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The map label for this gene is ubiE

Identifier: 154686523

GI number: 154686523

Start: 2189376

End: 2190077

Strand: Reverse

Name: ubiE

Synonym: RBAM_020910

Alternate gene names: 154686523

Gene position: 2190077-2189376 (Counterclockwise)

Preceding gene: 154686524

Following gene: 154686522

Centisome position: 55.89

GC content: 46.15

Gene sequence:

>702_bases
ATGCAGGAGTCAAAAGAACAGCGCGTACACGGCGTGTTTGAAAAAATCTATAAAAATTATGACCAAATGAACTCTGTTAT
CAGTTTTCAGCAGCATAAAAAATGGCGCGATAAAACGATGCAGATCATGAATGTAAAAGAAGGCGCAAAAGCGCTTGATG
TCTGCTGCGGAACGGCTGACTGGACGATTGCCCTCGCAGAAGCGGCCGGAAAAAGCGGCGAAATCAAAGGACTGGATTTC
AGCAAAAATATGCTGAGCATCGGTGAGAAAAAAGTGAAAGAGGGCGGTTACAGCCAAATTGAGCTTTTGCACGGAAATGC
GATGGAGCTTCCTTTCGCTGATGATTCTTTTGATTTTGTCACCATCGGCTTCGGGCTGCGGAACGTTCCCGACTATCTGA
CCGTGCTGAAAGAAATGCGGCGGGTCGTCAAACCGGGCGGGCAGGTTGTATGTCTGGAAACATCCCAGCCGGAAATGTTC
GGATTCAGACAGGCATATTTTCTTTATTTTAAATACATCATGCCTTTCTTCGGAAAAATGTTTGCGAAGAGCTATAAAGA
ATATTCTTGGCTTCAAGAATCGGCAAGAGAATTTCCCGGTATGAAAGAGCTTGCGCGTCTGTTTGAAGAAGCGGGCCTGA
CGAATGTCAAATACCATTCGTTTACCGGCGGAGTGGCCGCTACGCATATCGGTTGGAAATGA

Upstream 100 bases:

>100_bases
TGCCGCTCAATTCACCAATCCAAAACCTAATGCTGAACCGGCTTAAAGCGATCAGCCAGGACAAAACATATCATCAGAAA
GTGGAAGAAGGGTAATCAAC

Downstream 100 bases:

>100_bases
TGAATATACAGATGTTTGGGTGAATGATATGAAATTTAAAATGGCCTATTCTTTTTTAAATGACGATATTGATGTGATCG
AAAGGGAGCTTGAGCAAACG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MQESKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMQIMNVKEGAKALDVCCGTADWTIALAEAAGKSGEIKGLDF
SKNMLSIGEKKVKEGGYSQIELLHGNAMELPFADDSFDFVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF
GFRQAYFLYFKYIMPFFGKMFAKSYKEYSWLQESAREFPGMKELARLFEEAGLTNVKYHSFTGGVAATHIGWK

Sequences:

>Translated_233_residues
MQESKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMQIMNVKEGAKALDVCCGTADWTIALAEAAGKSGEIKGLDF
SKNMLSIGEKKVKEGGYSQIELLHGNAMELPFADDSFDFVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF
GFRQAYFLYFKYIMPFFGKMFAKSYKEYSWLQESAREFPGMKELARLFEEAGLTNVKYHSFTGGVAATHIGWK
>Mature_233_residues
MQESKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMQIMNVKEGAKALDVCCGTADWTIALAEAAGKSGEIKGLDF
SKNMLSIGEKKVKEGGYSQIELLHGNAMELPFADDSFDFVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF
GFRQAYFLYFKYIMPFFGKMFAKSYKEYSWLQESAREFPGMKELARLFEEAGLTNVKYHSFTGGVAATHIGWK

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=266, Percent_Identity=34.2105263157895, Blast_Score=149, Evalue=2e-36,
Organism=Escherichia coli, GI48994983, Length=233, Percent_Identity=36.0515021459227, Blast_Score=167, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17557039, Length=232, Percent_Identity=34.051724137931, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323526, Length=249, Percent_Identity=31.7269076305221, Blast_Score=113, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24641702, Length=246, Percent_Identity=32.1138211382114, Blast_Score=140, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_BACA2 (A7Z627)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001421684.1
- ProteinModelPortal:   A7Z627
- STRING:   A7Z627
- EnsemblBacteria:   EBBACT00000005827
- GeneID:   5462216
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_020910
- eggNOG:   COG2226
- GeneTree:   EBGT00050000000522
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- ProtClustDB:   PRK00216
- BioCyc:   BAMY326423:RBAM_020910-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR014122
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR02752
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 26619; Mature: 26619

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQESKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMQIMNVKEGAKALDVCCGTAD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
WTIALAEAAGKSGEIKGLDFSKNMLSIGEKKVKEGGYSQIELLHGNAMELPFADDSFDFV
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEECCCCCCCCCEE
TIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMFGFRQAYFLYFKYIMPFFGKM
EECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
FAKSYKEYSWLQESAREFPGMKELARLFEEAGLTNVKYHSFTGGVAATHIGWK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCCHHCCCCCC
>Mature Secondary Structure
MQESKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMQIMNVKEGAKALDVCCGTAD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
WTIALAEAAGKSGEIKGLDFSKNMLSIGEKKVKEGGYSQIELLHGNAMELPFADDSFDFV
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEECCCCCCCCCEE
TIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMFGFRQAYFLYFKYIMPFFGKM
EECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
FAKSYKEYSWLQESAREFPGMKELARLFEEAGLTNVKYHSFTGGVAATHIGWK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA