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The map label for this gene is gcvPA

Identifier: 154686719

GI number: 154686719

Start: 2420290

End: 2421636

Strand: Reverse

Name: gcvPA

Synonym: RBAM_022880

Alternate gene names: 154686719

Gene position: 2421636-2420290 (Counterclockwise)

Preceding gene: 154686720

Following gene: 154686718

Centisome position: 61.8

GC content: 49.52

Gene sequence:

>1347_bases
ATGAAGCATCGATATTTGCCCGCGACAGAACAGGATAAAAAAGAAATGCTGAAAGCCATCGGCGCAGAAACAATTGATGA
ACTGTTTGCCGATATTCCGGAAAATGTACGGTTTCAAAAAGACTACCAAATTAAAAAAGCAAAATCAGAAACAGAGCTGA
CGAGAGAGCTGACAAAGCTTGCGGCGAAAAATAAAGACGCTGTTACATATGCATCTTTTCTGGGCGCAGGAGTGTACGAT
CACTACCAGCCGGTTATCGTCGATCATGTGATATCCCGATCAGAGTTTTACACGGCATATACGCCTTACCAGCCTGAAAT
CTCACAAGGAGAGCTGCAGGCGATTTTTGAATTTCAAACGATGATCTGTGAATTAACGGGAATGGATATCGCAAACTCCT
CTATGTACGACGGGGGAACGGCGCTGGCGGAAGCGGCGATGCTTGCGTCGGGACATACGAAAAAGAAAAAAATCGTCATT
TCCGCAGCCGTTCATCCGGAATCGCGGGATGTTTTGAAAACATACGCAAAGGGCCAATATATTGAGGTTGTAGAGGTGCC
CGCGAAAAACGGCGTCACAGATCTTGAAGCATTGGAACATGCCGTTTGTGATGAAACGGCCGCCGTGATCGTCCAGTATC
CGAACTTCTTCGGACAAATCGAGCCGTTAAAGGACATTGAGCCGCTCGCACATAAAGGAAACAGCCAGCTGATTGTTTCT
TCAAACCCGCTCGCGCTCGGTATTTTGACACCGCCCGGGGCATACGGAGCTGATATCGTCGTCGGGGACGCGCAGCCTTT
CGGCATACCTGCGGCGTTCGGCGGCCCGCACTGCGGCTATTTTGCAGTAACGAAAAAACTGATGAGAAAGGTTCCGGGCC
GGCTTGTCGGCCAAACGGAGGATGAAAACGGGCGAAGAGGTTTTGTTCTCACTCTTCAGGCGCGCGAGCAGCATATCAGA
AGAGACAAAGCCACGTCTAACATTTGTTCAAATCAGGCGCTGAATGCTTTAGCGGCTTCAGCCGCGATGACGGCGCTCGG
AAAAAACGGCGTCAAAGACATGGCCCGCCAAAATATATTGAAAGCTGATTACGCGAGACGCCAAGCGGAAAAAGCCGGCT
TGCACGTAGCATTTGACGGCCCGATATTTAATGAATTTGCCGTCAGGCTGAATCTTCCCGTCAAGGAAGCAAACCGGCGG
CTCCTGCAAGACGGCATAATCGGCGGATATGACTTAGGCCTTGCGTATCCGGAACTGAATCAGCATATGCTCATTGCCGT
CACAGAGCTGAGAACAAAAGAAAAGATCGATTCGCTTATTGCGAGATTGGGGGATCAACATGAATAA

Upstream 100 bases:

>100_bases
CGGAAGTAGAAGTGGAAATCCGTAAAAAAACGGTAAAAGCGAAGATTGTCCGCACACCGTTTTATAAACGTCCAAAACAG
AGCTGAAAAAGGAGAGTCAT

Downstream 100 bases:

>100_bases
TCAAGATCAGGCGCTTATTTTTGAAATGTCCCGCGAAGGGCGTATCGGTTACAGCCTTCCGGAGCTTGATGTGCCGGAAA
CAGAGCTTGAAAGCCTTCTT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKHRYLPATEQDKKEMLKAIGAETIDELFADIPENVRFQKDYQIKKAKSETELTRELTKLAAKNKDAVTYASFLGAGVYD
HYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVI
SAAVHPESRDVLKTYAKGQYIEVVEVPAKNGVTDLEALEHAVCDETAAVIVQYPNFFGQIEPLKDIEPLAHKGNSQLIVS
SNPLALGILTPPGAYGADIVVGDAQPFGIPAAFGGPHCGYFAVTKKLMRKVPGRLVGQTEDENGRRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASAAMTALGKNGVKDMARQNILKADYARRQAEKAGLHVAFDGPIFNEFAVRLNLPVKEANRR
LLQDGIIGGYDLGLAYPELNQHMLIAVTELRTKEKIDSLIARLGDQHE

Sequences:

>Translated_448_residues
MKHRYLPATEQDKKEMLKAIGAETIDELFADIPENVRFQKDYQIKKAKSETELTRELTKLAAKNKDAVTYASFLGAGVYD
HYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVI
SAAVHPESRDVLKTYAKGQYIEVVEVPAKNGVTDLEALEHAVCDETAAVIVQYPNFFGQIEPLKDIEPLAHKGNSQLIVS
SNPLALGILTPPGAYGADIVVGDAQPFGIPAAFGGPHCGYFAVTKKLMRKVPGRLVGQTEDENGRRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASAAMTALGKNGVKDMARQNILKADYARRQAEKAGLHVAFDGPIFNEFAVRLNLPVKEANRR
LLQDGIIGGYDLGLAYPELNQHMLIAVTELRTKEKIDSLIARLGDQHE
>Mature_448_residues
MKHRYLPATEQDKKEMLKAIGAETIDELFADIPENVRFQKDYQIKKAKSETELTRELTKLAAKNKDAVTYASFLGAGVYD
HYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVI
SAAVHPESRDVLKTYAKGQYIEVVEVPAKNGVTDLEALEHAVCDETAAVIVQYPNFFGQIEPLKDIEPLAHKGNSQLIVS
SNPLALGILTPPGAYGADIVVGDAQPFGIPAAFGGPHCGYFAVTKKLMRKVPGRLVGQTEDENGRRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASAAMTALGKNGVKDMARQNILKADYARRQAEKAGLHVAFDGPIFNEFAVRLNLPVKEANRR
LLQDGIIGGYDLGLAYPELNQHMLIAVTELRTKEKIDSLIARLGDQHE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=420, Percent_Identity=36.4285714285714, Blast_Score=275, Evalue=5e-74,
Organism=Escherichia coli, GI1789269, Length=363, Percent_Identity=36.3636363636364, Blast_Score=202, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17535605, Length=396, Percent_Identity=39.1414141414141, Blast_Score=247, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=364, Percent_Identity=40.3846153846154, Blast_Score=263, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24645648, Length=358, Percent_Identity=38.8268156424581, Blast_Score=268, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_BACA2 (A7Z6M3)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001421880.1
- ProteinModelPortal:   A7Z6M3
- SMR:   A7Z6M3
- STRING:   A7Z6M3
- EnsemblBacteria:   EBBACT00000007636
- GeneID:   5461361
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_022880
- eggNOG:   COG0403
- GeneTree:   EBGT00050000001780
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   BAMY326423:RBAM_022880-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 49173; Mature: 49173

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHRYLPATEQDKKEMLKAIGAETIDELFADIPENVRFQKDYQIKKAKSETELTRELTKL
CCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHH
AAKNKDAVTYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHH
MICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVISAAVHPESRDVLKTYAKGQY
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHCCCE
IEVVEVPAKNGVTDLEALEHAVCDETAAVIVQYPNFFGQIEPLKDIEPLAHKGNSQLIVS
EEEEEECCCCCCHHHHHHHHHHHCCHHEEEEECCCHHCCCCCHHHCCHHHHCCCCEEEEE
SNPLALGILTPPGAYGADIVVGDAQPFGIPAAFGGPHCGYFAVTKKLMRKVPGRLVGQTE
CCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
DENGRRGFVLTLQAREQHIRRDKATSNICSNQALNALAASAAMTALGKNGVKDMARQNIL
CCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KADYARRQAEKAGLHVAFDGPIFNEFAVRLNLPVKEANRRLLQDGIIGGYDLGLAYPELN
HHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCC
QHMLIAVTELRTKEKIDSLIARLGDQHE
CEEEEEEHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKHRYLPATEQDKKEMLKAIGAETIDELFADIPENVRFQKDYQIKKAKSETELTRELTKL
CCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHH
AAKNKDAVTYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHH
MICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVISAAVHPESRDVLKTYAKGQY
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHCCCE
IEVVEVPAKNGVTDLEALEHAVCDETAAVIVQYPNFFGQIEPLKDIEPLAHKGNSQLIVS
EEEEEECCCCCCHHHHHHHHHHHCCHHEEEEECCCHHCCCCCHHHCCHHHHCCCCEEEEE
SNPLALGILTPPGAYGADIVVGDAQPFGIPAAFGGPHCGYFAVTKKLMRKVPGRLVGQTE
CCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
DENGRRGFVLTLQAREQHIRRDKATSNICSNQALNALAASAAMTALGKNGVKDMARQNIL
CCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
KADYARRQAEKAGLHVAFDGPIFNEFAVRLNLPVKEANRRLLQDGIIGGYDLGLAYPELN
HHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCC
QHMLIAVTELRTKEKIDSLIARLGDQHE
CEEEEEEHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA