Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 157368930

GI number: 157368930

Start: 754207

End: 755496

Strand: Direct

Name: thrC [H]

Synonym: Spro_0685

Alternate gene names: 157368930

Gene position: 754207-755496 (Clockwise)

Preceding gene: 157368929

Following gene: 157368933

Centisome position: 13.84

GC content: 56.98

Gene sequence:

>1290_bases
ATGAAACTGTACAACCTTAAGGATCATAACGAGCAGGTCAGCTTCACACAGGCGATCAAACAGGGCCTTGGCAAACAGCA
AGGGCTGTTTTTCCCGCTGGATCTGCCGGAGTTTGAACTGACCGAAATCGACCATCTGCTGGAACAGGATTTTGTCACGC
GCAGCAGCCGTATCCTGTCGGCATTTATTGGCGATGAAGTTTCTGAAGAAGCATTGCATAAGCGTGTGGCGGCGGCCTTT
GAGTTTCCGGCACCGGTAGCGCAAGTTGAAGATGATATCGCCTGCCTGGAGTTGTTCCACGGCCCAACGCTGGCGTTTAA
AGACTTCGGCGGCCGCTTTATGGCACAAATGCTGGCGGAAGTGGCGGGCGATCAGCCGGTCACTATCCTGACCGCGACCT
CCGGTGATACCGGCGCGGCGGTGGCCCATGCTTTCTACGGCCTGAAGAATGTGCGCGTGGTGATCCTGTATCCACAGGGC
AAAATCAGCCCGCTGCAGGAAAAACTGTTCTGCACCCTGGGTGGCAACATCCATACCGTGGCGATTGACGGCGATTTTGA
CGCCTGCCAGGCATTGGTGAAGCAGGCATTTGACGATCAGGAATTGAAAGAAGCCCTGCACCTGAACTCGGCCAACTCGA
TTAACATCAGCCGCCTGCTGGCGCAGATTTGTTATTACTTCGAAGCGGTTGCGCAATTGCCACAGGAAGCACGCAACCAG
TTGGTGATTTCAGTACCCAGCGGCAACTTCGGCGATCTGACCGCCGGGCTGCTGGCCAAGTCACTGGGCCTGCCGGTGAA
GCGTTTTATCGCCGCGACCAATGCCAACGACACCGTGCCGCGCTTCCTGACTAACGGTCAGTGGCAGCCTCATGCCACGG
TGGCTACGCTGTCTAATGCGATGGATGTCAGCCAGCCGAACAACTGGCCACGGGTTGAAGAGCTGTTCCGCCGTAAGATT
TGGCAGTTGAAAGAGCTGGGCCATGCCACGGTCAGTGACGAAACCACCAAAGATACTATGCGTGAACTGGCGAAGTTGGG
TTATCTCTCCGAGCCGCACGCGGCGATTGCTTACCGCGCGTTGCGTGACCAGTTGCAGGAAGGGGAGTTTGGTCTGTTCC
TCGGCACCGCGCATCCGGCCAAATTCAAAGAGAGCGTCGAGGACATTCTCGGCCAGGAATTGCCACTGCCGAAGGCGCTG
GCACTGCGTGCTGATTTGCCGCTGCTGTCTCACAACCTGCCCGCCGGCTTTGGCGAACTACGCAAGTTCCTGATGGCCTT
GCCAGCCTGA

Upstream 100 bases:

>100_bases
CATGGCCGACTGGCTGACTAATCACTATCTGCAAAACGACGAAGGTTTTGTTCATATTTGCCGCCTGGATACCGCAGGCG
CACGACTACTGGGATAACGC

Downstream 100 bases:

>100_bases
ATTTTATCGGCCCGATAAAAGCGAAAAGCCGTCATTGTGACGGCTTCAGACAACTGACAAAGCTCGTTATTAGGGAGAGC
GTGCCGAAGGGGTCGTAGCG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKLYNLKDHNEQVSFTQAIKQGLGKQQGLFFPLDLPEFELTEIDHLLEQDFVTRSSRILSAFIGDEVSEEALHKRVAAAF
EFPAPVAQVEDDIACLELFHGPTLAFKDFGGRFMAQMLAEVAGDQPVTILTATSGDTGAAVAHAFYGLKNVRVVILYPQG
KISPLQEKLFCTLGGNIHTVAIDGDFDACQALVKQAFDDQELKEALHLNSANSINISRLLAQICYYFEAVAQLPQEARNQ
LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLTNGQWQPHATVATLSNAMDVSQPNNWPRVEELFRRKI
WQLKELGHATVSDETTKDTMRELAKLGYLSEPHAAIAYRALRDQLQEGEFGLFLGTAHPAKFKESVEDILGQELPLPKAL
ALRADLPLLSHNLPAGFGELRKFLMALPA

Sequences:

>Translated_429_residues
MKLYNLKDHNEQVSFTQAIKQGLGKQQGLFFPLDLPEFELTEIDHLLEQDFVTRSSRILSAFIGDEVSEEALHKRVAAAF
EFPAPVAQVEDDIACLELFHGPTLAFKDFGGRFMAQMLAEVAGDQPVTILTATSGDTGAAVAHAFYGLKNVRVVILYPQG
KISPLQEKLFCTLGGNIHTVAIDGDFDACQALVKQAFDDQELKEALHLNSANSINISRLLAQICYYFEAVAQLPQEARNQ
LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLTNGQWQPHATVATLSNAMDVSQPNNWPRVEELFRRKI
WQLKELGHATVSDETTKDTMRELAKLGYLSEPHAAIAYRALRDQLQEGEFGLFLGTAHPAKFKESVEDILGQELPLPKAL
ALRADLPLLSHNLPAGFGELRKFLMALPA
>Mature_429_residues
MKLYNLKDHNEQVSFTQAIKQGLGKQQGLFFPLDLPEFELTEIDHLLEQDFVTRSSRILSAFIGDEVSEEALHKRVAAAF
EFPAPVAQVEDDIACLELFHGPTLAFKDFGGRFMAQMLAEVAGDQPVTILTATSGDTGAAVAHAFYGLKNVRVVILYPQG
KISPLQEKLFCTLGGNIHTVAIDGDFDACQALVKQAFDDQELKEALHLNSANSINISRLLAQICYYFEAVAQLPQEARNQ
LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLTNGQWQPHATVATLSNAMDVSQPNNWPRVEELFRRKI
WQLKELGHATVSDETTKDTMRELAKLGYLSEPHAAIAYRALRDQLQEGEFGLFLGTAHPAKFKESVEDILGQELPLPKAL
ALRADLPLLSHNLPAGFGELRKFLMALPA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=439, Percent_Identity=28.7015945330296, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI149193323, Length=419, Percent_Identity=29.1169451073986, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1786185, Length=425, Percent_Identity=84.4705882352941, Blast_Score=721, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319901, Length=447, Percent_Identity=33.1096196868009, Blast_Score=206, Evalue=7e-54,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 47203; Mature: 47203

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNLKDHNEQVSFTQAIKQGLGKQQGLFFPLDLPEFELTEIDHLLEQDFVTRSSRILS
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
AFIGDEVSEEALHKRVAAAFEFPAPVAQVEDDIACLELFHGPTLAFKDFGGRFMAQMLAE
HHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEHHHHCHHHHHHHHHH
VAGDQPVTILTATSGDTGAAVAHAFYGLKNVRVVILYPQGKISPLQEKLFCTLGGNIHTV
HCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHEEEECCCEEEE
AIDGDFDACQALVKQAFDDQELKEALHLNSANSINISRLLAQICYYFEAVAQLPQEARNQ
EECCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLTNGQWQPHATVATLSNA
EEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHH
MDVSQPNNWPRVEELFRRKIWQLKELGHATVSDETTKDTMRELAKLGYLSEPHAAIAYRA
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
LRDQLQEGEFGLFLGTAHPAKFKESVEDILGQELPLPKALALRADLPLLSHNLPAGFGEL
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHCCCCCCHHHH
RKFLMALPA
HHHHHHCCC
>Mature Secondary Structure
MKLYNLKDHNEQVSFTQAIKQGLGKQQGLFFPLDLPEFELTEIDHLLEQDFVTRSSRILS
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
AFIGDEVSEEALHKRVAAAFEFPAPVAQVEDDIACLELFHGPTLAFKDFGGRFMAQMLAE
HHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEHHHHCHHHHHHHHHH
VAGDQPVTILTATSGDTGAAVAHAFYGLKNVRVVILYPQGKISPLQEKLFCTLGGNIHTV
HCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHEEEECCCEEEE
AIDGDFDACQALVKQAFDDQELKEALHLNSANSINISRLLAQICYYFEAVAQLPQEARNQ
EECCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLTNGQWQPHATVATLSNA
EEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHH
MDVSQPNNWPRVEELFRRKIWQLKELGHATVSDETTKDTMRELAKLGYLSEPHAAIAYRA
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
LRDQLQEGEFGLFLGTAHPAKFKESVEDILGQELPLPKALALRADLPLLSHNLPAGFGEL
HHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHCCCCCCHHHH
RKFLMALPA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8423151 [H]