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The map label for this gene is fabG2 [H]

Identifier: 154248583

GI number: 154248583

Start: 5155426

End: 5156265

Strand: Direct

Name: fabG2 [H]

Synonym: Xaut_4664

Alternate gene names: 154248583

Gene position: 5155426-5156265 (Clockwise)

Preceding gene: 154248572

Following gene: 154248584

Centisome position: 97.11

GC content: 70.48

Gene sequence:

>840_bases
ATGAGACGACAACCGGCCTTGCGAACCGGAACGGCCGCAAGAGCCCATAGAAGCCATCACGGGGAGGACCTCATGAAGAT
CGACGGTCGCGTCTTTATCGTCACCGGCGCGGGCTCCGGCCTTGGCGCGGCGGTGTCGCGCATGCTGGTGGGCGAAGGCG
CGCGGGTGGTGATCGTGGACATCAATGCCGAGGCCGGCAGCGCCGTCGCCGCCGAGCTGGGCGACAGCGCCCGGTTCCAG
CGCGCGGACGTGACCAGCGAAGCCGACGGCCTCGCCGCCGTGGCGCTGGCCCGCGAGGCCTTCGGCCATGTTCATGGGCT
GGTGAATTGCGCCGGCGTCGCCCCCGGCGAGAAGGTGGTGGGCCGCGAGGGTCCTCACCGGCTCGACAGCTTCGCTCGGG
CCGTGGGCATCAACCTCATCGGCACCTTCAACATGCTGCGCCTTGCCGCCGACGCCATCGTGAAGGAAGAGCCCGACGCC
GACGGCGAGCGCGGCGTCATCATCAACACCGCCTCCATCGCCGCATTCGATGGCCAGATCGGCCAGGCCGCCTATGCGGC
CTCCAAGGGCGGTGTCGCGGCGCTCACCCTGCCGGTGGCGCGGGAGCTGGCGCGCTTCGGGGTGCGGGTCGTCACCATCG
CGCCGGGCATCTTCGAGACGCCCATGATGGCGGGCCTGCCGCAGGATGTGCAGGATTCCCTGGGCAAGACCGTGCCCTTC
CCGCCCCGGCTCGGCCGGCCGCCGGAATATGCCGCCCTCGTCAGACACATCTGCGAGAACACCATGCTCAACGGCGAGGT
CATCCGCCTCGACGGCGCCCTGCGCATGCCGCCCCGCTGA

Upstream 100 bases:

>100_bases
CGGAAATCATGCGCCGTTCCAGGGCGAGGCTCCTACATGGCAAAACCGCTCATCAATTTAGATCGATTGCGCCATCGAAT
GCCACTTCGCCATTCGCTAG

Downstream 100 bases:

>100_bases
CCCACAAGGAGGATCCCATGACCAACCGCACGGAAGATCCCATCGTCATCGTTGGCGCCGCCCGCACCCCCATGGGCGGG
TTCCAGGGCGACTTCAAGGA

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MRRQPALRTGTAARAHRSHHGEDLMKIDGRVFIVTGAGSGLGAAVSRMLVGEGARVVIVDINAEAGSAVAAELGDSARFQ
RADVTSEADGLAAVALAREAFGHVHGLVNCAGVAPGEKVVGREGPHRLDSFARAVGINLIGTFNMLRLAADAIVKEEPDA
DGERGVIINTASIAAFDGQIGQAAYAASKGGVAALTLPVARELARFGVRVVTIAPGIFETPMMAGLPQDVQDSLGKTVPF
PPRLGRPPEYAALVRHICENTMLNGEVIRLDGALRMPPR

Sequences:

>Translated_279_residues
MRRQPALRTGTAARAHRSHHGEDLMKIDGRVFIVTGAGSGLGAAVSRMLVGEGARVVIVDINAEAGSAVAAELGDSARFQ
RADVTSEADGLAAVALAREAFGHVHGLVNCAGVAPGEKVVGREGPHRLDSFARAVGINLIGTFNMLRLAADAIVKEEPDA
DGERGVIINTASIAAFDGQIGQAAYAASKGGVAALTLPVARELARFGVRVVTIAPGIFETPMMAGLPQDVQDSLGKTVPF
PPRLGRPPEYAALVRHICENTMLNGEVIRLDGALRMPPR
>Mature_279_residues
MRRQPALRTGTAARAHRSHHGEDLMKIDGRVFIVTGAGSGLGAAVSRMLVGEGARVVIVDINAEAGSAVAAELGDSARFQ
RADVTSEADGLAAVALAREAFGHVHGLVNCAGVAPGEKVVGREGPHRLDSFARAVGINLIGTFNMLRLAADAIVKEEPDA
DGERGVIINTASIAAFDGQIGQAAYAASKGGVAALTLPVARELARFGVRVVTIAPGIFETPMMAGLPQDVQDSLGKTVPF
PPRLGRPPEYAALVRHICENTMLNGEVIRLDGALRMPPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=53.3333333333333, Blast_Score=265, Evalue=3e-71,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=50.9803921568627, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=34.8837209302326, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=28.8, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI31542939, Length=262, Percent_Identity=27.8625954198473, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI59889578, Length=211, Percent_Identity=32.7014218009479, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4504505, Length=247, Percent_Identity=29.5546558704453, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI22507405, Length=245, Percent_Identity=26.530612244898, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=31.638418079096, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI150247226, Length=226, Percent_Identity=26.5486725663717, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=29.4820717131474, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=29.1338582677165, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787905, Length=260, Percent_Identity=30.7692307692308, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789057, Length=227, Percent_Identity=31.7180616740088, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082100, Length=273, Percent_Identity=27.8388278388278, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082160, Length=208, Percent_Identity=29.8076923076923, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790717, Length=259, Percent_Identity=29.3436293436293, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=30.3149606299213, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788459, Length=253, Percent_Identity=26.0869565217391, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=256, Percent_Identity=46.484375, Blast_Score=226, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=31.7460317460317, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17555706, Length=272, Percent_Identity=31.25, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=28.0769230769231, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=212, Percent_Identity=27.3584905660377, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=220, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=206, Percent_Identity=28.1553398058252, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=283, Percent_Identity=28.9752650176678, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=269, Percent_Identity=26.0223048327138, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=226, Percent_Identity=30.9734513274336, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322227, Length=222, Percent_Identity=25.6756756756757, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=53.1496062992126, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=35.408560311284, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24644339, Length=229, Percent_Identity=30.5676855895196, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI23397609, Length=201, Percent_Identity=32.8358208955224, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357041, Length=228, Percent_Identity=31.140350877193, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571526, Length=224, Percent_Identity=29.9107142857143, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI18859837, Length=254, Percent_Identity=29.5275590551181, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24665243, Length=211, Percent_Identity=27.0142180094787, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221331218, Length=211, Percent_Identity=27.0142180094787, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 29060; Mature: 29060

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRQPALRTGTAARAHRSHHGEDLMKIDGRVFIVTGAGSGLGAAVSRMLVGEGARVVIVD
CCCCCCCCCCCHHHHHHHCCCCHHEEECCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEE
INAEAGSAVAAELGDSARFQRADVTSEADGLAAVALAREAFGHVHGLVNCAGVAPGEKVV
ECCCCCCHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
GREGPHRLDSFARAVGINLIGTFNMLRLAADAIVKEEPDADGERGVIINTASIAAFDGQI
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECEEEEECCCC
GQAAYAASKGGVAALTLPVARELARFGVRVVTIAPGIFETPMMAGLPQDVQDSLGKTVPF
CHHHHHHCCCCEEEEHHHHHHHHHHCCEEEEEECCCHHHCCHHHCCCHHHHHHHCCCCCC
PPRLGRPPEYAALVRHICENTMLNGEVIRLDGALRMPPR
CCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MRRQPALRTGTAARAHRSHHGEDLMKIDGRVFIVTGAGSGLGAAVSRMLVGEGARVVIVD
CCCCCCCCCCCHHHHHHHCCCCHHEEECCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEE
INAEAGSAVAAELGDSARFQRADVTSEADGLAAVALAREAFGHVHGLVNCAGVAPGEKVV
ECCCCCCHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
GREGPHRLDSFARAVGINLIGTFNMLRLAADAIVKEEPDADGERGVIINTASIAAFDGQI
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECEEEEECCCC
GQAAYAASKGGVAALTLPVARELARFGVRVVTIAPGIFETPMMAGLPQDVQDSLGKTVPF
CHHHHHHCCCCEEEEHHHHHHHHHHCCEEEEEECCCHHHCCHHHCCCHHHHHHHCCCCCC
PPRLGRPPEYAALVRHICENTMLNGEVIRLDGALRMPPR
CCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]