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The map label for this gene is degP [H]

Identifier: 154247444

GI number: 154247444

Start: 3916973

End: 3918586

Strand: Direct

Name: degP [H]

Synonym: Xaut_3516

Alternate gene names: 154247444

Gene position: 3916973-3918586 (Clockwise)

Preceding gene: 154247443

Following gene: 154247445

Centisome position: 73.78

GC content: 69.21

Gene sequence:

>1614_bases
ATGCGACCGCCCATGACCCGCTCGCCCATGACCCGCTCCGACAACACCCCCTCCGTGACCAAGCGCCACCGCAAGGCTCT
CCTGGCCGGCGTGGTCGGTCTCGCGCTCGCCGGCGTCGTGGCCGGCCAGTTCGTGCCGCCGCTGAACGGTCCCGTCGCCG
CCCAGATCACCACCAGCCAGCCGGCCGGCACCTTCTCCTTCGCCGATATCGTCGAGAAGGTCTCGCCCGCCGTCGTCTCG
GTGAAGGTGAAGAAGGATGCCGGCAACGAACAGATGGCCATGGGCGGCGATTTCGGCGGCAATGTTCCGCCCCAGATCGA
GCAGTTCCTGAAGCGCTTCGGCTTCGGCGACGGCCAGGGCCCCATGGGTCCGGGTGGTCCCGGCGGCCCGGGCATGGGTC
CGCGCGGCGGCCACGGTCCCAAGGGCGAGCGCCCGGTGGTGGGCCAGGGCTCCGGCTTCATCATCTCGGCTGACGGCTAT
GTGGTGACCAACAACCACGTGGTGGACGGCGCCGACGAGGTGGACGTGACCACCACCGACGGCAAGGAATACCAGGCCAA
GGTGATCGGCACCGATCCGCGCACCGACGTGGCCCTGCTGAAGATCGAGAACGTCACCAACCTGCCGTGGGTGAAGCTCG
CGGACGGCGCCCCGCGCGTCGGTGACTGGGTGATCGCGGTGGGCAATCCCTTCGGCCTCGGCGGCACCGTGACCGCCGGC
ATCGTCTCGGCCCGTGGCCGCGACATTGGCTCGGGTCCCTATGACGACTTCATCCAGATCGACGCCCCCATCAACCGGGG
CAATTCGGGCGGCCCGACCTTCTCGCTGAACGGCGAGGTGATCGGCATGAACACCGCCATCGTCTCCCCCTCGGGTGGCA
ACGTGGGCATTGCCTTCGCCATTCCGTCCGAGACCGTGAAGACGGTGGTGGCCCAGCTGCGCGACAAGGGCTCGGTGGCC
CGCGGCTACATCGGCGTGCAGATCCAGCCGGTGACCGAGGACCTCGCCTCCGGCCTCGGCATCAAGGACGCCGAGGGCGC
CCTGGTGGCGCAGGTTCAGCCCAACACCCCCGGCGCCAAGGCAGGCCTGAAGGCCGGCGACGTGATCGTGAAGGTCAACA
ACGAGCCGATCAAGGAAGCCCGCGATCTGACCCGCAAGGTGGGCATGATGAAGCCGGGTACCGAGATCAAGCTCTCGCTG
ATCCGCGATGCCAAGCCCATGGACCTGTCCCTGGTGCTCGACCAGCTGCCCAACGATCAGGTCGCCTCGCGCTCCGGTGC
GCCCCAGCAGGGCGAGGATGACACCGCCGGCGCCACCAAGGACCTGCCGCGCCTCGGCCTCCAGCTCGCCCCGTCCAAGA
GCGTTCAGGGCGCCGGCGGCGAAGGCGTGGTGGTGACCGGTGTGGAGCCCAACGGCCCCGCCGCCCAGCGCGGTTTCAAG
ACCGGCGACGTGATCCTGAAGGTGGGCGACAAAGCGGTCTCCACCCCGAAGGATGTGCGCGACGGCCTCGCCGCCGCCAA
GGCCGACAACCGCAAGGCGGTGCTCATCCAGGTGAAGAGCGGCGAGGGCGTGCGCTTCGTCGCCATCACCCTCGACGCCA
AGGCCAAGGGCTGA

Upstream 100 bases:

>100_bases
TGAGCCACATTACGGATCCTTAATTCCGCAGCCAGACTGCCGTAACGGTCCACGCACTAGCTTGCCTCTCGAACCTGCCG
ACAAGGCAGACAACAGAGAG

Downstream 100 bases:

>100_bases
GCCTCGCGCTGAACCTGAAGGCTCCGGTGGCCTGGCGCCGCCGGAGCAGGTCTACCGGAGCCGAGGCGGGTTAGCATCGC
CCCCCTGATGCCACTTCGGC

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MRPPMTRSPMTRSDNTPSVTKRHRKALLAGVVGLALAGVVAGQFVPPLNGPVAAQITTSQPAGTFSFADIVEKVSPAVVS
VKVKKDAGNEQMAMGGDFGGNVPPQIEQFLKRFGFGDGQGPMGPGGPGGPGMGPRGGHGPKGERPVVGQGSGFIISADGY
VVTNNHVVDGADEVDVTTTDGKEYQAKVIGTDPRTDVALLKIENVTNLPWVKLADGAPRVGDWVIAVGNPFGLGGTVTAG
IVSARGRDIGSGPYDDFIQIDAPINRGNSGGPTFSLNGEVIGMNTAIVSPSGGNVGIAFAIPSETVKTVVAQLRDKGSVA
RGYIGVQIQPVTEDLASGLGIKDAEGALVAQVQPNTPGAKAGLKAGDVIVKVNNEPIKEARDLTRKVGMMKPGTEIKLSL
IRDAKPMDLSLVLDQLPNDQVASRSGAPQQGEDDTAGATKDLPRLGLQLAPSKSVQGAGGEGVVVTGVEPNGPAAQRGFK
TGDVILKVGDKAVSTPKDVRDGLAAAKADNRKAVLIQVKSGEGVRFVAITLDAKAKG

Sequences:

>Translated_537_residues
MRPPMTRSPMTRSDNTPSVTKRHRKALLAGVVGLALAGVVAGQFVPPLNGPVAAQITTSQPAGTFSFADIVEKVSPAVVS
VKVKKDAGNEQMAMGGDFGGNVPPQIEQFLKRFGFGDGQGPMGPGGPGGPGMGPRGGHGPKGERPVVGQGSGFIISADGY
VVTNNHVVDGADEVDVTTTDGKEYQAKVIGTDPRTDVALLKIENVTNLPWVKLADGAPRVGDWVIAVGNPFGLGGTVTAG
IVSARGRDIGSGPYDDFIQIDAPINRGNSGGPTFSLNGEVIGMNTAIVSPSGGNVGIAFAIPSETVKTVVAQLRDKGSVA
RGYIGVQIQPVTEDLASGLGIKDAEGALVAQVQPNTPGAKAGLKAGDVIVKVNNEPIKEARDLTRKVGMMKPGTEIKLSL
IRDAKPMDLSLVLDQLPNDQVASRSGAPQQGEDDTAGATKDLPRLGLQLAPSKSVQGAGGEGVVVTGVEPNGPAAQRGFK
TGDVILKVGDKAVSTPKDVRDGLAAAKADNRKAVLIQVKSGEGVRFVAITLDAKAKG
>Mature_537_residues
MRPPMTRSPMTRSDNTPSVTKRHRKALLAGVVGLALAGVVAGQFVPPLNGPVAAQITTSQPAGTFSFADIVEKVSPAVVS
VKVKKDAGNEQMAMGGDFGGNVPPQIEQFLKRFGFGDGQGPMGPGGPGGPGMGPRGGHGPKGERPVVGQGSGFIISADGY
VVTNNHVVDGADEVDVTTTDGKEYQAKVIGTDPRTDVALLKIENVTNLPWVKLADGAPRVGDWVIAVGNPFGLGGTVTAG
IVSARGRDIGSGPYDDFIQIDAPINRGNSGGPTFSLNGEVIGMNTAIVSPSGGNVGIAFAIPSETVKTVVAQLRDKGSVA
RGYIGVQIQPVTEDLASGLGIKDAEGALVAQVQPNTPGAKAGLKAGDVIVKVNNEPIKEARDLTRKVGMMKPGTEIKLSL
IRDAKPMDLSLVLDQLPNDQVASRSGAPQQGEDDTAGATKDLPRLGLQLAPSKSVQGAGGEGVVVTGVEPNGPAAQRGFK
TGDVILKVGDKAVSTPKDVRDGLAAAKADNRKAVLIQVKSGEGVRFVAITLDAKAKG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=262, Percent_Identity=39.6946564885496, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI22129776, Length=354, Percent_Identity=33.3333333333333, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI24308541, Length=264, Percent_Identity=37.8787878787879, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI7019477, Length=258, Percent_Identity=36.8217054263566, Blast_Score=144, Evalue=3e-34,
Organism=Escherichia coli, GI1786356, Length=490, Percent_Identity=39.5918367346939, Blast_Score=294, Evalue=8e-81,
Organism=Escherichia coli, GI1789629, Length=485, Percent_Identity=38.3505154639175, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI1789630, Length=274, Percent_Identity=38.6861313868613, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24646839, Length=293, Percent_Identity=32.4232081911263, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 54941; Mature: 54941

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPPMTRSPMTRSDNTPSVTKRHRKALLAGVVGLALAGVVAGQFVPPLNGPVAAQITTSQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCC
PAGTFSFADIVEKVSPAVVSVKVKKDAGNEQMAMGGDFGGNVPPQIEQFLKRFGFGDGQG
CCCCCHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCC
PMGPGGPGGPGMGPRGGHGPKGERPVVGQGSGFIISADGYVVTNNHVVDGADEVDVTTTD
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEECCCEEEECCEEECCCCCEEEEECC
GKEYQAKVIGTDPRTDVALLKIENVTNLPWVKLADGAPRVGDWVIAVGNPFGLGGTVTAG
CCEEEEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHH
IVSARGRDIGSGPYDDFIQIDAPINRGNSGGPTFSLNGEVIGMNTAIVSPSGGNVGIAFA
HHECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCEEEEEEEEEECCCCCCEEEEEE
IPSETVKTVVAQLRDKGSVARGYIGVQIQPVTEDLASGLGIKDAEGALVAQVQPNTPGAK
CCHHHHHHHHHHHHCCCCEEEEEEEEEEEECHHHHHCCCCCCCCCCCEEEEECCCCCCHH
AGLKAGDVIVKVNNEPIKEARDLTRKVGMMKPGTEIKLSLIRDAKPMDLSLVLDQLPNDQ
CCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCH
VASRSGAPQQGEDDTAGATKDLPRLGLQLAPSKSVQGAGGEGVVVTGVEPNGPAAQRGFK
HHHCCCCCCCCCCCCCCCCCCHHHCCCEECCCCCCCCCCCCCEEEECCCCCCCHHHCCCC
TGDVILKVGDKAVSTPKDVRDGLAAAKADNRKAVLIQVKSGEGVRFVAITLDAKAKG
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEEEECCCCC
>Mature Secondary Structure
MRPPMTRSPMTRSDNTPSVTKRHRKALLAGVVGLALAGVVAGQFVPPLNGPVAAQITTSQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCC
PAGTFSFADIVEKVSPAVVSVKVKKDAGNEQMAMGGDFGGNVPPQIEQFLKRFGFGDGQG
CCCCCHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCC
PMGPGGPGGPGMGPRGGHGPKGERPVVGQGSGFIISADGYVVTNNHVVDGADEVDVTTTD
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEECCCEEEECCEEECCCCCEEEEECC
GKEYQAKVIGTDPRTDVALLKIENVTNLPWVKLADGAPRVGDWVIAVGNPFGLGGTVTAG
CCEEEEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHH
IVSARGRDIGSGPYDDFIQIDAPINRGNSGGPTFSLNGEVIGMNTAIVSPSGGNVGIAFA
HHECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCEEEEEEEEEECCCCCCEEEEEE
IPSETVKTVVAQLRDKGSVARGYIGVQIQPVTEDLASGLGIKDAEGALVAQVQPNTPGAK
CCHHHHHHHHHHHHCCCCEEEEEEEEEEEECHHHHHCCCCCCCCCCCEEEEECCCCCCHH
AGLKAGDVIVKVNNEPIKEARDLTRKVGMMKPGTEIKLSLIRDAKPMDLSLVLDQLPNDQ
CCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCH
VASRSGAPQQGEDDTAGATKDLPRLGLQLAPSKSVQGAGGEGVVVTGVEPNGPAAQRGFK
HHHCCCCCCCCCCCCCCCCCCHHHCCCEECCCCCCCCCCCCCEEEECCCCCCCHHHCCCC
TGDVILKVGDKAVSTPKDVRDGLAAAKADNRKAVLIQVKSGEGVRFVAITLDAKAKG
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]