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The map label for this gene is gcvPB

Identifier: 154686718

GI number: 154686718

Start: 2418822

End: 2420297

Strand: Reverse

Name: gcvPB

Synonym: RBAM_022870

Alternate gene names: 154686718

Gene position: 2420297-2418822 (Counterclockwise)

Preceding gene: 154686719

Following gene: 154686716

Centisome position: 61.76

GC content: 49.53

Gene sequence:

>1476_bases
ATGAATAATCAAGATCAGGCGCTTATTTTTGAAATGTCCCGCGAAGGGCGTATCGGTTACAGCCTTCCGGAGCTTGATGT
GCCGGAAACAGAGCTTGAAAGCCTTCTTCCCGGTGACTATATCCGCGATGAAGACGCAAAGCTGCCGGAAGTATCAGAGC
TCGATATTATGCGGCATTATACCGCTCTTTCTAAGAGGAACCACGGAGTTGATTCAGGCTTTTATCCGCTCGGCTCCTGT
ACGATGAAATACAATCCGAAATTAAATGAAAAAATTGCCCGGATCGCAGGTTTTTCCGCCATTCATCCGCTTCAGGACGA
GGACACGGTTCAGGGGGCGCTTGAGCTTTTATACGATTTAAGCGGACACTTGGAGGAGATTACGGGCATGGACGAGGTGA
CGCTGCAGCCTGCGGCGGGCGCTCACGGCGAATGGACCGGCCTGATGATGATCCGCGCCTACCACGAAGCGCGGGGAGAC
TTCGGACGGACGAAAGTGATTGTCCCTGATTCAGCCCACGGTACGAATCCGGCATCCGCCACGGTCGCCGGTTTTGAAAC
GATTACCGTTAAGTCAAATGAGCACGGGCTGGTTGACATTGAAGATTTGAAAAGAGCAGTAAACGAAGAAACAGCGGCGC
TGATGCTGACGAATCCGAACACCCTCGGGTTATTTGAGGAAAACATTACGGAAATGGCTGAAATCGTCCATCAGGCCGGC
GGAAAGCTTTATTATGACGGAGCGAATTTAAATGCCGTTTTAAGTAAAGCAAGACCGGGAGATATGGGATTTGACGTCGT
TCACCTTAATCTGCATAAAACATTTACCGGGCCGCACGGCGGGGGAGGACCGGGCTCAGGTCCGGTCGGAGTGAAAAAAG
AATTCATTCCGTATCTGCCGAAACCCGTTCTCACGAAAAAAGAGGGCCGTTTGACTTTTGACTATGATCGGCCGCAGTCG
ATCGGGCGCGTAAAACCTTATTACGGCAACTTCGGCATTAATGTCAGAGCCTACACGTATATCCGTTCCATGGGGCCTGA
CGGCTTAAAAGCTGTGACCGAAAACGCGGTTTTAAATGCAAATTATATGATGAGAAGACTCGCGCCTTATTATGATCTCC
CGTATGACCGTCATTGCAAGCATGAATTTGTGTTATCGGGAAGAAGGCAGAAAAAGCTCGGCGTTCGAACGCTTGATATT
GCCAAACGGCTTTTGGATTTCGGCTATCATCCGCCGACTGTGTATTTTCCTCTCAATGTTGAAGAAAGCATTATGATCGA
ACCGACGGAAACGGAATCAAAGGAAACGCTAGATGCGTTTATAGATGCCATGATTCAAATTGCGCGGGAAGCGGAGGAAT
CGCCTGAAATCGTTCAGGAAGCGCCCCATACAACAGTTGTCAAAAGAATGGATGAAACCAAGGCGGCAAGAAAGCCCGTT
TTAAAATACGAACGTACACTTGACGGCAGCCGCTGA

Upstream 100 bases:

>100_bases
CTTGCGTATCCGGAACTGAATCAGCATATGCTCATTGCCGTCACAGAGCTGAGAACAAAAGAAAAGATCGATTCGCTTAT
TGCGAGATTGGGGGATCAAC

Downstream 100 bases:

>100_bases
CACGGTGTAAAAAAAGAGCTGTCCGTTTTATACGGAAGCTCTTTTTTATGATTAGTTTTTTGCTTTAATTTTTCCGCCCC
ATTTTTTAAATCCGCCTTTC

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNNQDQALIFEMSREGRIGYSLPELDVPETELESLLPGDYIRDEDAKLPEVSELDIMRHYTALSKRNHGVDSGFYPLGSC
TMKYNPKLNEKIARIAGFSAIHPLQDEDTVQGALELLYDLSGHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD
FGRTKVIVPDSAHGTNPASATVAGFETITVKSNEHGLVDIEDLKRAVNEETAALMLTNPNTLGLFEENITEMAEIVHQAG
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKKEFIPYLPKPVLTKKEGRLTFDYDRPQS
IGRVKPYYGNFGINVRAYTYIRSMGPDGLKAVTENAVLNANYMMRRLAPYYDLPYDRHCKHEFVLSGRRQKKLGVRTLDI
AKRLLDFGYHPPTVYFPLNVEESIMIEPTETESKETLDAFIDAMIQIAREAEESPEIVQEAPHTTVVKRMDETKAARKPV
LKYERTLDGSR

Sequences:

>Translated_491_residues
MNNQDQALIFEMSREGRIGYSLPELDVPETELESLLPGDYIRDEDAKLPEVSELDIMRHYTALSKRNHGVDSGFYPLGSC
TMKYNPKLNEKIARIAGFSAIHPLQDEDTVQGALELLYDLSGHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD
FGRTKVIVPDSAHGTNPASATVAGFETITVKSNEHGLVDIEDLKRAVNEETAALMLTNPNTLGLFEENITEMAEIVHQAG
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKKEFIPYLPKPVLTKKEGRLTFDYDRPQS
IGRVKPYYGNFGINVRAYTYIRSMGPDGLKAVTENAVLNANYMMRRLAPYYDLPYDRHCKHEFVLSGRRQKKLGVRTLDI
AKRLLDFGYHPPTVYFPLNVEESIMIEPTETESKETLDAFIDAMIQIAREAEESPEIVQEAPHTTVVKRMDETKAARKPV
LKYERTLDGSR
>Mature_491_residues
MNNQDQALIFEMSREGRIGYSLPELDVPETELESLLPGDYIRDEDAKLPEVSELDIMRHYTALSKRNHGVDSGFYPLGSC
TMKYNPKLNEKIARIAGFSAIHPLQDEDTVQGALELLYDLSGHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD
FGRTKVIVPDSAHGTNPASATVAGFETITVKSNEHGLVDIEDLKRAVNEETAALMLTNPNTLGLFEENITEMAEIVHQAG
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKKEFIPYLPKPVLTKKEGRLTFDYDRPQS
IGRVKPYYGNFGINVRAYTYIRSMGPDGLKAVTENAVLNANYMMRRLAPYYDLPYDRHCKHEFVLSGRRQKKLGVRTLDI
AKRLLDFGYHPPTVYFPLNVEESIMIEPTETESKETLDAFIDAMIQIAREAEESPEIVQEAPHTTVVKRMDETKAARKPV
LKYERTLDGSR

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=408, Percent_Identity=44.1176470588235, Blast_Score=296, Evalue=3e-80,
Organism=Escherichia coli, GI1789269, Length=409, Percent_Identity=41.8092909535452, Blast_Score=291, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI17535605, Length=409, Percent_Identity=41.0757946210269, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI32564013, Length=363, Percent_Identity=42.6997245179063, Blast_Score=263, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6323843, Length=432, Percent_Identity=43.0555555555556, Blast_Score=320, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24645648, Length=412, Percent_Identity=42.2330097087379, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_BACA2 (A7Z6M2)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001421879.1
- ProteinModelPortal:   A7Z6M2
- STRING:   A7Z6M2
- EnsemblBacteria:   EBBACT00000007531
- GeneID:   5461360
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_022870
- eggNOG:   COG1003
- GeneTree:   EBGT00050000001780
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- BioCyc:   BAMY326423:RBAM_022870-MONOMER
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 54700; Mature: 54700

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNQDQALIFEMSREGRIGYSLPELDVPETELESLLPGDYIRDEDAKLPEVSELDIMRHY
CCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
TALSKRNHGVDSGFYPLGSCTMKYNPKLNEKIARIAGFSAIHPLQDEDTVQGALELLYDL
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHH
SGHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGDFGRTKVIVPDSAHGTNPASA
HHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCE
TVAGFETITVKSNEHGLVDIEDLKRAVNEETAALMLTNPNTLGLFEENITEMAEIVHQAG
EEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKKEFIPYLP
CEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCC
KPVLTKKEGRLTFDYDRPQSIGRVKPYYGNFGINVRAYTYIRSMGPDGLKAVTENAVLNA
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEHHCCCCHHHHHHHCCEECH
NYMMRRLAPYYDLPYDRHCKHEFVLSGRRQKKLGVRTLDIAKRLLDFGYHPPTVYFPLNV
HHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCC
EESIMIEPTETESKETLDAFIDAMIQIAREAEESPEIVQEAPHTTVVKRMDETKAARKPV
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHH
LKYERTLDGSR
HHHHHHCCCCC
>Mature Secondary Structure
MNNQDQALIFEMSREGRIGYSLPELDVPETELESLLPGDYIRDEDAKLPEVSELDIMRHY
CCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
TALSKRNHGVDSGFYPLGSCTMKYNPKLNEKIARIAGFSAIHPLQDEDTVQGALELLYDL
HHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHH
SGHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGDFGRTKVIVPDSAHGTNPASA
HHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCE
TVAGFETITVKSNEHGLVDIEDLKRAVNEETAALMLTNPNTLGLFEENITEMAEIVHQAG
EEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
GKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKKEFIPYLP
CEEEECCCCHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCC
KPVLTKKEGRLTFDYDRPQSIGRVKPYYGNFGINVRAYTYIRSMGPDGLKAVTENAVLNA
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEHHCCCCHHHHHHHCCEECH
NYMMRRLAPYYDLPYDRHCKHEFVLSGRRQKKLGVRTLDIAKRLLDFGYHPPTVYFPLNV
HHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCC
EESIMIEPTETESKETLDAFIDAMIQIAREAEESPEIVQEAPHTTVVKRMDETKAARKPV
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHH
LKYERTLDGSR
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA