEECCCEEEHHHHHHHCCCCCCHHHHHHHHH VKEYHLLNPVIVDCTSSQAVADQYADFLADGFHVVTPNKKANTSSMNYYQQLRTAAAGSR HHHHHHCCCEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCC RKFLYDTNVGAGLPVIENLQNLLNAGDELTRFSGILSGSLSFIFGKLDEGMSLSAATLEA CEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHH KAKGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPPSFDASGDVETFMA HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHCCCCCCCCCCCHHHHHH RLPELDKEYARNVANATEQGKVLRYVGAIENGRCQVRIDAVDGNDPLYKVKNGENALAFY HCCHHHHHHHHHHHCCHHCCCCEEEEECCCCCEEEEEEEEECCCCCEEEECCCCCHHHHH SRYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV HHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC >Mature Secondary Structure MRVLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIDKTVAGQDI CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCHHHHHHHHHHHHHHCCCCCC LPNMSDAERIFADLLSGLTQALPGFEYDRLKTLVDQEFSQLKQVLHGVALLGQCPDSVNA CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE AIICRGEKLSIAIMEGVFRAKGFPVTVINPVEKLLAQGHYLESTVDIAESTLRIAAAAIP EEEEECCCEEEHHHHHHHHCCCCCEEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC ADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV CCEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC PDARLLKSMSYQEAMELSYFGASVLHPRTIAPIAQFQIPCLIKNTANPQAPGTLIGGENL CHHHHHHHCCHHHHHHHHHCCHHHCCCCHHCCHHHEECCEEEECCCCCCCCCEEECCCCC DTDTPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRAGISVVLITQSSSEYSISF CCCCCCHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEE CVPQSELQRARRALEDEFYLELKDGLLEPLDVMEQLAIISVVGDGMRTLRGISASFFSAL ECCHHHHHHHHHHHCHHHHHEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ARANINIVAIAQGSSERSISVVVSNDSATTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL HHCCCEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCHHHEEEEEEEECCCCCHHH IEQIYRQQPWLKQKHIDLRVCGIANSRAMLTNIHGIALDSWRDELAGAQEPFNLGRLIRL HHHHHHCCCCCHHCCCCEEEEECCCCCEEEEECCCEEEHHHHHHHCCCCCCHHHHHHHHH VKEYHLLNPVIVDCTSSQAVADQYADFLADGFHVVTPNKKANTSSMNYYQQLRTAAAGSR HHHHHHCCCEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCC RKFLYDTNVGAGLPVIENLQNLLNAGDELTRFSGILSGSLSFIFGKLDEGMSLSAATLEA CEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHH KAKGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPPSFDASGDVETFMA HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEHHHCCCCCCCCCCCHHHHHH RLPELDKEYARNVANATEQGKVLRYVGAIENGRCQVRIDAVDGNDPLYKVKNGENALAFY HCCHHHHHHHHHHHCCHHCCCCEEEEECCCCCEEEEEEEEECCCCCEEEECCCCCHHHHH SRYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV HHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8423151 [H]