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The map label for this gene is cusR [H]

Identifier: 154247445

GI number: 154247445

Start: 3918834

End: 3919550

Strand: Direct

Name: cusR [H]

Synonym: Xaut_3517

Alternate gene names: 154247445

Gene position: 3918834-3919550 (Clockwise)

Preceding gene: 154247444

Following gene: 154247446

Centisome position: 73.82

GC content: 68.34

Gene sequence:

>717_bases
ATGACAGCGAATCTCGATCCGGATCCCCTCACTGCCATGCGCCTCCTCCTTGTCGAGGACGACCGCGACGCCGCCGAATA
TCTGCGCAAGGCCTTCCGCGAGGCTGGGCACGTGGTGGACCTTGCTGCCGACGGGGAGGAGGGCCTCGCCCTCGCCCTGG
ACGGCAAGTACGACGTGATGGTGGTAGACCGCATGCTGCCCGCGCGCGACGGGCTCTCCCTCGTCACCGAGCTGCGCGGG
CGCGGGCACACCACGCCAGTGCTCATCCTTTCCGCCCTCGGCCAGGTGGACGACCGGGTGCAGGGCCTGCGCGCCGGCGG
TGACGACTACCTGCCCAAGCCCTACGCCTTCACCGAGCTTCTGGCGCGGGTGGAAGCCCTGTCGCGGCGCGGCGTCTCGC
AAGGCGCGGAGACGGTCTACAAGGTGTCCGACCTGGAGCTGGACCGTCTTGCCCATCGCGTCACCCGCTCCGGCAAGGAG
ATCCCGCTGCAGCCGCGGGAGTTCCGGCTGCTGGAATATCTCCTGCGCCATGCCGGGCAGGTGGTGACCCGCACCATGCT
GCTGGAAAACGTGTGGGACTACCATTTCGACCCACAGACCAACGTCATCGACGTGCACGTCTCCCGCCTGCGCTCCAAGA
TCGACAAGGGCTTCGACGTGCCGCTGATCCACACCGTGCGCGGCGCCGGCTACATGGTGCGGGCGGGTGCCGCTTGA

Upstream 100 bases:

>100_bases
CAGCAACGCCGCGCGCTTCGCCCTTTTCCCAGCGGAAGGGGCGAGCCGTCACGCAAGGCGGACACCCCGCATGGACCTGC
CGGCAAGGTGAGCTAGAGTG

Downstream 100 bases:

>100_bases
GTCCGGCGGGCGCGGGCCGCTCGCCGTCGGCGGCGTGATCTGGCGGGTTCTCATGCGCTTTTTCGCCCACCTCGCGCGGC
TGGTGCGCACCACGGCGTTC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MTANLDPDPLTAMRLLLVEDDRDAAEYLRKAFREAGHVVDLAADGEEGLALALDGKYDVMVVDRMLPARDGLSLVTELRG
RGHTTPVLILSALGQVDDRVQGLRAGGDDYLPKPYAFTELLARVEALSRRGVSQGAETVYKVSDLELDRLAHRVTRSGKE
IPLQPREFRLLEYLLRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIDKGFDVPLIHTVRGAGYMVRAGAA

Sequences:

>Translated_238_residues
MTANLDPDPLTAMRLLLVEDDRDAAEYLRKAFREAGHVVDLAADGEEGLALALDGKYDVMVVDRMLPARDGLSLVTELRG
RGHTTPVLILSALGQVDDRVQGLRAGGDDYLPKPYAFTELLARVEALSRRGVSQGAETVYKVSDLELDRLAHRVTRSGKE
IPLQPREFRLLEYLLRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIDKGFDVPLIHTVRGAGYMVRAGAA
>Mature_237_residues
TANLDPDPLTAMRLLLVEDDRDAAEYLRKAFREAGHVVDLAADGEEGLALALDGKYDVMVVDRMLPARDGLSLVTELRGR
GHTTPVLILSALGQVDDRVQGLRAGGDDYLPKPYAFTELLARVEALSRRGVSQGAETVYKVSDLELDRLAHRVTRSGKEI
PLQPREFRLLEYLLRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIDKGFDVPLIHTVRGAGYMVRAGAA

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=50.6787330316742, Blast_Score=225, Evalue=2e-60,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=41.5525114155251, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=37.10407239819, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=37.5, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=34.5454545454545, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786911, Length=203, Percent_Identity=34.9753694581281, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=36.6379310344828, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=32.3008849557522, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=33.0396475770925, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=33.1818181818182, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=27.8761061946903, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=28.695652173913, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=26.8398268398268, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1787487, Length=106, Percent_Identity=37.7358490566038, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=33.9285714285714, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790437, Length=124, Percent_Identity=31.4516129032258, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26482; Mature: 26350

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANLDPDPLTAMRLLLVEDDRDAAEYLRKAFREAGHVVDLAADGEEGLALALDGKYDVM
CCCCCCCCHHHHHEEHHEECCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCEEEE
VVDRMLPARDGLSLVTELRGRGHTTPVLILSALGQVDDRVQGLRAGGDDYLPKPYAFTEL
ECCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LARVEALSRRGVSQGAETVYKVSDLELDRLAHRVTRSGKEIPLQPREFRLLEYLLRHAGQ
HHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
VVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIDKGFDVPLIHTVRGAGYMVRAGAA
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHEEECCCCEEEECCCC
>Mature Secondary Structure 
TANLDPDPLTAMRLLLVEDDRDAAEYLRKAFREAGHVVDLAADGEEGLALALDGKYDVM
CCCCCCCHHHHHEEHHEECCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCEEEE
VVDRMLPARDGLSLVTELRGRGHTTPVLILSALGQVDDRVQGLRAGGDDYLPKPYAFTEL
ECCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LARVEALSRRGVSQGAETVYKVSDLELDRLAHRVTRSGKEIPLQPREFRLLEYLLRHAGQ
HHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
VVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIDKGFDVPLIHTVRGAGYMVRAGAA
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHEEECCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]