Click here to switch to the map view.

The map label for this gene is tmk [H]

Identifier: 154248245

GI number: 154248245

Start: 4797988

End: 4798641

Strand: Direct

Name: tmk [H]

Synonym: Xaut_4325

Alternate gene names: 154248245

Gene position: 4797988-4798641 (Clockwise)

Preceding gene: 154248244

Following gene: 154248246

Centisome position: 90.38

GC content: 74.62

Gene sequence:

>654_bases
ATGACCCAGGGGCGATTCATCACGCTGGAAGGCGGGGAGGGGACCGGCAAGTCCACCCAGGCCCGCCGCCTCGCGGCGCA
TCTGCGCACCCTTGGCCACACGGTGGTGGAGACCCGCGAGCCCGGCGGCTCGCCGGGGGCGGAGGCGGTGCGCCATGTGC
TGCTCTCTGGAGCGGCCGAGCCGCTGGGGCCGGTGGCCGAGGCGCTGCTGTTCGCCGCCGCTCGCACCGACCATGTGCAA
ACGCTGATCCGTCCGGCGCTGGCGGCGGGCACCATCGTGATCTGTGACCGCTTCATCGATTCCACCCGGGTCTACCAGGG
CGCGGTGGGCCAGGTGGCGCCGCCCCTCCTCGATGCGCTGGAAGAGATGGCGACGGGCGGCACCCGGCCGGACCTCACCC
TGATCCTGGACGTGCCGCCGGAAACCGGGCTGGCCCGCGCCGCCGCGCGCGGCAATGGCGATCCGGACCGGTTCGAGAAG
GAAGGCGCCGCCTATCATGCCGCCGTGCGCGAGGCCTTCGTCGCCCGTGCGGCGGCGGCCCCCGCGCGCTGCGTGCTGGT
GGACGCGACGCCCGATCCGGACGCGGTCGCGGCGCAGATCGCCGGCATCGTCGCCGCCCGCCTCGGACTTCACGCCACGG
CCGAGGCGTCCTGA

Upstream 100 bases:

>100_bases
CGGTGGGTTCGCTGACGGATCGCGCCCTCGACGGCGGGCTGACGCTGATGGGCGACAGCGTGCGCGATCTGGCCAAGCGC
GCTCTGGCGAAGATTCACAA

Downstream 100 bases:

>100_bases
TGGCGCAGGCCGTGAGCGAGATCGTCTCCGGCGATGTCCTGCCCGGCGCGCCACACCCGCGCGACCAGGCGCGGCTGTTC
GGCCACGGGGTGGTGGAAGC

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MTQGRFITLEGGEGTGKSTQARRLAAHLRTLGHTVVETREPGGSPGAEAVRHVLLSGAAEPLGPVAEALLFAAARTDHVQ
TLIRPALAAGTIVICDRFIDSTRVYQGAVGQVAPPLLDALEEMATGGTRPDLTLILDVPPETGLARAAARGNGDPDRFEK
EGAAYHAAVREAFVARAAAAPARCVLVDATPDPDAVAAQIAGIVAARLGLHATAEAS

Sequences:

>Translated_217_residues
MTQGRFITLEGGEGTGKSTQARRLAAHLRTLGHTVVETREPGGSPGAEAVRHVLLSGAAEPLGPVAEALLFAAARTDHVQ
TLIRPALAAGTIVICDRFIDSTRVYQGAVGQVAPPLLDALEEMATGGTRPDLTLILDVPPETGLARAAARGNGDPDRFEK
EGAAYHAAVREAFVARAAAAPARCVLVDATPDPDAVAAQIAGIVAARLGLHATAEAS
>Mature_216_residues
TQGRFITLEGGEGTGKSTQARRLAAHLRTLGHTVVETREPGGSPGAEAVRHVLLSGAAEPLGPVAEALLFAAARTDHVQT
LIRPALAAGTIVICDRFIDSTRVYQGAVGQVAPPLLDALEEMATGGTRPDLTLILDVPPETGLARAAARGNGDPDRFEKE
GAAYHAAVREAFVARAAAAPARCVLVDATPDPDAVAAQIAGIVAARLGLHATAEAS

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=202, Percent_Identity=41.0891089108911, Blast_Score=119, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22259; Mature: 22128

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQGRFITLEGGEGTGKSTQARRLAAHLRTLGHTVVETREPGGSPGAEAVRHVLLSGAAE
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
PLGPVAEALLFAAARTDHVQTLIRPALAAGTIVICDRFIDSTRVYQGAVGQVAPPLLDAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
EEMATGGTRPDLTLILDVPPETGLARAAARGNGDPDRFEKEGAAYHAAVREAFVARAAAA
HHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PARCVLVDATPDPDAVAAQIAGIVAARLGLHATAEAS
CCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TQGRFITLEGGEGTGKSTQARRLAAHLRTLGHTVVETREPGGSPGAEAVRHVLLSGAAE
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
PLGPVAEALLFAAARTDHVQTLIRPALAAGTIVICDRFIDSTRVYQGAVGQVAPPLLDAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
EEMATGGTRPDLTLILDVPPETGLARAAARGNGDPDRFEKEGAAYHAAVREAFVARAAAA
HHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PARCVLVDATPDPDAVAAQIAGIVAARLGLHATAEAS
CCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]