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The map label for this gene is glyA [H]

Identifier: 156937879

GI number: 156937879

Start: 973088

End: 974389

Strand: Reverse

Name: glyA [H]

Synonym: Igni_1091

Alternate gene names: 156937879

Gene position: 974389-973088 (Counterclockwise)

Preceding gene: 156937880

Following gene: 156937878

Centisome position: 75.1

GC content: 55.76

Gene sequence:

>1302_bases
ATGCACGAGACCTTAAAGAAGATAATAGAAATAGTTGAGGCCCACGACGAGTGGAGGCACCAAACGATAAACCTCATAGC
AAGCGAAAACGTGATGAGTCCTCTGGCGGAAAGCTTGTACTTGAACGACATGATGCACCGCTACGCCGAAGGCAAGCCTT
TCAAGAGGTACTACCAGGGGACCAAGTACATAGACGAAATAGAGGTATTGGCCACGGAACTCATGAAGAAGCTCTTCAAC
TCCGAGTACGCCGAGGTGAGGCCCGTCAGCGGCACCACGGCCAACGGGACGGTGTTCTACGTCTTAGGACAAGAGAAGAA
GAAAGCAATAATACCCCCGGTACAAGCGGGCTCCCACGTCAGCCACACCAAGTTCGGCATACTCGGAGCCTTGTGCATAG
AGCAAGTAGAGATGCCCTACGACGAGGAGAACCTAAACATAGACGTCGATAAGGCGGTAAAGATGATAGAGGAGGTGGAG
CCCGCCTTCGTGGTCCTCGGGGGCAGCATGTACCCCTTCCCCCACCCCGTGAAGGAGATAGCCGAGGCGGCCCACTCCGT
GGGGGCGAAGGTGGTTTACGACGCCGCCCACGTGTTGGGGCTCATAGCCGGCAAGGCCTTAGAGAACCCCTTGTCTGAGG
GCGCGGACGTGATGACCGCCTCCACCCACAAGACCTTCCCCGGCCCCCAAGGGGGAGTAATACTCACTAACGACAAGGAC
GTTTACAAGAAGGTGTCTAGGACCGTCTTCCCGGTCTTCGTGAGCAACCACCACGCCCACCGCCTCCCCTCCTTAGCGGT
CACCGCGTTGGAGATGTTGGAGTTCGGCGAACAGTACGCCTCTCAAGTGGTTTCTAACGCGAAGGCCTTAGCGGAGGAGC
TCCACGCCTTGGGGGTGAAGGTGCTCGGCGAACGCTTGGGCTTCACCAGGACACATCAAGTGGTGATAGACGTGAGGGAG
TTCGGAGGAGGGTCGGAGATAGCTAAGAAGCTCGAAGAGGCTAACATAATAGTTAACAAGAACTTGTTGCCGTGGGACCC
CCCAGACGCCATAGCGAACCCCAGCGGAATAAGGATGGGAGTCCAAGAGATGACGAGGTTCGGGATGAAGGAAGGGGAGA
TGAAGGAGGTCGCGAGGCTCATAAAGAGGGTCATGGACGGCGAGGACCCGAAGAAGGTAAAGGAAGACGTCGTGGAGTTG
AGGAAACAGTTCGTAGAGGTGAAGTACGGCTACAAGTTGAGCGATTTAAAGGAGGCTGAGGAGAGGTTCAAGAAGTACTT
GAAGCTGGCCTTGGAGCTCTGA

Upstream 100 bases:

>100_bases
AGTCACCGAACTTGGAGGAGGACGCGGTAATGATGAAGAAGTACTGGTACCAACTGTCAATATTTACTCCCGCGGGCTGA
GAGTTTTTAGGGACAAGGGG

Downstream 100 bases:

>100_bases
GCCCTACGTCCTTTTTAAACTAATAAGGAAGCTCCCGAGACTACAAAGGGCTTAGAAATGCCCAAGCAGCGCGTCCAGAG
CGAGAGGGGCGAGGAGCGCT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MHETLKKIIEIVEAHDEWRHQTINLIASENVMSPLAESLYLNDMMHRYAEGKPFKRYYQGTKYIDEIEVLATELMKKLFN
SEYAEVRPVSGTTANGTVFYVLGQEKKKAIIPPVQAGSHVSHTKFGILGALCIEQVEMPYDEENLNIDVDKAVKMIEEVE
PAFVVLGGSMYPFPHPVKEIAEAAHSVGAKVVYDAAHVLGLIAGKALENPLSEGADVMTASTHKTFPGPQGGVILTNDKD
VYKKVSRTVFPVFVSNHHAHRLPSLAVTALEMLEFGEQYASQVVSNAKALAEELHALGVKVLGERLGFTRTHQVVIDVRE
FGGGSEIAKKLEEANIIVNKNLLPWDPPDAIANPSGIRMGVQEMTRFGMKEGEMKEVARLIKRVMDGEDPKKVKEDVVEL
RKQFVEVKYGYKLSDLKEAEERFKKYLKLALEL

Sequences:

>Translated_433_residues
MHETLKKIIEIVEAHDEWRHQTINLIASENVMSPLAESLYLNDMMHRYAEGKPFKRYYQGTKYIDEIEVLATELMKKLFN
SEYAEVRPVSGTTANGTVFYVLGQEKKKAIIPPVQAGSHVSHTKFGILGALCIEQVEMPYDEENLNIDVDKAVKMIEEVE
PAFVVLGGSMYPFPHPVKEIAEAAHSVGAKVVYDAAHVLGLIAGKALENPLSEGADVMTASTHKTFPGPQGGVILTNDKD
VYKKVSRTVFPVFVSNHHAHRLPSLAVTALEMLEFGEQYASQVVSNAKALAEELHALGVKVLGERLGFTRTHQVVIDVRE
FGGGSEIAKKLEEANIIVNKNLLPWDPPDAIANPSGIRMGVQEMTRFGMKEGEMKEVARLIKRVMDGEDPKKVKEDVVEL
RKQFVEVKYGYKLSDLKEAEERFKKYLKLALEL
>Mature_433_residues
MHETLKKIIEIVEAHDEWRHQTINLIASENVMSPLAESLYLNDMMHRYAEGKPFKRYYQGTKYIDEIEVLATELMKKLFN
SEYAEVRPVSGTTANGTVFYVLGQEKKKAIIPPVQAGSHVSHTKFGILGALCIEQVEMPYDEENLNIDVDKAVKMIEEVE
PAFVVLGGSMYPFPHPVKEIAEAAHSVGAKVVYDAAHVLGLIAGKALENPLSEGADVMTASTHKTFPGPQGGVILTNDKD
VYKKVSRTVFPVFVSNHHAHRLPSLAVTALEMLEFGEQYASQVVSNAKALAEELHALGVKVLGERLGFTRTHQVVIDVRE
FGGGSEIAKKLEEANIIVNKNLLPWDPPDAIANPSGIRMGVQEMTRFGMKEGEMKEVARLIKRVMDGEDPKKVKEDVVEL
RKQFVEVKYGYKLSDLKEAEERFKKYLKLALEL

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=452, Percent_Identity=26.7699115044248, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI261862352, Length=452, Percent_Identity=26.7699115044248, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI261862350, Length=452, Percent_Identity=26.7699115044248, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI261862348, Length=452, Percent_Identity=26.7699115044248, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI261862346, Length=450, Percent_Identity=26.8888888888889, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI22547186, Length=453, Percent_Identity=27.5938189845475, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI22547189, Length=437, Percent_Identity=27.2311212814645, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1788902, Length=386, Percent_Identity=35.7512953367876, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25144729, Length=446, Percent_Identity=28.47533632287, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25144732, Length=446, Percent_Identity=28.47533632287, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323087, Length=411, Percent_Identity=30.4136253041363, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319739, Length=430, Percent_Identity=28.3720930232558, Blast_Score=146, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=32.5, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI221329721, Length=405, Percent_Identity=32.0987654320988, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 48326; Mature: 48326

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHETLKKIIEIVEAHDEWRHQTINLIASENVMSPLAESLYLNDMMHRYAEGKPFKRYYQG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
TKYIDEIEVLATELMKKLFNSEYAEVRPVSGTTANGTVFYVLGQEKKKAIIPPVQAGSHV
CHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
SHTKFGILGALCIEQVEMPYDEENLNIDVDKAVKMIEEVEPAFVVLGGSMYPFPHPVKEI
CHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHH
AEAAHSVGAKVVYDAAHVLGLIAGKALENPLSEGADVMTASTHKTFPGPQGGVILTNDKD
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEECCHH
VYKKVSRTVFPVFVSNHHAHRLPSLAVTALEMLEFGEQYASQVVSNAKALAEELHALGVK
HHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGERLGFTRTHQVVIDVREFGGGSEIAKKLEEANIIVNKNLLPWDPPDAIANPSGIRMG
HHHHHHCCCCHHHEEEEHHHCCCHHHHHHHHHHCCEEEECCCCCCCCCHHCCCCCHHHHH
VQEMTRFGMKEGEMKEVARLIKRVMDGEDPKKVKEDVVELRKQFVEVKYGYKLSDLKEAE
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ERFKKYLKLALEL
HHHHHHHHHHHCC
>Mature Secondary Structure
MHETLKKIIEIVEAHDEWRHQTINLIASENVMSPLAESLYLNDMMHRYAEGKPFKRYYQG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
TKYIDEIEVLATELMKKLFNSEYAEVRPVSGTTANGTVFYVLGQEKKKAIIPPVQAGSHV
CHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
SHTKFGILGALCIEQVEMPYDEENLNIDVDKAVKMIEEVEPAFVVLGGSMYPFPHPVKEI
CHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHH
AEAAHSVGAKVVYDAAHVLGLIAGKALENPLSEGADVMTASTHKTFPGPQGGVILTNDKD
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEECCHH
VYKKVSRTVFPVFVSNHHAHRLPSLAVTALEMLEFGEQYASQVVSNAKALAEELHALGVK
HHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGERLGFTRTHQVVIDVREFGGGSEIAKKLEEANIIVNKNLLPWDPPDAIANPSGIRMG
HHHHHHCCCCHHHEEEEHHHCCCHHHHHHHHHHCCEEEECCCCCCCCCHHCCCCCHHHHH
VQEMTRFGMKEGEMKEVARLIKRVMDGEDPKKVKEDVVELRKQFVEVKYGYKLSDLKEAE
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ERFKKYLKLALEL
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA