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The map label for this gene is pcnA [H]

Identifier: 156937403

GI number: 156937403

Start: 547026

End: 547772

Strand: Direct

Name: pcnA [H]

Synonym: Igni_0610

Alternate gene names: 156937403

Gene position: 547026-547772 (Clockwise)

Preceding gene: 156937401

Following gene: 156937405

Centisome position: 42.16

GC content: 50.87

Gene sequence:

>747_bases
TTGAAGATCGTATACCCTGAGGCAAAAATCTTTCAAAGCCTTGTGGACGCTATCGGAAAGATAGTAGACGAAGTCGCGTT
GGTCGCGAAGCCCGAAGGGGTAGAAATGAAGGCGATAGACCCAGCCCAAGTAGTTATGATAAGAATATACATTCCCGCCG
ACGCCTTTAGCGAGTACGAGGTCGAAGAGGAGGAGAGCTTGGGATTCAACATAGGTGACATCCTCAAGTTCTTCAAGAGA
GCAAAGAAGGGCTACAAACTTGAGCTGGGGAGCGAGGCTGAAGGGTCTAAAATAAGGATAGTGTTGGAGGGCGCTCTGAT
AAAGAAATACGTTATACCGAACTTAGAGGTGGTGTCGGAGGAACTGCCCGACTTGAGCAACCTCGATTTTAAAGTCAAAG
CTTTGTTGTTGGCCTCAGTGATAAAGGAGGCTATCAAGGACATAGAGGCGGTAAGCGACGTAATGATAGTTGAGGCGCCG
GACGCGGACAACCTCTACTTGAAGGGAGCCGGCGTAGCAGAGGCCGTTACCAGAGTTTCCAGAGCTTCCTCGGCGCTCCT
AGAGCTCGAGGTGGAGGAGCCTTCAAAGGCCGCTTACGACCTAACGTACCTCAAGCACATAGTGGGAATCACGAAAGTAT
CGGACAACGTCGAGGTGAGGTTTGGAACCGACATGCCGTTGTACTTGAAGTTTAACATACTGGCGGGAGGAGAGGCGGAA
TACGTAGTGGCGCCCCAAGCCTTGTGA

Upstream 100 bases:

>100_bases
CCCTATCCCTTCACGGTGAAGCCTTTTTATAAAGATCTTGAAGGAGGGCGCAGAAGGGCTTCAAATAACTCTCCGGCGCC
AAAGGACGTGGAAGGTAAGC

Downstream 100 bases:

>100_bases
CAAAAAAGGTGTGGAAACCTATACCCCGTCCCCTTCGACCAAGGAGCGGTCCGCGTTACCTCCGACGACCTTCTTGGCCT
CTAAGTTGCGAACGATGAAC

Product: DNA polymerase sliding clamp subunit A

Products: NA

Alternate protein names: Proliferating cell nuclear antigen homolog A; PCNA A [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MKIVYPEAKIFQSLVDAIGKIVDEVALVAKPEGVEMKAIDPAQVVMIRIYIPADAFSEYEVEEEESLGFNIGDILKFFKR
AKKGYKLELGSEAEGSKIRIVLEGALIKKYVIPNLEVVSEELPDLSNLDFKVKALLLASVIKEAIKDIEAVSDVMIVEAP
DADNLYLKGAGVAEAVTRVSRASSALLELEVEEPSKAAYDLTYLKHIVGITKVSDNVEVRFGTDMPLYLKFNILAGGEAE
YVVAPQAL

Sequences:

>Translated_248_residues
MKIVYPEAKIFQSLVDAIGKIVDEVALVAKPEGVEMKAIDPAQVVMIRIYIPADAFSEYEVEEEESLGFNIGDILKFFKR
AKKGYKLELGSEAEGSKIRIVLEGALIKKYVIPNLEVVSEELPDLSNLDFKVKALLLASVIKEAIKDIEAVSDVMIVEAP
DADNLYLKGAGVAEAVTRVSRASSALLELEVEEPSKAAYDLTYLKHIVGITKVSDNVEVRFGTDMPLYLKFNILAGGEAE
YVVAPQAL
>Mature_248_residues
MKIVYPEAKIFQSLVDAIGKIVDEVALVAKPEGVEMKAIDPAQVVMIRIYIPADAFSEYEVEEEESLGFNIGDILKFFKR
AKKGYKLELGSEAEGSKIRIVLEGALIKKYVIPNLEVVSEELPDLSNLDFKVKALLLASVIKEAIKDIEAVSDVMIVEAP
DADNLYLKGAGVAEAVTRVSRASSALLELEVEEPSKAAYDLTYLKHIVGITKVSDNVEVRFGTDMPLYLKFNILAGGEAE
YVVAPQAL

Specific function: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication [H]

COG id: COG0592

COG function: function code L; DNA polymerase sliding clamp subunit (PCNA homolog)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PCNA family [H]

Homologues:

Organism=Homo sapiens, GI33239451, Length=256, Percent_Identity=20.3125, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI4505641, Length=256, Percent_Identity=20.3125, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319564, Length=251, Percent_Identity=21.1155378486056, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17136790, Length=255, Percent_Identity=21.1764705882353, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45552759, Length=255, Percent_Identity=21.1764705882353, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000730
- InterPro:   IPR022649
- InterPro:   IPR022659
- InterPro:   IPR022648 [H]

Pfam domain/function: PF02747 PCNA_C; PF00705 PCNA_N [H]

EC number: NA

Molecular weight: Translated: 27151; Mature: 27151

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVYPEAKIFQSLVDAIGKIVDEVALVAKPEGVEMKAIDPAQVVMIRIYIPADAFSEYE
CEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEEECCCCCCCCC
VEEEESLGFNIGDILKFFKRAKKGYKLELGSEAEGSKIRIVLEGALIKKYVIPNLEVVSE
CCCHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECHHHHHHHCCCHHHHHH
ELPDLSNLDFKVKALLLASVIKEAIKDIEAVSDVMIVEAPDADNLYLKGAGVAEAVTRVS
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEECCCHHHHHHHHH
RASSALLELEVEEPSKAAYDLTYLKHIVGITKVSDNVEVRFGTDMPLYLKFNILAGGEAE
HHCCEEEEEEECCCCCHHHHHHHHHHHHHHEEECCCEEEEECCCCCEEEEEEEEECCCCC
YVVAPQAL
EEECCCCC
>Mature Secondary Structure
MKIVYPEAKIFQSLVDAIGKIVDEVALVAKPEGVEMKAIDPAQVVMIRIYIPADAFSEYE
CEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEEECCCCCCCCC
VEEEESLGFNIGDILKFFKRAKKGYKLELGSEAEGSKIRIVLEGALIKKYVIPNLEVVSE
CCCHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECHHHHHHHCCCHHHHHH
ELPDLSNLDFKVKALLLASVIKEAIKDIEAVSDVMIVEAPDADNLYLKGAGVAEAVTRVS
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEECCCHHHHHHHHH
RASSALLELEVEEPSKAAYDLTYLKHIVGITKVSDNVEVRFGTDMPLYLKFNILAGGEAE
HHCCEEEEEEECCCCCHHHHHHHHHHHHHHEEECCCEEEEECCCCCEEEEEEEEECCCCC
YVVAPQAL
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11139078 [H]