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The map label for this gene is galK1 [H]

Identifier: 154685648

GI number: 154685648

Start: 1183754

End: 1184923

Strand: Reverse

Name: galK1 [H]

Synonym: RBAM_012150

Alternate gene names: 154685648

Gene position: 1184923-1183754 (Counterclockwise)

Preceding gene: 154685649

Following gene: 154685647

Centisome position: 30.24

GC content: 48.38

Gene sequence:

>1170_bases
ATGGATGCCAAACTTTTGAAATCAAGATTCGAAGACATTTTCAAGAGAAGTAACGGAGAACTGTTTTTCGCACCCGGCCG
GATCAACCTGATCGGGGAACATACGGATTATATAGGCGGTCACGTTCTTCCATGCGCGATCACGATCGGAACATATGCCG
TATGCGCAAAACGCGGAGATCACCAGATCCGGTTATACTCAGAAAACTTTCCTGACAGCGGCATTGTCTGTCTTGATCTT
TCCGCCACAGCATACAAAAAAGAAGACGGCTGGGCCAATTATCCGAAGGGGATGATCCATTACCTTCTTAAAGCCGGCGG
CCAAATAGACAGCGGAATGGATATTCTTTTTCACGGTACGATTCCAAACGGAGCCGGTTTAAGCTCCTCTGCTTCCATTG
AAATGTTAACCGGTTCCATTTTAAAAAAGTTATTCAGCCTGGATGTTTCCGATACTGAACTGGCGCTTATCGGAAAAAGA
GTCGAAAATGAATTTATCGGCGTGAATTCAGGCATTATGGATCAATTCGCAGTGCAAAAAGGCAAAAAGAACATGGCCAT
TCTGTTAAACTGCGATAAGCTTGAGCACGAAATGATTCCGGCTGCTTTTAACGGATATAAAATCGTCATTATGAATACGA
ACAAGCGCCGGGAGCTGGCCGCTTCAAAATATAATGAACGCCGCAGCGAATGTGACGAGGCTCTTTCAGAACTGCGGCAA
TATCGGAATATCGCATCACTTGCGGAATTGACGTCAGAAGAATTCAACAAACTCGAATCCCTTCTCTCCTGTGAAACGTT
GCGTAAAAGAGCCCGGCACGCGGTCAATGAAAACGAGCGGACCCTCTCAGCCGCGGAGGCTCTCAAATCGAATGATTTGA
AAACGTTCGGCGAGCTGATGAATGCGTCCCACCGTTCGTTACGCGATGATTATGAAGTGACCGGTGACGAATTAGACGCG
CTCGCTGAAGCAGCCTGGAAAGAAGGAGCGCTCGGAGCACGGATGACGGGCGCGGGGTTCGGCGGCTGCGCCATAGCCAT
TGTGGAAAGTGAAGAAACCGCCGGCTTTATCCGGGCCGTTTCATCTCACTACCGCAGCAGGACAGGTCTTGAAGCTTCTT
TTTACATCGCGGATATAAGCGATGGCGCGGCTGAATGGAGGGAAAAATAA

Upstream 100 bases:

>100_bases
CGCAACGAAAGGAGCGGAATATATCAGTCTCACAAGAAATTCACAAAAAGCCATTCAGTTCATACTGGAGCATACCTCAA
AATAGAATCGGAGGTTTATC

Downstream 100 bases:

>100_bases
ATCATGGCGATTCTCGTTCTCGGCGGAGCCGGCTATATCGGTTCTCATGCGGTTGATCAATTATTAAACAAAGGATTTAA
AACGATAGCTGTGGATCATC

Product: GalK1

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MDAKLLKSRFEDIFKRSNGELFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFPDSGIVCLDL
SATAYKKEDGWANYPKGMIHYLLKAGGQIDSGMDILFHGTIPNGAGLSSSASIEMLTGSILKKLFSLDVSDTELALIGKR
VENEFIGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNERRSECDEALSELRQ
YRNIASLAELTSEEFNKLESLLSCETLRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDA
LAEAAWKEGALGARMTGAGFGGCAIAIVESEETAGFIRAVSSHYRSRTGLEASFYIADISDGAAEWREK

Sequences:

>Translated_389_residues
MDAKLLKSRFEDIFKRSNGELFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFPDSGIVCLDL
SATAYKKEDGWANYPKGMIHYLLKAGGQIDSGMDILFHGTIPNGAGLSSSASIEMLTGSILKKLFSLDVSDTELALIGKR
VENEFIGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNERRSECDEALSELRQ
YRNIASLAELTSEEFNKLESLLSCETLRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDA
LAEAAWKEGALGARMTGAGFGGCAIAIVESEETAGFIRAVSSHYRSRTGLEASFYIADISDGAAEWREK
>Mature_389_residues
MDAKLLKSRFEDIFKRSNGELFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFPDSGIVCLDL
SATAYKKEDGWANYPKGMIHYLLKAGGQIDSGMDILFHGTIPNGAGLSSSASIEMLTGSILKKLFSLDVSDTELALIGKR
VENEFIGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNERRSECDEALSELRQ
YRNIASLAELTSEEFNKLESLLSCETLRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDA
LAEAAWKEGALGARMTGAGFGGCAIAIVESEETAGFIRAVSSHYRSRTGLEASFYIADISDGAAEWREK

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=366, Percent_Identity=40.4371584699454, Blast_Score=241, Evalue=6e-64,
Organism=Homo sapiens, GI4503897, Length=417, Percent_Identity=28.537170263789, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI48527957, Length=417, Percent_Identity=28.537170263789, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1786972, Length=382, Percent_Identity=39.2670157068063, Blast_Score=277, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI71989053, Length=402, Percent_Identity=29.8507462686567, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24661292, Length=429, Percent_Identity=26.8065268065268, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21355577, Length=429, Percent_Identity=26.8065268065268, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24661285, Length=429, Percent_Identity=26.8065268065268, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42850; Mature: 42850

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAKLLKSRFEDIFKRSNGELFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGD
CCHHHHHHHHHHHHHCCCCCEEEECCEEEEEECCCHHCCCCHHHHHHHHHHHHHHHCCCC
HQIRLYSENFPDSGIVCLDLSATAYKKEDGWANYPKGMIHYLLKAGGQIDSGMDILFHGT
CEEEEEECCCCCCCEEEEECCCHHEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
IPNGAGLSSSASIEMLTGSILKKLFSLDVSDTELALIGKRVENEFIGVNSGIMDQFAVQK
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHC
GKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNERRSECDEALSELRQ
CCCCEEEEEECCHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YRNIASLAELTSEEFNKLESLLSCETLRKRARHAVNENERTLSAAEALKSNDLKTFGELM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHH
NASHRSLRDDYEVTGDELDALAEAAWKEGALGARMTGAGFGGCAIAIVESEETAGFIRAV
HHHHHHHCCCHHCCHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEEEECCHHHHHHHHH
SSHYRSRTGLEASFYIADISDGAAEWREK
HHHHHHHCCCCEEEEEEECCCCHHHHCCC
>Mature Secondary Structure
MDAKLLKSRFEDIFKRSNGELFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGD
CCHHHHHHHHHHHHHCCCCCEEEECCEEEEEECCCHHCCCCHHHHHHHHHHHHHHHCCCC
HQIRLYSENFPDSGIVCLDLSATAYKKEDGWANYPKGMIHYLLKAGGQIDSGMDILFHGT
CEEEEEECCCCCCCEEEEECCCHHEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
IPNGAGLSSSASIEMLTGSILKKLFSLDVSDTELALIGKRVENEFIGVNSGIMDQFAVQK
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHC
GKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNERRSECDEALSELRQ
CCCCEEEEEECCHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YRNIASLAELTSEEFNKLESLLSCETLRKRARHAVNENERTLSAAEALKSNDLKTFGELM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHH
NASHRSLRDDYEVTGDELDALAEAAWKEGALGARMTGAGFGGCAIAIVESEETAGFIRAV
HHHHHHHCCCHHCCHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEEEECCHHHHHHHHH
SSHYRSRTGLEASFYIADISDGAAEWREK
HHHHHHHCCCCEEEEEEECCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]