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The map label for this gene is ilvC [H]

Identifier: 156937401

GI number: 156937401

Start: 543699

End: 544730

Strand: Direct

Name: ilvC [H]

Synonym: Igni_0608

Alternate gene names: 156937401

Gene position: 543699-544730 (Clockwise)

Preceding gene: 156937397

Following gene: 156937403

Centisome position: 41.9

GC content: 56.49

Gene sequence:

>1032_bases
ATGGGGTTAAACGCTGGCGCCTTGCGACGCGTAGGTGTGACCGTGGCCCAGATATGGAAGGACAGCGACGTCTCCCTGGA
ACCGCTAAAGGGTAGGAAGGTAGCCATCATAGGCTACGGCTCCCAAGGCAGGGCGTGGGCGCTGAACATAAGGGACAGCG
GAGTGGACGTAGTGGTCGGGCTGAGGCCCGGAGGCAAGAGTTGGGAGCTAGCTACCAAAGACGGCTTCGAACCCAAGCCT
ATCCCGGAGGCGGCTAAGGAGGGCGACGTCATAGCTATGCTCATCCCCGACATGGCCCAACCAGAGATATACGAGAAGTA
CGTGGAGCCCAACCTCCACGAGGGCAACGCACTGGTGTTCGCCCACGGCTTCAACATTCACTACGGACTCATAAAGCCTC
CCAAGAACGTAGACGTCATAATGGTTGCCCCCAAGAGTCCGGGGCCTAAGGTCAGAGAGGCCTTCCTCTCCGGAAGGGGC
GTTCCGGCCTTAGTGGCCGTACACCAAGATTACACCGGGAAGGCTTGGGACTTGGTGCTAGCTTTAGCCAAGGCGTTAGG
GTGCACCAGAGCCGGCGTGATAAAGACCACCTTCAAGGAGGAGACCGAGAGCGACCTCATAGGCGAACAGACCGTACTCG
TGGGCGGCTTGATGGAGCTGTTGAAGAAGGGCTTCGAGAACTTAGTAGAGCTCGGCTACCAGCCTGAAGTGGCTTACTTC
GAGGCCATAAACGAAGCAAAGCTGATAATGGACCTCATCTGGCAGTACGGCTTCTACGGCATGCTCTTGAGGGTTAGCGA
CACTGCCAAGTACGGCGGCCTTACAGTGGGGCCTAAGGTCATTGACGAACACGTGAAAGAGAACATGAAGAAGGCGTCAG
AGAGGGTAATAAGCGGCGAGTTCGCAAAGGAGTGGGTGGAGGAGTACAAGAAGGGCATGCCCACTTTGAAGGAGTTGATG
GAGAAGGTTAAGGAGCACCAAGCTGAGAAGGTGGGTAAGGAGCTCAGAAAGCTCATGGGCTTGGAAGAGTAA

Upstream 100 bases:

>100_bases
TGATTATCCAGCTCCTTAAGTCCTATTTCCACGAGTCTCAAAACGTCGCCCGTGAGACCGGCTCACCTAGGGCTTCTAAA
TTTGGGAAGCCCGCGGAGAA

Downstream 100 bases:

>100_bases
CGAAGTTCCCGTAACGGACGTTCTTTTTATTGTTCACTTCTCTCTGAGAAGGGAACTCACTTGAGAAGGGAAAGCACGTA
GTTACCGTACGCGTAGAGGA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MGLNAGALRRVGVTVAQIWKDSDVSLEPLKGRKVAIIGYGSQGRAWALNIRDSGVDVVVGLRPGGKSWELATKDGFEPKP
IPEAAKEGDVIAMLIPDMAQPEIYEKYVEPNLHEGNALVFAHGFNIHYGLIKPPKNVDVIMVAPKSPGPKVREAFLSGRG
VPALVAVHQDYTGKAWDLVLALAKALGCTRAGVIKTTFKEETESDLIGEQTVLVGGLMELLKKGFENLVELGYQPEVAYF
EAINEAKLIMDLIWQYGFYGMLLRVSDTAKYGGLTVGPKVIDEHVKENMKKASERVISGEFAKEWVEEYKKGMPTLKELM
EKVKEHQAEKVGKELRKLMGLEE

Sequences:

>Translated_343_residues
MGLNAGALRRVGVTVAQIWKDSDVSLEPLKGRKVAIIGYGSQGRAWALNIRDSGVDVVVGLRPGGKSWELATKDGFEPKP
IPEAAKEGDVIAMLIPDMAQPEIYEKYVEPNLHEGNALVFAHGFNIHYGLIKPPKNVDVIMVAPKSPGPKVREAFLSGRG
VPALVAVHQDYTGKAWDLVLALAKALGCTRAGVIKTTFKEETESDLIGEQTVLVGGLMELLKKGFENLVELGYQPEVAYF
EAINEAKLIMDLIWQYGFYGMLLRVSDTAKYGGLTVGPKVIDEHVKENMKKASERVISGEFAKEWVEEYKKGMPTLKELM
EKVKEHQAEKVGKELRKLMGLEE
>Mature_342_residues
GLNAGALRRVGVTVAQIWKDSDVSLEPLKGRKVAIIGYGSQGRAWALNIRDSGVDVVVGLRPGGKSWELATKDGFEPKPI
PEAAKEGDVIAMLIPDMAQPEIYEKYVEPNLHEGNALVFAHGFNIHYGLIKPPKNVDVIMVAPKSPGPKVREAFLSGRGV
PALVAVHQDYTGKAWDLVLALAKALGCTRAGVIKTTFKEETESDLIGEQTVLVGGLMELLKKGFENLVELGYQPEVAYFE
AINEAKLIMDLIWQYGFYGMLLRVSDTAKYGGLTVGPKVIDEHVKENMKKASERVISGEFAKEWVEEYKKGMPTLKELME
KVKEHQAEKVGKELRKLMGLEE

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=300, Percent_Identity=37, Blast_Score=155, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=349, Percent_Identity=36.1031518624642, Blast_Score=164, Evalue=2e-41,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 37773; Mature: 37642

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLNAGALRRVGVTVAQIWKDSDVSLEPLKGRKVAIIGYGSQGRAWALNIRDSGVDVVVG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEE
LRPGGKSWELATKDGFEPKPIPEAAKEGDVIAMLIPDMAQPEIYEKYVEPNLHEGNALVF
ECCCCCCCEECCCCCCCCCCCCCHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCEEEE
AHGFNIHYGLIKPPKNVDVIMVAPKSPGPKVREAFLSGRGVPALVAVHQDYTGKAWDLVL
EECCEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
ALAKALGCTRAGVIKTTFKEETESDLIGEQTVLVGGLMELLKKGFENLVELGYQPEVAYF
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
EAINEAKLIMDLIWQYGFYGMLLRVSDTAKYGGLTVGPKVIDEHVKENMKKASERVISGE
HHHHHHHHHHHHHHHHCHHEEEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCHH
FAKEWVEEYKKGMPTLKELMEKVKEHQAEKVGKELRKLMGLEE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GLNAGALRRVGVTVAQIWKDSDVSLEPLKGRKVAIIGYGSQGRAWALNIRDSGVDVVVG
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEE
LRPGGKSWELATKDGFEPKPIPEAAKEGDVIAMLIPDMAQPEIYEKYVEPNLHEGNALVF
ECCCCCCCEECCCCCCCCCCCCCHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCEEEE
AHGFNIHYGLIKPPKNVDVIMVAPKSPGPKVREAFLSGRGVPALVAVHQDYTGKAWDLVL
EECCEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHH
ALAKALGCTRAGVIKTTFKEETESDLIGEQTVLVGGLMELLKKGFENLVELGYQPEVAYF
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
EAINEAKLIMDLIWQYGFYGMLLRVSDTAKYGGLTVGPKVIDEHVKENMKKASERVISGE
HHHHHHHHHHHHHHHHCHHEEEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCHH
FAKEWVEEYKKGMPTLKELMEKVKEHQAEKVGKELRKLMGLEE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]