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The map label for this gene is ilvA [H]

Identifier: 154248214

GI number: 154248214

Start: 4761170

End: 4762447

Strand: Reverse

Name: ilvA [H]

Synonym: Xaut_4294

Alternate gene names: 154248214

Gene position: 4762447-4761170 (Counterclockwise)

Preceding gene: 154248215

Following gene: 154248213

Centisome position: 89.71

GC content: 71.28

Gene sequence:

>1278_bases
ATGACAGCCCCCGCCGTCGCCTCCAGCGACCGCCCCCTCGACCTCAACGTCGACCTGCCCGTCACCCTCGCGGACGTGGA
GGCGGCGCGGGCGCTGGTGAGCGGCGCGGTATTGCACACGCCCACCCTGCACGCCCCGCGCCTGTCCGCCCTCACCGGTG
CGGATGTGTACGTGAAGTATGAGAATCTCCAGGTCACCGCCTCGTTCAAGGAGCGCGGCGCGCTGGTGAAGCTGGCGCGC
CTCACCCCCGAGGAGGCGCGGCGGGGCGTGGTGGCCATGTCGGCGGGCAACCATGCCCAGGCGGTGGCCTATCACGGTAC
GCGGCTGAAGATTTCCACCCTCATCGTCATGCCGGAGACCACCCCCCAGGTGAAGGTGGCCGCCACTGAAGCCTTCGGCG
CCGAGGTGGTGCTGTTCGGCGATACGGTCGCCGACGCCTTCGAGGAGGCAACGCGCATCTCCAAGGCGCAAGGGCGCATC
TTCGTCCACCCCTATGACGACGTGGACGTGATCGCCGGCCAGGGCTCGCTGGCGCTGGAGATGATGGAGGACGGGCCGGC
CTTCGACGCCGTGGTGGTGCCCATCGGCGGAGGCGGGCTGATCGCCGGCATGGCGCTGGCCTTCGCCGGGCGCTCGCCGG
CGACGCAGGTGGTGGGGGTCGAGACCCAGCTCTATCCCGCCATGTGGTCCGCCATGACCGGAGAGGCGCGCCCCTGCGGC
GGGCCGACGCTGGCGGAGGGCATCGCGGTGCGCGACGTGGGTGTCATCACCTCGCAGATCGTGCGGCGCCTGGTACCCCA
CGTGGTGCTGGTGGACGAGACCGCGCTGGAGCGGGCGGTGAACGCCTTCCTCATGCACCAGAAGACCTTGGCCGAAGGCG
CCGGCGCCGCCGGCCTTGCCGCGCTCCTCGCCGAACCCGAGCGCTTCCGCGGCAAGACGGTGGGGCTGGTGGTCTCCGGC
GGCAACATCGATCCGCGCATGATTGCCGGCATCCTGCTGCGCGAGCTGGAGCGGGAGGAGCGCATCGTCTCCTTCCGCCT
CACCATCCTCGACCGGCCTGGCATGCTGGGGCGCATCGCCACGCTGCTCGGCAAGCTCGGGGCCAACATCCTGGAGGTGC
ACCACCGGCGCACCTTCCTCGACGTGCCGGCCAAGGGCACGCGGCTCGACCTCACCGTGGAGACCCGGGACCAGGCCCAT
GCCGAGCTGATCCAGAAGGCGCTGGAGGGCGAGGGCCTGCCGGTCCAGCGCCTGGGCGCCGGAGGCGCCGATTGGTGA

Upstream 100 bases:

>100_bases
GCTTCACGCTCCAGCTTTTCGAGCTTGCGCATTTTCGTCACGCGGACCGGAGTCCCCCTCGCTTGAAAATGCTCAAAGCG
CCCGCGCCGGGAGAGACAAG

Downstream 100 bases:

>100_bases
AGTGCGCCGGCGGCGCGGACTGGTGATGCCGTGATCTTGCGCTGCAGGGAGGCCTTCACCACCTGAAGGTGTCGGAAGGA
GTCTTCAACCCATGAGCAAC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTAPAVASSDRPLDLNVDLPVTLADVEAARALVSGAVLHTPTLHAPRLSALTGADVYVKYENLQVTASFKERGALVKLAR
LTPEEARRGVVAMSAGNHAQAVAYHGTRLKISTLIVMPETTPQVKVAATEAFGAEVVLFGDTVADAFEEATRISKAQGRI
FVHPYDDVDVIAGQGSLALEMMEDGPAFDAVVVPIGGGGLIAGMALAFAGRSPATQVVGVETQLYPAMWSAMTGEARPCG
GPTLAEGIAVRDVGVITSQIVRRLVPHVVLVDETALERAVNAFLMHQKTLAEGAGAAGLAALLAEPERFRGKTVGLVVSG
GNIDPRMIAGILLRELEREERIVSFRLTILDRPGMLGRIATLLGKLGANILEVHHRRTFLDVPAKGTRLDLTVETRDQAH
AELIQKALEGEGLPVQRLGAGGADW

Sequences:

>Translated_425_residues
MTAPAVASSDRPLDLNVDLPVTLADVEAARALVSGAVLHTPTLHAPRLSALTGADVYVKYENLQVTASFKERGALVKLAR
LTPEEARRGVVAMSAGNHAQAVAYHGTRLKISTLIVMPETTPQVKVAATEAFGAEVVLFGDTVADAFEEATRISKAQGRI
FVHPYDDVDVIAGQGSLALEMMEDGPAFDAVVVPIGGGGLIAGMALAFAGRSPATQVVGVETQLYPAMWSAMTGEARPCG
GPTLAEGIAVRDVGVITSQIVRRLVPHVVLVDETALERAVNAFLMHQKTLAEGAGAAGLAALLAEPERFRGKTVGLVVSG
GNIDPRMIAGILLRELEREERIVSFRLTILDRPGMLGRIATLLGKLGANILEVHHRRTFLDVPAKGTRLDLTVETRDQAH
AELIQKALEGEGLPVQRLGAGGADW
>Mature_424_residues
TAPAVASSDRPLDLNVDLPVTLADVEAARALVSGAVLHTPTLHAPRLSALTGADVYVKYENLQVTASFKERGALVKLARL
TPEEARRGVVAMSAGNHAQAVAYHGTRLKISTLIVMPETTPQVKVAATEAFGAEVVLFGDTVADAFEEATRISKAQGRIF
VHPYDDVDVIAGQGSLALEMMEDGPAFDAVVVPIGGGGLIAGMALAFAGRSPATQVVGVETQLYPAMWSAMTGEARPCGG
PTLAEGIAVRDVGVITSQIVRRLVPHVVLVDETALERAVNAFLMHQKTLAEGAGAAGLAALLAEPERFRGKTVGLVVSGG
NIDPRMIAGILLRELEREERIVSFRLTILDRPGMLGRIATLLGKLGANILEVHHRRTFLDVPAKGTRLDLTVETRDQAHA
ELIQKALEGEGLPVQRLGAGGADW

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=315, Percent_Identity=34.6031746031746, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1789505, Length=325, Percent_Identity=41.5384615384615, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1790207, Length=378, Percent_Identity=33.8624338624339, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71991565, Length=421, Percent_Identity=34.4418052256532, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17537387, Length=394, Percent_Identity=32.994923857868, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17508781, Length=285, Percent_Identity=28.7719298245614, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322631, Length=313, Percent_Identity=35.1437699680511, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320930, Length=393, Percent_Identity=29.2620865139949, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319788, Length=190, Percent_Identity=31.0526315789474, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21355833, Length=394, Percent_Identity=37.8172588832487, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24645328, Length=298, Percent_Identity=35.5704697986577, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44858; Mature: 44727

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPAVASSDRPLDLNVDLPVTLADVEAARALVSGAVLHTPTLHAPRLSALTGADVYVKY
CCCCCCCCCCCCEEEECCCCEEEHHHHHHHHHHHCCEEECCCCCCCCCHHCCCCEEEEEE
ENLQVTASFKERGALVKLARLTPEEARRGVVAMSAGNHAQAVAYHGTRLKISTLIVMPET
ECEEEEEEHHHCCCEEEEECCCHHHHHCCEEEEECCCCEEEEEECCCEEEEEEEEEECCC
TPQVKVAATEAFGAEVVLFGDTVADAFEEATRISKAQGRIFVHPYDDVDVIAGQGSLALE
CCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCEEEE
MMEDGPAFDAVVVPIGGGGLIAGMALAFAGRSPATQVVGVETQLYPAMWSAMTGEARPCG
EECCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCC
GPTLAEGIAVRDVGVITSQIVRRLVPHVVLVDETALERAVNAFLMHQKTLAEGAGAAGLA
CCHHHCCEEEEHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ALLAEPERFRGKTVGLVVSGGNIDPRMIAGILLRELEREERIVSFRLTILDRPGMLGRIA
HHHCCHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHH
TLLGKLGANILEVHHRRTFLDVPAKGTRLDLTVETRDQAHAELIQKALEGEGLPVQRLGA
HHHHHHCCHHHHHHHCCEEEECCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCHHHCCC
GGADW
CCCCC
>Mature Secondary Structure 
TAPAVASSDRPLDLNVDLPVTLADVEAARALVSGAVLHTPTLHAPRLSALTGADVYVKY
CCCCCCCCCCCEEEECCCCEEEHHHHHHHHHHHCCEEECCCCCCCCCHHCCCCEEEEEE
ENLQVTASFKERGALVKLARLTPEEARRGVVAMSAGNHAQAVAYHGTRLKISTLIVMPET
ECEEEEEEHHHCCCEEEEECCCHHHHHCCEEEEECCCCEEEEEECCCEEEEEEEEEECCC
TPQVKVAATEAFGAEVVLFGDTVADAFEEATRISKAQGRIFVHPYDDVDVIAGQGSLALE
CCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCEEEE
MMEDGPAFDAVVVPIGGGGLIAGMALAFAGRSPATQVVGVETQLYPAMWSAMTGEARPCG
EECCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCC
GPTLAEGIAVRDVGVITSQIVRRLVPHVVLVDETALERAVNAFLMHQKTLAEGAGAAGLA
CCHHHCCEEEEHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ALLAEPERFRGKTVGLVVSGGNIDPRMIAGILLRELEREERIVSFRLTILDRPGMLGRIA
HHHCCHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHH
TLLGKLGANILEVHHRRTFLDVPAKGTRLDLTVETRDQAHAELIQKALEGEGLPVQRLGA
HHHHHHCCHHHHHHHCCEEEECCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCHHHCCC
GGADW
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA