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The map label for this gene is thlA [H]

Identifier: 154248584

GI number: 154248584

Start: 5156283

End: 5157479

Strand: Direct

Name: thlA [H]

Synonym: Xaut_4665

Alternate gene names: 154248584

Gene position: 5156283-5157479 (Clockwise)

Preceding gene: 154248583

Following gene: 154248585

Centisome position: 97.12

GC content: 72.01

Gene sequence:

>1197_bases
ATGACCAACCGCACGGAAGATCCCATCGTCATCGTTGGCGCCGCCCGCACCCCCATGGGCGGGTTCCAGGGCGACTTCAA
GGATGTGGCCGCCCCCGTCCTCGGCTCAACCGCCATCGCGGCGGCGCTGGCCCGCGCCGGCCTCGCGCCGGAAGCGGTGG
ACGAGGTGGTGTTCGGCTGCGTTCTGCCCGCCGGACAGGGCCAGGCCCCCGCCCGCCAGGCGGCGCTGGGCGCCGGCCTG
CCGCTCTCCACCGGCGCCACCACCGTCAACAAGATGTGCGGCTCCGGCATGAAGGCGGCCATGTTTGCCCATGACCTGCT
GCTGGCCGGCTCCGCCGAGGTGGCGGTGGCCGGCGGCATGGAGAGCATGAGCAACGCCCCCTACCTGCTTGACCGCGCCC
GCGCCGGCTATCGCATGGGCCACGGCCGGGTACTCGACCACATGTTCCTCGACGGGCTGGAGGACGCCTACGAGAAGGGC
CGCCTCATGGGCACCTTCGCCGAGGATTGCGCCGAGGCCTACCAGTTCACCCGCGAGGCGCAGGACGCCTTCGCCATCGC
CTCCCTGAGCAAGGCGCAGAAGGCCATGGCGGACGGCGCCTTCGACGCCGAGATCACCCCGGTCACGGTGAAGGCCGGTA
AGGCCGAGCGCGTGGTCAACGCCGACGAGCAGCCGCCCAAGGCCAAGCTCGACAAGATCCCCACCCTCAAGCCCGCCTTC
CGCGACGGCGGCACGGTGACGGCGGCCAACTCCTCCTCCATCTCGGACGGCGCGGCGGCGCTCGTGCTGATGCGTCGGTC
GCAGGCGGAAGCGCGCGGGCTCACCCCCCTCGCCACCATCGTCGGCCACGCCACCCACGCCCAGGCGCCGAACCTGTTCG
CCACTGCGCCCGTCGGCGCGGTGCGCAAGCTCTCCGAGCGCACCGGCTGGGCGTTGACGGACGTGGACTTGTTCGAGATC
AACGAGGCGTTCGCCGTGGTGCCCATGGCCGCCATCCACGACCTCGGCCTGCCGGCGGACAAGGTGAACATCCACGGCGG
CGCCTGCGCGCTGGGCCACCCCATCGGCGCCTCGGGTGCGCGGGTGATGGTGACGCTGCTGGCCGCGCTGCAGAGACACG
GCCTGAAGCGCGGCATCGCCTCCCTGTGCATCGGCGGCGGTGAGGCTACGGCGGTGGCACTGGAACTGGCGCACTGA

Upstream 100 bases:

>100_bases
TCGTCAGACACATCTGCGAGAACACCATGCTCAACGGCGAGGTCATCCGCCTCGACGGCGCCCTGCGCATGCCGCCCCGC
TGACCCACAAGGAGGATCCC

Downstream 100 bases:

>100_bases
GGCTGGCGCGGGAAGGCATCTCAAATAAGCGCCATTCCCTCTGCCCACGCAGGACCGCTCCCTCTCCCGCCTGCGGGGGA
GGGTTGGGGTGGGGGCAGAG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTNRTEDPIVIVGAARTPMGGFQGDFKDVAAPVLGSTAIAAALARAGLAPEAVDEVVFGCVLPAGQGQAPARQAALGAGL
PLSTGATTVNKMCGSGMKAAMFAHDLLLAGSAEVAVAGGMESMSNAPYLLDRARAGYRMGHGRVLDHMFLDGLEDAYEKG
RLMGTFAEDCAEAYQFTREAQDAFAIASLSKAQKAMADGAFDAEITPVTVKAGKAERVVNADEQPPKAKLDKIPTLKPAF
RDGGTVTAANSSSISDGAAALVLMRRSQAEARGLTPLATIVGHATHAQAPNLFATAPVGAVRKLSERTGWALTDVDLFEI
NEAFAVVPMAAIHDLGLPADKVNIHGGACALGHPIGASGARVMVTLLAALQRHGLKRGIASLCIGGGEATAVALELAH

Sequences:

>Translated_398_residues
MTNRTEDPIVIVGAARTPMGGFQGDFKDVAAPVLGSTAIAAALARAGLAPEAVDEVVFGCVLPAGQGQAPARQAALGAGL
PLSTGATTVNKMCGSGMKAAMFAHDLLLAGSAEVAVAGGMESMSNAPYLLDRARAGYRMGHGRVLDHMFLDGLEDAYEKG
RLMGTFAEDCAEAYQFTREAQDAFAIASLSKAQKAMADGAFDAEITPVTVKAGKAERVVNADEQPPKAKLDKIPTLKPAF
RDGGTVTAANSSSISDGAAALVLMRRSQAEARGLTPLATIVGHATHAQAPNLFATAPVGAVRKLSERTGWALTDVDLFEI
NEAFAVVPMAAIHDLGLPADKVNIHGGACALGHPIGASGARVMVTLLAALQRHGLKRGIASLCIGGGEATAVALELAH
>Mature_397_residues
TNRTEDPIVIVGAARTPMGGFQGDFKDVAAPVLGSTAIAAALARAGLAPEAVDEVVFGCVLPAGQGQAPARQAALGAGLP
LSTGATTVNKMCGSGMKAAMFAHDLLLAGSAEVAVAGGMESMSNAPYLLDRARAGYRMGHGRVLDHMFLDGLEDAYEKGR
LMGTFAEDCAEAYQFTREAQDAFAIASLSKAQKAMADGAFDAEITPVTVKAGKAERVVNADEQPPKAKLDKIPTLKPAFR
DGGTVTAANSSSISDGAAALVLMRRSQAEARGLTPLATIVGHATHAQAPNLFATAPVGAVRKLSERTGWALTDVDLFEIN
EAFAVVPMAAIHDLGLPADKVNIHGGACALGHPIGASGARVMVTLLAALQRHGLKRGIASLCIGGGEATAVALELAH

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=396, Percent_Identity=47.7272727272727, Blast_Score=342, Evalue=4e-94,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=46.0559796437659, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=36.2467866323907, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=37.9746835443038, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4504327, Length=421, Percent_Identity=31.5914489311164, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=28.7917737789203, Blast_Score=128, Evalue=7e-30,
Organism=Escherichia coli, GI1788554, Length=388, Percent_Identity=49.7422680412371, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=43.8144329896907, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI1787663, Length=395, Percent_Identity=37.4683544303797, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=38.3458646616541, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1788683, Length=408, Percent_Identity=30.8823529411765, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=43.3766233766234, Blast_Score=303, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=43.765903307888, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=38.659793814433, Blast_Score=274, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17535917, Length=389, Percent_Identity=35.73264781491, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=30.8788598574822, Blast_Score=171, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=393, Percent_Identity=46.8193384223919, Blast_Score=323, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=35.25, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24655093, Length=388, Percent_Identity=46.9072164948454, Blast_Score=343, Evalue=9e-95,
Organism=Drosophila melanogaster, GI24640423, Length=389, Percent_Identity=45.7583547557841, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=38.2051282051282, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=29.5774647887324, Blast_Score=151, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40740; Mature: 40609

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRTEDPIVIVGAARTPMGGFQGDFKDVAAPVLGSTAIAAALARAGLAPEAVDEVVFGC
CCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VLPAGQGQAPARQAALGAGLPLSTGATTVNKMCGSGMKAAMFAHDLLLAGSAEVAVAGGM
CCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCH
ESMSNAPYLLDRARAGYRMGHGRVLDHMFLDGLEDAYEKGRLMGTFAEDCAEAYQFTREA
HHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
QDAFAIASLSKAQKAMADGAFDAEITPVTVKAGKAERVVNADEQPPKAKLDKIPTLKPAF
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHCCCCCCCCHHHHCCCCCCCCHH
RDGGTVTAANSSSISDGAAALVLMRRSQAEARGLTPLATIVGHATHAQAPNLFATAPVGA
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCHHHCCCCCCEEECCHHH
VRKLSERTGWALTDVDLFEINEAFAVVPMAAIHDLGLPADKVNIHGGACALGHPIGASGA
HHHHHHHCCCEEECCHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCEEECCCCCCCCHH
RVMVTLLAALQRHGLKRGIASLCIGGGEATAVALELAH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC
>Mature Secondary Structure 
TNRTEDPIVIVGAARTPMGGFQGDFKDVAAPVLGSTAIAAALARAGLAPEAVDEVVFGC
CCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VLPAGQGQAPARQAALGAGLPLSTGATTVNKMCGSGMKAAMFAHDLLLAGSAEVAVAGGM
CCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCH
ESMSNAPYLLDRARAGYRMGHGRVLDHMFLDGLEDAYEKGRLMGTFAEDCAEAYQFTREA
HHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
QDAFAIASLSKAQKAMADGAFDAEITPVTVKAGKAERVVNADEQPPKAKLDKIPTLKPAF
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHCCCCCCCCHHHHCCCCCCCCHH
RDGGTVTAANSSSISDGAAALVLMRRSQAEARGLTPLATIVGHATHAQAPNLFATAPVGA
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCHHHCCCCCCEEECCHHH
VRKLSERTGWALTDVDLFEINEAFAVVPMAAIHDLGLPADKVNIHGGACALGHPIGASGA
HHHHHHHCCCEEECCHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCEEECCCCCCCCHH
RVMVTLLAALQRHGLKRGIASLCIGGGEATAVALELAH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]