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The map label for this gene is glpA [H]

Identifier: 157368449

GI number: 157368449

Start: 224999

End: 226642

Strand: Direct

Name: glpA [H]

Synonym: Spro_0200

Alternate gene names: 157368449

Gene position: 224999-226642 (Clockwise)

Preceding gene: 157368446

Following gene: 157368450

Centisome position: 4.13

GC content: 61.62

Gene sequence:

>1644_bases
ATGAGCAGCCATTCACCGGATAACGAAACGGATGTGATCATTATTGGCGGCGGCGCGACCGGTGCGGGCATTGCTCGTGA
CTGCGCGCGTCGTGGCCTGCGTTGCATACTGCTGGAGCGTCACGATATTGCCACCGGTGCCACTGGCCGTAACCACGGGC
TGCTGCACAGTGGAGCACGCTATGCGGTGACCGACGGTGAGTCGGCGCGCGAATGCATAGAAGAAAACCAAATCCTCAAG
CGTATTGCGCACCACTGCATCGAACGTACCGATGGGCTGTTTATTACGCTGCCGCAGGATTCGCTGGCCTATCAACAACA
GTTTATTGCCTCCTGCCACAGCGCCGGTATCAACGCCGAAGCGATCGACCCACAGCTGGCGCTGCGTCTGGAGCCGGCGG
CCAACCCGGCTCTGATCGGTGCGGTGCGGGTGCCGGACGGCACTGTCGATCCCTTCCGTCTCACCGCCGCCAATATGCTC
GACGCCCGTGAGCACGGTGCGCAGATCCTCACCTATCATCAGGTAGTCGGTTTGCTTCGCGCTGGCGATCGCGTTACCGG
GGTGCGCGTTTTCGACCATCAATCTGCACAGCGCTACGATATTCATGCCGAAGTGGTGGTCAATGCCGCGGGCATCTGGG
GCCAGCAGATAGCGGAATATGCCGATCTGCGCATTCGCATGTTCCCGGCCAAGGGCGCTTTGCTGATCCTCGGCCACCGC
ATCAACAACATGGTGATCAACCGCTGCCGCAAACCGGCGGACGCCGACATTTTGGTGCCGGGCGACACCATCTCGGTGAT
TGGCACCACCTCCACCCATATTGATTATGACCAGATCGACAACATGCTGGTGACGCCGCAGGAAGTGGACATTCTGATCC
GCGAAGGGGCGCTGCTGGCGCCGGAGCTGGCGCAGACGCGTATTCTGCGCGCCTATGCCGGTGTGCGCCCATTGGTAGCC
AGTGACGACGACCCCAGCGGCCGCAACGTCAGCCGCGGCATCGTGCTGCTCGATCACGCCAGCCGCGACGGCCTGGAAGG
CTTTATCACCATTACCGGCGGCAAGTTGATGACCTACCGGCTGATGGCGCAGTGGGCGACCGATAAAGTGTGCGAAAAGC
TCGGAATCGACAGCCCCTGTACCACCGCGCAGGAAGCCTTGCCCGGTTCGCGGCAGTCGGCGGAAGAAACGGTGCGCAGC
GTGGTTTCCCTGCCTGCCAGCATTCGCGGCTCGGCGGTTTATCGCCACGGCGACAGGGCCAGTCAGGTACCGGCCGGCGA
TCGGCTGGATAACAGCCTGGTGTGCGAATGCGAAGCGGTGACCGCTGGTGAAGTGCGTTATGCGGTGAACTCCCTCACCG
TTAATAACCTGGTCGATCTACGCCGCCGCACCCGCGTCGGCATGGGCACCTGCCAGGGGGAGCTTTGCGCCTGCCGTGCC
GCCGGGCTGTTGACGCGTTTTAACGTCACCACCCCGCAGCAGTCTATCGATCAGCTATCGCATTTCCTTAACGAGCGTTG
GAAAGGGGTAAGACCGATCGCCTGGGGCGATGCGCTACGTGAAAGTGAGTTTACCAGTTGGGTTTATCAGGGATTGTGCG
GGCTCGATGCCCGGGGGGAACAGGAGGCCGATGATGCGATTTGA

Upstream 100 bases:

>100_bases
ATTTGGTTTTCGTTTCGAGTTCGTTATTGTTCCTTATCAAACAAAGACCCCAATGACTGTGGCTCAATAGGCTAATAATC
ACGGATCCTGAGAGAGCCTC

Downstream 100 bases:

>100_bases
CGTAGTGGTGATTGGCGGTGGCCTGGCAGGCATGAGTTGTGCCATTCGATTGGCAGAGCAAGGTAAGCGCTGCGCCGTGG
TCAGTTCAGGCCAGAGTGCA

Product: sn-glycerol-3-phosphate dehydrogenase subunit A

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MSSHSPDNETDVIIIGGGATGAGIARDCARRGLRCILLERHDIATGATGRNHGLLHSGARYAVTDGESARECIEENQILK
RIAHHCIERTDGLFITLPQDSLAYQQQFIASCHSAGINAEAIDPQLALRLEPAANPALIGAVRVPDGTVDPFRLTAANML
DAREHGAQILTYHQVVGLLRAGDRVTGVRVFDHQSAQRYDIHAEVVVNAAGIWGQQIAEYADLRIRMFPAKGALLILGHR
INNMVINRCRKPADADILVPGDTISVIGTTSTHIDYDQIDNMLVTPQEVDILIREGALLAPELAQTRILRAYAGVRPLVA
SDDDPSGRNVSRGIVLLDHASRDGLEGFITITGGKLMTYRLMAQWATDKVCEKLGIDSPCTTAQEALPGSRQSAEETVRS
VVSLPASIRGSAVYRHGDRASQVPAGDRLDNSLVCECEAVTAGEVRYAVNSLTVNNLVDLRRRTRVGMGTCQGELCACRA
AGLLTRFNVTTPQQSIDQLSHFLNERWKGVRPIAWGDALRESEFTSWVYQGLCGLDARGEQEADDAI

Sequences:

>Translated_547_residues
MSSHSPDNETDVIIIGGGATGAGIARDCARRGLRCILLERHDIATGATGRNHGLLHSGARYAVTDGESARECIEENQILK
RIAHHCIERTDGLFITLPQDSLAYQQQFIASCHSAGINAEAIDPQLALRLEPAANPALIGAVRVPDGTVDPFRLTAANML
DAREHGAQILTYHQVVGLLRAGDRVTGVRVFDHQSAQRYDIHAEVVVNAAGIWGQQIAEYADLRIRMFPAKGALLILGHR
INNMVINRCRKPADADILVPGDTISVIGTTSTHIDYDQIDNMLVTPQEVDILIREGALLAPELAQTRILRAYAGVRPLVA
SDDDPSGRNVSRGIVLLDHASRDGLEGFITITGGKLMTYRLMAQWATDKVCEKLGIDSPCTTAQEALPGSRQSAEETVRS
VVSLPASIRGSAVYRHGDRASQVPAGDRLDNSLVCECEAVTAGEVRYAVNSLTVNNLVDLRRRTRVGMGTCQGELCACRA
AGLLTRFNVTTPQQSIDQLSHFLNERWKGVRPIAWGDALRESEFTSWVYQGLCGLDARGEQEADDAI
>Mature_546_residues
SSHSPDNETDVIIIGGGATGAGIARDCARRGLRCILLERHDIATGATGRNHGLLHSGARYAVTDGESARECIEENQILKR
IAHHCIERTDGLFITLPQDSLAYQQQFIASCHSAGINAEAIDPQLALRLEPAANPALIGAVRVPDGTVDPFRLTAANMLD
AREHGAQILTYHQVVGLLRAGDRVTGVRVFDHQSAQRYDIHAEVVVNAAGIWGQQIAEYADLRIRMFPAKGALLILGHRI
NNMVINRCRKPADADILVPGDTISVIGTTSTHIDYDQIDNMLVTPQEVDILIREGALLAPELAQTRILRAYAGVRPLVAS
DDDPSGRNVSRGIVLLDHASRDGLEGFITITGGKLMTYRLMAQWATDKVCEKLGIDSPCTTAQEALPGSRQSAEETVRSV
VSLPASIRGSAVYRHGDRASQVPAGDRLDNSLVCECEAVTAGEVRYAVNSLTVNNLVDLRRRTRVGMGTCQGELCACRAA
GLLTRFNVTTPQQSIDQLSHFLNERWKGVRPIAWGDALRESEFTSWVYQGLCGLDARGEQEADDAI

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=583, Percent_Identity=24.5283018867925, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI285002231, Length=583, Percent_Identity=24.5283018867925, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI197927446, Length=285, Percent_Identity=25.6140350877193, Blast_Score=66, Evalue=1e-10,
Organism=Homo sapiens, GI21361378, Length=285, Percent_Identity=25.6140350877193, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1788574, Length=522, Percent_Identity=76.8199233716475, Blast_Score=814, Evalue=0.0,
Organism=Escherichia coli, GI2367226, Length=372, Percent_Identity=23.9247311827957, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17509253, Length=423, Percent_Identity=29.0780141843972, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI115534726, Length=517, Percent_Identity=24.7582205029014, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI161077125, Length=511, Percent_Identity=27.2015655577299, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653942, Length=511, Percent_Identity=27.2015655577299, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653944, Length=511, Percent_Identity=27.2015655577299, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20130025, Length=511, Percent_Identity=27.2015655577299, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20130091, Length=237, Percent_Identity=29.957805907173, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24586295, Length=388, Percent_Identity=24.2268041237113, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 59326; Mature: 59195

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00977 FAD_G3PDH_1 ; PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHSPDNETDVIIIGGGATGAGIARDCARRGLRCILLERHDIATGATGRNHGLLHSGAR
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEECCCE
YAVTDGESARECIEENQILKRIAHHCIERTDGLFITLPQDSLAYQQQFIASCHSAGINAE
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCC
AIDPQLALRLEPAANPALIGAVRVPDGTVDPFRLTAANMLDAREHGAQILTYHQVVGLLR
CCCCEEEEEECCCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHH
AGDRVTGVRVFDHQSAQRYDIHAEVVVNAAGIWGQQIAEYADLRIRMFPAKGALLILGHR
CCCCEEEEEEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHCCEEEEECCCCEEEEEECH
INNMVINRCRKPADADILVPGDTISVIGTTSTHIDYDQIDNMLVTPQEVDILIREGALLA
HHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCCHHHHCCEEECCHHHEEEEECCCCCC
PELAQTRILRAYAGVRPLVASDDDPSGRNVSRGIVLLDHASRDGLEGFITITGGKLMTYR
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEHHH
LMAQWATDKVCEKLGIDSPCTTAQEALPGSRQSAEETVRSVVSLPASIRGSAVYRHGDRA
HHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCC
SQVPAGDRLDNSLVCECEAVTAGEVRYAVNSLTVNNLVDLRRRTRVGMGTCQGELCACRA
CCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AGLLTRFNVTTPQQSIDQLSHFLNERWKGVRPIAWGDALRESEFTSWVYQGLCGLDARGE
HHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
QEADDAI
CCCCCCC
>Mature Secondary Structure 
SSHSPDNETDVIIIGGGATGAGIARDCARRGLRCILLERHDIATGATGRNHGLLHSGAR
CCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEECCCE
YAVTDGESARECIEENQILKRIAHHCIERTDGLFITLPQDSLAYQQQFIASCHSAGINAE
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCCCC
AIDPQLALRLEPAANPALIGAVRVPDGTVDPFRLTAANMLDAREHGAQILTYHQVVGLLR
CCCCEEEEEECCCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHH
AGDRVTGVRVFDHQSAQRYDIHAEVVVNAAGIWGQQIAEYADLRIRMFPAKGALLILGHR
CCCCEEEEEEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHCCEEEEECCCCEEEEEECH
INNMVINRCRKPADADILVPGDTISVIGTTSTHIDYDQIDNMLVTPQEVDILIREGALLA
HHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCCHHHHCCEEECCHHHEEEEECCCCCC
PELAQTRILRAYAGVRPLVASDDDPSGRNVSRGIVLLDHASRDGLEGFITITGGKLMTYR
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEHHH
LMAQWATDKVCEKLGIDSPCTTAQEALPGSRQSAEETVRSVVSLPASIRGSAVYRHGDRA
HHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCC
SQVPAGDRLDNSLVCECEAVTAGEVRYAVNSLTVNNLVDLRRRTRVGMGTCQGELCACRA
CCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AGLLTRFNVTTPQQSIDQLSHFLNERWKGVRPIAWGDALRESEFTSWVYQGLCGLDARGE
HHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
QEADDAI
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]