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The map label for this gene is glmS [H]

Identifier: 154248338

GI number: 154248338

Start: 4899266

End: 4901089

Strand: Reverse

Name: glmS [H]

Synonym: Xaut_4418

Alternate gene names: 154248338

Gene position: 4901089-4899266 (Counterclockwise)

Preceding gene: 154248339

Following gene: 154248337

Centisome position: 92.32

GC content: 67.38

Gene sequence:

>1824_bases
ATGTGCGGCATCGTCGGCATTCTCGGGAAGGGCGCTGTCGCGGACAAGGTGGTGGAGGCGCTGCGCCGCCTCGAATATCG
CGGCTATGATTCCACCGGCATCGCGACCCTTGAGAACGGCCACCTGGAGGTTTGCCGGGCCGAAGGCAAGCTCAGGCACC
TGGAAGCCAAGCTCGACAAGCATCCGCTGAACGGCCATTCGGGCATCGGGCACACCCGCTGGGCCACCCACGGCAAGCCC
TCCGAGCGCAACGCCCATCCTCATGGCACCAAGCGCGTGGCCGTGGTGCATAACGGCATCATCGAGAACTTCCGCGAGCT
GAAGCAGGAGCTGGAAGCCCAGGGCGTCAGCTTCAAGAGCGATACCGACACCGAGATCGTCGCCCAGCTGGTGGACCGCG
AGCTGCTCGCCGGCAGCGAGCCGGTGGCGGCGGTGGCCGCCGTGCTGCCGCGCCTGAAGGGCGCCTTCGCCCTGGCCTTC
CTGTTCGACGGCAAGACCGACCTGTTGATCGGCGCCCGCCGCGGCTCGCCGCTGGCCATCGGCTACGGCAAGGGGGAGAT
GTTCCTCGGCTCGGACGCCATAGCACTCGGCCCGTTCACCGACACCATCGCCTATCTGGAGGAGGGCGACTGGGCCGTCC
TCACCCGCGAGCGCGTCGAGATTCGCGACGAGACCGGGCGGCTGGTGGAACGCACCATCCAGAAGGTGCCGGCCGGTGCC
ATGCTGGTGGACAAGGGCAACCACCGCCACTTCATGGCGAAGGAGATCTACGAGCAGCCGGAGGTCATCTCCCACACCTT
CGGCCACTATCTGGACCTCGCCGCCGAGACCGTCACCCTGCCGGAGCTGCCGTTCGACCCCAAGACGGTGACGAACATCT
CCATCACCGCCTGCGGCACGGCGCTCTATGCCGGCGCGGTGGCGGAATACTGGTTCGAGCGGTTCGGCCGGGTGCCGGTC
TCCACCGACATCGCCTCCGAATTCCGCTATCGCGAGACGCCGCTGACGCCGGACGGCATCACCATCGTCATCTCCCAGTC
GGGCGAGACGGCCGATACCCTGGCTTCCCTGCGCTATGCCAAGGAGTGCGGGCAGAAGGTGGTGGCCGTGGTGAACGTGC
CCACCTCAACCATCGCCCGCGAGGCGGACGTGGTGCTGCCCATCCTCGCCGGGCCGGAGATCGGGGTGGCCTCCACCAAG
GCCTTCACCTGCCAGCTGGCGACGCTGGCCTGCCTCGCCGTGGCGTTCGGACGGGCCAAGGGCGTGCTGGAGGAGGCGGA
CGAGCACAAGCTGGTGCGCGCCTTCATGGAAGTGCCGCGGCTGATGACCGAGGCGCTGAAGCTCTCGCCGGAGATCGAGG
TGCTGGCCCGCACCCTCGCCAAGGCACGGGACGTGCTCTATCTCGGCCGCGGCTCCAACTATCCGCTGGCCCTGGAAGGC
GCGCTGAAGCTCAAGGAAATCTCCTACATCCACGCCGAAGGCTATGCCGGCGGCGAGCTGAAGCACGGCCCCATCGCCCT
CATCGACGAGAAGATGCCGGTGGTGGTCATCGCTCCCCACGACCGCATCTTCGACAAGACCGTCTCCAACATGGAGGAGG
TGGCGGCACGCGGCGGCCGGATCATCCTCGTCACCGATCCCCTGGGCGCCGCGGCGGTGGACGTGGGCGCGGTGCAGAAG
CTGATCCTGCCGGAGATGCCCTCCACCGTGTGCCCCATGGTCTATTCCATCCCGGTGCAGTTGATCGCCTATCACACAGC
GGTCATCATGGGCACCGACGTGGACCAGCCGCGCAACCTCGCCAAGTCGGTGACGGTGGAATAG

Upstream 100 bases:

>100_bases
TGAGTGAACGGGCGGGAACGGTCCATTCAGCTTTGGAGTGGACTTTTGGGATCAGGCGGGCGCCGACCTTTGGCGACCGG
AACCAGCGGAGCTTTTGTGC

Downstream 100 bases:

>100_bases
GCTGAATGGTGCATCGCTCCGCGGCGCGCCCGCCGCTGACGTCAAAGTCGCATCGTGCTTATGGTGTGCGCTCACCGTGT
ACGGACGACGCCGCATGCAC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MCGIVGILGKGAVADKVVEALRRLEYRGYDSTGIATLENGHLEVCRAEGKLRHLEAKLDKHPLNGHSGIGHTRWATHGKP
SERNAHPHGTKRVAVVHNGIIENFRELKQELEAQGVSFKSDTDTEIVAQLVDRELLAGSEPVAAVAAVLPRLKGAFALAF
LFDGKTDLLIGARRGSPLAIGYGKGEMFLGSDAIALGPFTDTIAYLEEGDWAVLTRERVEIRDETGRLVERTIQKVPAGA
MLVDKGNHRHFMAKEIYEQPEVISHTFGHYLDLAAETVTLPELPFDPKTVTNISITACGTALYAGAVAEYWFERFGRVPV
STDIASEFRYRETPLTPDGITIVISQSGETADTLASLRYAKECGQKVVAVVNVPTSTIAREADVVLPILAGPEIGVASTK
AFTCQLATLACLAVAFGRAKGVLEEADEHKLVRAFMEVPRLMTEALKLSPEIEVLARTLAKARDVLYLGRGSNYPLALEG
ALKLKEISYIHAEGYAGGELKHGPIALIDEKMPVVVIAPHDRIFDKTVSNMEEVAARGGRIILVTDPLGAAAVDVGAVQK
LILPEMPSTVCPMVYSIPVQLIAYHTAVIMGTDVDQPRNLAKSVTVE

Sequences:

>Translated_607_residues
MCGIVGILGKGAVADKVVEALRRLEYRGYDSTGIATLENGHLEVCRAEGKLRHLEAKLDKHPLNGHSGIGHTRWATHGKP
SERNAHPHGTKRVAVVHNGIIENFRELKQELEAQGVSFKSDTDTEIVAQLVDRELLAGSEPVAAVAAVLPRLKGAFALAF
LFDGKTDLLIGARRGSPLAIGYGKGEMFLGSDAIALGPFTDTIAYLEEGDWAVLTRERVEIRDETGRLVERTIQKVPAGA
MLVDKGNHRHFMAKEIYEQPEVISHTFGHYLDLAAETVTLPELPFDPKTVTNISITACGTALYAGAVAEYWFERFGRVPV
STDIASEFRYRETPLTPDGITIVISQSGETADTLASLRYAKECGQKVVAVVNVPTSTIAREADVVLPILAGPEIGVASTK
AFTCQLATLACLAVAFGRAKGVLEEADEHKLVRAFMEVPRLMTEALKLSPEIEVLARTLAKARDVLYLGRGSNYPLALEG
ALKLKEISYIHAEGYAGGELKHGPIALIDEKMPVVVIAPHDRIFDKTVSNMEEVAARGGRIILVTDPLGAAAVDVGAVQK
LILPEMPSTVCPMVYSIPVQLIAYHTAVIMGTDVDQPRNLAKSVTVE
>Mature_607_residues
MCGIVGILGKGAVADKVVEALRRLEYRGYDSTGIATLENGHLEVCRAEGKLRHLEAKLDKHPLNGHSGIGHTRWATHGKP
SERNAHPHGTKRVAVVHNGIIENFRELKQELEAQGVSFKSDTDTEIVAQLVDRELLAGSEPVAAVAAVLPRLKGAFALAF
LFDGKTDLLIGARRGSPLAIGYGKGEMFLGSDAIALGPFTDTIAYLEEGDWAVLTRERVEIRDETGRLVERTIQKVPAGA
MLVDKGNHRHFMAKEIYEQPEVISHTFGHYLDLAAETVTLPELPFDPKTVTNISITACGTALYAGAVAEYWFERFGRVPV
STDIASEFRYRETPLTPDGITIVISQSGETADTLASLRYAKECGQKVVAVVNVPTSTIAREADVVLPILAGPEIGVASTK
AFTCQLATLACLAVAFGRAKGVLEEADEHKLVRAFMEVPRLMTEALKLSPEIEVLARTLAKARDVLYLGRGSNYPLALEG
ALKLKEISYIHAEGYAGGELKHGPIALIDEKMPVVVIAPHDRIFDKTVSNMEEVAARGGRIILVTDPLGAAAVDVGAVQK
LILPEMPSTVCPMVYSIPVQLIAYHTAVIMGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=35.6622998544396, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=35.3801169590643, Blast_Score=388, Evalue=1e-108,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=48.6133768352365, Blast_Score=559, Evalue=1e-160,
Organism=Escherichia coli, GI1788651, Length=223, Percent_Identity=29.1479820627803, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082251, Length=315, Percent_Identity=20.6349206349206, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=712, Percent_Identity=33.5674157303371, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17532899, Length=716, Percent_Identity=33.7988826815642, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=36.5740740740741, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17554892, Length=148, Percent_Identity=30.4054054054054, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322745, Length=488, Percent_Identity=36.8852459016393, Blast_Score=273, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=29.3706293706294, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6323730, Length=211, Percent_Identity=37.914691943128, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=35.4136429608128, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI28573187, Length=143, Percent_Identity=32.1678321678322, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65579; Mature: 65579

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGILGKGAVADKVVEALRRLEYRGYDSTGIATLENGHLEVCRAEGKLRHLEAKLDK
CCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEEECCCHHHHHHHHHCC
HPLNGHSGIGHTRWATHGKPSERNAHPHGTKRVAVVHNGIIENFRELKQELEAQGVSFKS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCC
DTDTEIVAQLVDRELLAGSEPVAAVAAVLPRLKGAFALAFLFDGKTDLLIGARRGSPLAI
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCEEEE
GYGKGEMFLGSDAIALGPFTDTIAYLEEGDWAVLTRERVEIRDETGRLVERTIQKVPAGA
EECCCCEEECCCCEEECCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCE
MLVDKGNHRHFMAKEIYEQPEVISHTFGHYLDLAAETVTLPELPFDPKTVTNISITACGT
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEEEHHH
ALYAGAVAEYWFERFGRVPVSTDIASEFRYRETPLTPDGITIVISQSGETADTLASLRYA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
KECGQKVVAVVNVPTSTIAREADVVLPILAGPEIGVASTKAFTCQLATLACLAVAFGRAK
HHCCCEEEEEEECCHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GVLEEADEHKLVRAFMEVPRLMTEALKLSPEIEVLARTLAKARDVLYLGRGSNYPLALEG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEEC
ALKLKEISYIHAEGYAGGELKHGPIALIDEKMPVVVIAPHDRIFDKTVSNMEEVAARGGR
CEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCE
IILVTDPLGAAAVDVGAVQKLILPEMPSTVCPMVYSIPVQLIAYHTAVIMGTDVDQPRNL
EEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHH
AKSVTVE
HHHCCCC
>Mature Secondary Structure
MCGIVGILGKGAVADKVVEALRRLEYRGYDSTGIATLENGHLEVCRAEGKLRHLEAKLDK
CCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEEECCCHHHHHHHHHCC
HPLNGHSGIGHTRWATHGKPSERNAHPHGTKRVAVVHNGIIENFRELKQELEAQGVSFKS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCC
DTDTEIVAQLVDRELLAGSEPVAAVAAVLPRLKGAFALAFLFDGKTDLLIGARRGSPLAI
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCEEEE
GYGKGEMFLGSDAIALGPFTDTIAYLEEGDWAVLTRERVEIRDETGRLVERTIQKVPAGA
EECCCCEEECCCCEEECCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCE
MLVDKGNHRHFMAKEIYEQPEVISHTFGHYLDLAAETVTLPELPFDPKTVTNISITACGT
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEEEHHH
ALYAGAVAEYWFERFGRVPVSTDIASEFRYRETPLTPDGITIVISQSGETADTLASLRYA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
KECGQKVVAVVNVPTSTIAREADVVLPILAGPEIGVASTKAFTCQLATLACLAVAFGRAK
HHCCCEEEEEEECCHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GVLEEADEHKLVRAFMEVPRLMTEALKLSPEIEVLARTLAKARDVLYLGRGSNYPLALEG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEEC
ALKLKEISYIHAEGYAGGELKHGPIALIDEKMPVVVIAPHDRIFDKTVSNMEEVAARGGR
CEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCE
IILVTDPLGAAAVDVGAVQKLILPEMPSTVCPMVYSIPVQLIAYHTAVIMGTDVDQPRNL
EEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHH
AKSVTVE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]