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The map label for this gene is glmU

Identifier: 154248339

GI number: 154248339

Start: 4901249

End: 4902595

Strand: Reverse

Name: glmU

Synonym: Xaut_4419

Alternate gene names: 154248339

Gene position: 4902595-4901249 (Counterclockwise)

Preceding gene: 154248341

Following gene: 154248338

Centisome position: 92.35

GC content: 69.86

Gene sequence:

>1347_bases
ATGAGTGACCGGAGCCTGCTCGTTGTGGTTCTCGCGGCCGGGGAGGGCACGCGGATGGCCTCACGGCTGCCGAAGGTGCT
GCACAAGGTCGCCGGCAGAACCATGCTGCACCACGTGCTGGCCGCCACCCGCGCCGCCGGCGCCACCCGCACCGCCGTGG
TCGTCGGTCCTGGGCGGGAGGATGTCGCCGCCGAGGTGCGCAAGATCGTGCCCGACGCCGAGGTGTTCGAGCAGACCGAG
CGCCTCGGCACCGCCCATGCCGTCCTCGCCGCCCGCGCCGCGCTTGAGAACGGCGCCGACGATGTGCTGGTGCTTTATGC
CGACACGCCTCTGGTGCGACCGGAAACCCTCGGCCTGCTGCGCGCGCCGCTCAAGGCCGGCGCGGCGGTGGCGGCTTTGG
GCTTCGAGCCCGCGGACCCCACCGGCTACGGTCGCCTCGTGACGGCCGGTGATGAACTCGTCGCCATTCGCGAGGAGAAG
GACGCGAGCGCTGCGGAAAAGGCCATCCGGTTCTGCAATGCCGGCCTGATGGCGCTCGCCGGCGCCCACGCCCTCTCCAT
TCTGGAGCGCATCGGCAACGCCAATGCCAAGGGCGAATATTACCTTACCGACGCGGTGGAGATTGCCCGCGCCGACGGGC
TTTCGGCCGTGGCCGCCCGGGCGGATGCGGACGAGGTGGCCGGCGTCAACAGCCGGGTCCAGCTCGCCGAGGCAGAAGCC
ATCCTGCAACGCCGCCTGCGCCTTGCCGCCATGGCCGGCGGCGCCACGCTGGTGGCCCCGGAGACGGTGTTCCTGAGCGC
CGACACGGTGCTGGGCCGCGACGTGATCGTCGAGCCCCACGTGGTGTTCGGCCCGGGGGTGAGCGTCGGCGACGACGTGG
TCATCCACTCCTTCTGCCACCTGGAAGGTGCGCGGCTGGAATCGGGAGTGACCATCGGTCCCTATGCACGGCTGCGGCCG
GGCACCCAGCTGGATTCGGGGGTGCGCATCGGCAATTTCGTGGAGACCAAGGCCGCTCATATTGAAAGCGGCGCCAAGGT
GAACCACCTGTCCTACGTGGGCGACGCCCATGTGGGGGCGGACGCCAATCTCGGCGCCGGGACCATCACCTGCAATTATG
ACGGCTTCGGCAAGTACCGCACCGAGATCGGGGCAGGGGCTTTCATCGGCGTGAATTCCGCGCTGGTTGCGCCCGTGACG
GTCGGGAAGGGCGCTTTTGTCGGCACCGGCGCTGTCATCACCTCGGATGTGCCGGAGGATGCCCTCGCCATCGCCCGTAG
CCGGCAGGTGGTGAAGGAGGGCTGGGCCAAGGCGTTTCGCGCCGCGCGCAGCAAGCCGAAGGGCTGA

Upstream 100 bases:

>100_bases
GGCGCCGGACGGGTCCAGTGGCAAGCCGGCCGGCAAAGGCGGGATGGCGCATGCGGCTGAGCCGGGGTAAGGGACAGCGC
TTCGCCGAGGAGGGGTGAGA

Downstream 100 bases:

>100_bases
GATTACTCTTGGGACCTGTCCTGACAGGAAGCGAATGCGGAAGTGATGCCGCCTGGGCTTGAGTGAACGGGCGGGAACGG
TCCATTCAGCTTTGGAGTGG

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSDRSLLVVVLAAGEGTRMASRLPKVLHKVAGRTMLHHVLAATRAAGATRTAVVVGPGREDVAAEVRKIVPDAEVFEQTE
RLGTAHAVLAARAALENGADDVLVLYADTPLVRPETLGLLRAPLKAGAAVAALGFEPADPTGYGRLVTAGDELVAIREEK
DASAAEKAIRFCNAGLMALAGAHALSILERIGNANAKGEYYLTDAVEIARADGLSAVAARADADEVAGVNSRVQLAEAEA
ILQRRLRLAAMAGGATLVAPETVFLSADTVLGRDVIVEPHVVFGPGVSVGDDVVIHSFCHLEGARLESGVTIGPYARLRP
GTQLDSGVRIGNFVETKAAHIESGAKVNHLSYVGDAHVGADANLGAGTITCNYDGFGKYRTEIGAGAFIGVNSALVAPVT
VGKGAFVGTGAVITSDVPEDALAIARSRQVVKEGWAKAFRAARSKPKG

Sequences:

>Translated_448_residues
MSDRSLLVVVLAAGEGTRMASRLPKVLHKVAGRTMLHHVLAATRAAGATRTAVVVGPGREDVAAEVRKIVPDAEVFEQTE
RLGTAHAVLAARAALENGADDVLVLYADTPLVRPETLGLLRAPLKAGAAVAALGFEPADPTGYGRLVTAGDELVAIREEK
DASAAEKAIRFCNAGLMALAGAHALSILERIGNANAKGEYYLTDAVEIARADGLSAVAARADADEVAGVNSRVQLAEAEA
ILQRRLRLAAMAGGATLVAPETVFLSADTVLGRDVIVEPHVVFGPGVSVGDDVVIHSFCHLEGARLESGVTIGPYARLRP
GTQLDSGVRIGNFVETKAAHIESGAKVNHLSYVGDAHVGADANLGAGTITCNYDGFGKYRTEIGAGAFIGVNSALVAPVT
VGKGAFVGTGAVITSDVPEDALAIARSRQVVKEGWAKAFRAARSKPKG
>Mature_447_residues
SDRSLLVVVLAAGEGTRMASRLPKVLHKVAGRTMLHHVLAATRAAGATRTAVVVGPGREDVAAEVRKIVPDAEVFEQTER
LGTAHAVLAARAALENGADDVLVLYADTPLVRPETLGLLRAPLKAGAAVAALGFEPADPTGYGRLVTAGDELVAIREEKD
ASAAEKAIRFCNAGLMALAGAHALSILERIGNANAKGEYYLTDAVEIARADGLSAVAARADADEVAGVNSRVQLAEAEAI
LQRRLRLAAMAGGATLVAPETVFLSADTVLGRDVIVEPHVVFGPGVSVGDDVVIHSFCHLEGARLESGVTIGPYARLRPG
TQLDSGVRIGNFVETKAAHIESGAKVNHLSYVGDAHVGADANLGAGTITCNYDGFGKYRTEIGAGAFIGVNSALVAPVTV
GKGAFVGTGAVITSDVPEDALAIARSRQVVKEGWAKAFRAARSKPKG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=458, Percent_Identity=40.174672489083, Blast_Score=313, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_XANP2 (A7INP6)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001419297.1
- ProteinModelPortal:   A7INP6
- STRING:   A7INP6
- GeneID:   5423857
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_4419
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   CLSK980299
- BioCyc:   XAUT78245:XAUT_4419-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 46230; Mature: 46099

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 349-349 BINDING 78-78 BINDING 144-144 BINDING 158-158 BINDING 173-173 BINDING 373-373 BINDING 409-409 BINDING 426-426

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRSLLVVVLAAGEGTRMASRLPKVLHKVAGRTMLHHVLAATRAAGATRTAVVVGPGRE
CCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCH
DVAAEVRKIVPDAEVFEQTERLGTAHAVLAARAALENGADDVLVLYADTPLVRPETLGLL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHH
RAPLKAGAAVAALGFEPADPTGYGRLVTAGDELVAIREEKDASAAEKAIRFCNAGLMALA
HHHHHCCCEEEEECCCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHCCCHHHHH
GAHALSILERIGNANAKGEYYLTDAVEIARADGLSAVAARADADEVAGVNSRVQLAEAEA
HHHHHHHHHHHCCCCCCCCEEEEHHHHHHHCCCCHHHHHHCCHHHHCCCCCHHHHHHHHH
ILQRRLRLAAMAGGATLVAPETVFLSADTVLGRDVIVEPHVVFGPGVSVGDDVVIHSFCH
HHHHHHHHHHHCCCEEEECCCEEEEECCHHCCCCEEECCEEEECCCCCCCCHHHHHHHHH
LEGARLESGVTIGPYARLRPGTQLDSGVRIGNFVETKAAHIESGAKVNHLSYVGDAHVGA
CCCCCCCCCCEECCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCC
DANLGAGTITCNYDGFGKYRTEIGAGAFIGVNSALVAPVTVGKGAFVGTGAVITSDVPED
CCCCCCCEEEECCCCCCHHHHHCCCCEEEECCCCEEEEEEECCCCEEECCCEEECCCCHH
ALAIARSRQVVKEGWAKAFRAARSKPKG
HHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDRSLLVVVLAAGEGTRMASRLPKVLHKVAGRTMLHHVLAATRAAGATRTAVVVGPGRE
CCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCH
DVAAEVRKIVPDAEVFEQTERLGTAHAVLAARAALENGADDVLVLYADTPLVRPETLGLL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHH
RAPLKAGAAVAALGFEPADPTGYGRLVTAGDELVAIREEKDASAAEKAIRFCNAGLMALA
HHHHHCCCEEEEECCCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHCCCHHHHH
GAHALSILERIGNANAKGEYYLTDAVEIARADGLSAVAARADADEVAGVNSRVQLAEAEA
HHHHHHHHHHHCCCCCCCCEEEEHHHHHHHCCCCHHHHHHCCHHHHCCCCCHHHHHHHHH
ILQRRLRLAAMAGGATLVAPETVFLSADTVLGRDVIVEPHVVFGPGVSVGDDVVIHSFCH
HHHHHHHHHHHCCCEEEECCCEEEEECCHHCCCCEEECCEEEECCCCCCCCHHHHHHHHH
LEGARLESGVTIGPYARLRPGTQLDSGVRIGNFVETKAAHIESGAKVNHLSYVGDAHVGA
CCCCCCCCCCEECCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCC
DANLGAGTITCNYDGFGKYRTEIGAGAFIGVNSALVAPVTVGKGAFVGTGAVITSDVPED
CCCCCCCEEEECCCCCCHHHHHCCCCEEEECCCCEEEEEEECCCCEEECCCEEECCCCHH
ALAIARSRQVVKEGWAKAFRAARSKPKG
HHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA